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Apoptosis

Apoptosis

Los inhibidores de la apoptosis son compuestos que previenen o retrasan el proceso de muerte celular programada, conocido como apoptosis. Estos inhibidores son vitales para estudiar los mecanismos de supervivencia celular y se utilizan para investigar enfermedades donde la apoptosis está desregulada, como el cáncer, los trastornos neurodegenerativos y las enfermedades autoinmunes. Al modular la apoptosis, estos inhibidores pueden ayudar en el desarrollo de terapias dirigidas a controlar la muerte celular. En CymitQuimica, ofrecemos una amplia selección de inhibidores de la apoptosis de alta calidad para apoyar su investigación en biología celular, oncología y campos relacionados.

Subcategorías de "Apoptosis"

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Se han encontrado 5622 productos de "Apoptosis"

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  • STAT3-IN-12
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    STAT3-IN-12

    CAS:
    <p>STAT3-IN-12,STAT3 signaling inhibitor. Blocks IL-6-induced JAK/STAT3 activation. Induces apoptosis. Used in HCC and esophageal cancer research.</p>
    Fórmula:C28H30N4O2
    Pureza:99.19%
    Forma y color:Soild
    Peso molecular:454.56

    Ref: TM-T62803

  • Tofacitinib Prodrug-1
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    Tofacitinib Prodrug-1

    Tofacitinib Prodrug-1: an oral prodrug reducing Tofacitinib's side effects, treats ulcerative colitis in mice effectively with low toxicity.
    Fórmula:C36H39ClN10O7
    Forma y color:Solid
    Peso molecular:759.21

    Ref: TM-T72406

  • Logo de CymitQuimica
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    PIM-1/HDAC-IN-1

    <p>PIM-1/HDAC-IN-1 (4d): inhibits PIM-1 (IC50: 343.87nM), HDAC1 (63.65nM), HDAC6 (62.39nM); induces apoptosis in MCF-7 cells.</p>
    Fórmula:C22H19N3O3
    Forma y color:Solid
    Peso molecular:373.4

    Ref: TM-T61510

  • Logo de CymitQuimica
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    JH-XVII-10

    <p>JH-XVII-10: potent, oral DYRK1A/B inhibitor (IC50: 3/5 nM), shows antitumor activity in HNSCC.</p>
    Fórmula:C21H16F4N8O
    Forma y color:Solid
    Peso molecular:472.4

    Ref: TM-T63050

  • Logo de CymitQuimica
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    TAS-117 hydrochloride

    <p>TAS-117 HCl: potent oral Akt inhibitor (Akt1 IC50: 4.8nM, Akt2: 1.6nM, Akt3: 44nM), boosts anti-myeloma effects, induces cell death.</p>
    Fórmula:C26H25ClN4O2
    Forma y color:Solid
    Peso molecular:460.96

    Ref: TM-T62907

  • Logo de CymitQuimica
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    ZLWT-37

    <p>ZLWT-37: Oral CDK inhibitor, CDK9 IC50=0.002 µM, CDK2 IC50=0.054 µM; halts HCT116 cells at G2/M, induces apoptosis.</p>
    Fórmula:C26H30ClN5O
    Forma y color:Solid
    Peso molecular:464

    Ref: TM-T62943

  • Logo de CymitQuimica
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    VEGFR-2-IN-18

    <p>VEGFR-2-IN-18 is a potent VEGFR-2 inhibitor with a 60 nM IC50, promoting cell apoptosis and anticancer effects.</p>
    Fórmula:C20H13ClN4O2
    Forma y color:Solid
    Peso molecular:376.8

    Ref: TM-T61561

  • YK5
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    YK5

    CAS:
    <p>YK5 is an allosteric inhibitor pocket of Hsp70 and represents a previously unknown chemical tool to investigate cellular mechanisms associated with Hsp70.</p>
    Fórmula:C18H24N8O3S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:432.50

    Ref: TM-T26343

  • Fluvastatin sodium monohydrate
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    Fluvastatin sodium monohydrate

    CAS:
    <p>Fluvastatin (XU 62-320) sodium monohydrate, a fully synthetic competitive HMG-CoA reductase inhibitor, features an IC 50 of 8 nM. This compound also safeguards vascular smooth muscle cells from oxidative stress via the Nrf2-dependent antioxidant pathway [1] [2].</p>
    Fórmula:C24H27FNNaO5
    Forma y color:Solid
    Peso molecular:451.46

    Ref: TM-T86463

  • Logo de CymitQuimica
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    FLT3-IN-13

    <p>FLT3-IN-13 inhibits topoisomerase II/FLT3 in leukemia with IC50 of 2.26 μM, causes G2/M arrest, and promotes apoptosis.</p>
    Fórmula:C20H14N4O2
    Forma y color:Solid
    Peso molecular:342.35

