Apoptosis
Los inhibidores de la apoptosis son compuestos que previenen o retrasan el proceso de muerte celular programada, conocido como apoptosis. Estos inhibidores son vitales para estudiar los mecanismos de supervivencia celular y se utilizan para investigar enfermedades donde la apoptosis está desregulada, como el cáncer, los trastornos neurodegenerativos y las enfermedades autoinmunes. Al modular la apoptosis, estos inhibidores pueden ayudar en el desarrollo de terapias dirigidas a controlar la muerte celular. En CymitQuimica, ofrecemos una amplia selección de inhibidores de la apoptosis de alta calidad para apoyar su investigación en biología celular, oncología y campos relacionados.
Subcategorías de "Apoptosis"
- ASK(9 productos)
- BCL(8 productos)
- Caspasa(147 productos)
- FOXO1(3 productos)
- IAP(67 productos)
- Mdm2(12 productos)
- PD-1 / PD-L1(140 productos)
- PDK(9 productos)
- PERK(26 productos)
- Serina / treonina quinasa(19 productos)
- Survivin(14 productos)
- TNF(91 productos)
- c-RET(61 productos)
- p53(63 productos)
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Se han encontrado 6114 productos de "Apoptosis"
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hMAO-B-IN-11
hMAO-B-IN-11 (Compound 12) is a selective and reversible inhibitor of human monoamine oxidase B (hMAO-B) with an IC50 value of 0.11 µM. It operates by competitively binding to the active site of hMAO-B, thereby preventing the oxidative deamination of monoamines and reducing hydrogen peroxide production. Additionally, hMAO-B-IN-11 inhibits pro-inflammatory mediators (NO, TNF-α, IL-1β) in activated microglia. This compound holds potential for research in neurodegenerative diseases such as Parkinson's and Alzheimer's.Forma y color:Odour SolidThalidomide-N-C3-O-C4-O-C3-OH
Thalidomide-N-C3-O-C4-O-C3-OH is a conjugate of an E3 ligase ligand and a linker, used in the synthesis of the Aster-APROTAC degrader.Fórmula:C23H31N3O7Peso molecular:461.2162Fludarabine triphosphate trisodium
Fludarabine triphosphate (F-ara-ATP) trisodium inhibits DNA synthesis; IC50 2.3 μM, Ki 6.1 μM, blocks DNA primase, prompts apoptosis.Fórmula:C10H12FN5Na3O13P3Forma y color:SolidPeso molecular:591.12Hypoxia inducer-1
Hypoxia inducer-1 (Compound N6) is a NO donor compound that is orally active and activated under hypoxic conditions. It exhibits high selectivity in releasing NO, inhibiting apoptosis, necrosis, and elevated levels of reactive oxygen species (ROS) associated with hypoxia. It modulates vasodilation and shows protective effects in a mouse model of myocardial hypoxic injury, making it useful for coronary heart disease research.Fórmula:C14H12FN3O4Forma y color:SolidPeso molecular:305.261Placulumab
CAS:Placulumab (ART621), an anti-TNF α monoclonal antibody, targets inflammation, potentially aiding arthritis treatment.Forma y color:LiquiddTAG-47
CAS:dTAG-47 targets FKBP12 F36V for protein degradation, useful in basal-like breast cancer research.Fórmula:C59H73N5O14Forma y color:SolidPeso molecular:1076.24Albanol B
CAS:Albanol B, from mulberries, combats Alzheimer's, bacteria, and oxidation, hinders cancer growth, and triggers cell arrest and apoptosis.Fórmula:C34H22O8Forma y color:SolidPeso molecular:558.53Endoplasmic Reticulum Stress Compound Library
A unique collection of 193 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS);
Forma y color:Odour SolidYN14-H
