Apoptosis
Los inhibidores de la apoptosis son compuestos que previenen o retrasan el proceso de muerte celular programada, conocido como apoptosis. Estos inhibidores son vitales para estudiar los mecanismos de supervivencia celular y se utilizan para investigar enfermedades donde la apoptosis está desregulada, como el cáncer, los trastornos neurodegenerativos y las enfermedades autoinmunes. Al modular la apoptosis, estos inhibidores pueden ayudar en el desarrollo de terapias dirigidas a controlar la muerte celular. En CymitQuimica, ofrecemos una amplia selección de inhibidores de la apoptosis de alta calidad para apoyar su investigación en biología celular, oncología y campos relacionados.
Subcategorías de "Apoptosis"
- ASK(6 productos)
- BCL(11 productos)
- Caspasa(127 productos)
- FOXO1(3 productos)
- IAP(65 productos)
- Mdm2(12 productos)
- PD-1 / PD-L1(126 productos)
- PDK(9 productos)
- PERK(24 productos)
- Serina / treonina quinasa(15 productos)
- Survivin(13 productos)
- TNF(91 productos)
- c-RET(51 productos)
- p53(62 productos)
Mostrar 6 subcategorías más
Se han encontrado 5622 productos de "Apoptosis"
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Nauclefine
CAS:<p>Nauclefine, a plant alkaloid, triggers cancer cell death through PDE3A-SLFN12, binding but not inhibiting PDE3A.</p>Fórmula:C18H13N3OPureza:99.92%Forma y color:SolidPeso molecular:287.32Cannflavin A
CAS:<p>Cannflavin A, isolated from Cannabis sativa L., exhibits anti-cancer, neuroprotective, and anti-inflammatory activities by inhibiting Aβ1-42 aggregation and</p>Fórmula:C26H28O6Forma y color:SolidPeso molecular:436.5Diprovocim-1
CAS:<p>Diprovocim-1: TLR1/2 agonist; triggers TNF-α in THP-1 cells; boosts ovalbumin IgG1 & CTLs against tumors with anti-PD-L1 in mice.</p>Fórmula:C56H56N6O6Forma y color:SolidPeso molecular:909.1DAPK Substrate Peptide TFA
<p>DAPK Substrate Peptide TFA is a synthetic peptide that serves as a substrate for the enzyme death-associated protein kinase (DAPK), exhibiting a Michaelis</p>Fórmula:C72H116F3N25O19Forma y color:SolidPeso molecular:1692.84VEGFR-2-IN-64
<p>VEGFR-2-IN-64 (Compound 28) is an inhibitor of VEGFR2 with an IC50 of 27.8 nM. It suppresses the proliferation of cancer cells A549, T-47D, and Caco-2, exhibits anti-migration and anti-colony formation activities in T-47D cells, and induces apoptosis in T-47D cells.</p>Fórmula:C72H123N9O6Forma y color:SolidPeso molecular:1210.8SDH-IN-26
<p>SDH-IN-26 (Compound C3) is a succinate dehydrogenase (SDH) inhibitor with significant inhibitory activity against various plant pathogenic fungi, including solanrhizoctonia and Botrytis cinerea. It exhibits an EC50 value of 0.270 μg/mL against solanrhizoctonia. SDH-IN-26 compromises fungal cell membrane integrity, increases membrane permeability, disrupts cell structure, reduces mitochondrial count, and affects normal hyphal growth. It also decreases mitochondrial membrane potential, inducing apoptosis. SDH-IN-26 holds potential for studying plant diseases caused by fungi.</p>Forma y color:Odour SolidNTR 368
CAS:cytoplasmic peptide of the neurotrophin receptor p75NTRFórmula:C69H124N22O19Pureza:98%Forma y color:SolidPeso molecular:1565.86PROTAC Bcl-xL degrader-3
CAS:<p>PROTAC Bcl-xL degrader-3 is a potent ROTAC Bcl-xL degrader.</p>Fórmula:C82H105ClF3N11O11S4Forma y color:SolidPeso molecular:1641.49Anti-Mouse PD-1 Antibody (D265A) Antibody (RMP1-14)
