CAS 113507-06-5

Moxidectin

Beschreibung:

Moxidectin ist eine semi-synthetische makrocyclische Lacton, die zur Klasse der Verbindungen gehört, die als Avermectine bekannt sind, die aus der Fermentation des Bakteriums Streptomyces avermitilis gewonnen werden. Es wird hauptsächlich als antiparasitäres Mittel verwendet, insbesondere in der Tiermedizin, zur Behandlung verschiedener parasitärer Infektionen bei Tieren, einschließlich Nematoden und Ektoparasiten. Moxidectin zeigt ein breites Wirkungsspektrum und ist bekannt für seine lange Wirkungsdauer, die eine weniger häufige Dosierung im Vergleich zu anderen antiparasitären Mitteln ermöglicht. Die Verbindung wirkt, indem sie an glutamatgesteuerte Chloridkanäle im Nervensystem der Parasiten bindet, was zur Lähmung und zum Tod des Organismus führt. Moxidectin wird typischerweise oral oder durch Injektion verabreicht, und seine Pharmakokinetik ist durch eine gute Absorption und Verteilung in den Geweben gekennzeichnet. Es ist wichtig zu beachten, dass Moxidectin zwar gegen viele Parasiten wirksam ist, jedoch nicht gegen alle, und seine Anwendung sollte durch veterinärmedizinische Empfehlungen geleitet werden, um Sicherheit und Wirksamkeit zu gewährleisten.

Formel: C₃₇H₅₃NO₈

InChl: InChI=1/C37H53NO8/c1-21(2)14-25(6)33-26(7)31(38-42-8)19-36(46-33)18-29-17-28(45-36)13-12-23(4)15-22(3)10-9-11-27-20-43-34-32(39)24(5)16-30(35(40)44-29)37(27,34)41/h9-12,14,16,21-22,26,28-30,32-34,39,41H,13,15,17-20H2,1-8H3/b10-9+,23-12+,25-14+,27-11+,38-31-/t22-,26-,28+,29-,30-,32+,33+,34+,36-,37+/m0/s1

InChI Key: InChIKey=YZBLFMPOMVTDJY-LSGXYNIPSA-N

SMILES: C(=C\C(C)C)(\C)/[C@H]1O[C@@]2(C[C@@]3(C[C@](O2)(C/C=C(\C)/C[C@@H](C)/C=C/C=C\4/[C@@]5(O)[C@](C(=O)O3)(C=C(C)[C@@H](O)[C@]5(OC4)[H])[H])[H])[H])C/C(=N\OC)/[C@@H]1C

Synonyme:

• (2aE,4E,4'E,5'S,6R,8E,11R,13R,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-4'-(methoxyimino)-5',6,8,19-tetramethyl-6'-[(2E)-4-methylpent-2-en-2-yl]-3',4',5',6,6',7,10,11,14,15,17a,20,20a,20b-tetradecahydro-2H,17H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-17-one
• (6R,23E,25S)-5-O-Demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-(methoxyimino)milbemycin B
• 23-Methoxime-LL-F 28249α
• 5-O-demethyl-28-deoxy-25-(1E)-1,3-dimethyl-1-butenyl-6,28-epoxy-23-(methoxyimino)-, (6R,23E,25S)-
• Cl 301423
• Cydectin
• Equest
• Milbemycin B, 5-O-demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)-6,28-epoxy-23-(methoxyimino)-, [6R,23E,25S(E)]-
• Milbemycin B, 5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-(methoxyimino)-, (6R,23E,25S)-
• Milbemycin B, 5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-butenyl]-6,28-epoxy-23-(methoxyimino)-, (6R,23E,25S)-
• MilbemycinB
• Moxidextin
• ProHeart 6
• Proheart
• Quest
• Quest (parasiticide)
• Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran], milbemycin B deriv.
• Vetdectin Oral Drench
• Moxidectin@100 μg/mL in Acetonitrile
• [6R,23E,25S(E)]-5-O-DeMethyl-28-deoxy-25-(1,3-diMethyl-1-butenyl)-6,28-epoxy-23-(MethoxyiMino)MilbeMycin B
• Moxidectin powder CAS 113507-06-5 fiona
• Moxidectin Solution, 100ppm
• Moxidectin CRS
• Moxidectin
• (1R,4S,4'E,5'S,6R,6'S,8R,10E,13R,14E,16E,20R,21R,24S)-21,24-dihydroxy-4'-methoxyimino-5',11,13,22-tetramethyl-6'-[(E)-4-methylpent-2-en-2-yl]spiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one
• milbemycin B
• Moxidectin, >=98%
• (2R,2a'E,2a1'S,4Z,4'E,5S,6S,6'R,8'E,11'R,15'S,17a'R,20'R,20a'R)-2a1',20'-Dihydroxy-4-(methoxyimino)-5,6',8',19'-tetramethyl-6-((E)-4-methylpent-2-en-2-yl)-2a1',3,4,5,6,6',7',10',11',14',15',17a',20',20a'-tetradecahydro-2'H,17'H-spiro[pyran-2,13'-[11,15]methano[1,5]dioxacyclooctadecino[9,8,7-cd]benzofuran]-17'-one
• Milbemycin B,
• Moxidectin for system suitability CRS
• Milbemycin B,5-O-demethyl-28-deoxy-25-(1,3-dimethyl-1-buten-1-yl)-6,28-epoxy-23-(methoxyimino)-,(6R,23E,25S)-
• Moxidectin,MilbeMycin B,23-MethoxiMe-LL-F 28249α,Equest,ProHeart 6
• Moxidectin Solution in Methanol, 100μg/mL
• Moxdectin
• (6R,23E,25S)-5-O-DeMethyl-28-deoxy-25-[(1E)-1,3-diMethyl-1-buten-1-yl]-6,28-epoxy-23-(MethoxyiMino)
• Moxidectin HOUSE STANDARD

