Apoptosis
Los inhibidores de la apoptosis son compuestos que previenen o retrasan el proceso de muerte celular programada, conocido como apoptosis. Estos inhibidores son vitales para estudiar los mecanismos de supervivencia celular y se utilizan para investigar enfermedades donde la apoptosis está desregulada, como el cáncer, los trastornos neurodegenerativos y las enfermedades autoinmunes. Al modular la apoptosis, estos inhibidores pueden ayudar en el desarrollo de terapias dirigidas a controlar la muerte celular. En CymitQuimica, ofrecemos una amplia selección de inhibidores de la apoptosis de alta calidad para apoyar su investigación en biología celular, oncología y campos relacionados.
Subcategorías de "Apoptosis"
- ASK(6 productos)
- BCL(11 productos)
- Caspasa(127 productos)
- FOXO1(3 productos)
- IAP(65 productos)
- Mdm2(12 productos)
- PD-1 / PD-L1(126 productos)
- PDK(9 productos)
- PERK(24 productos)
- Serina / treonina quinasa(15 productos)
- Survivin(13 productos)
- TNF(91 productos)
- c-RET(51 productos)
- p53(62 productos)
Mostrar 6 subcategorías más
Se han encontrado 5622 productos de "Apoptosis"
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Thalidomide-O-C4-COOH
CAS:<p>Thalidomide-O-C4-COOH is a synthetic E3 ligase linker derived from Thalidomide for PROTAC tech.</p>Fórmula:C18H18N2O7Forma y color:SolidPeso molecular:374.3447Apoptolidin
CAS:<p>Apoptolidin, from Nocardiopsis, induces apoptosis, targets mitochondrial ATPase (Ki 4-5 μM), kills glial cells, and has antibiotic and antifungal properties.</p>Fórmula:C58H96O21Forma y color:SolidPeso molecular:1129.385Zeluvalimab
CAS:<p>Zeluvalimab (AMG-404) is a monoclonal antibody designed to target the PD-1 receptor, and is utilized in cancer research [1].</p>Forma y color:LiquidHDAC3-IN-6
<p>HDAC3-IN-6 (Compound SC26) is a selective HDAC3 inhibitor with an IC50 of 53 nM. It induces PD-L1 expression in a dose-dependent manner and leads to significant apoptosis and reactive oxygen species (ROS) production. HDAC3-IN-6 exhibits strong antitumor efficacy against colorectal cancer.</p>Fórmula:C23H23N5O3Forma y color:SolidPeso molecular:417.46Lenercept
CAS:<p>Lenercept (Ro 45-2081) is a recombinant fusion protein combining the soluble TNF-receptor (p55) with the Fc portion of human IgG1 [1].</p>Forma y color:LiquidAnticancer agent 102
CAS:<p>Anticancer Agent 102, a tetracaine derivative, exhibits anti-cancer activity by inducing apoptosis [1].</p>Fórmula:C20H19F6N3OForma y color:SolidPeso molecular:431.37BCL6-IN-6
CAS:<p>BCL6-IN-6 is an inhibitor of Bcl-6 and can be used in studies about diffuse large B-cell lymphoma.</p>Fórmula:C27H31FN6O2SPureza:98.90%Forma y color:SolidPeso molecular:522.64Betamethasone
CAS:<p>Betamethasone (NSC-39470), a glucocorticoid steroid, has immunosuppressive and anti-inflammatory properties.</p>Fórmula:C22H29FO5Pureza:98% - 99.71%Forma y color:White Or Almost White Powder Solid CrystallinePeso molecular:392.46Sasanlimab
CAS:<p>Sasanlimab (PF-06801591), a humanized IgG4-κ antibody, selectively targets PD-1 and is primarily produced in Chinese Hamster Ovary (CHO) cells [1].</p>Pureza:98%Forma y color:LiquidBesufetamig
CAS:<p>Besufetamig is a bispecific antibody targeting programmed cell death protein 1 (PD-1) and the CD3ε chain. It modulates immune cell activity, exerting both immunosuppressive and antitumor effects. Besufetamig holds promise for cancer research.</p>Forma y color:LiquidEGFR-IN-86