<p>Anti-Mouse PD-1 Antibody (D265A) is an IgG2a, κ antibody inhibitor derived from mice, specifically targeting mouse PD-1.</p>Forma y color:Odour LiquidMcl1-IN-26
CAS:<p>Mcl1-IN-26 is an effective and selective myeloid cell leukemia 1 inhibitor.</p>Fórmula:C45H52ClN5O6SForma y color:SolidPeso molecular:826.44YB-0158
CAS:<p>YB-0158 inhibits Wnt, targets colorectal CSCs, disrupts Sam68/Src, induces apoptosis, and has anti-cancer properties.</p>Fórmula:C32H32N7Na2O7PForma y color:SolidPeso molecular:703.5912-Deoxyphorbol 13-palmitate
CAS:<p>12-Deoxyphorbol 13-palmitate, a monomer derived from the roots of Euphorbia fischeriana, exhibits notable antitumor activity. This compound induces cell cycle arrest and apoptosis in gastric cancer cells by modulating key cell cycle regulators, such as cyclin B, cyclin A, and CDC2. Additionally, 12-Deoxyphorbol 13-palmitate significantly diminishes liver fibrosis by targeting APOL2 and impairing the APOL2–SERCA2–PERK–HES1 signaling pathway.</p>Fórmula:C36H58O6Forma y color:SolidPeso molecular:586.84F1324 acetate
F1324 acetate is an efficient, high-affinity b-cell lymphoma inhibitor with IC50 of 1 nM.Fórmula:C85H125N21O22SPureza:98%Forma y color:SolidPeso molecular:1825.09PROTAC EGFR degrader 6
CAS:<p>PROTAC EGFR degrader 6 effectively degrades EGFR Del19 in HCC827 cells (DC50=45.2 nM) and induces apoptosis and G1 arrest.</p>Fórmula:C49H57FN12O5Forma y color:SolidPeso molecular:913.05Ferroptosis inducer-4
Ferroptosisinducer-4 (Compound 5) is a phospholipid-based ferroptosis inducer featuring a terminal double bond at the sn-2 position. It exhibits significant cytotoxicity towards HT-1080 cells with an IC50 value of 18 μM. The toxicity mechanism involves the generation of lipid peroxides and oxidative damage to the cell membrane induced by the terminal double bond. Ferroptosisinducer-4 can be utilized in studies pertaining to the regulation of ferroptosis.Fórmula:C33H64NO7PForma y color:SolidPeso molecular:617.84MY-943
<p>MY-943, a potent inhibitor of tubulin polymerization and LSD1, exhibits anticancer properties by inducing G2/M phase arrest, promoting apoptosis, and</p>Fórmula:C30H36N4O6S2Forma y color:SolidPeso molecular:612.76Fludarabine triphosphate
CAS:<p>Fludarabine triphosphate inhibits key enzymes, causing cell death.</p>Fórmula:C10H15FN5O13P3Forma y color:SolidPeso molecular:525.173-Hydroxyterphenyllin
CAS:<p>3-Hydroxyterphenyllin from A. candidus is a fungal compound with antioxidant, anticancer, antibacterial, and antiviral effects.</p>Fórmula:C20H18O6Forma y color:SolidPeso molecular:354.35Petromurin C
CAS:<p>Petromurin C, a bis-indolyl benzenoid from P. muricatus, is cytotoxic to NS-1 cells (IC50=33μg/ml) and active against T. foetus (IC50=100μg/ml).</p>Fórmula:C26H24N2O5Forma y color:SolidPeso molecular:444.487Rosamultic acid
<p>Rosamultic acid is a useful organic compound for research related to life sciences and the catalog number is T125342.</p>Fórmula:C30H46O5Forma y color:SolidPeso molecular:486.693mTOR inhibitor-27
<p>mTORinhibitor-27 (Compound 7e) is an inhibitor of mammalian target of rapamycin (mTOR) with an IC50 value of 5.47 μM. It can induce apoptosis in tumor cells and arrest the cell cycle in the S phase, thereby inhibiting cancer cell growth. mTORinhibitor-27 presents potential for research in cancer, including skin cancer.</p>Forma y color:Odour SolidLorigerlimab
