FAK
Los inhibidores de la quinasa de adhesión focal (FAK) se dirigen a la FAK, una quinasa involucrada en la adhesión celular, la migración y la angiogénesis. La FAK está frecuentemente sobreexpresada en los tumores y contribuye a la formación de nuevos vasos sanguíneos que suministran nutrientes al tumor. Inhibir la FAK puede interrumpir estos procesos, lo que convierte a los inhibidores de la FAK en herramientas valiosas en la terapia contra el cáncer y la investigación de la angiogénesis. En CymitQuimica, ofrecemos una gama completa de inhibidores de FAK de alta calidad para apoyar su investigación en biología celular, cáncer y angiogénesis.
Se han encontrado 71 productos para "FAK".
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Ifebemtinib
CAS:Ifebemtinib (BI-853520) is an adhesion plaque kinase inhibitor with anti-tumour activity for the study of breast cancer.Fórmula:C28H28F4N6O4Pureza:98.47% - 99.93%Forma y color:White SolidPeso molecular:588.55Ref: TM-T64167
1mg146,00€5mg245,00€1mL*10mM (DMSO)316,00€10mg369,00€25mg572,00€50mg882,00€100mg1.243,00€FAK-IN-6
FAK-IN-6: Potent FAK inhibitor (IC50=1.415 nM), anti-cancer, for pancreatic studies.Fórmula:C25H31ClN5O6PSForma y color:SolidPeso molecular:596.04FAK-IN-26
CAS:FAK-IN-26 is a blood-brain barrier-penetrating inhibitor of Focal Adhesion Kinase (FAK) with an IC50 of 0.87 nM. It significantly reduces tumor cell viability, cancer stem cell activity, and cell migration in A549 and SKOV-3 cell lines. FAK-IN-26 exhibits potent anticancer activity, achieving tumor inhibition rates of 59.15% and 57.9% in A549 and SKOV-3 tumor mouse models, respectively.Fórmula:C20H19BrFN5O2Forma y color:SolidPeso molecular:460.30Pyk2-IN-2
CAS:Pyk2-IN-2 (compound 13j) acts as a Pyk2 inhibitor, exhibiting an IC 50 value of 0.608 μM for FAK kinase [1].Fórmula:C27H27N7OForma y color:SolidPeso molecular:465.55FAK-IN-21
CAS:FAK-IN-21 (compound 9) is a FAK inhibitor with an IC50 value of 37.52 nM. It inhibits cell growth and the phosphorylation of FAK, making it useful for research into diffuse gastric cancer.Fórmula:C22H22F2N8O3SForma y color:SolidPeso molecular:516.52JP-153
CAS:JP-153 is an inhibitor of Src-FAK-Paxillin signaling. It suppresses Src-dependent phosphorylation of paxillin (Y118) and subsequent activation of Akt (S473). JP-153 reduces VEGF-induced migration and proliferation of retinal endothelial cells and is applicable in the study of neovascular eye diseases.Fórmula:C21H19NO5Forma y color:SolidPeso molecular:365.379OXA-11
CAS:OXA-11 (FAK-IN-16) is a FAK inhibitor with anti-tumor activity, useful for cancer research.Fórmula:C37H49F3N7O5PPureza:98.70% - 99.20%Forma y color:White SolidPeso molecular:759.8FAK-IN-23
CAS:FAK-IN-23 (Compound II) is an inhibitor of focal adhesion kinase (FAK).Fórmula:C32H38F3N5O8Forma y color:SolidPeso molecular:677.668Ifebemtinib tosylate
CAS:Ifebemtinib (tosylate) (BI-853520 (tosylate); IN-10018 (tosylate)) is a highly selective PTK2 kinase inhibitor with anti-tumor properties. It inhibits FAK autophosphorylation in prostate cancer cells and suppresses spheroid formation and in situ tumor growth in vivo. Ifebemtinib (tosylate) is applicable in cancer research, including studies on solid tumors, breast cancer, and malignant pleural mesothelioma.Fórmula:C35H36F4N6O7SForma y color:SolidPeso molecular:760.76FAK inhibitor 6
CAS:Compound 26F: potent enzyme inhibitor (IC50=28.2nM), low cytotoxicity (IC50=3.32μM), induces dose-dependent apoptosis in MDA-MB-231, blocks G0/G1 phase.Fórmula:C25H24FN5O2SForma y color:SolidPeso molecular:477.55FAK-IN-3
FAK-IN-3 inhibits FAK, reduces PA-1 cell migration/invasion, and tumor growth, with no major side effects.Fórmula:C28H28N6O4Forma y color:SolidPeso molecular:512.56
