Amino Acids (AA)

<p>Applications 3-Methylcrotonic acid is used as a starting material to synthesize 3-Methylcrotonyl-CoA, an intermediate in the metabolism of Leucine.<br>References Anderson, M., et al.: Plant Physiol., 118, 1127 (1998); Hector, M., et al.: Biochemistry, 15, 3465 (1976)<br></p>

<p>Applications 6-Methyl-3-pyridineacetonitrile is a reactant used in the preparation of pyrazolopyrimidine derivatives as agents for treatment of autoimmune diseases and orally active corticotropin-releasing factor receptor antagonists.<br>References Chen, C. et al.: J. Med. Chem., 47, 4787 (2004)<br></p>

<p>Applications N-Cbz-D-alanine is the Cbz-protected form of D-Alanine (A480995). D-Alanine is an amino acid that is commonly found in bacteria, such as Streptococcus faecalis. It is essential for the biosynthesis of peptidoglycan crosslinking sub-units that are used for bacterial cell walls. D-Alanine is also known to cause cytotoxic oxidative stress in brain tumour cells.<br>References Ellsworth, B., et al.: Chem. Biol., 3, 37 (1996); Ferrari, E. et al.: Nat. Biotech., 3, 1003 (1985); Stegman, L., et al.: Human Gene Ther., 9, 185 (1998); Wood, W. &amp; Gunsalus, I.: J. Biol. Chem., 190, 403 (1951)<br></p>

<p>Applications labelled 5-Methyl-3-heptanol.<br></p>

<p>Applications L-Isoleucine methyl ester is a protected form of L-Isoleucine (I820175). L-Isoleucine is classified as an essential amino acid, and is also a tumour promoter of bladder cancer in rats.<br>References Hatch, T., et al.: Infect. Immun., 12, 211 (1975); Nishio, Y., et al.: Science, 231, 843 (1986)<br></p>

<p>Applications N-Carbobenzoxyglycine-13C2,15N is the isotope labelled analog of N-Carbobenzoxyglycine (C175995); a compound used in dipeptide synthesis.<br>References Hans, D., et al.: Med. Chem., 2, 627 (2006); Guzman, F., et al.: J. Biotechnol., 10, 279 (2007); Vlieghe, P., et al.: Drug Discov. Today, 15, 40 (2010)<br></p>

<p>Applications (αR)-5,6-Dihydro-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine is synthetically prepared though a double bond migration in Heck reaction during the preparation of cinacalcet congeners. This enantiomerically pure material is seperated from its counter part, (αR)-7,8-Dihydro-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine (D455330) using HPLC.<br>References Wang, X., et al.: Tetrahedron Lett., 45, 8355 (2004)<br></p>

<p>Applications S)-β-Phenylalanine is a key building block used as an intermediate in the synthesis of pharmaceuticals.<br>References Hisashi, K., et al.: Biosci, Biotechnol,Biochem, 70, 99 (2006);<br></p>