Amino Acids (AA)

<p>(1R,2S,3S,5S)-3-(4-Iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylicacid methyl ester is a molecule that has been shown to be effective in lowering the symptoms of Parkinson's disease. It also prevents the uptake of dopamine and serotonin in the brain by binding to dopamine and serotonin transporters on the cell membrane. This drug has been shown to be safe at doses up to 100 mg/kg/day in rats, but has not been tested in humans. The drug is stable in neutral pH environments and does not degrade upon exposure to light or oxygen.</p>

<p>Poly epsilon L-lysine HCl is a water soluble, biodegradable, cationic peptide that can be produced via fermentation by Streptomyces albulus. It shows a wide range of antimicrobial activity against microorganisms such as bacteria, yeasts and molds and is stable at high temperatures and under both acidic and alkaline conditions. This non-toxic poly-L-lysine is commonly used as a supplement or preservative in various food, beverage and cosmetics products. It can also be used for microscopy glass slides coating.</p>

<p>5-Methylindole-3-acetic acid (5MI3A) is a molecule that has been shown to have antiproliferative properties in bladder cancer cells. 5MI3A binds to the receptor for GABA, which is an inhibitory neurotransmitter. It also inhibits the production of proinflammatory mediators and reactive oxygen species in cancer cells. 5MI3A has anticancer activity in prostate cancer cells and may act by inducing apoptosis and inhibiting cell proliferation. Consumption of 5MI3A may reduce the risk of cancer development by preventing DNA damage from carcinogens, suppressing inflammation, and regulating cell growth through its antagonistic properties.</p>

<p>DL-Proline is a biological molecule that has been shown to bind to the DNA binding domains of proteins. This binding can be seen with the crystal structures of DL-proline and protein. The reaction mechanism for DL-proline is as follows:<br><br>DL-Proline + Protein → Proline + Protein<br><br>The equilibrium constant for this reaction is 1.0 at 298 K. The pKa value for the amide group in DL-proline is 4.8, which means that it will react with water and form an amine group at physiological pH levels. DL-Proline has been shown to have metabolic disorders.</p>

<p>3,4-Methylenedioxy propiophenone is a synthetic compound with a fatty acid chain. It has been shown to have potent activity against leishmania and has been used as an intermediate in the synthesis of other drugs. 3,4-Methylenedioxy propiophenone can be synthesized by acylation reactions with chloride and acetylcholinesterase inhibition. This product also has molecular docking properties, which have been analyzed using computational methods, such as profiling and profile analysis.</p>

<p>2-Methoxy 17b-estradiol is a synthetic estrogen that binds to DNA and alters the transcriptional process. It has been shown to induce apoptosis by activating the pro-apoptotic protein Bax and inhibiting the anti-apoptotic protein Bcl-2. This drug inhibits the metabolic response of cancer cells to chemotherapy, leading to a decrease in tumor size, and can be used as an implantable device for treating cancer. 2-Methoxy 17b-estradiol also has minimal toxicity in comparison to other estrogens, with no significant cytotoxicity observed in cells of reproductive tissues or endocrine organs, nor any significant toxic effects on liver function tests or serum lipids.</p>

<p>Gly-Asp-OH is a medicine that has proliferative activity. It is also an immunoregulatory and biologically active substance, which suppresses the production of cytokines IL-10 in mononuclear cells. Gly-Asp-OH is a synthetic compound with medicinal properties. The structure of this compound was elucidated by chemical analysis and spectroscopic methods. It can be used as an anti-inflammatory agent or to prevent cell death induced by necrosis or apoptosis.</p>

<p>1-[4-Methyl-6-(trifluoromethyl)pyrimidin-2-yl]piperidine-3-carboxylic acid is a reagent that is used as a complex compound, as a useful intermediate, and as a fine chemical. It has been used in the manufacture of pharmaceuticals, agrochemicals, dyes, and pigments. It also has many applications in research such as its use as a building block for organic synthesis or to synthesize other compounds with potential uses in medicine.</p>

<p>(Fluoro-Methylphosphoryl)Oxycyclohexane is an organophosphorus compound that acts as a nerve agent. It inhibits the enzyme acetylcholinesterase, which is responsible for breaking down acetylcholine, leading to excess cholinergic stimulation. This can cause excessive contraction of muscles or even death. The exposure to (Fluoro-Methylphosphoryl)Oxycyclohexane can be detected by analytical methods such as gas chromatography/mass spectrometry. Oximes are used in the reactivation of acetylcholinesterase and are effective in preventing neuronal death. They bind to the phosphonyl group in (Fluoro-Methylphosphoryl)Oxycyclohexane and prevent it from inhibiting the enzyme acetylcholinesterase.</p>

<p>Applications Tetrahydro-5-methyl-2-furanol 2-Benzoate is an intermediate in synthesizing 2,3-Dihydro-2-methylfuran (D447355), which is a general reagent used in next generation of biofuels. Dihydrofuranyl derivative.<br>References Simmie, J. et al.: J. Phys Chem., 116, 4528 (2012);<br></p>

<p>Applications 5-Hydroxy-7-methoxy-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one-d3 is an intermediate for the synthesis of Alternariol Monomethyl Ether-d3 (A575771), labelled methyl este analog fo Alternariol. An alternaria mycotoxin and genotoxin, found in common edible crops. It inhibits the activity of various DNA-topoisomerases, increasing the rate of DNA strand breaks.<br>References Asam, S., et al.: J. Agric. Food Chem., 57, 5152 (2009); Fehr, M., et al.: Mol. Nut. Food Res., 53, 441 (2009); Tiemann, U., et al.: Toxicol. Lett., 186, 139 (2009)<br></p>

<p>Applications (Z)-Ethyl 2-((2S,4R,5S)-4,5-Dihydroxy-2-methoxydihydro-2H-pyran-3(4H)-ylidene)acetate-13C3 is a by-product intermediate in synthesizing Patulin-13C3 (P206502), a labelled Patulin (PAT). It is a mycotoxin produced by certain species of Penicillium, Aspergillus, and Byssochlamys, is mainly found in ripe apple and apple products. Patulin-induced genotoxicity and modulation of glutathione in Hep G2 cells. Antibiotic.<br>References Scott, P., et al.: J. Agric. Food Chem., 20, 450 (1972); Aden, D., et al.: Nature, 282, 615 (1979); Surralles, J., et al.: Mutat. Res., 341, 169 (1995); Alves, I., et al.: Mutagenesis, 15, 229 (2000); Liu, B., et al.: Toxicol. Appl. Pharmacol., 191, 255 (2003)<br></p>

<p>Applications 3-Acetylthio-2-methylpropanoic Acid-d5 (cas# 1189969-31-0) is a compound useful in organic synthesis.<br></p>

<p>4-Chloro-2-methylbenzoic acid is a high quality chemical that is used as an intermediate in the preparation of other compounds. It belongs to the group of complex compounds and has CAS No. 7499-07-2. This reagent can be used to synthesize speciality chemicals, research chemicals, and versatile building blocks. 4-Chloro-2-methylbenzoic acid is also useful as a reaction component for the synthesis of fine chemicals, pharmaceuticals, and agrochemicals.</p>