FAK
Los inhibidores de la quinasa de adhesión focal (FAK) se dirigen a la FAK, una quinasa involucrada en la adhesión celular, la migración y la angiogénesis. La FAK está frecuentemente sobreexpresada en los tumores y contribuye a la formación de nuevos vasos sanguíneos que suministran nutrientes al tumor. Inhibir la FAK puede interrumpir estos procesos, lo que convierte a los inhibidores de la FAK en herramientas valiosas en la terapia contra el cáncer y la investigación de la angiogénesis. En CymitQuimica, ofrecemos una gama completa de inhibidores de FAK de alta calidad para apoyar su investigación en biología celular, cáncer y angiogénesis.
Se han encontrado 72 productos de "FAK"
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GSK215
CAS:<p>GSK215: potent, selective PROTAC degrader of FAK (pDC50=8.4), combines FAK inhibitor VS-4718 and VHL E3 ligase binder, causes fast, lasting FAK degradation.</p>Fórmula:C50H59F3N10O6SPureza:99.3%Forma y color:SoildPeso molecular:985.13VnP-16
<p>VnP-16 enhances bone formation by stimulating the differentiation and activity of osteoblasts via direct β1 integrin engagement, which subsequently activates</p>Fórmula:C82H112N20O17Pureza:98%Forma y color:SolidPeso molecular:1649.89FAK-IN-10
CAS:<p>FAK-IN-10 is an inhibitor of FAK (IC50:76.3 μM).FAK-IN-10 z MCF-7 and A431 cell lines showed antitumor activity with IC50 of 4.23 and 0.78 μM, respectively.</p>Fórmula:C15H10BrN3O2SPureza:99.78%Forma y color:SoildPeso molecular:376.23FAK-IN-27
<p>FAK-IN-27 (compound 8A) is a potent and selective inhibitor of FAK, with an IC50 of 4.968 nM. It effectively inhibits the proliferation of H1299 cells, with an IC50 of 0.28 μM, and is applicable for research in non-small cell lung cancer (NSCLC).</p>Fórmula:C32H28ClN5O6Forma y color:SolidPeso molecular:613.17281Anti-PTK2 Antibody (4T687)
<p>Anti-PTK2 Antibody (4T687) is an antibody targeting PTK2. Anti-PTK2 Antibody (4T687) can be used in ELISA, IHC.</p>Forma y color:Odour LiquidConteltinib tetrahydrochloride
<p>Conteltinibtetrahydrochloride (CT-707 tetrahydrochloride) is the tetrahydrochloride form of Conteltinib. It acts as an inhibitor for FAK (IC50=1.6 nM), ALK, and Pyk2. When used in combination with Cabozantinib, Conteltinib tetrahydrochloride exhibits a synergistic antitumor effect.</p>Fórmula:C32H49Cl4N9O3SForma y color:SolidPeso molecular:781.667BI-3663
CAS:<p>BI-3663 is a selective PTK2/FAK PROTAC with cereblon ligands, degrading PTK2 (IC50: 18 nM), and shows anti-cancer properties.</p>Fórmula:C44H42F3N7O12Pureza:98%Forma y color:SolidPeso molecular:917.84Y15
CAS:<p>Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity,</p>Fórmula:C6H14Cl4N4Pureza:98% - 99.32%Forma y color:Dark Brown CrystalsPeso molecular:284.01SU6656
CAS:<p>SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.</p>Fórmula:C19H21N3O3SPureza:98.21% - 98.73%Forma y color:SolidPeso molecular:371.45Masitinib
CAS:<p>Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs.</p>Fórmula:C28H30N6OSPureza:97.56% - >99.99%Forma y color:SolidPeso molecular:498.64GSK2256098
CAS:<p>GSK2256098 (GTPL7939) is a small molecule FAK kinase inhibitor.</p>Fórmula:C20H23ClN6O2Pureza:99.46% - 99.74%Forma y color:SolidPeso molecular:414.89PF-431396
CAS:<p>PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).</p>Fórmula:C22H21F3N6O3SPureza:98.83% - 99.82%Forma y color:SolidPeso molecular:506.5Fangchinoline
CAS:<p>Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.</p>Fórmula:C37H40N2O6Pureza:99.86% - >99.99%Forma y color:SolidPeso molecular:608.72AMP-945
CAS:<p>AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.</p>Fórmula:C28H32F3N5O2Pureza:99.76%Forma y color:SolidPeso molecular:527.58PF-562271 hydrochloride
CAS:<p>PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK.</p>Fórmula:C21H20F3N7O3SHClPureza:97.08%Forma y color:SolidPeso molecular:543.95PF-573228
CAS:<p>PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM.</p>Fórmula:C22H20F3N5O3SPureza:96.58% - 99.51%Forma y color:SolidPeso molecular:491.49Nitidine chloride
CAS:<p>1.</p>Fórmula:C21H18ClNO4Pureza:96.59% - 98.91%Forma y color:SolidPeso molecular:383.82BI-4464
CAS:<p>BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC</p>Fórmula:C28H28F3N5O4Pureza:97.43%Forma y color:SolidPeso molecular:555.55Batatasin III
CAS:<p>Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer</p>Fórmula:C15H16O3Pureza:99.16%Forma y color:SolidPeso molecular:244.29Defactinib
CAS:<p>Defactinib (VS-6063) is a second-generation inhibitor of FAK. Defactinib has potential antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C20H21F3N8O3SPureza:98% - 99.71%Forma y color:SolidPeso molecular:510.49
