Amino Acids (AA)

<p>7-[5-(Fluoro-methyl-phosphoryl)oxypentyl]-4-nitro-2,1,3-benzoxadiazole is a reactivator of the central nervous system. It is a noncompetitive antagonist at muscarinic receptors and blocks postsynaptic acetylcholine release from cholinergic neurons. It has been shown to have no effect on blood pressure but does cause an increase in locomotor activity in animals. This drug binds to the hippocampal formation and the ventral hippocampus, which are areas of the brain that are involved in memory and spatial navigation. The distribution of this drug postulated to be due to its ability to penetrate micron sized openings in cell membranes.</p>

<p>(Fluoro-Methylphosphoryl)Oxycyclohexane is an organophosphorus compound that acts as a nerve agent. It inhibits the enzyme acetylcholinesterase, which is responsible for breaking down acetylcholine, leading to excess cholinergic stimulation. This can cause excessive contraction of muscles or even death. The exposure to (Fluoro-Methylphosphoryl)Oxycyclohexane can be detected by analytical methods such as gas chromatography/mass spectrometry. Oximes are used in the reactivation of acetylcholinesterase and are effective in preventing neuronal death. They bind to the phosphonyl group in (Fluoro-Methylphosphoryl)Oxycyclohexane and prevent it from inhibiting the enzyme acetylcholinesterase.</p>

<p>1-(3,4-Methylenedioxyphenyl) 2-nitropropene (1-MPNP) is a phosphatase inhibitor that is active against gram-negative bacteria by inhibiting enterotoxins and chlamydia. 1-MPNP inhibits the activity of tyrosine phosphatases, which are enzymes that play a major role in bacterial virulence. 1-MPNP competitively inhibits the activity of tyrosine phosphatases and prevents them from catalyzing the hydrolysis of polyphosphate substrates. This inhibition leads to an accumulation of polyphosphates in the bacterial cell membrane, which disrupts its permeability and leads to cell death.</p>

<p>L-Methionine is a non-essential amino acid that belongs to the group of essential amino acids. It is a major constituent of proteins and is used in the metabolism of lipids, carbohydrates, and nucleic acids. Methionine is also involved in the synthesis of cysteine, which is an important antioxidant. L-Methionine can be found in many foods such as eggs, dairy products, fish, poultry, soybean products, peanuts, beans and seeds. Studies have shown that L-methionine has effects on liver function and may be useful for prevention or treatment of liver disorders such as primary sclerosing cholangitis (PSC). This compound also plays a role in the formation of body tissues and cells. L-Methionine has been shown to increase glutathione levels which are important for detoxification reactions and protection against oxidative stress. It also helps regulate calcium metabolism by reducing calcium absorption from food and increasing excretion via</p>

<p>2-Amino-3-methylpyridine is a colorless crystalline compound. It has the molecular formula of CHN and a molecular weight of 115.2 g/mol. 2-Amino-3-methylpyridine has an asymmetric carbon atom, so it is chiral and can be found in two different forms, enantiomers. The intermolecular hydrogen bond between nitrogen atoms is responsible for the high melting point of -40°C. The coordination geometry of group P2 is pyramidal with the nitrogen atom at the apex and two hydrogen atoms bonded to each other on either side of the nitrogen atom at 120° angles. X ray crystal structures have shown that 2-amino-3-methylpyridine exists as a molecule with an acylation reaction mechanism and intramolecular hydrogen bonding. Methanol solvent was used in this study to dissolve 2 amino 3 methyl pyridine because it does not react with copper chloride</p>

<p>(1R,2S,3S,5S)-3-(4-Iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylicacid methyl ester is a molecule that has been shown to be effective in lowering the symptoms of Parkinson's disease. It also prevents the uptake of dopamine and serotonin in the brain by binding to dopamine and serotonin transporters on the cell membrane. This drug has been shown to be safe at doses up to 100 mg/kg/day in rats, but has not been tested in humans. The drug is stable in neutral pH environments and does not degrade upon exposure to light or oxygen.</p>

<p>N,N'-Di-boc-(L)-cystine-dimethyl ester is a fine chemical that can be used as a versatile building block. It is a complex compound with CAS No. 77826-55-2 and can be used as a reagent or speciality chemical in research. This chemical is also useful for the synthesis of various compounds and has been proven to be an excellent scaffold for chemical reactions.</p>

<p>5-Methylindole-3-acetic acid (5MI3A) is a molecule that has been shown to have antiproliferative properties in bladder cancer cells. 5MI3A binds to the receptor for GABA, which is an inhibitory neurotransmitter. It also inhibits the production of proinflammatory mediators and reactive oxygen species in cancer cells. 5MI3A has anticancer activity in prostate cancer cells and may act by inducing apoptosis and inhibiting cell proliferation. Consumption of 5MI3A may reduce the risk of cancer development by preventing DNA damage from carcinogens, suppressing inflammation, and regulating cell growth through its antagonistic properties.</p>

<p>Antimicrobial cationic peptide; used for microscopy glass slides coating</p>

<p>Applications 3-Acetylthio-2-methylpropanoic Acid-d5 (cas# 1189969-31-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Hydroxy-7-methoxy-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one-d3 is an intermediate for the synthesis of Alternariol Monomethyl Ether-d3 (A575771), labelled methyl este analog fo Alternariol. An alternaria mycotoxin and genotoxin, found in common edible crops. It inhibits the activity of various DNA-topoisomerases, increasing the rate of DNA strand breaks.<br>References Asam, S., et al.: J. Agric. Food Chem., 57, 5152 (2009); Fehr, M., et al.: Mol. Nut. Food Res., 53, 441 (2009); Tiemann, U., et al.: Toxicol. Lett., 186, 139 (2009)<br></p>

<p>Applications (Z)-Ethyl 2-((2S,4R,5S)-4,5-Dihydroxy-2-methoxydihydro-2H-pyran-3(4H)-ylidene)acetate-13C3 is a by-product intermediate in synthesizing Patulin-13C3 (P206502), a labelled Patulin (PAT). It is a mycotoxin produced by certain species of Penicillium, Aspergillus, and Byssochlamys, is mainly found in ripe apple and apple products. Patulin-induced genotoxicity and modulation of glutathione in Hep G2 cells. Antibiotic.<br>References Scott, P., et al.: J. Agric. Food Chem., 20, 450 (1972); Aden, D., et al.: Nature, 282, 615 (1979); Surralles, J., et al.: Mutat. Res., 341, 169 (1995); Alves, I., et al.: Mutagenesis, 15, 229 (2000); Liu, B., et al.: Toxicol. Appl. Pharmacol., 191, 255 (2003)<br></p>

<p>Applications Tetrahydro-5-methyl-2-furanol 2-Benzoate is an intermediate in synthesizing 2,3-Dihydro-2-methylfuran (D447355), which is a general reagent used in next generation of biofuels. Dihydrofuranyl derivative.<br>References Simmie, J. et al.: J. Phys Chem., 116, 4528 (2012);<br></p>

<p>4-Chloro-2-methylbenzoic acid is a high quality chemical that is used as an intermediate in the preparation of other compounds. It belongs to the group of complex compounds and has CAS No. 7499-07-2. This reagent can be used to synthesize speciality chemicals, research chemicals, and versatile building blocks. 4-Chloro-2-methylbenzoic acid is also useful as a reaction component for the synthesis of fine chemicals, pharmaceuticals, and agrochemicals.</p>