Apoptosis

PI3K/HDAC-IN-4 (Compound 31f) is a dual inhibitor targeting PI3K and HDAC, with an IC50 of 0.2μM. It demonstrates high selectivity for HDAC1-3, with IC50 values of 75.5 nM, 70.9 nM, and 1.9 nM, respectively. As a potent pan-PI3K inhibitor, PI3K/HDAC-IN-4 has IC50 values of 2.5 nM, 80.5 nM, 10.0 nM, and 57.2 nM for PI3Kα, β, δ, and γ, respectively. This compound effectively induces apoptosis in tumor cells by concurrently inhibiting the PI3K/AKT/mTOR signaling pathway and HDAC1-3. It shows significant antiproliferative activity across various tumor cell lines, such as MV4-11, Jeko-1, HL60, and MCF-7, with IC50 values of 0.2, 0.9, 0.8, and 1.5 μM, respectively. PI3K/HDAC-IN-4 is applicable in the study of lymphoma and leukemia.

Nrf2 activator-9 (compound D-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of HUVEC cells induced by oxidized low-density

LeDSF3 controls HSAF production in Lysobacter, has antifungal properties, and acts as an anti-tumor by inhibiting p-AKT and activating caspase-3.

<p>NU 9056 is an effective and selective inhibitor of KAT5 histone acetyltransferase with an IC50 of 2 µM.</p>

Pexidartinib hydrochloride (PLX-3397 HCl) is a selective, orally active, ATP-competitive CSF1R/M-CSFR and c-Kit inhibitor with IC50 values of 20 and 10 nM.

<p>BCL6-IN-5 is a highly effective inhibitor of BCL6. It exhibits a pIC50 value of 5.82.</p>

Fenitrothion (Arbogal) is a insecticide that exhibits reproductive toxicity, inhibits acetylcholinesterase, and is commonly used in agriculture.

Methylisothiazolinone is a powerful synthetic biocide and preservative.

Dynole 34-2 is a non-competitive inhibitor of dynamin1 and dynamin2 GTPases that inhibits receptor-mediated endocytosis and synaptic vesicle endocytosis.

Gum Arabic, from A. Senegal, is an antioxidant that defends against hepatic, renal, and cardiac toxicities and aids in immunohistochemistry.

Mepazine hydrochloride (Pecazine hydrochloride) is a MALT1 inhibitor with anticancer and antitumor activity, inhibiting RANK-induced osteoclastogenesis.

PR-924 is a selective inhibitor of tripeptide epoxyketone immunoproteasome subunit LMP-7 (IC50: 22 nM).

KRA-533 is an effective KRAS agonist that targets the GTP/GDP binding pocket within the KRAS protein, inhibiting GTP cleavage.

L-Cystine, hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T124989 and the CAS number is 34760-60-6.

(Rac)-Apremilast D5 is a deuterium-labeled version of the enantiomer (R)-Apremilast, also known as (R)-CC-10004, which itself is one specific form of Apremilast

Thalidomide-piperazine HCl may aid leprosy, multiple myeloma research, and developmental biology studies.

Ancitabine is an antitumour drug that improves Hailey-Hailey disease-related phenotypes in yeast models. inhibits DNA synthesis, acute leukaemia.

Isovalerylcarnitine (3-methylbutyrylcarnitine) is a selective effective calpain activator that can promote cell apoptosis and is related to isovaleric acidemia.