<p>EGFR-IN-86 (compound 4i), an EGFR inhibitor (IC50: 1.5 nM), demonstrates potent activity against glioblastoma by inducing apoptosis and causing G2/M phase cell</p>Fórmula:C20H21N7O2SPureza:98%Forma y color:SolidPeso molecular:423.49IPH10
<p>IPH10 is an anticancer agent with strong antitumor effects in vivo and exhibits no liver or kidney toxicity. It significantly increases the reactive oxygen species (ROS) levels in tumor cells, decreases mitochondrial membrane potential, and induces apoptosis (apoptosis) in these cells.</p>Fórmula:C32H33NO4Forma y color:SolidPeso molecular:495.61KRASG12C IN-16
<p>KRASG12C IN-16 (Compound SK-17) is a selective, covalent, and orally active KRASG12C inhibitor. It can induce apoptosis and effectively prevent the activation of the MAPK and PI3K/mTOR signaling pathways. Additionally, KRASG12C IN-16 exhibits antitumor activity against pancreatic cancer.</p>Fórmula:C28H35ClN8O2Forma y color:SolidPeso molecular:551.08MBC-11 triethylamine
<p>MBC-11 triethylamine, a first-in-class etidronate-araC conjugate, may treat TIBD.</p>Fórmula:C17H35N4O14P3Pureza:98%Forma y color:SolidPeso molecular:612.4Caerin 1.1 TFA
<p>Caerin 1.1 TFA, a host defense peptide derived from the Australian tree frog Litoria's glandular secretions, exhibits anti-proliferative effects on HeLa cells</p>Pureza:98%Forma y color:Odour SolidPro-GA
CAS:<p>Pro-GA is a cell-permeable γ-glutamylcyclotransferase (γ-GGCT) inhibitor that inhibit proliferation in multiple bladder cancer cell lines. antitumour.</p>Fórmula:C12H19NO7Forma y color:SolidPeso molecular:289.28Tubulin/MMP-IN-3
<p>Tubulin/MMP-IN-3 (Compound 15j) is a dual inhibitor of tubulin polymerization and MMP, effectively inhibiting MMP-2 and MMP-9 with IC50 values of 21.13 μM and 19.24 μM, respectively. It disrupts the NF-κB signaling pathway, leading to mitochondrial dysfunction and mitochondrial-dependent apoptosis. Tubulin/MMP-IN-3 shows antiproliferative activity in various cancer cells by causing cell cycle arrest at the G2/M phase and demonstrates antitumor effects in mouse models.</p>Fórmula:C38H41N2O12PForma y color:SolidPeso molecular:748.712Thalidomide-O-C8-COOH
CAS:<p>Thalidomide-O-C8-COOH, also known as Cereblon ligand 3, is a Thalidomide-derived compound that serves as a Cereblon (CRBN) ligand for the targeted recruitment</p>Fórmula:C22H26N2O7Forma y color:SolidPeso molecular:430.45MDM2-IN-21
CAS:<p>MDM2-IN-21 is a potent MDM2 inhibitor. MDM2-IN-21 can be used for the research of cancer.</p>Fórmula:C34H40Cl2N4O2Forma y color:SolidPeso molecular:607.62Angiogenesis inhibitor 3
CAS:<p>Angiogenesis Inhibitor 3 (compound 8) is a potent anti-cancer agent, blocking HUVEC/HCT-15 cell growth and inducing apoptosis.</p>Fórmula:C44H42BrN3O9Forma y color:SolidPeso molecular:836.724-Nitro-3-cresol
CAS:<p>4-Nitro-3-cresol exhibits ciliate toxicity against Tetrahymena pyriformis and is widely used in biochemical experiments and drug synthesis research.</p>Fórmula:C7H7NO3Pureza:99.87%Forma y color:Beige PowderPeso molecular:153.14Poly (I:C):Kanamycin (1:1)
<p>Poly (I:C):Kanamycin (1:1) is an equimolar mixture of Poly(I:C) and kanamycin. TLR3 agonist commonly used as a vaccine adjuvant; enhanced Poly(I:C) stability.</p>Forma y color:SolidDanburstotug
