Trombina
Los inhibidores de trombina son compuestos que bloquean la trombina, una enzima involucrada en el proceso de coagulación de la sangre que también desempeña un papel en la promoción de la angiogénesis. La trombina puede estimular la formación de nuevos vasos sanguíneos en los tumores, favoreciendo su crecimiento y metástasis. Al inhibir la trombina, estos compuestos pueden reducir la angiogénesis y la progresión tumoral. Los inhibidores de trombina son importantes tanto en la investigación del cáncer como en el estudio de enfermedades vasculares. En CymitQuimica, ofrecemos una selección de inhibidores de trombina de alta calidad para apoyar su investigación en hemostasia, oncología y angiogénesis.
Se han encontrado 53 productos de "Trombina"
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Dabigatran ethyl ester hydrochloride
CAS:Dabigatran prevents blood clots, inhibiting NQO2 and thrombin with IC50 0.8 μM.Fórmula:C27H30ClN7O3Pureza:99.65%Forma y color:SolidPeso molecular:536.03Dabigatran etexilate
CAS:Dabigatran etexilate (BIBR 1048) is a thrombin inhibitor, which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation.Fórmula:C34H41N7O5Pureza:98.19% - 99.98%Forma y color:White PowderPeso molecular:627.73Sulodexide
CAS:Sulodexide is an orally administered combination of glycosaminoglycans, consisting of low molecular weight heparin (80%) and dermatan sulfate (20%). It demonstrates antithrombotic properties by interacting with antithrombin III (AT III) and heparin cofactor II (HC II), and by inhibiting thrombin formation. Additionally, sulodexide enhances profibrinolytic activity by releasing tissue plasminogen activator (tPA). It also offers endothelial protection, possesses anti-inflammatory effects, and alleviates chronic venous disease.Forma y color:SolidIdarucizumab
CAS:Idarucizumab, a humanized monoclonal antibody fragment, serves as the first reversal agent for direct oral anticoagulants (DOACs).Forma y color:LiquidThrombin inhibitor 13
Thrombin inhibitor 13 (Compound 13a) acts as a covalent reversible inhibitor of thrombin (thrombin, FIIa) with an IC50 of 0.7 nM. This compound prolongs activated partial thromboplastin time (aPTT) and prothrombin time (PT), demonstrating both antithrombotic and anticoagulant properties.Fórmula:C16H17ClN6OSForma y color:SolidPeso molecular:376.864Hirudin (55-65) (sulfated)
CAS:Hirudin (55-65) (sulfated), a fragment of Hirudin, is a thrombin inhibitor with anticoagulant effects and blood anticoagulant properties.Fórmula:C64H90N12O27SForma y color:SolidPeso molecular:1491.53Acetyl-Hirudin (54-65) (sulfated)
CAS:Acetyl-Hirudin (54-65) (sulfated) binds thrombin-rHCII(L444R), blocking rHCII's N-terminal/thrombin exosite I interaction, stabilizing the complex.Fórmula:C68H95N13O29SForma y color:SolidPeso molecular:1590.63Knob A peptide GPRPFPAC
CAS:Knob A peptide GPRPFPAC is a fibrin knob peptide. The PEGylated form of Knob A peptide GPRPFPAC exhibits enhanced anticoagulant activity.Fórmula:C38H57N11O9SForma y color:SolidPeso molecular:843.99Befovacimab
CAS:Befovacimab, a human IgG2 antibody, targets TFPI for hemophilia A/B research.Forma y color:LiquidHirudin (54-65) (TFA)
Hirudin (54-65) TFA, a segment of the 65-amino-acid protein Hirudin, exhibits anticoagulant properties [1].Forma y color:Odour SolidFibrinogen-Binding Peptide
CAS:Fibrinogen-binding peptide mimics vitronectin site and activates platelets; thrombin turns it to fibrin.Fórmula:C25H39N7O8Pureza:98%Forma y color:SolidPeso molecular:565.62Thrombin (MW 37kDa)
CAS:Thrombin (MW 37kDa) is a trypsin-like allosteric serine protease.Pureza:98%Forma y color:SolidPeso molecular:37kDaH-Gly-Arg-pNA dihydrochloride
CAS:H-Gly-Arg-pNA 2HCl, a peptide, binds 1,2 thrombin; colorimetric quantification at 405 nm indicates thrombin activity.Fórmula:C14H23Cl2N7O4Pureza:99.14%Forma y color:SolidPeso molecular:424.28Metolazone
CAS:Metolazone (SR-720-22) is a quinazoline-sulfonamide derived diuretic that inhibits sodium chloride symporters.