CAS:<p>Lorigerlimab (MGD019) is a bispecific IgG4 DART that blocks PD-1/CTLA-4, enhancing T-cells for mCRPC research.</p>Forma y color:LiquidGSK-3β inhibitor 15
<p>GSK-3β inhibitor 15 (Compound 54), with an IC50 of 3.4 nM, effectively suppresses Aβ 1-42-induced phosphorylation of GSK-3β and tau protein, as well as LPS-</p>Fórmula:C17H16N6OSForma y color:SolidPeso molecular:352.41Baceridin
CAS:<p>Baceridin, a cyclic hexapeptide and proteasome inhibitor, can be isolated from the culture medium of Epiphytic Bacillus.</p>Fórmula:C37H57N7O6Pureza:98%Forma y color:SolidPeso molecular:695.89Calphostin C
CAS:Calphostin C is a protein kinase C inhibitor.Fórmula:C44H38O14Pureza:98%Forma y color:Red To Brown PowderPeso molecular:790.76RIP2 Kinase Inhibitor 4
CAS:<p>RIP2 Kinase Inhibitor 4, a selective RIPK2 PROTAC, degrades RIPK2 (pIC50=8), inhibits TNF-α release.</p>Fórmula:C50H66F2N14O7SForma y color:SolidPeso molecular:1045.23TRP-601
CAS:<p>TRP-601 is a caspase inhibitor.</p>Fórmula:C40H48F2N6O11Pureza:98%Forma y color:SolidPeso molecular:826.852Conglobatin
CAS:<p>Conglobatin is a natural product for research related to life sciences. The catalog number is T36494 and the CAS number is 72263-05-9.</p>Fórmula:C28H38N2O6Forma y color:SolidPeso molecular:498.62(Rac)-AMXT-1501 4HCl
CAS:<p>AMXT-1501 tetrahydrochloride is an inhibitor of polyamine transport.</p>Fórmula:C32H72Cl4N6O2Pureza:98.31%Forma y color:SolidPeso molecular:714.77Antiangiogenic agent 6
Antiangiogenic agent 6 (Pt-1) effectively inhibits angiogenesis and induces necroptosis in tumor cells.Fórmula:C37H24F6N3PPtForma y color:SolidPeso molecular:850.66PD1-PDL1-IN 1 TFA
<p>PD1-PDL1-IN 1 TFA (compound 16) is a potent inhibitor of programmed cell death 1 (PD-1), functioning as an immune modulator [1].</p>Fórmula:C16H24F3N7O8Forma y color:SolidPeso molecular:499.4PKM2-IN-8
<p>PKM2-IN-8 (Compound 9b) is an inhibitor of pyruvate kinase M2 (PKM2) with an IC50 of 0.31 μM. It exhibits potent antiproliferative activity against U87MG glioma cells. PKM2-IN-8 induces early apoptosis and reduces lactate levels. This compound is useful for research in glioblastoma.</p>Fórmula:C19H13N7OForma y color:SolidPeso molecular:355.353TQB-2858
<p>TQB-2858 is a bifunctional fusion protein composed of an anti-PD-L1 monoclonal antibody fused with the extracellular domain of the TGF-β receptor. It exhibits high affinity for PD-L1, TGF-β1, and TGF-β3, and demonstrates a high target occupancy rate for PD-L1. TQB-2858 can be used in research on osteosarcoma and alveolar soft part sarcoma (ASPS).</p>Forma y color:Odour LiquidLZ-07
<p>LZ-07 is an IRAK4 PROTAC degrader (DC50 = 1.14 nM), that, upon degradation of IRAK4, significantly inhibits the expression of cytokines such as IL-6, IL-1β, TNF-α, and IL-10. It is applicable in research related to autoimmune diseases.</p>Forma y color:Odour SolidVEGFR/PARP-IN-1
<p>VEGFR/PARP-IN-1 (Compound 14b) is a dual inhibitor of VEGFR and PARP with IC50 values of 191 nM and 60.9 nM, respectively.</p>Fórmula:C29H27N9OPureza:98%Forma y color:SolidPeso molecular:517.58Diazepinomicin
CAS:<p>Diazepinomicin, from Micromonospora, blocks EGF-Ras-ERK pathway and induces apoptosis; an anti-tumor agent for K-Ras mutants.</p>Fórmula:C28H34N2O4Pureza:98%Forma y color:SolidPeso molecular:462.58FTO-IN-14