CAS:<p>Danburstotug (IMC-001), an immunostimulant and antineoplastic [1], is a humanized IgG1-lambda monoclonal antibody targeting CD274 (PDL1, B7 homologue 1, B7H1).</p>Pureza:98%Forma y color:LiquidProlgolimab
CAS:<p>Prolgolimab (BCD-100) is an anti-PD-1 antibody used in melanoma research.</p>Pureza:>95%Forma y color:LiquidMYC-RIBOTAC
<p>MYC-RIBOTAC, a ribonuclease-targeting chimera (RIBOTAC) specific to the MYC internal ribosome entry site (IRES), comprises an MYC mRNA-binding element tethered</p>Fórmula:C55H58N10O11SPureza:98%Forma y color:SolidPeso molecular:1067.17Lacto-N-fucopentaose I
CAS:<p>Lacto-N-fucopentaose I is a milk oligosaccharide.</p>Fórmula:C32H55NO25Forma y color:SolidPeso molecular:853.774PKM2 modulator 1
<p>PKM2 modulator 1 (compound C998) is an effective PKM2 inhibitor with antiproliferative activity. It induces apoptosis and holds potential for research in glioblastoma studies.</p>Fórmula:C26H25N3O3Forma y color:SolidPeso molecular:427.5Nofazinlimab
CAS:<p>Nofazinlimab (CS1003) is a human anti-PD-1 IgG4 monoclonal antibody for the study of unresectable hepatocellular carcinoma (uHCC).</p>Pureza:98.6% (SDS-PAGE); 99.7% (SEC-HPLC) - 98.6% (SDS-PAGE); 99.7% (SEC-HPLC)Forma y color:LiquidBRAFV600E/JNK-IN-1
<p>BRAFV600E/JNK-IN-1 (Compound 14c) is an inhibitor of JNK1, JNK2, JNK3, and BRAFV600E, with IC50 values of 0.51 μM, 0.53 μM, 1.02 μM, and 0.009 μM, respectively. It also inhibits the phosphorylation of MEK1/2 and ERK1/2. Additionally, BRAFV600E/JNK-IN-1 suppresses tumor cell proliferation, NO release, and PGE2 production, exhibiting both antitumor and anti-inflammatory activities.</p>Forma y color:Odour SolidFeladilimab
CAS:<p>Feladilimab (GSK3359609) is an IgG4 monoclonal antibody that is an ICOS agonist.</p>Pureza:SDS-PAGE:95% SEC-HPLC:98%Forma y color:LiquidPeso molecular:145.24 kDaEciskafusp alfa
CAS:<p>Eciskafusp alfa, a cis-targeted IL2v immunocytokine, acts on programmed cell death 1 (PDCD1, commonly known as PD-1), preferentially targeting antigen-specific</p>Pureza:98%Forma y color:SolidATPase-IN-3
CAS:ATPase-IN-3 is an ATPase (ATPase) inhibitor that can be used in the study of metabolism-related diseases.Fórmula:C10H6N2O3S2Pureza:97.76%Forma y color:SoildPeso molecular:266.3sEH inhibitor-19
<p>sEH inhibitor-19 (Compound (R)-14i) is an orally active soluble epoxide hydrolase (sEH) inhibitor with an IC50 of 1.2 nM. This compound suppresses the expression of TNF-α and IL-6 and exhibits anti-inflammatory effects in mouse models of acute pancreatitis and Carrageenan-induced edema.</p>Fórmula:C28H28F3N3O4Forma y color:SolidPeso molecular:527.535Latikafusp
CAS:<p>Latikafusp (AMG 256) is a fusion protein that is a PD-1 blocker and IL-21R agonist with antitumor activity.</p>Pureza:97.1% (SDS-PAGE); 97.4% (SEC-HPLC) - 97.1% (SDS-PAGE); 97.4% (SEC-HPLC)Forma y color:LiquidTopo I/II-IN-2
<p>Topo I/II-IN-2 (Compound 3g) is an inhibitor of both Topo I and Topo II. It exhibits inhibitory activity against NCI-H446 and NCI-H1048 cells with IC50 values of 1.30 μM and 1.42 μM, respectively. Topo I/II-IN-2 induces mitochondrial apoptosis, disrupts mitochondrial function, and stimulates activity generation. Additionally, it inhibits the PI3K/Akt/mTOR pathway, effectively preventing the proliferation, invasion, and migration of small cell lung cancer (SCLC) cells in vitro.</p>Fórmula:C25H26N2O4Forma y color:SolidPeso molecular:418.48AXL/Angiokinase-IN-1
