Amino Acids (AA)

<p>Applications 5-Methyl-2-hexanone is used in the preparation od S1P1 receptor agonists. Also used in the preparation of indoles in an efficient synthesis involving the use of TCT (2,4,6-trichloro-1,3,5-triazine).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bolli, M. et al.: J. Med. Chem., 57, 78 (2014); Siddalingamurthy, E. et al.: Tetrahedron Lett., 54, 5591 (2013);<br></p>

<p>Applications 4'-Chloro-N-methylformanilide (cas# 26772-93-0) is a useful research chemical.<br></p>

<p>Applications 2,5-Dimethyl-3-(2-methylphenyl)-1-propylimidazolini-4-one Hydrochloride is the labelled salt analogue of 2,5-Dimethyl-3-(2-methylphenyl)-1-propylimidazolini-4-one (D477055), an impurity of Prilocaine (Prilocaine Hydrochloride P725000). Prilocaine is a local anesthetic of the amino amide type and is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA) towards the treatment of conditions like paresthesia.<br>References Caliaro, G., et al.: J. Pharm. Biomed. Anal., 26, 427 (2001), Ulmeanu, S., et al.: Pharm. Res., 20, 1317 (2003)<br></p>

<p>Applications 5-Hydroxy-L-lysine is a non-proteinogenic amino acid that can be used in the formation of crosslinks in engineered neocartilage and gelatin.<br>References Makris, Eleftherios A., et al.: FASEB J., 27(6), 2421-2430, 10.1096/fj.12-224030 (2013);Murphy, Meghan K., et al.: J. of the Royal Soc., Interface, 12(103), 20141075/1-20141075/9  (2015);Bozzini, Sabrina, et al.: J. of App. Biomat. &amp; Biomech., 7(3), 194-199 (2009)<br></p>

<p>Applications N-Benzyloxycarbonylglycine thioamide (cas# 49548-40-5) is a useful research chemical.<br></p>

<p>Applications 6-Methyl-5-hepten-2-one-1,1,1,3,3-d5 is an intermediate used in the synthesis of Geraniol-D5 (G367003), which is a deuterium labelled analog of Geraniol, which is used in the synthesis of insect repellant. It is also used in the synthesis of Angelicoin A and Herecinone J, which inhibit collagen-induced platelet aggregation.<br>References Barnard, D. et al.: J. Med. Entomol., 41, 726 (2004); Mori K. et al.: Phytomedicine, 17, 1082 (2010);<br></p>

<p>Applications An intermediate in the synthesis of Erlotinib (E625000).<br></p>

<p>Applications 3-Ethyl-3-methyloxolane-2,5-dione was useful in studying the effect of sugar on liquid-vapor partition of volatile compounds in coffee beverages.<br>References Piccone, P., et al.: J. Mass Spectrom., 47, 1120 (2012)<br></p>

<p>Applications Mirabegron Hydroxylamine-O-Glucuronide is a metabolite of Mirabegron (M364900).<br></p>

<p>Applications 5-Methoxy-1-naphthalenol (cas# 3588-80-5) is a compound useful in organic synthesis.<br></p>

<p>Applications A precursor to 3-Methyl-2-butenyl-1-thiol-d6 which is very prone to oxidation to the disulfide. We will provide a detailed procedure for the preparation of the thiol from the thioacetate with spectral data upon request.<br></p>

<p>Applications 2-Amino-5-methoxypyrimidine (cas# 13418-77-4) is a compound useful in organic synthesis.<br></p>

<p>Applications N-t-Boc-valacyclovir-d8 is an intermediate in the synthesis of Valacyclovir-d8 Hydrochloride, a labeled impurity of Acyclovir (A192400), an orally active acyclic nucleoside with inhibitory activity towards several herpes viruses. Antiviral.<br>References Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979); Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988); Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992)<br></p>