<p>FTO-IN-14 (Compound F97) is an inhibitor of the RNA demethylase Fat mass and obesity-associated protein (FTO), with an IC50 of 0.45 μM. It modulates the expression of the ASB2, RARA, and MYC proteins. FTO-IN-14 demonstrates antiproliferative activity in AML cancer cells, with IC50 values of 0.7-5.5 μM against MOLM13, NB4, HEL, OCI-AML3, MV4-11, and MONOMAC6, and induces apoptosis in NB4 cells. Additionally, FTO-IN-14 exhibits antitumor activity in a mouse NB4 xenograft model.</p>Fórmula:C22H23N3O2SForma y color:SolidPeso molecular:393.502Tubulysin B
CAS:<p>Tubulysin B: a potent, cytotoxic microtubule-disrupting peptide from Archangium geophyra and Angiococcus disciformis.</p>Fórmula:C42H63N5O10SPureza:98%Forma y color:SolidPeso molecular:830.04Eriosematin
CAS:<p>Eriosematin has anti-proliferative and apoptosis-inducing properties and is a compound extracted from the root of Flemingia philippinensis in the Philippines.</p>Fórmula:C19H20O4Pureza:98%Forma y color:SolidPeso molecular:312.36(-)-Rasfonin
CAS:<p>Rasfonin, a fungal metabolite from T. terrophilus, halts mouse splenocyte growth; IC50: 0.7 μg/ml (ConA), 0.5 μg/ml (LPS).</p>Fórmula:C25H38O6Forma y color:SolidPeso molecular:434.57Dehydroaltenusin
CAS:<p>Dehydroaltenusin is a selective eukaryotic DNA polymerase α inhibitor and a type of antibiotic produced by a fungus (IC50: 0.68 μM).</p>Fórmula:C15H12O6Pureza:98%Forma y color:SolidPeso molecular:288.255EM 163
CAS:<p>EM 163是一种 TIR-TIR 相互作用抑制剂，它是MyD88蛋白的TIR（Toll/白细胞介素-1受体）结构域拟态。EM 163针对IL-1受体中的TIR 结构域，阻断与MyD88的相互作用。EM 163抑制葡萄球菌肠毒素B（SEB）引起的体内炎症细胞因子的产生。EM 163能保护小鼠免受SEB 冲击引起的死亡。在体外的大鼠海马神经元中，EM 163阻断p38的激活和IL-1β对化学诱导的长期电位（LTP）引发的蛋白质合成的抑制作用。</p>Fórmula:C44H60IN5O4Pureza:97.97%Forma y color:SolidPeso molecular:849.88MRIA9
CAS:<p>MRIA9 inhibits SIK1/2/3 & PAK2/3 with IC50: SIK1 (516 nM), SIK2 (180 nM), SIK3 (127 nM); ATP-competitive.</p>Fórmula:C24H22ClFN6O3Forma y color:SolidPeso molecular:496.92Thalidomide-O-C7-acid
CAS:<p>Thalidomide-O-C7-acid: A cereblon ligand from Thalidomide linked via a PROTAC-used linker.</p>Fórmula:C21H24N2O7Forma y color:SolidPeso molecular:416.43EGCG-4″-sulfate
CAS:<p>EGCG-4″-sulfate, a predominant polyphenol in green tea, demonstrates notable anticancer, antioxidant, and anti-inflammatory effects, particularly against</p>Fórmula:C22H18O14SForma y color:SolidPeso molecular:538.43SLF TFA
CAS:<p>SLF TFA, a synthetic FKBP ligand, binds FKBP51 (3.1 μM) and inhibits FKBP12 (IC50 2.6 μM); used in PROTAC synthesis.</p>Fórmula:C32H41F3N2O8Forma y color:SolidPeso molecular:638.67DAPK Substrate Peptide
CAS:<p>DAPK Substrate Peptide is a synthetic peptide substrate for death-associated protein kinase (DAPK) (Km = 9 μM).</p>Fórmula:C70H115N25O17Pureza:98%Forma y color:SolidPeso molecular:1578.82Bim BH3, Peptide IV
CAS:<p>This Bim peptide belongs to the pro-apoptotic group of the Bcl-2 family of proteins.</p>Fórmula:C145H222N44O41SPureza:98%Forma y color:SolidPeso molecular:3269.65Nrf2 activator-11
<p>Nrf2 activator-11 (compound M11) is a Nrf2 activator that possesses blood-brain barrier permeability and offers anti-oxidation, anti-inflammation, anti-ferroptosis, and anti-apoptosis properties. It is applicable for use in studying cerebral ischemia-reperfusion (CI/R) injury models.</p>Fórmula:C20H23N3O2Forma y color:SolidPeso molecular:337.42c-Met-IN-24
<p>c-Met-IN-24 (compound 3g) serves as a dual-target inhibitor for STAT-3 (=4.7 μM) and c-MET (=12.67 μM), exhibiting anticancer properties. It arrests the G2/M cell cycle and induces apoptosis in SNB-75 cells, making it applicable in the research of central nervous system cancers.</p>Fórmula:C20H15ClN4O4SForma y color:SolidPeso molecular:442.88Biotin-PEG6-Thalidomide