<p>AXL/Angiokinase-IN-1 (compound 11b) is an inhibitor of AXL/triple angiokinase, with an IC50 of 3.75 nM for AXL expression. This compound suppresses epithelial-mesenchymal transition (EMT) in Bxpc-3 cells and prevents metastasis in lung cancer cells. Additionally, AXL/Angiokinase-IN-1 impairs the functions of vascular and fibroblast cells and induces apoptosis in both cancer and fibroblast cells. It is characterized by low toxicity and favorable metabolic stability.</p>Fórmula:C31H34ClN5O2Forma y color:SolidPeso molecular:544.09Thalidomide-NH-amido-C6-NH2 hydrochloride
Thalidomide-NH-amido-C6-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate that includes a thalidomide-based cereblon ligand and a linker, designed for the synthesis of PROTAC.Fórmula:C21H28ClN5O5Peso molecular:465.1779EGFR/BRAFV600E-IN-4
<p>EGFR/BRAFV600E-IN-4 (Compound 10f) is a dual inhibitor of EGFR and BRAFV600E, with IC50 values of 61 nM and 43 nM, respectively. It halts the cell cycle, induces apoptosis in both early and late stages, and inhibits cancer cell growth in vitro, showing broad-spectrum anticancer activity.</p>Fórmula:C22H16N4OSForma y color:SolidPeso molecular:384.45Camrelizumab
CAS:<p>Camrelizumab (SHR-1210) is a human IgG4-κ monoclonal antibody with high affinity and directed against PD-1.Camrelizumab binds PD-1 with a binding affinity of up</p>Pureza:95% - 98.6%Forma y color:LiquidPeso molecular:143.7 kDaCu(I) chelator 1
<p>Cu(I) chelator 1 (Compound LH2) is a chelating agent specifically targeting the Cu(I) redox state. It inhibits the production of ROS.</p>Fórmula:C16H27NO4S3Peso molecular:393.11022EGFR-IN-107
<p>EGFR-IN-107 (compound 3r) is an orally active EGFR inhibitor with IC50 values of 0.4333 μM for EGFRWT and 0.0438 μM for EGFRL858R/T790M. It exhibits antiproliferative activity, effectively inhibiting the proliferation of H1975 cells and inducing apoptosis (apoptosis). EGFR-IN-107 is applicable in cancer research.</p>Fórmula:C34H36FN7O2Peso molecular:593.29145P-gp inhibitor 16
<p>P-gp inhibitor 16 (compound 14) is an inhibitor of p-glycoprotein. It significantly enhances apoptosis induced by doxorubicin and displays anticancer properties.</p>Fórmula:C35H35N5O4Peso molecular:589.2689Chlopynostat
<p>Chlopynostat (Compound 6c) is an HDAC1 inhibitor with an IC50 value of 67 nM. It induces apoptosis by inhibiting HDAC1, thereby reversing STAT4/p66Shc defects.</p>Fórmula:C22H17ClN4O2Peso molecular:404.104NCA029
<p>NCA029 is a potent activator of human caseinolytic protease P (HsClpP) with an EC50 of 0.15 μM. It targets HsClpPP and triggers an ATF3-dependent integrated stress response, resulting in the death of colon cancer cells.</p>Fórmula:C22H20F3N3OPeso molecular:399.15585Lw13
<p>Lw13 is a PROTAC targeting Hsp90, exhibiting maximal degradation efficacy at a concentration of 0.05 μM in Siha cells. Lw13 induces apoptosis and demonstrates potent antitumor activity both in vitro and in vivo.</p>Fórmula:C46H55F3N8O8Peso molecular:904.4095p53 (17-26)
CAS:<p>Peptide is p53's amino acids 17-26, contacts Mdm-2 binding domain, also called p53N.</p>Fórmula:C60H90N12O17Pureza:98%Forma y color:SolidPeso molecular:1251.43FKBP12 PROTAC dTAG-7
CAS:dTAG-7 selectively degrades BRD4 and FKBP12F36V by linking BET bromodomains to E3 ligase CRBN; it's a heterobifunctional degrader.Fórmula:C63H79N5O19Pureza:98%Forma y color:SolidPeso molecular:1210.32HDAC6-IN-28
