Apoptosis
Los inhibidores de la apoptosis son compuestos que previenen o retrasan el proceso de muerte celular programada, conocido como apoptosis. Estos inhibidores son vitales para estudiar los mecanismos de supervivencia celular y se utilizan para investigar enfermedades donde la apoptosis está desregulada, como el cáncer, los trastornos neurodegenerativos y las enfermedades autoinmunes. Al modular la apoptosis, estos inhibidores pueden ayudar en el desarrollo de terapias dirigidas a controlar la muerte celular. En CymitQuimica, ofrecemos una amplia selección de inhibidores de la apoptosis de alta calidad para apoyar su investigación en biología celular, oncología y campos relacionados.
Subcategorías de "Apoptosis"
- ASK(6 productos)
- BCL(11 productos)
- Caspasa(127 productos)
- FOXO1(3 productos)
- IAP(66 productos)
- Mdm2(12 productos)
- PD-1 / PD-L1(126 productos)
- PDK(9 productos)
- PERK(23 productos)
- Serina / treonina quinasa(15 productos)
- Survivin(13 productos)
- TNF(91 productos)
- c-RET(51 productos)
- p53(62 productos)
Mostrar 6 subcategorías más
Se han encontrado 5618 productos de "Apoptosis"
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YN14-H
<p>YN14-H is a PROTAC degrader that targets KRASG12C. It effectively inhibits the growth of NCI-H358 and MIA PaCa-2 cells, with IC50 values of 0.042 μM and 0.021 μM, respectively, and DC50 values of 28.9 nM and 18.1 nM. YN14-H significantly induces apoptosis and suppresses cell migration. It demonstrates favorable pharmacokinetics and excellent in vivo antitumor activity.</p>Forma y color:Odour SolidThalidomide-O-C7-NH2
CAS:<p>Thalidomide-O-C7-NH2 is a cereblon ligand-linked E3 ligase for PROTAC use.</p>Fórmula:C20H25N3O5Forma y color:SolidPeso molecular:387.436BMH-7 HCl
<p>BMH-7 HCl is a p53 activator, showing anti-cancer activity by activating the p53 pathway.</p>Fórmula:C20H22ClN5OPureza:99.62%Forma y color:SolidPeso molecular:383.88Gliotoxin
CAS:<p>Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.</p>Fórmula:C13H14N2O4S2Pureza:98%Forma y color:SolidPeso molecular:326.39PARP1-IN-15
<p>PARP1-IN-15 (Compound 6) is a PARP1 inhibitor that also inhibits tankyrase (TNKS) and promotes DNA double-strand breaks, leading to tumor cell apoptosis.</p>Fórmula:C16H12N2O2Pureza:98%Forma y color:SolidPeso molecular:264.28Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2
CAS:<p>Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate compound that combines a Thalidomide-based cereblon ligand and a linker, which is commonly</p>Fórmula:C25H34N4O9Pureza:98%Forma y color:SolidPeso molecular:534.566S-Adenosyl-L-methionine
CAS:<p>S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.</p>Fórmula:C15H22N6O5SPureza:99.08%Forma y color:SolidPeso molecular:398.44A011
<p>A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycle</p>Fórmula:C27H28N6OPureza:98%Forma y color:SolidPeso molecular:452.55Thalidomide-O-amido-C3-PEG3-C1-NH2
CAS:<p>Thalidomide-based E3 ligase linker for PROTACs with a 3-unit PEG chain.</p>Fórmula:C27H35F3N4O11Forma y color:SolidPeso molecular:648.589Kdo2-Lipid A ammonium
CAS:<p>Kdo2-Lipid A ammonium (KLA) is a selective and potent TLR4 agonist, a lipopolysaccharide.Kdo2-Lipid A ammonium induces the release of TNF and PGE2.</p>Fórmula:C110H214N6O39P2Pureza:98%Forma y color:SolidPeso molecular:2306.84VEGFR-2-IN-66
<p>VEGFR-2-IN-66 (Compound 6) is an orally active VEGFR-2 inhibitor with an IC50 of 0.509 µM and an IC50 value of 7.48 μM for inhibiting MCF-7 cell proliferation. Its anticancer activity is exerted through cell cycle arrest, induction of apoptosis (Apoptosis), and modulation of gene expression, making it suitable for breast cancer research.</p>Forma y color:Odour SolidEGFR/HER2/DHFR-IN-3