CAS:<p>Biotin-PEG6-Thalidomide is a PROTAC linker based on PEG.</p>Fórmula:C37H53N5O12SPureza:98%Forma y color:SolidPeso molecular:791.91Xylopine
CAS:<p>Xylopine: an aporphine alkaloid, cytotoxic to cancer cells, induces oxidative stress, G2/M arrest, and apoptosis.</p>Fórmula:C18H17NO3Forma y color:SolidPeso molecular:295.33Antitumor agent-64
CAS:<p>Antitumor Agent-64 (Compound 8d), a diosgenin derivative, exhibits potent cytotoxic activity against the A549 cell line and induces apoptosis in A549 cells</p>Fórmula:C35H47N3O3SForma y color:SolidPeso molecular:589.83MEDI-7352
<p>MEDI-7352 is a human bispecific antibody targeting NGF/bNGF and TNF. It can be utilized in research focused on osteoarthritis (OA) pain.</p>Forma y color:Odour LiquidHQY1428
<p>HQY1428 is an orally active CDK12 inhibitor. It impedes DNA replication, causing cell cycle arrest at the G2/M phase in SKOV3 cells, and induces DNA double-strand breaks as well as apoptosis. In the SKOV3 xenograft mouse model, HQY1428 demonstrates antitumor activity. Additionally, when combined with the HER2 inhibitor Lapatinib in the NCI-N87 xenograft mouse model, HQY1428 produces a synergistic therapeutic effect.</p>Fórmula:C25H28ClFN6O3SForma y color:SolidPeso molecular:546.16162Gemcitabine monophosphate sodium salt hydrate
CAS:<p>Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine.</p>Fórmula:C9H12F2N3Na2O8PPureza:98%Forma y color:SolidPeso molecular:405.16Isoharringtonine
CAS:<p>Isoharringtonine, an alkaloid from Cephalotaxus koreana, inhibits and induces apoptosis in cancer cells.</p>Fórmula:C28H37NO9Forma y color:SolidPeso molecular:531.59cis-Clovamide
CAS:<p>cis-Clovamide is a naturally occurring phenolic compound with noteworthy antioxidant, anti-inflammatory, and antiapoptotic properties.</p>Fórmula:C18H17NO7Forma y color:SolidPeso molecular:359.334Bcl-2-IN-4
CAS:<p>Bcl-2-IN-4: potent, selective, oral Bcl-2 inhibitor with 1.5 nM IC50, >200x selectivity over Bcl-xL.</p>Fórmula:C46H50ClN9O7SForma y color:SolidPeso molecular:908.46PZ703b
CAS:PZ703b is a novel BCL-XL PROTAC degrader with enhanced BCL-2 inhibition.Fórmula:C80H102ClF3N10O11S4Forma y color:SolidPeso molecular:1600.44eIF4E-IN-5
<p>eIF4E-IN-5 (Compound 6n) is a cell-permeable eIF4E inhibitor that binds to capped mRNA, thereby inhibiting cap-dependent translation [1].</p>Fórmula:C30H39Cl2N6O8PForma y color:SolidPeso molecular:713.55Apoptolidin
CAS:<p>Apoptolidin, from Nocardiopsis, induces apoptosis, targets mitochondrial ATPase (Ki 4-5 μM), kills glial cells, and has antibiotic and antifungal properties.</p>Fórmula:C58H96O21Forma y color:SolidPeso molecular:1129.385INF200
<p>INF200 (compound 5), a sulfonylurea-based inhibitor of NLRP3 and associated pyroptosis, exhibits cardiometabolic benefits in a rat model of high-fat diet (HFD)-</p>Fórmula:C13H13ClN2O4Pureza:98%Forma y color:SolidPeso molecular:296.71Pamlectabart
<p>Pamlectabart is a humanised antibody targeting TNFRSF17/BCMA, (ADC) Pamlectabart tismanitin multiple myeloma.</p>Pureza:95%Forma y color:Odour LiquidHDAC3-IN-6
<p>HDAC3-IN-6 (Compound SC26) is a selective HDAC3 inhibitor with an IC50 of 53 nM. It induces PD-L1 expression in a dose-dependent manner and leads to significant apoptosis and reactive oxygen species (ROS) production. HDAC3-IN-6 exhibits strong antitumor efficacy against colorectal cancer.</p>Fórmula:C23H23N5O3Forma y color:SolidPeso molecular:417.46CRA-026440 hydrochloride