<p>HDAC6-IN-28 (compound 10C) is a potent inhibitor of HDAC6 with an IC50 of 261 nM. It significantly induces apoptosis in B16-F10 cells and causes S phase arrest. Additionally, HDAC6-IN-28 effectively increases the expression of acetylated-α-tubulin both in vitro and in vivo.</p>Fórmula:C23H16FN3O2Peso molecular:385.12265Apoptosis inducer 11
<p>Apoptosis Inducer 11 (compound 3u) promotes apoptosis via the mitochondrial pathway and elicits a G2/M block alongside a marked reduction in the S phase within</p>Fórmula:C27H28N2O5Pureza:98%Forma y color:SolidPeso molecular:460.52Thalidomide-PEG3-NH2
CAS:<p>Thalidomide-PEG3-NH2: a cereblon-based E3 ligase ligand-linker for PROTAC tech.</p>Fórmula:C19H23N3O7Forma y color:SolidPeso molecular:405.407BT44
CAS:<p>BT44, a potent second-gen GDNF mimetic, is a lead for treating neurodegeneration.</p>Fórmula:C28H27F4N3O4SPureza:99.87%Forma y color:SoildPeso molecular:577.59Antitumor agent-170
<p>Antitumor agent-170 (Compound C6) inhibits PD-1/PD-L1 interaction and PARP7 with IC50 values of 0.342 μM and 7.05 nM, respectively. It shows high affinity for human PD-L1, with a Ki of 9.31 nM, and can restore T cell function while increasing IFN-γ secretion. In mouse models, Antitumor agent-170 exhibits antitumor effects against melanoma and demonstrates favorable pharmacokinetic properties.</p>Fórmula:C59H69ClF3N11O9Peso molecular:1167.49204RIPK1-IN-30
<p>RIPK1-IN-30 (compound 24) is a potent RIPK1 inhibitor with an IC50 of 2.01 μM. It demonstrates a protective effect in the HT-29 cell model of TSZ-induced necroptosis, with an EC50 of 6.77 μM.</p>Fórmula:C27H25FN2O4Forma y color:SolidPeso molecular:460.179842,4,6-trichloroanisole
CAS:<p>2,4,6-trichloroanisole inhibits the cell viability of CHO and C32 cell lines and apoptosis, antibacterial activity against Plasmodium falciparum.</p>Fórmula:C7H5Cl3OPureza:99.93%Forma y color:SolidPeso molecular:211.47DA5-HTL
<p>DA5-HTL is a compound that combines dasatinib with the HaloTag system, effectively inhibiting the growth of tumor cells, with a GI50 of 1.923 nM.</p>Fórmula:C39H58Cl2N8O8SPeso molecular:868.34754EGFR-PK/JNK-2-IN-1
<p>EGFR-PK/JNK-2-IN-1 (Compound 6c) is a dual inhibitor of EGFR-PK and JNK-2, with IC50 values of 2.7 and 3.0 μM, respectively. It can induce apoptosis and cause cell cycle arrest at various stages. This compound is applicable in cancer research.</p>Fórmula:C22H17ClN4O3SPeso molecular:452.07099Bcl-2-IN-5
CAS:Bcl-2-IN-5: BCL-2 inhibitor, IC50: 0.12 nM (wt), 0.14 nM (D103Y), 0.22 nM (G101V); Cell growth IC50: 0.2 nM, 0.44 nM (RS4;11).Fórmula:C55H63FN8O8SForma y color:SolidPeso molecular:1015.2Thalidomide-5-PEG2-Cl
CAS:<p>Thalidomide-5-PEG2-Cl is a cereblon ligand that recruits CRBN protein and forms PROTACs through linker conjugation.</p>Fórmula:C17H17ClN2O6Forma y color:SolidPeso molecular:380.78S65487 sulfate
CAS:<p>S65487 (VOB560) sulfate, a potent and selective Bcl-2 inhibitor, demonstrates activity against BCL-2 mutations, including G101V and D103Y.</p>Fórmula:C41H43ClN6O8SForma y color:SolidPeso molecular:815.34Anticancer agent 204
<p>Anticanceragent 204 (Compound 6) is a fluorinated derivative of cinnamamides with anticancer activity. It can arrest the cell cycle of HepG2 cells in the G1 phase and induces apoptosis by reducing mitochondrial membrane polarization (MMP) levels.</p>Fórmula:C26H18FN5O3SPeso molecular:499.11144Top1-IN-2