    Ref: TM-T61101

  • AKT-IN-3
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    AKT-IN-3

    CAS:
    AKT-IN-3: potent oral Akt inhibitor with low hERG blockage. IC50: 1.4-1.7 nM for Akt1-3. Inhibits AGC kinases like PKA, PKC.
    Fórmula:C23H23Cl2F2N5O3
    Pureza:98%
    Forma y color:Solid
    Peso molecular:526.36

    Ref: TM-T10275

  • GLI1-IN-1
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    GLI1-IN-1

    CAS:
    <p>GLI1-IN-1 (CBC-1), a GLI-1 inhibitor, exhibits superior water solubility and anticancer properties. It effectively induces apoptosis and inhibits colorectal cancer growth by targeting the Hedgehog (HH) pathway (IC 50 = 1.3 μM) [1].</p>
    Fórmula:C42H60N2O9
    Forma y color:Solid
    Peso molecular:736.93

    Ref: TM-T86501

  • MA242
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    MA242

    CAS:
    <p>MA242 is a nuclear factor of activated T cells 1 (NFAT1) for Pancreatic Cancer Therapy and dual inhibitor of murine double minute 2 (MDM2).</p>
    Fórmula:C26H21ClF3N3O5S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:579.98

    Ref: TM-T11931

  • [D-Leu-4]-OB3
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    [D-Leu-4]-OB3

    CAS:
    [D-Leu-4]-OB3 suppresses the expression of genes associated with inflammation, proliferation, and metastasis, as well as the expression of PD-L1.
    Fórmula:C29H50N8O12S
    Forma y color:Solid
    Peso molecular:734.82

    Ref: TM-T72906

  • Tubulin polymerization-IN-61
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    Tubulin polymerization-IN-61

    CAS:
    <p>Tubulin polymerization-IN-61 (Compound 9a), a tubulin polymerization inhibitor, disrupts the microtubule skeleton, arrests the cell cycle at the G2/M phase, induces Apoptosis, and impedes cancer cell migration and colony formation. This compound demonstrates antitumor efficacy in vivo within the 4T1 xenograft model [1].</p>
    Fórmula:C22H21N3O5
    Forma y color:Solid
    Peso molecular:407.42

    Ref: TM-T87579

  • VDX-111
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    VDX-111

    CAS:
    <p>VDX-111, an analog of vitamin D, exhibits cytotoxicity in ovarian cancer cells by upregulating the RIPK1/RIPK3 pathway and inducing necroptosis. It also promotes the expression of cytokines and demonstrates antitumor activity in a mouse model [1].</p>
    Fórmula:C29H45BrO4
    Forma y color:Solid
    Peso molecular:537.57

    Ref: TM-T87611

  • Necrosis inhibitor 3
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    Necrosis inhibitor 3

    CAS:
    <p>Necrosis Inhibitor 3 (compound B3) effectively inhibits necrosis, demonstrating an IC50 of 0.29 nM in HT29 cells [1].</p>
    Fórmula:C25H26N4O4S
    Forma y color:Solid
    Peso molecular:478.56

    Ref: TM-T86990

  • GQN-B37-E
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    GQN-B37-E

    CAS:
    <p>GQN-B37-E is an effective selective binder and inhibitor of MCL-1. It binds to the BH3-binding domain of MCL-1. GQN-B37-E demonstrates binding affinity for MCL-1 within the sub-micromolar range (Ki= 0.6 μM), yet shows negligible binding to BCL-2 or BCL-XL.</p>
    Fórmula:C29H23ClN4O4
    Forma y color:Solid
    Peso molecular:526.97

    Ref: TM-T88454

  • AQIM-I
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    AQIM-I

    CAS:
    <p>AQIM-I is a survivin inhibitor that reduces survivin expression and colony formation. It promotes reactive oxygen species (ROS) production, apoptosis, cell cycle arrest, DNA damage, and autophagy. Moreover, AQIM-I effectively inhibits nonsmall cell lung cancer cells A549, with an IC 50 value of 9 nM [1].</p>
    Fórmula:C17H13IN2O2
    Forma y color:Solid
    Peso molecular:404.20

    Ref: TM-T85715

  • HBV/HDV-IN-2
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    HBV/HDV-IN-2

    CAS:
    <p>HBV/HDV-IN-2 (Compd 143) functions as an inhibitor for HBV, HDV, and PD-1/PD-L1, demonstrating an EC 50 of 35 nM in T cell activation.</p>
    Fórmula:C38H44ClN7O5
    Forma y color:Solid
    Peso molecular:714.25

    Ref: TM-T88316