CAS:<p>CRA-026440 hydrochloride is a potent and broad-spectrum HDAC inhibitor.</p>Fórmula:C23H25ClN4O4Pureza:99.78%Forma y color:SoildPeso molecular:456.92Apoptosis inducer 24
CAS:<p>Apoptosisinducer 24 (Compound 4) inhibits the proliferation of gastric cancer cells with an IC50 range of 1.2-4.8 μM. It arrests the cell cycle at the G2/M phase, induces apoptosis in BGC-823 cells, and causes mitochondrial dysfunction. In mice, Apoptosisinducer 24 exhibits antitumor activity without significant toxicity, having an LD50 of 91.2 mg/kg.</p>Fórmula:C55H70BNO9Forma y color:SolidPeso molecular:899.96Human PD-L1 inhibitor IV
CAS:<p>PD-L1 inhibitor IV, a polypeptide, competitively blocks hPD-1 with a Kd of 1.38 μM, preventing hPD-1/hPD-L1 interaction.</p>Fórmula:C80H113N25O27Forma y color:SolidPeso molecular:1856.9322,2-Dimethyl-2,3-dihydrobenzofuran-7-ol
CAS:<p>2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol inhibits the proliferation of the THP-1 cell line and anti-infective Leishmania and Toxoplasma gondii RH.</p>Fórmula:C10H12O2Pureza:99.07%Forma y color:SolidPeso molecular:164.20DPP-4-IN-8
<p>DPP-4-IN-8 (compound 27) is a potent and selective inhibitor of dipeptidyl peptidase 4 (DPP4), with an inhibition constant (Ki) of 0.96 μM.</p>Fórmula:C16H12ClNO6Forma y color:SolidPeso molecular:349.72Taxamairin B
CAS:<p>Taxamairin B is a potent anti-inflammatory compound that inhibits the expression of proinflammatory cytokines (TNF-α, IL-1β, and IL-6) and reduces the</p>Fórmula:C22H24O4Forma y color:SolidPeso molecular:352.42Apoptosis inducer 3
CAS:<p>Apoptosis Inducer 3 (Compound 3), a selective apoptosis triggering agent, induces both apoptosis and late-apoptosis phases, demonstrating cytotoxic effects</p>Fórmula:C49H55ClN2O7Forma y color:SolidPeso molecular:819.428-hydroxy Efavirenz
CAS:<p>8-hydroxy Efavirenz, a main efavirenz metabolite by CYP2B6, causes apoptosis in rat neurons at 0.01 μM.</p>Fórmula:C14H9ClF3NO3Forma y color:SolidPeso molecular:331.68Anagrelide hydrochloride monohydrate
CAS:<p>Anagrelide HCl monohydrate is a platelet-reducing imidazoquinazoline for ET and PV research.</p>Fórmula:C10H10Cl3N3O2Forma y color:SolidPeso molecular:310.56Thalidomide-O-amido-PEG4-azide
CAS:Thalidomide-O-amido-PEG4-azide is a polyethylene glycol (PEG) derivative serving as a linker for Proteolysis Targeting Chimeras (PROTACs) synthesis [1].Fórmula:C25H32N6O10Pureza:98%Forma y color:SolidPeso molecular:576.56ERK-IN-6
<p>ERK-IN-6, a potent agent, inhibits ESCC growth and induces apoptosis through the ERK pathway.</p>Fórmula:C19H18BrN3O3SForma y color:SolidPeso molecular:448.33VEGFR-2-IN-66
<p>VEGFR-2-IN-66 (Compound 6) is an orally active VEGFR-2 inhibitor with an IC50 of 0.509 µM and an IC50 value of 7.48 μM for inhibiting MCF-7 cell proliferation. Its anticancer activity is exerted through cell cycle arrest, induction of apoptosis (Apoptosis), and modulation of gene expression, making it suitable for breast cancer research.</p>Forma y color:Odour SolidBfl-1-IN-6
<p>Bfl-1-IN-6 (Compound 20) is an orally active inhibitor of Bcl-2-related protein A1 (BFL1) with an IC50 of 19 nM. This compound can stabilize BFL1 protein, activate cleaved caspase 3, and demonstrates antitumor activity in mouse models.</p>Fórmula:C22H24ClFN2O2Forma y color:SolidPeso molecular:402.89Aspidin BB