<p>EGFR/HER2/DHFR-IN-3 (compound 4c) serves as an efficacious dual inhibitor specifically targeting EGFR/HER2, exhibiting IC50 values of 0.138 μM for EGFR and 0.</p>Pureza:98%Forma y color:Odour SolidPamrevlumab
CAS:<p>FG-3019 (Pamrevlumab), a human antibody, targets CTGF, potentially treating idiopathic pulmonary fibrosis.</p>Pureza:100% (SEC-HPLC) - 95%Forma y color:LiquidXerophilusin B
CAS:<p>Xerophilusin B from Isodon xerophilus halts ESCC cell growth, causes G2/M arrest, and induces apoptosis.</p>Fórmula:C20H26O5Forma y color:SolidPeso molecular:346.42Stem bromelain
CAS:<p>Stem bromelain: cysteine protease from pineapple stem with fibrinolytic, anti-inflammatory, antitumoral properties.</p>Forma y color:SolidNarasin
CAS:<p>Narasin inhibits dengue virus, treats coccidiosis without harm to cells, and induces cancer cell apoptosis.</p>Fórmula:C43H72O11Forma y color:SolidPeso molecular:765.03RET ligand-1
CAS:<p>RETligand-1 is a target protein ligand that specifically interacts with RET and can be utilized in the synthesis of the PROTAC LDD39.</p>Fórmula:C28H24F2N6O3Forma y color:SolidPeso molecular:530.525W1131 TFA
<p>W1131 TFA is a STAT3 inhibitor and ferroptosis inducer that regulates the IL6-JAK-STAT3 and ferroptosis pathways,gastric cancer.</p>Fórmula:C25H20F3N5O6Pureza:98.1%Forma y color:SolidPeso molecular:543.45ADPM06
CAS:<p>ADPM06: nonporphyrin PDT agent; leads in apoptosis, strong IC50 in µM against human tumors.</p>Fórmula:C34H24BBr2F2N3O2Forma y color:SolidPeso molecular:715.19KH16
<p>KH16 is an HDAC inhibitor.KH16 stimulates apoptosis and is able to inhibit gene expression patterns in a variety of tumor cells.</p>Fórmula:C18H20N6O2Pureza:98.15%Forma y color:SolidPeso molecular:352.39ChoKα inhibitor-3
<p>ChoKα Inhibitor-3, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoK α1 with an IC50 value of 0.66 μM and possesses the capability to</p>Fórmula:C50H54Br2Cl2N4S2Forma y color:SolidPeso molecular:1005.83F1324 acetate
F1324 acetate is an efficient, high-affinity b-cell lymphoma inhibitor with IC50 of 1 nM.Fórmula:C85H125N21O22SPureza:98%Forma y color:SolidPeso molecular:1825.09Episilvestrol
CAS:<p>Episilvestrol is a derivative of silvestrol with eIF4A-targeted antitumor properties, found in Aglaia silvestris fruits and twigs.</p>Fórmula:C34H38O13Pureza:98%Forma y color:SolidPeso molecular:654.66mTOR inhibitor-27
<p>mTORinhibitor-27 (Compound 7e) is an inhibitor of mammalian target of rapamycin (mTOR) with an IC50 value of 5.47 μM. It can induce apoptosis in tumor cells and arrest the cell cycle in the S phase, thereby inhibiting cancer cell growth. mTORinhibitor-27 presents potential for research in cancer, including skin cancer.</p>Forma y color:Odour SolidDeoxynyboquinone
CAS:<p>Deoxynyboquinone is a potent inducer of cancer cell death with IC(50) values between 16 and 210 nM.</p>Fórmula:C15H12N2O4Pureza:98%Forma y color:SolidPeso molecular:284.27Targaprimir-96 TFA
Targaprimir-96 TFA is a selective inhibitor of miR-96 in cancer, inducing apoptosis with high affinity for pri-miR-96 but not affecting healthy cells.Fórmula:C79H103F3N18O9Forma y color:SolidPeso molecular:1505.77Hematein
CAS:<p>Hematein blocks Akt/PKB, Wnt signaling, promotes apoptosis in lung cancer, is a dye from hematoxylin, and inhibits casein kinase II (IC50: 0.74 μM).</p>Fórmula:C16H12O6Pureza:98%Forma y color:Dark Brown Crystalline PowderPeso molecular:300.26LY3415244
<p>LY3415244 is a human bispecific antibody (bsAb) that targets B7-H1/PD-L1/CD274 and TIM-3/HAVCR2/CD366. This compound is applicable in the study of advanced solid tumors.</p>Forma y color:Odour LiquidRasagiline
CAS:<p>Rasagiline (AGN1135) is an inhibitor of monamine oxidase used as adjunctive therapy in combination with levodopa and carbidopa in the management of Parkinsons</p>Fórmula:C12H13NPureza:98% - 99.87%Forma y color:SolidPeso molecular:171.24Psalmotoxin 1