Moxidectin

CAS: 113507-06-5

Formel: C₃₇H₅₃NO₈

Reinheit: >98.0%(N)

Farbe und Form: White to Almost white powder to crystal

Molekulargewicht: 639.83

Ref: 3B-M3136

Moxidectin

CAS: 113507-06-5

Moxidectin

Formel: C₃₇H₅₃NO₈

Reinheit: 94.2%

Farbe und Form: Off-White

Molekulargewicht: 639.37712

Ref: 47-1109

MOXIDECTIN FOR SYSTEM SUITABILITY CRS

CAS: 113507-06-5

MOXIDECTIN FOR SYSTEM SUITABILITY CRS

Formel: C₃₇H₅₃NO₈

Farbe und Form: Powder

Molekulargewicht: 639.8186

Ref: 41-Y0000747

MOXIDECTIN CRS

CAS: 113507-06-5

MOXIDECTIN CRS

Formel: C₃₇H₅₃NO₈

Farbe und Form: Added

Molekulargewicht: 639.8186

Ref: 41-Y0000772

Moxidectin

CAS: 113507-06-5

Lactones, nesoi

Formel: C₃₇H₅₃NO₈

Farbe und Form: White Powder

Molekulargewicht: 639.37712

Ref: 45-1448559

Moxidectin

CAS: 113507-06-5

Moxidectin

Formel: C₃₇H₅₃NO₈

Reinheit: 98%

Molekulargewicht: 639.82

Ref: 54-OR1030356

Milbemycin B,5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-butenyl]-6,28-epoxy-23-(methoxyimino)-, (6R,23E,25S)-

CAS: 113507-06-5

Formel: C₃₇H₅₃NO₈

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 639.8186

Ref: IN-DA00HCQ4

Moxidectin

CAS: 113507-06-5

Moxidectin (CL301423) is an anthelmintic for heartworm/intestinal worms in dogs, cats, horses, cattle, and sheep; oral/topical/injectable.