CAS:<p>Aspidin BB, a phloroglucinol from Dryopteris, inhibits cancer by causing cell cycle arrest and apoptosis in HO-8910 cells.</p>Fórmula:C25H32O8Forma y color:SolidPeso molecular:460.52Nrf2 activator 19
<p>Nrf2 activator 19 is a compound capable of crossing the blood-brain barrier and acts as an NRF2/HO-1 activator, offering potent antioxidant and neuroprotective effects. It effectively reduces brain damage and minimizes the accumulation of Reactive Oxygen Species (ROS). Additionally, Nrf2 activator 19 inhibits neuronal apoptosis, aiding in the recovery of neural function and motor skills. It has demonstrated significant potential in ischemic stroke research.</p>Forma y color:Odour SolidApoptosis inducer 26
<p>Apoptosisinducer 26 (compound [AgCl(dap2SH)(PPh3)2]) is a mononuclear Ag(I) ligand-based autophagy inducer that exhibits antibacterial and anticancer activities against various bacterial strains and cancer cell lines. This compound facilitates the accumulation of Ag(I) ions in the periphery of bacteria, effectively inhibiting the growth of both Gram-positive (+) and Gram-negative (-) bacteria. Additionally, Apoptosisinducer 26 can intercalate between the base pairs of CT DNA, inducing apoptosis in A549 cells. It also possesses radical scavenging properties, which helps prevent oxidative stress.</p>Fórmula:C40H36AgClN4P2SForma y color:SolidPeso molecular:810.07GPLGIAGQ
CAS:GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting.Fórmula:C31H53N9O10Pureza:98%Forma y color:SolidPeso molecular:711.81Chloranthalactone B
CAS:<p>Chloranthalactone B, a sesquiterpenoid from Sarcandra glabra, inhibits inflammation via AP-1 & p38 MAPK.</p>Fórmula:C15H16O3Forma y color:SolidPeso molecular:244.29LS-106
<p>LS-106 is an orally active, effective epidermal growth factor receptor (EGFR) inhibitor displaying antitumor activity both in vitro and in vivo. It inhibits the kinase activities of EGFR19del/T790M/C797S and EGFRL858R/T790M/C797S, with IC50 values of 2.4 nmol/L and 3.1 nmol/L, respectively, demonstrating stronger inhibition than Osimertinib. LS-106 induces cell apoptosis (Apoptosis), suppresses the proliferation of tumor cells carrying EGFR19del/T790M/C797S, and results in significant tumor reduction in a C797S mutant xenograft model.</p>Fórmula:C24H28BrClN5OPForma y color:SolidPeso molecular:548.84NSC90616
<p>NSC90616 is a mutant p53 rescue compound [1] .</p>Fórmula:C23H30FNa2O9PForma y color:SolidPeso molecular:546.43sEH inhibitor-19
<p>sEH inhibitor-19 (Compound (R)-14i) is an orally active soluble epoxide hydrolase (sEH) inhibitor with an IC50 of 1.2 nM. This compound suppresses the expression of TNF-α and IL-6 and exhibits anti-inflammatory effects in mouse models of acute pancreatitis and Carrageenan-induced edema.</p>Fórmula:C28H28F3N3O4Forma y color:SolidPeso molecular:527.535DMUP
CAS:<p>DMUP inhibits CD47-SIRPα, induces apoptosis, boosts macrophage activity in A549 cells, and has antitumor properties.</p>Fórmula:C24H24Cl2N2O10PtForma y color:SolidPeso molecular:766.45ZX782
<p>ZX782 acts as a GPX4 protein degrader and an inducer of ferroptosis (Ferroptosis), targeting GPX4 for destruction via both the ubiquitin-proteasome system and the autophagy-lysosome pathway. Following the degradation of GPX4 induced by ZX782, there is a significant increase in the accumulation of lipid reactive oxygen species (ROS) in HT1080 cells.</p>Fórmula:C39H48ClN5O8Forma y color:SolidPeso molecular:750.28QZ2135