<p>Top1-IN-2 (Compound 1a) is an inhibitor of topoisomerase 1 (Top1). It suppresses the growth of P-gp drug-resistant tumor cells and induces apoptosis.</p>Forma y color:Odour Solid8-Bromo-cAMP
CAS:<p>8-Bromo-cAMP is a cell-permeable cAMP analogue and activator of CAMP-dependent protein kinase A that induces cell death and reduces proliferation.</p>Fórmula:C10H11BrN5O6PPureza:97.30%Forma y color:SolidPeso molecular:408.1Tauro-β-muricholic acid
CAS:<p>Tauro-β-muricholic acid (TβMCA), a trihydroxylated bile acid, acts as a competitive and reversible FXR antagonist (IC 50 = 40 μM) and exhibits antiapoptotic</p>Fórmula:C26H45NO7SPureza:98%Forma y color:SolidPeso molecular:515.7Thalidomide-O-amido-C3-NH2
CAS:<p>Thalidomide-derived cereblon ligand linked to a PROTAC technology linker, Thalidomide-O-amido-C3-NH2, is a synthetic E3 ligase ligand-linker.</p>Fórmula:C18H20N4O6Forma y color:SolidPeso molecular:388.37Thalidomide-O-amido-C4-N3
CAS:<p>Thalidomide-O-amido-C4-N3 (Cereblon Ligand-Linker Conjugates 4) is an E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and</p>Fórmula:C19H20N6O6Pureza:97.01%Forma y color:SolidPeso molecular:428.4Bcl-B inhibitor 1
CAS:<p>Bcl-B inhibitor 1 is a Bcl-B inhibitor with antitumor activity that binds to and inactivates pro-apoptotic proteins in the BH3 structural domain.</p>Fórmula:C17H15N3OSPureza:97.77%Forma y color:SoildPeso molecular:309.39Diphenhydramine hydrochloride
CAS:<p>DPH: antihistamine for cough, nausea, itching, allergy, Parkinson's, sleep aid, cold remedy.</p>Fórmula:C17H22ClNOPureza:99.84%Forma y color:Taste Ph (5% Aqueous Solution) 4-6 (Ntp 1992)Peso molecular:291.82D-Trimannuronic acid
CAS:<p>D-Trimannuronic acid from seaweed induces TNF-α in mouse macrophages; useful in pain, dementia studies.</p>Fórmula:C18H26O19Forma y color:SolidPeso molecular:546.387Bcl-2-IN-15
<p>Bcl-2-IN-15 (Compound 13d) is a Bcl-2 inhibitor with an IC50 of 363 nM, which impedes the proliferation of the NCI leukemia cancer cell line [1].</p>Forma y color:Odour SolidRaptinal
CAS:<p>Raptinal activates caspase-3 directly and initiates intrinsic caspase-dependent apoptosis pathway in multiple cell lines.</p>Fórmula:C28H18O2Pureza:≥98%Forma y color:SolidPeso molecular:386.44RMC-4998 formic
<p>RMC-4998 formic is an orally active inhibitor targeting the GTP-bound state of the KRASG12C mutant. It forms a trimeric complex with intracellular CYPA and the activated KRASG12C mutant, displaying an IC50 value of 28 nM. This compound inhibits ERK signaling and induces apoptosis in KRASG12C mutant cancer cells and is utilized in tumor research.</p>Forma y color:Odour SolidThalidomide-N-C3-O-C4-O-C3-OH
<p>Thalidomide-N-C3-O-C4-O-C3-OH is a conjugate of an E3 ligase ligand and a linker, used in the synthesis of the Aster-APROTAC degrader.</p>Fórmula:C23H31N3O7Peso molecular:461.2162Cytostatin (sodium salt)
CAS:<p>Cytostatin: natural antitumor, inhibits cell adhesion, blocks melanoma, induces apoptosis, targets PP2A selectively, IC50s: 1.3-3.1 µg/ml & 29 nM.</p>Fórmula:C21H33NaO7PForma y color:SolidPeso molecular:451.452Anticancer agent 178
<p>Anticanceragent 178 (compound C2) is a potent anticancer compound. It effectively inhibits the proliferation and metabolic activity of MDA-MB 231 cells, with IC50 values of 1.1 and 4.2 μM, respectively. Additionally, Anticanceragent 178 induces ferroptosis and necroptosis in cells.</p>Fórmula:C32H30ClFeN2O6Peso molecular:629.11418Mangafodipir trisodium