Fórmula:C16H16ClN3O3SPureza:98.14% - 98.5%Forma y color:Crystals From Ethanol SolidPeso molecular:365.83Ichorcumab
CAS:Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets thrombin. It binds to exosite 1 of thrombin, inhibiting substrate binding without affecting its catalytic activity. For isotype control, refer to HumanIgG1kappa, Isotype Control.
Forma y color:LiquidPM 102
CAS:Peptide that reverses the anticoagulant effect of heparin. Potently binds heparin (Kd = 36 nM in vitro).Fórmula:C235H425N111O64Pureza:98%Forma y color:SolidPeso molecular:5830Fibrinopeptide B, human
CAS:Fibrinopeptide B (FPB) is produced during the cleavage of fibrinogen, by thrombin, to fibrin monomer.Fórmula:C66H93N19O25Pureza:98%Forma y color:SolidPeso molecular:1552.56Protease Inhibitor Library
A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;Forma y color:Odour SolidRef: TM-L1100
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarPlatelet aggregation-IN-1
Platelet aggregation-IN-1 (Compound 10e) acts as an inhibitor of platelet aggregation and can achieve complete (100%) inhibition of thrombin-induced platelet aggregation at a concentration of 50 μM.Fórmula:C18H13N3O4Peso molecular:335.09061Coagulation Factor II Protein, Rat, Recombinant (His)
Coagulation Factor II Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Forma y color:Lyophilized PowderPeso molecular:69.5 kDa (predicted)Anti-Coagulation Factor II Antibody (2P591)
Anti-Coagulation Factor II Antibody (2P591) is a Rabbit antibody targeting Coagulation Factor II. Anti-Coagulation Factor II Antibody (2P591) can be used in WB.Forma y color:Odour LiquidAnti-Coagulation Factor II Antibody (8M286)
Anti-Coagulation Factor II Antibody (8M286) is a Rabbit antibody targeting Coagulation Factor II. Anti-Coagulation Factor II Antibody (8M286) can be used in ELISA.Forma y color:Odour LiquidDabigatran ethyl ester
CAS:Dabigatran ethyl ester (Dabigatran (ethyl ester)) is an emerging oral anticoagulant and it also is a direct inhibitor of thrombin activity.Fórmula:C27H29N7O3Pureza:99.98%Forma y color:SolidPeso molecular:499.56Coagulation Factor II Protein, Mouse, Recombinant (His)
Coagulation Factor II Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Forma y color:Lyophilized PowderPeso molecular:69.3 kDa (predicted); 85 kDa (reducing conditions)Dabigatran
CAS:Dabigatran (BIBR 953ZW), a thrombin inhibitor, prevents thrombus formation, reducing stroke and embolism risk in nonvalvular atrial fibrillation patients.