Formel: C₃₇H₅₃NO₈

Reinheit: 97.38%

Farbe und Form: White Solid

Molekulargewicht: 639.82

Ref: TM-T1157

Moxidectin

CAS: 113507-06-5

Moxidectin

Formel: C₃₇H₅₃NO₈

Reinheit: ≥95%

Molekulargewicht: 639.82

Ref: 54-BUP13574

Moxidectin-d3

CAS: 113507-06-5

Formel: C₃₇H₅₀D₃NO₈

Molekulargewicht: 642.85

Ref: 4Z-M-591

Moxidectin

CAS: 113507-06-5

Formel: C₃₇H₅₃NO₈

Reinheit: ≥ 95.0%

Farbe und Form: White to off-white or yellow powder

Molekulargewicht: 639.82

Ref: 7W-GW5324

Moxidectin

CAS: 113507-06-5

Formel: C₃₇H₅₃NO₈

Farbe und Form: White To Off-White Solid

Molekulargewicht: 639.84

Ref: 4Z-M-592

Moxidectin

Kontrolliertes Produkt

CAS: 113507-06-5

Formel: C₃₇H₅₃NO₈

Farbe und Form: Neat

Molekulargewicht: 639.82

Ref: 04-CA15335000

PharmaVetResiMix 1 Avermectins-v6 10 µg/mL in Methanol

Kontrolliertes Produkt

CAS: 113507-06-5, 117704-25-3, 123997-26-2, 155569-91-8, 70288-86-7, 71751-41-2

Farbe und Form: Mixture

Ref: 04-A30000031ME

Moxidectin 100 µg/mL in Acetonitrile

CAS: 113507-06-5

Formel: C₃₇H₅₃NO₈

Farbe und Form: Single Solution

Molekulargewicht: 639.82

Ref: 04-A15335000AL-100

Moxidectin

CAS: 113507-06-5

(2R,2a'E,2a1'S,4Z,4'E,5S,6S,6'R,8'E,11'R,15'S,17a'R,20'R,20a'R)-2a1',20'-Dihydroxy-4-(methoxyimino)-5,6',8',19'-tetramethyl-6-((E)-4-methylpent-2-en-2-yl)-2a1',3,4,5,6,6',7',10',11',14',15',17a',20',20a'-tetradecahydro-2'H,17'H-spiro[pyran-2,13'-[11,15]methano[1,5]dioxacyclooctadecino[9,8,7-cd]benzofuran]-17'-one

Formel: C₃₇H₅₃NO₈

Reinheit: 98%

Molekulargewicht: 639.82

Ref: IN-DG140452

Moxidectin

CAS: 113507-06-5

Applications Moxidectin is a macrocyclic lactone and semisynthetic derivative of nemadectin. Moxidectin is a parasiticide used for the prevention and control of heartworm and intestinal worms. Moxidectin is found in veterinary medicine used to treat animals such as dogs, cats, horses, cattle and sheep.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bisset, S.A. et al.: New Zeal. Vet. J., 40, 97 (1992); Monahan, C.M. et al.: Vet. Parasitol., 63, 225 (1996); Glickman, L.T. et al.: Int. J. Appl. Res. Vet. Med., 3, 49 (2005);

Formel: C₃₇H₅₃NO₈

Farbe und Form: Neat

Molekulargewicht: 639.82

Ref: TR-M744800

Moxidectin EP H

Kontrolliertes Produkt

CAS: 113507-06-5

Applications Moxidectin EP H is an impurity of Moxidectin which is a macrocyclic lactone and semisynthetic derivative of nemadectin. Moxidectin is a parasiticide used for the prevention and control of heartworm and intestinal worms. Moxidectin is found in veterinary medicine used to treat animals such as dogs, cats, horses, cattle and sheep.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bisset, S.A. et al.: New Zeal. Vet. J., 40, 97 (1992); Monahan, C.M. et al.: Vet. Parasitol., 63, 225 (1996); Glickman, L.T. et al.: Int. J. Appl. Res. Vet. Med., 3, 49 (2005);

Formel: C₃₇H₅₁NO₇

Farbe und Form: Neat

Molekulargewicht: 621.8

Ref: TR-M744815

Moxidectin-d3

Kontrolliertes Produkt

CAS: 113507-06-5

Stability Light Sensitive
Applications Moxidectin-d3 is a the labelled form of Moxidectin (M744800). Moxidectin is a macrocyclic lactone and semisynthetic derivative of nemadectin. Moxidectin is a parasiticide used for the prevention and control of heartworm and intestinal worms. Moxidectin is found in veterinary medicine used to treat animals such as dogs, cats, horses, cattle and sheep.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bisset, S.A. et al.: New Zeal. Vet. J., 40, 97 (1992); Monahan, C.M. et al.: Vet. Parasitol., 63, 225 (1996); Glickman, L.T. et al.: Int. J. Appl. Res. Vet. Med., 3, 49 (2005)

Formel: C₃₇H₅₀D₃NO₈

Farbe und Form: Neat

Molekulargewicht: 642.84

Ref: TR-M744802

Moxidectin

CAS: 113507-06-5

Moxidectin is a milbemycin derivative that belongs to the class of macrocyclic lactones. It is used in veterinary medicine to treat infections caused by Diptera larvae, such as the sheep blowfly, Lucilia sericata. Moxidectin has been shown to be an effective drug against c. glabrata, which is resistant to ivermectin and other drugs. Moxidectin binds to P-glycoprotein substrate site 1 and prevents drug efflux from cells by competing with other substrates for binding sites on the transporter. This inhibition of drug efflux may be due to its ability to block P-glycoprotein function or act as a direct inhibitor of ATPase activity. The analytical method used in this study was high performance liquid chromatography (HPLC).

Formel: C₃₇H₅₃NO₈

Reinheit: Min. 92 Area-%

Farbe und Form: White Powder

Molekulargewicht: 639.82 g/mol

Ref: 3D-FM31082