<p>QZ2135 (compound 20) is a PROTAC degrader that specifically targets RET and exhibits antitumor activity in vivo within a Ba/F3-KIF5B-RET-G810C xenograft mouse model. The compound demonstrates degradation activity with DC50 values of 4.7 nM (WT), 17.2 nM (V804M), and 73.8 nM (G810C) when targeting KIF5B-RET. QZ2135 is composed of the target protein ligand (red part) RETligand-3, the E3 ligase ligand (blue part) Lenalidomide-F, and the PROTAC Linker (black part) 7-Iodohept-1-yne, wherein the target protein ligand combined with the linker forms the conjugate RETLigand-Linker Conjugate-1.</p>Fórmula:C53H54N12O4Forma y color:SolidPeso molecular:923.07SH-5
CAS:<p>SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products</p>Fórmula:C29H59O10PForma y color:SolidPeso molecular:598.75AFMK
CAS:<p>AFMK (Formyl-N-acetyl-5-methoxykynurenamine) is an active metabolite of Melatonin with antioxidant and free radical scavenging activity.</p>Fórmula:C13H16N2O4Pureza:98.34% - 99.81%Forma y color:SolidPeso molecular:264.28PROTAC FLT3/CDK9 degrader-1
<p>Potent PROTAC degrader for FLT3/CDK9, induces apoptosis, and shows promise for FLT3-ITD mutated AML research.</p>Fórmula:C48H62N12O7Forma y color:SolidPeso molecular:919.08AS-99 TFA
<p>AS-99 TFA: potent ASH1L inhibitor, IC50=0.79 μM, combats leukemia, inhibits cell growth, induces apoptosis.</p>Forma y color:SolidZeluvalimab
CAS:<p>Zeluvalimab (AMG-404) is a monoclonal antibody designed to target the PD-1 receptor, and is utilized in cancer research [1].</p>Forma y color:LiquidAntiproliferative agent-23
<p>Antiproliferative agent-23: destabilizes microtubules, induces apoptosis in cancer cells via mitochondrial path, and triggers ER stress.</p>Fórmula:C23H28Cl3N3O6PtForma y color:SolidPeso molecular:743.93MYC-RIBOTAC
<p>MYC-RIBOTAC, a ribonuclease-targeting chimera (RIBOTAC) specific to the MYC internal ribosome entry site (IRES), comprises an MYC mRNA-binding element tethered</p>Fórmula:C55H58N10O11SPureza:98%Forma y color:SolidPeso molecular:1067.17Ilicicolin A
CAS:<p>Ilicicolin A is a useful organic compound for research related to life sciences. The catalog number is T125289 and the CAS number is 22581-06-2.</p>Fórmula:C23H31ClO3Forma y color:SolidPeso molecular:390.95HDSI-18
<p>HDSI-18 is an orally active selective inhibitor of HDAC6 with an IC50 of 1.6 nM. It exhibits cytotoxic effects against K562, MV4-11, MOLM-13, THP-1, and Jurkat cells with IC50 values of 0.48, 0.58, 0.91, 1.79, and 4.31 μM, respectively. HDSI-18 can activate Caspase-3, induce mitochondrial depolarization, and trigger apoptosis (Apoptosis), demonstrating antitumor activity.</p>Fórmula:C28H28N4O5Forma y color:SolidPeso molecular:500.20597PROTAC MNK1 degrader-1
<p>ROTACMNK1degrader-1 is a selective MNK1 PROTAC degrader with a DC50 of 11.92 nM and a Dmax greater than 96% in MV4-11 cells. It significantly reduces p-eIF4E levels with an IC50 of 22.07 nM, induces apoptosis, and causes cell cycle arrest at the G1 phase. This compound exhibits potent antitumor activity, demonstrating strong anti-leukemic effects in MV4-11 xenograft mouse models with acceptable drug safety.</p>Fórmula:C35H38N6O6SForma y color:SolidPeso molecular:670.78Zapalog
CAS:<p>Zapalog: photocleavable dimerizer controlling instant protein interactions.</p>Fórmula:C58H73N7O15Pureza:98%Forma y color:SolidPeso molecular:1108.24
