Amino Acids (AA)

<p>H-Leu-Pro-Pro-OH is a synthetic tripeptide that has been shown to increase endothelial function in humans. The peptide is thought to work by increasing nitric oxide production and by inhibiting angiotensin II production. H-Leu-Pro-Pro-OH also reportedly increases uptake of glucose in the intestine and decreases blood pressure. In placebo-controlled, crossover studies, H-Leu-Pro-Pro-OH increased plasma concentrations of angiotensin I and II, suggesting that it may be a potent inhibitor of angiotensin converting enzyme (ACE).</p>

<p>Endothelin-1 (ET-1) is a peptide that is produced by the endothelium. ET-1 is involved in numerous biological processes, including vasoconstriction, inflammation, and cell proliferation. Endothelin-1 (human ET-1) acetate salt H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-(Glu)-Cys-(Val)-Tyr-(Phe)-Cys-(His)-Leu -Asp(-Ile)-Ile(-Trp)) acetate salt is a recombinant protein that has been shown to significantly upregulate the production of endothelin in primary pulmonary hypertension. It also plays an important role in bowel disease, where it may be involved in the development of chronic inflammatory bowel disease.</p>