FAK
Los inhibidores de la quinasa de adhesión focal (FAK) se dirigen a la FAK, una quinasa involucrada en la adhesión celular, la migración y la angiogénesis. La FAK está frecuentemente sobreexpresada en los tumores y contribuye a la formación de nuevos vasos sanguíneos que suministran nutrientes al tumor. Inhibir la FAK puede interrumpir estos procesos, lo que convierte a los inhibidores de la FAK en herramientas valiosas en la terapia contra el cáncer y la investigación de la angiogénesis. En CymitQuimica, ofrecemos una gama completa de inhibidores de FAK de alta calidad para apoyar su investigación en biología celular, cáncer y angiogénesis.
Se han encontrado 72 productos de "FAK"
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NVP-TAE 226
CAS:<p>NVP-TAE 226: Potent FAK inhibitor, IC50=5.5nM, stronger vs Pyk2, IC50=3.5nM, weaker against IGF-1R, InsR, c-Met, ALK.</p>Fórmula:C23H25ClN6O3Pureza:98.07% - 98.78%Forma y color:SolidPeso molecular:468.94PF-562271 besylate
CAS:<p>PF-562271 besylate: potent, ATP-competitive FAK inhibitor, IC50 1.5 nM, 10x less effective on Pyk2, highly selective vs other kinases.</p>Fórmula:C21H20F3N7O3S·C6H6O3SPureza:97.65% - 99.01%Forma y color:SolidPeso molecular:665.66PND-1186
CAS:<p>PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).</p>Fórmula:C25H26F3N5O3Pureza:99.14% - 99.75%Forma y color:SolidPeso molecular:501.5CEP-37440
CAS:<p>CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).</p>Fórmula:C30H38ClN7O3Pureza:98.86% - 99.98%Forma y color:SolidPeso molecular:580.12PF-562271
CAS:<p>PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).</p>Fórmula:C21H20F3N7O3SPureza:97.17% - >99.99%Forma y color:SolidPeso molecular:507.49FAK activator 1
CAS:<p>ZINC40099027 is a FAK activator that induces gastric mucosal repair in persistent aspirin-associated gastric injury.</p>Fórmula:C23H26F3N3O3Pureza:99.19%Forma y color:SoildPeso molecular:449.47Y 11
CAS:<p>focal adhesion kinase (FAK) inhibitor</p>Fórmula:C8H17BrN4OPureza:98%Forma y color:SolidPeso molecular:265.15FAK-IN-8
CAS:<p>FAK-IN-8 (compound 5h), a FAK inhibitor with an IC50 of 5.32 μM, exhibits potent anti-proliferative activity, making it suitable for use in cancer research [1].</p>Fórmula:C15H9Cl2N3O2SForma y color:SolidPeso molecular:366.22TG53
CAS:<p>TG53 is a tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction inhibitor.</p>Fórmula:C21H22ClN5O2Pureza:98%Forma y color:SolidPeso molecular:411.88FLT3-IN-17
CAS:<p>FLT3-IN-17: FAK inhibitor, IC50 of 12 nM; blocks CYPs, FLT3 mutants; IC50 <0.5 nM for D835Y in cancer studies.</p>Fórmula:C23H24N6O2S2Forma y color:SolidPeso molecular:480.61ProMMP-9 inhibitor-3c
CAS:<p>ProMMP-9 inhibitor-3c hinders MMP-9 homodimers, blocks proMMP-9/α4β1 integrin/CD44 binding, and detaches EGFR.</p>Fórmula:C18H20FN3O2SForma y color:SolidPeso molecular:361.43FAK inhibitor 5
CAS:<p>FAK inhibitor 5 is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range.</p>Fórmula:C20H21N3O2SPureza:98%Forma y color:SolidPeso molecular:367.46NAMI-A
CAS:<p>NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.</p>Fórmula:C8H15Cl4N4ORuSPureza:98%Forma y color:SolidPeso molecular:458.18FAK inhibitor 2
CAS:<p>FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM .</p>Fórmula:C29H33F3N8O2S2Forma y color:SolidPeso molecular:646.75Adhesamine
CAS:<p>Adhesamine, a dumbbell molecule, enhances cell adhesion, growth, neuron differentiation, and survival via MAPK/FAK.</p>Fórmula:C24H32Cl4N8O2S2Forma y color:SolidPeso molecular:670.51Defactinib hydrochloride
CAS:<p>Defactinib hydrochloride (PF 04554878 hydrochloride) is a novel inhibitor of FAK.</p>Fórmula:C20H22ClF3N8O3SPureza:98.06% - 98.78%Forma y color:SolidPeso molecular:546.95Conteltinib
CAS:<p>Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK and Pyk2. It can be used to study lymphoma.</p>Fórmula:C32H45N9O3SPureza:98.12% - 99.54%Forma y color:SolidPeso molecular:635.82Roslin 2 bromide
CAS:<p>Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5.</p>Fórmula:C13H19BrN4Pureza:99.34%Forma y color:SolidPeso molecular:311.22FC 11
CAS:<p>FC 11 is a reversible FAK PROTAC Degrader with DC50 of 40-370 pM and degrades pFAKtyr397 in TM3 cells within 3 hours at 100 nM.</p>Fórmula:C41H42F3N13O9SForma y color:SolidPeso molecular:949.91Ifebemtinib
CAS:<p>Ifebemtinib (BI-853520) is an adhesion plaque kinase inhibitor with anti-tumour activity for the study of breast cancer.</p>Fórmula:C28H28F4N6O4Pureza:98.84% - 99.85%Forma y color:SolidPeso molecular:588.55