Fórmula:C25H25N7O3Pureza:97.44% - 98.7%Forma y color:Tan SolidPeso molecular:471.51Argatroban Monohydrate
CAS:Argatroban Monohydrate is a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.Fórmula:C23H38N6O6SPureza:99.51%Forma y color:SolidPeso molecular:526.65TRAP-6
CAS:TRAP-6 (Thrombin Receptor Activator Peptide 6)(2TFA) is an agonist of protease-activated receptor 1 (PAR1).Fórmula:C34H56N10O9Pureza:>99.99%Forma y color:SolidPeso molecular:748.87Ref: TM-T7625
1mg40,00€2mg52,00€5mg88,00€10mg126,00€25mg274,00€50mg411,00€100mg550,00€200mg785,00€1mL*10mM (DMSO)126,00€Edoxaban Tosylate Monohydrate
CAS:Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.Fórmula:C31H40ClN7O8S2Pureza:99.86% - 99.91%Forma y color:SolidPeso molecular:738.27Dabigatran Etexilate Mesylate
CAS:Dabigatran Etexilate Mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor.Fórmula:C34H41N7O5·CH4O3SPureza:99.91%Forma y color:SolidPeso molecular:723.84Ref: TM-T5133
5mg42,00€10mg57,00€25mg74,00€50mg95,00€100mg111,00€200mg169,00€500mg240,00€1mL*10mM (DMSO)64,00€Bivalirudin
CAS:Bivalirudin (BG-8967) is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clottingFórmula:C98H138N24O33Pureza:98.8% - >99.99%Forma y color:White To Off-White PowderPeso molecular:2180.29H-D-Phe-Pip-Arg-pNA dihydrochloride
CAS:H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238) is a sensitive and accurate thrombin detection substrate for measuring antithrombin-heparin cofactor (AT-III).
Fórmula:C27H38Cl2N8O5Pureza:99.47%Forma y color:SolidPeso molecular:625.55AEBSF hydrochloride
CAS:AEBSF hydrochloride (Pefabloc SC) is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, thrombin, plasmin, and trypsin.Fórmula:C8H11ClFNO2SPureza:98% - 99.81%Forma y color:White PowderPeso molecular:239.69Cycloolivil
CAS:Cycloolivil (Isoolivil) is a natural polyphenolic compound with a significant radical scavenging activity present in olive trees.Fórmula:C20H24O7Pureza:98%Forma y color:SolidPeso molecular:376.4NQ301
CAS:NQ301, an antithrombotic agent, inhibits collagen-challenged rabbit platelet aggregation (IC50: 10 mg/mL).Fórmula:C18H12ClNO3Pureza:99.74% - 99.76%Forma y color:SolidPeso molecular:325.75Ximelagatran
CAS:Ximelagatran, oral direct thrombin inhibitor, transforms to active melagatran in body.Fórmula:C24H35N5O5Pureza:95.48% - 99.60%Forma y color:SolidPeso molecular:473.57Enoxaparin sodium
CAS:Enoxaparin, a low-weight heparin approved by FDA for STEMI, enhances antithrombin and prevents clotting by inhibiting factors XIa, IXa, Xa, IIa.Fórmula:C42H59N3Na4O35S2Pureza:98%Forma y color:SolidPeso molecular:1322MNS
CAS:MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.Fórmula:C9H7NO4Pureza:98.53%Forma y color:Yellow PowderPeso molecular:193.16Lusutrombopag
CAS:Lusutrombopag (Mulpleta) is an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist for chronic liver disease (CLD) patients withFórmula:C29H32Cl2N2O5SPureza:99.96%Forma y color:SolidPeso molecular:591.55Ref: TM-TQ0223
1mg64,00€2mg92,00€5mg137,00€10mg208,00€25mg416,00€50mg628,00€100mg938,00€200mg1.293,00€1mL*10mM (DMSO)170,00€Avatrombopag
CAS:Avatrombopag (YM477) is a new oral thrombopoietin (TPO) receptor agonist, activating TPO receptor and increasing megakaryocytic proliferation/differentiationFórmula:C29H34Cl2N6O3S2Pureza:99.01% - 99.63%Forma y color:SolidPeso molecular:649.65Ref: TM-T7417
