Amino Acids (AA)

Applications 4-(1,3-Benzodioxol-5-yl)-1,4,6,7-tetrahydro-1-methyl-7-oxo-3-phenyl-8H-pyrazolo[3,4-e][1,4]thiazepine-8-acetic Acid

Applications 1-Methoxy-4-(2-nitrovinyl)benzene (cas# 3179-10-0) is a useful research chemical.

Stability Hygroscopic
Applications L-beta-Homoglutamic Acid Hydrochloride

Applications 2-(2,6-Difluoro-4-methoxyphenyl)-2-oxoacetic Acid is a derivative of 3,5-Difluoroanisole (D445395), which is used in the preparation of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 antagonists. Also used in the preparation of imidazo[1,5-a]pyrido[3,2-e]pyrazines and imidazo[1,5-a]quinoxalines as orally active phosphodiesterase 10A inhibitors.
References Procopiou, P.A., et al.: J. Med. Chem., 56, 1946 (2013); Malamas, M.S., et al.: J. Med. Chem., 54, 7621 (2011)

Applications Glyphosate-C2-d2 is an isotopic analog of Glyphosate (G765000) which is used as a herbicide.
References Davis, V., et al.: Weed Sci., 57, 494 (2009), Bellaloui, N., et al.: J. Agric. Food Chem., 57, 9050 (2009),

Applications Nα-Boc-L-histidine is an N-Boc-protected form of L-Histidine (H456010). L-Histidine is an essential amino acid that plays an important role in mitochondrial glutamine transport and has potential of abolishing oxidative stress caused by brain edema.L-Histidine promotes zinc uptake in human erythrocyes and also has potential as an antioxidant therapy for acute mammary inflammation in cattle.
References Chaiyotwittayakun, A., et al.: J. Dairy Sci., 85, 60 (2002); Horn, N., et al.: J. Phys., 489, 73 (1995); Rama Rao, K., et al.: Am. J. Path., 176, 1400 (2010);

Applications N-Methyl 1,2-Dihydro-4,5,6-trimethyoxy-3H-indol-3-one is a derivative of 1,2-Dihydro-4,5,6-trimethoxy-3H-indol-3-one (M303555) which is a derivative of aurone as a potential miccrobicide.
References Chu, W., et al.: U. S., US 6307070 B1 20011023 (2001)

Applications A metabolite of Acrylonitrile (ACN).
References Guengerich, F., et al.: Cancer Res., 41, 4925 (1981), Leonard, A., et al.: Mutation Res., 436, 263 (1999), Stadler, R., et al.: J. Agric. Food Chem., 52, 5550 (2004), Dybing, E., et al.: Food Chem. Toxicol., 43, 365 (2005), Rice, J., et al.: Mutation Res., 580, 3 (2005),

Applications A cysteine derivative as potential antitumor agent. (A609645)A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate. (F680300)
References Paul, B., et al.: J. Med. Chem., et al.: 19, 1002 (1976), Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),

Applications L-Isoleucine methyl ester is a protected form of L-Isoleucine (I820175). L-Isoleucine is classified as an essential amino acid, and is also a tumour promoter of bladder cancer in rats.
References Hatch, T., et al.: Infect. Immun., 12, 211 (1975); Nishio, Y., et al.: Science, 231, 843 (1986)

Applications α-[[[2-(4-Methoxy-3-methylphenyl)-1-methylethyl](phenylmethyl)amino]methyl]-3-nitro-4-(phenylmethoxy)benzenemethanol is an intermediate in the synthesis of (3R,5S)-Fluvastatin.
References Faming Zhuanli Shenqing (2014), CN 103896795 A 20140702.

Stability Store Tightly Sealed at RT
Applications 6-Amino-5-(4-sulfonamidobenzoyl)-N-(methylamino)-1-methyluracil (cas# 149981-39-5) is a compound useful in organic synthesis.
References J. Med. Chem., 38, 2639 (1993); Biochem. Biophys. Res. Commun., 198, 626 (1994)

Applications N-Cbz-L-Leucine is an N-Cbz-protected form of L-Leucine (L330110). L-Leucine is an essential amino acid that induces a sharp decrease in blood glucose levels in individuals with idiopathic familial hypoglycemia, but has no known effects on normal, healthy individuals. L-Leucine also acts as an Isoleucine (I820210) antagonist in the rat, causing delays in growth, and is a potential tumour promoter of bladder cancer.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Fajans, S., et al.: J. Clin. Inv., 42, 216 (1963); Harper, A., et al.: Arch. Biochem. Biophys., 57, 1 (1955); Nishio, Y., et al.: Science, 231, 843 (1986)

Stability Light and Moisture Sensitive
Applications A cross-linking reagent.
References Biltresse, S., et al.: Bioorg. Med. Chem., 12, 5379 (2004), Shimokawa, K., et al.: Bioorg. Med. Chem. Lett., 19, 92 (2009),

Applications Fmoc-Asp(OMe)-OH is a useful research intermediate used in the solid phase synthesis of peptides as selective caspase-3 peptide inhibitors.
References Grimm, Erich L., et al.: Bioorg. Med. Chem., 12, 845 (2004); Vickers, C. J., et al.: J. Am. Chem. Soc., 135, 12869 (2013)

Applications N-Cbz-D-methionine is an N-Cbz-protected form of D-Methionine (M260550). D-Methionine is an isomer of L-Methionine (M260440), and is known to be a cytoprotectant against Cisplatin (C499500), an anticancer agent. D-Methionine is also used to prevent noise- and drug-induced hearing loss, as well as hair loss (all of which may also be caused by Cisplatin or aminoglycosides).
References Campbell, K., et al.: Hear. Res., 92, 103 (2007); Cloven, N., et al.: Antican. Res., 20.6B, 4205 (1999); Vuyyuri, S., et al.: Clin. Cancer Res., 14, 2161 (2008)

Applications D-Isoleucine is not biosynthesized in the human body and is therefore categorized as an essential amino acid that must be obtained through diet. It is also an important building block that is used in the formation of hemoglobin in humans.
References Albanese, A.: J. Biol. Chem., 157, 613 (1945); Martin, R. & Kirk, K.: Blood, 109, 2217 (2007)