CAS:<p>Mangafodipir trisodium can enhance contrast in magnetic resonance imaging (MRI) of the liver, is a contrast agent delivered intravenously.</p>Fórmula:C22H27MnN4Na3O14P2Pureza:98%Forma y color:SolidPeso molecular:757.32Pidilizumab
CAS:<p>Pidilizumab (CT-011), a humanized IgG1κ anti-PD-1 monoclonal antibody, serves as a DLL1 antagonist with potential applications in researching hematologic</p>Pureza:98%Forma y color:LiquidMcl-1 inhibitor 16
<p>Mcl-1 Inhibitor 16 (Compound 9), a platinum-based mitochondrial-targeting agent, inhibits Mcl-1 and induces Bax/Bak-dependent apoptosis in cancer cells.</p>Fórmula:C25H29Cl2N3PtForma y color:SolidPeso molecular:637.51AKT-IN-18
<p>AKT-IN-18, an Akt inhibitor, demonstrates an IC50 value of 69.45 μM in A549 cells, effectively impeding Akt activity.</p>Fórmula:C19H14ClN5O2SPureza:98%Forma y color:SolidPeso molecular:411.86TAPI 0
CAS:<p>ADAM-17 (TACE) and MMP inhibitor; attenuates TNF-α processing. Acts in concert with GM6001 to inhibit Chlamydia trachomatis growth.</p>Fórmula:C24H32N4O5Pureza:98%Forma y color:SolidPeso molecular:456.54Acrixolimab
CAS:<p>Acrixolimab is a humanized IgG4-κ monoclonal antibody that selectively targets PD-1 [1] [2].</p>Pureza:98%Forma y color:Liquid1-Methyl-1H-pyrrolo[2,3-b]pyridine
CAS:<p>1-Methyl-1H-pyrrolo[2,3-b]pyridine exhibits cytotoxicity against MCF-7 cells and can be used in related research in the field of life sciences.</p>Fórmula:C8H8N2Pureza:98.89%Forma y color:SolidPeso molecular:132.16PPIA-IN-1
<p>PPIA-IN-1 (Compound 20b) is an inhibitor of peptidyl-prolyl isomerase A (PPIA) with a KD of 0.52 μM. It demonstrates antiproliferative activity across various cancer cell lines, including an IC50 of 0.69 μM in HCT116 cells, induces cell cycle arrest at the G0/G1 phase, and exhibits antimetastatic effects in HCT116 cells. PPIA-IN-1 elevates ROS levels, causing DNA damage, ER stress, and mitochondrial dysfunction, and induces apoptosis in HCT116 cells via the MAPK pathway. Additionally, PPIA-IN-1 shows antitumor activity in a CT26 xenograft mouse model.</p>Fórmula:C23H21Cl2FN4O7Forma y color:SolidPeso molecular:555.34Thalidomide-NH-C10-COOH
<p>Compound 6b is a synthetic Thalidomide-VHL E3 ligase-linker for PROTACs.</p>Fórmula:C24H31N3O6Pureza:98%Forma y color:SolidPeso molecular:457.52Thalidomide-O-C8-Boc
CAS:<p>Thalidomide-O-C8-Boc: CRBN ligand for PROTAC creation, derived from Thalidomide.</p>Fórmula:C26H34N2O7Forma y color:SolidPeso molecular:486.565Zalypsis
CAS:<p>Zalypsis, a transcription factor inhibitor, is used potentially for the treatment of lymphoma, and cervical carcinoma.</p>Fórmula:C37H38F3N3O8Forma y color:SolidPeso molecular:709.71(Rac)-BIO8898
CAS:<p>(Rac)-BIO8898 is a chemical compound that serves as an inhibitor of the co-stimulatory interaction between CD40 and CD154.</p>Fórmula:C53H64N8O6Forma y color:SolidPeso molecular:909.13Bax inhibitor peptide, negative control
CAS:<p>The compound is a negative control peptide for the Bax inhibitor peptides V5 and P5.</p>Fórmula:C28H52N6O6SPureza:98%Forma y color:SolidPeso molecular:600.81Ganoderic acid T1
<p>Ganoderic acid T1, a derivative of Ganoderic acid T, triggers cancer cell apoptosis by boosting ROS and activating caspases.</p>Fórmula:C34H50O7Forma y color:SolidPeso molecular:570.76HG-7-85-01