1mg57,00€5mg120,00€10mg187,00€25mg339,00€50mg540,00€100mg747,00€200mg1.035,00€1mL*10mM (DMSO)167,00€Argatroban
CAS:Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.Fórmula:C23H36N6O5SPureza:99.77% - >99.99%Forma y color:White To Off-White Crystalline SolidPeso molecular:508.63Ref: TM-T0155
5mg39,00€10mg59,00€25mg103,00€50mg160,00€100mg235,00€200mg349,00€500mg567,00€1mL*10mM (DMSO)46,00€Efegatran sulfate
CAS:Efegatran sulfate (LY294468 sulfate) is a potent thrombin inhibitor used in the treatment of thrombotic disorders.Fórmula:C21H34N6O7SPureza:≥98% - ≥98%Forma y color:SolidPeso molecular:514.6Flovagatran
CAS:Flovagatran (TGN 255) is a potent, and selective inhibitor of thrombin and parenteral direct factor II.Flovagatran is used to study venous thromboembolism.Fórmula:C27H36BN3O7Pureza:99.56%Forma y color:SolidPeso molecular:525.4OM-189
CAS:OM-189 is a selective inhibitor of synthetic thrombin.Fórmula:C24H36N6O3SPureza:98%Forma y color:SolidPeso molecular:488.65Atopaxar
CAS:Atopaxar (E5555), a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling.Fórmula:C29H38FN3O5Pureza:97.07% - 98.07%Forma y color:SolidPeso molecular:527.63Atopaxar Hydrobromide
CAS:Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling.Fórmula:C29H39BrFN3O5Pureza:98%Forma y color:SolidPeso molecular:608.54NP-313
CAS:NP-313 (NSC-4264) is a potent antithrombotic that blocks platelet aggregation via thromboxane A2 synthesis inhibition and targets SOCC-mediated Ca2+ efflux.Fórmula:C12H8ClNO3Pureza:99.92%Forma y color:SolidPeso molecular:249.65Melagatran
CAS:Melagatran is an orally available, direct synthetic thrombin inhibitor that does not require endogenous cofactors other than thrombin.Cost-effective and quality-assured.Fórmula:C22H31N5O4Pureza:98.29% - >99.99%Forma y color:SolidPeso molecular:429.51Ref: TM-T11994
1mg487,00€5mg1.134,00€10mg1.468,00€25mg2.215,00€50mg2.962,00€100mg4.024,00€1mL*10mM (DMSO)1.071,00€SCH79797 dihydrochloride
CAS:SCH79797 dihydrochloride is a PAR1 antagonist with IC50 70 nM, Ki 35 nM, antiproliferative, and pro-apoptotic properties.Fórmula:C23H27Cl2N5Pureza:99.5%Forma y color:SolidPeso molecular:444.4Thrombin inhibitor 1
CAS:Thrombin inhibitor 1 is a potent inhibitor of thrombin (Ki: 0.66 nM, 2xaPTT=0.43 μM).Fórmula:C22H20Cl2F2N4O3Pureza:98%Forma y color:SolidPeso molecular:497.32Antiplatelet agent 3
CAS:Antiplatelet agent 3 (Compound K-10) is a compound with antiplatelet aggregation activity, exhibiting IC50 values of 2.55, 3.22, and 2.09 mg/mL for platelet aggregation induced by ADP, AA, and COL, respectively. It holds potential for research in cardiovascular diseases.Fórmula:C38H32N2O5Forma y color:SolidPeso molecular:596.671Odiparcil
CAS:Odiparcil is an orally active beta-d-thioxyloside analog.Fórmula:C15H16O6SPureza:98%Forma y color:SolidPeso molecular:324.35SAR107375
CAS:SAR107375 is a potent, orally active dual inhibitor of thrombin and factor Xa, with K_i values of 1 nM and 8 nM for factor Xa and thrombin, respectively [1].Fórmula:C24H30ClN5O5S2Forma y color:SolidPeso molecular:568.11NAPAP
CAS:NAPAP is a thrombin inhibitor with potent anticoagulant activity (Ki: 2.1 nM). It selectively inhibits thrombin through a rapid binding mechanism while exhibiting weaker inhibition of trypsin, Factor Xa, and plasmin. NAPAP can be utilized for research into thrombotic conditions, including venous thrombosis and myocardial infarction.Fórmula:C27H31N5O4SForma y color:SolidPeso molecular:521.63
