Amino Acids (AA)

Applications N-Fmoc-D-methionine is an N-Fmoc-protected form of D-Methionine (M260550). D-Methionine is an isomer of L-Methionine (M260440), and is known to be a cytoprotectant against Cisplatin (C499500), an anticancer agent. D-Methionine is also used to prevent noise- and drug-induced hearing loss, as well as hair loss (all of which may also be caused by Cisplatin or aminoglycosides).
References Campbell, K., et al.: Hear. Res., 92, 103 (2007); Cloven, N., et al.: Antican. Res., 20.6B, 4205 (1999); Vuyyuri, S., et al.: Clin. Cancer Res., 14, 2161 (2008)

Applications D-Lysine Methyl Ester is a protected form of D-Lysine (L468930). D-Lysine is the unnatural isomer of L-Lysine (L468895) that has the ability to reduce non-enzymatic glycation in vitro. D-Lysine also exists as polypeptide chains of poly-D-lysine, a nonspecific adhesion-promoting molecule that has the potential to be a polymeric drug carrier.
References Chen, Q. et al.: J. Biol. Chem., 269, 26602 (1994); Sensi, M., et al.: Diabetologia, 36, 797 (1993); Vermeersch, H. & Remon, J.: J. Control. Rel., 32, 225 (1994)

Applications N-Cbz-L-aspartic acid is an N-Cbz-protected form of L-Aspartic acid (A790024). L-Aspartic acid is a nonessential amino acid that is used to biosynthesize other amino acids within the human body. L-Aspartic acid also increases membrane conductance of mammalian neurons by voltage-dependent means, causing depolarization and nerve impulses that travel to key areas of the central nervous system.
References Anderson, H., et al.: J. Nutr., 99, 82 (1969); Honey, C., et al.: Neurosci. Lett., 61, 135 (1985); MacDonald, J., et al.: Brain Res., 237, 248 (1982)

Applications L-tert-Leucine acts as a catalyst for the enantioselective oxidative coupling and cyclization of benzophenathrenols to oxa[9]helicenes.
References Sako, M., et al.: J. Amer. Chem. Society., 138, 11481-11484 (2016)

Applications (S)-adamantylglycine is used to prepare saxagliptin (BMS-477118) as highly potent and long-acting and orally active dipeptidyl peptidase IV inhibitor for treatment of type 2 diabetes.
References Augeri, D., et al.: J. Med. Chem., 48, 5025 (2005)

Applications 2-(4-Benzyloxy-2-methoxyphenoxy)ethylamine (cas# 887353-05-1) is a compound useful in organic synthesis.

Stability Temperature Senstive
Applications D,L-3-Indolylglycine (cas# 6747-15-5) is a compound useful in organic synthesis.
References J. Chem. Soc., 458 (1940)

Applications D-Cysteine Methyl Ester is a protected form of D-Cysteine (C995020) which is a strong inhibitor of Escherichia coli growth and also functions to provide inorganic sulfates for the sulfation of xenobiotics. D-Cysteine is a non-physiological isomer of L-Cysteine (C995000), and is not involved in protein or glutathione synthesis.
References Glazenburg, E., et al.: Biochem. Pharm., 33, 625 (1984); Klassen, C. & Boles, J.: FASEB J., 11, 404 (1997); Soutourina, J., et al.: J. Biol. Chem., 276, 40864 (2001)

Applications Intermediate in the preparation of labelled Trimebutine metabolites.

Applications 2-(1-Methylpiperidin-3-yl)ethan-1-ol (cas# 101257-32-3) is a useful reagent for preparing 3-(ω-hydroxyalkyl)-substituted N-methylpiperdines and N-methyl-2-piperidones.
References Schneider, W., et al.: Archiv der Pharmazie., 300, 540 (1967)

Applications L-Valine Benzyl Ester is a L-Valine derivative useful as intermediate for the preparation of peptides.
References Kimura, S., et al.: Int. J. Biol. Macromolec., 3, 225 (1981),

Applications Isotope labelled D-Proline (P755990), which is used in the synthesis of (R)-(+)-N-Boc-Pipecolic Acid, (S)-(-)-Coniine, (S)-(+)-Pelletierine, (+)-.beta.-Conhydrine, and (S)-(-)-Ropivacaine and formal synthesis of (-)-Lasubine II and (+)-Cermizine C.
References Gawley, R., et al.: Org. Biomol. Chem., 4, 4285 (2006),