YN14-H is a PROTAC degrader that targets KRASG12C. It effectively inhibits the growth of NCI-H358 and MIA PaCa-2 cells, with IC50 values of 0.042 μM and 0.021 μM, respectively, and DC50 values of 28.9 nM and 18.1 nM. YN14-H significantly induces apoptosis and suppresses cell migration. It demonstrates favorable pharmacokinetics and excellent in vivo antitumor activity.Forma y color:Odour SolidType-I/-II Photosensitizer-1
Type-I/-II Photosensitizer-1 (compound 8b) is a photosensitizer with anticancer properties. It exhibits significant phototoxicity against A549 and 4T1 tumor cells. Under laser irradiation, Type-I/-II Photosensitizer-1 demonstrates strong oxygen-independent antitumor activity with an IC50 ranging from 1.50 to 1.76 μM.Fórmula:C60H48F12N8P2RuForma y color:SolidPeso molecular:1272.07CYP51/PD-L1-IN-1
CYP51/PD-L1-IN-1 (compound L11), a quinazoline with antifungal properties, simultaneously inhibits CYP51 (IC50: 0.884 μM) and PD-L1 (IC50: 0.083 μM).Fórmula:C20H15N5O2Forma y color:SolidPeso molecular:357.37Tasisulam sodium
CAS:Tasisulam triggers apoptosis, halts mitosis, and normalizes blood vessels to combat cancer.Fórmula:C11H5BrCl2NNaO3S2Forma y color:SolidPeso molecular:437.09CS4
CS4 is a selective HDAC inhibitor, with IC50 values for HDAC1, HDAC6, HDAC8, HDAC4, and HDAC11 reported as 38 nM, 12 nM, 5.8 μM, 19 μM, and 61 μM, respectively. It enhances the acetylation of α-tubulin and histone 3 (histone 3). Additionally, CS4 activates PPARγ and blocks glycolysis (glycolysis). It induces cell cycle arrest at the G2 phase and triggers apoptosis (apoptosis), exhibiting anticancer effects both in vitro and in vivo.Forma y color:Odour SolidAspidin BB
CAS:Aspidin BB, a phloroglucinol from Dryopteris, inhibits cancer by causing cell cycle arrest and apoptosis in HO-8910 cells.Fórmula:C25H32O8Forma y color:SolidPeso molecular:460.52BMf-BH3
BMf-BH3 is a Bcl-2 family peptide, key in HDAC inhibition affecting acetylation balance.Fórmula:C131H214N45O35SPureza:98%Forma y color:SolidPeso molecular:3012.5Apoptosis Compound Library
A unique collection of 1760 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;Forma y color:Odour SolidRef: TM-L9000
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarTaxamairin B
CAS:Taxamairin B is a potent anti-inflammatory compound that inhibits the expression of proinflammatory cytokines (TNF-α, IL-1β, and IL-6) and reduces theFórmula:C22H24O4Forma y color:SolidPeso molecular:352.42HJC0416 hydrochloride
CAS:HJC0416 hydrochloride: potent oral STAT3 inhibitor, better anticancer effects than Stattic, promising for breast cancer research.Fórmula:C18H18Cl2N2O4SForma y color:SolidPeso molecular:429.31PROTAC KDM4 degrader-1
PROTACKDM4 degrader-1 (Compound 11) is a proteolysis-targeting chimera (PROTAC) degrader specifically designed for KDM4. It effectively degrades KDM4A-C while sparing KDM4D. In esophageal cancer cells, PROTACKDM4 degrader-1 demonstrates strong antiproliferative activity, inducing apoptosis and cell cycle arrest, and inhibits lysine demethylation of histone H3.Forma y color:Odour SolidPD-L1/VISTA-IN-2
PD-L1/VISTA-IN-2 (Compound S8) is an orally active dual inhibitor targeting PD-L1 and VISTA, with an IC50 of 1.4 μM for PD-L1 and a KD of 2.1 μM for VISTA. This compound can activate the tumor immune microenvironment, exerting anticancer effects.Fórmula:C22H22N2O3Forma y color:SolidPeso molecular:362.42