CAS:<p>HG-7-85-01 is a novel ATP-competitive and type II tyrosine kinase inhibitor targeting both wild-type and watchman mutant BCR-ABL, PDGFRα, Kit, and Src kinases.</p>Fórmula:C31H31F3N6O2SPureza:98.08%Forma y color:SolidPeso molecular:608.68BU 224 hydrochloride
CAS:<p>BU 224 hydrochloride is a selective imidazoline I(2) binding site ligand and has antinociceptive and antidepressant-like activities.</p>Fórmula:C12H12ClN3Pureza:99.51%Forma y color:SolidPeso molecular:233.7GPLGIAGQ
CAS:GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting.Fórmula:C31H53N9O10Pureza:98%Forma y color:SolidPeso molecular:711.81AChE-IN-81
<p>AChE-IN-81 (compound 22) is a reversible, selective inhibitor of AChE with an 80.0% inhibition rate and an IC50 of 3.7 μM. It binds to AChE with an affinity (Kd) of 5.37 μM. AChE-IN-81 effectively reduces apoptosis in zebrafish brain cells and shows potential neuroprotective activity in an H2O2-induced SH-SY5Y cell damage model.</p>Fórmula:C37H54ClNO5Forma y color:SolidPeso molecular:628.28PUMA BH3
PUMA BH3 activates Bak, binds Bcl-2; triggers apoptosis via cytochrome C release; Kd 26 nM.Fórmula:C128H202N42O43SPureza:98%Forma y color:SolidPeso molecular:3049.3JAK05
JAK05 exhibits inhibitory activity against Helicobacter pylori, effectively suppressing strains J63, J196, and J107, with a MIC of 3-5 µg/mL. It shows affinity for binding to H+/K+-ATPase, COX-1/2, TNF-α, and PGE2, and possesses antioxidant and anti-inflammatory properties. In a rat model of ethanol-induced gastric ulcers, JAK05 demonstrates anti-ulcer activity.Fórmula:C27H27ClN4O9SForma y color:SolidPeso molecular:619.043WD6305
WD6305 is an effective and selective METTL3-METTL14 PROTAC degrader, with DC50 values of 140 nM and 194 nM for METTL3 and METTL14, respectively. It inhibits m6A modification and the proliferation of acute myeloid leukemia cells while inducing apoptosis. WD6305 also exhibits antitumor activity.Fórmula:C61H75F2N11O5SPeso molecular:1111.56414AEG 3482
CAS:<p>AEG 3482 blocks JNK, induces HSP70, binds HSP90, and boosts HSP25 expression, preventing cell death.</p>Fórmula:C10H8N4O2S2Pureza:99.76%Forma y color:SolidPeso molecular:280.33Anti-Mouse PD-1 Antibody (RMP1-14)
Anti-Mouse PD-1 Antibody (RMP1-14) is an IgG2a antibody inhibitor against mouse PD-1 and can block PD-1/PD-L1 signaling. High-Quality, Low-Cost!Pureza:14.68mg/ml - >95%Forma y color:Odour LiquidFKBP12 Ligand-Linker Conjugate 1
CAS:<p>FKBP12 Ligand-Linker Conjugate 1 is a complex comprising a target protein ligand for FKBP12 and a linker, which is utilized in the synthesis of the PROTAC degrader MC-25B.</p>Fórmula:C42H63N3O11Forma y color:SolidPeso molecular:785.963Jacaric Acid
CAS:<p>Conjugated 18-C ω-6 fatty acid from Jacaranda seeds, induces cancer cell apoptosis via oxidative stress; metabolizes to cytotoxic CLA.</p>Fórmula:C18H30O2Forma y color:SolidPeso molecular:278.436Ru-Poma
<p>Ru-Poma is an Ru(II)-based photosensitizer designed to enhance the efficacy of photodynamic therapy (PDT) against tumors resistant to Cisplatin. It targets Pomalidomide to partially degrade CRBN, inducing ferroptosis by increasing lipid peroxides and downregulating GPX4 and GAPDH expression. In A549 cells, Ru-Poma exhibits cytotoxicity with IC50 values of 18.46 μM in the dark and 0.37 μM under illumination.</p>Fórmula:C89H75Cl2N11O11Ru·7H2O
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