CAS:<p>Psalmotoxin 1 is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker.</p>Fórmula:C200H312N62O57S6Pureza:98%Forma y color:SolidPeso molecular:4689.41SP3N hydrochloride
<p>SP3N hydrochloride is a specific degrader of the prolyl isomerase (FKBP12). Its alkylamine moiety is metabolized into an active aldehyde (SP3CHO), which recruits the SCFFBXO22 ligase for the degradation of FKBP12. SP3N hydrochloride is applicable in cancer research.</p>Forma y color:Odour SolidSuramin
CAS:<p>Suramin is an RdRp and PTPase inhibitor with anti-parasitic, anti-tumor, and anti-angiogenic activities, inhibiting sirtuins and DNA topoisomerase II.</p>Fórmula:C51H40N6O23S6Pureza:99.80%Forma y color:SolidPeso molecular:1297.28SDH-IN-26
<p>SDH-IN-26 (Compound C3) is a succinate dehydrogenase (SDH) inhibitor with significant inhibitory activity against various plant pathogenic fungi, including solanrhizoctonia and Botrytis cinerea. It exhibits an EC50 value of 0.270 μg/mL against solanrhizoctonia. SDH-IN-26 compromises fungal cell membrane integrity, increases membrane permeability, disrupts cell structure, reduces mitochondrial count, and affects normal hyphal growth. It also decreases mitochondrial membrane potential, inducing apoptosis. SDH-IN-26 holds potential for studying plant diseases caused by fungi.</p>Forma y color:Odour SolidBarakol
CAS:<p>Barakol, a primary compound found in Cassia siamea, inhibits MMP-3 activity and enhances the anti-metastatic effects of doxorubicin. Additionally, Barakol induces apoptosis (Apoptosis), generates reactive oxygen species, increases the Bax/Bcl-2 expression ratio, and activates caspase-9. This compound also exhibits laxative, anti-anxiety, central nervous system depressant, antioxidant, and anticancer properties.</p>Fórmula:C13H12O4Forma y color:SolidPeso molecular:232.23HSP90-IN-33
<p>HSP90-IN-33 (compound 24e) is an effective Hsp90 inhibitor, demonstrating dissociation constants (Kd) of ≥200 µM for Hsp90α and 7.3 µM for Hsp90β. This compound induces cellular apoptosis (apoptosis) and arrests the cell cycle at the G0/G1 phase. Additionally, HSP90-IN-33 reduces the protein expression of ERα, CDK4, and Akt.</p>Fórmula:C21H25Cl2N5O2Forma y color:SolidPeso molecular:450.36Shepherdin (79-87)
CAS:<p>Shepherdin 79-87: Amino acid fragment 79-87 of Hsp90/Survivin antagonist with anticancer properties.</p>Fórmula:C41H64N12O12SPureza:98%Forma y color:SolidPeso molecular:949.09TOPOI/PARP-1-IN-2
<p>TOPOI/PARP-1-IN-2 (compound 6c) serves as a dual inhibitor targeting both PARP-1 and topoisomerase 1 (TOPO-1), with IC50 values of 32.2 nM and 46.2 nM, respectively. This compound exhibits greater selectivity for PARP-1 over PARP-2. Additionally, TOPOI/PARP-1-IN-2 disrupts the S phase of the cell cycle and induces apoptosis in the NCI-60 cancer cell lines.</p>Fórmula:C16H11ClN4O2SForma y color:SolidPeso molecular:358.80Bfl-1-IN-5
<p>Bfl-1-IN-5 (Compound (R,R,S)-26) is a selective inhibitor of Bfl-1, demonstrating an IC50 of 0.022 μM. This compound enhances the activity of caspase-3/7, with an EC50 of 0.37 μM, and also inhibits the viability of SU-DHL-1 cells, showing an EC50 of 1.3 μM.</p>Fórmula:C24H24F3N3O2Forma y color:SolidPeso molecular:443.46LBM22
<p>LBM22, a CLK2 inhibitor, exhibits an IC50 value of 3.9 nM. It possesses anti-proliferative properties by inhibiting the phosphorylation of SR proteins. Additionally, LBM22 downregulates the expression of Wnt-related proteins and anti-apoptotic proteins, making it applicable in the study of non-small cell lung cancer.</p>Fórmula:C28H22F2N6O2Forma y color:SolidPeso molecular:512.51PTD-p65-P1 Peptide
<p>PTD-p65-P1: a NF-kappaB inhibitor blocking activation from multiple inflammatory stimuli.</p>Fórmula:C168H275N57O44SPureza:98%Forma y color:SolidPeso molecular:3829.5CDK2-IN-32
<p>CDK2-IN-32 (Compound 5g) is a selective CDK2 inhibitor with an IC50 of 0.21 μM. It exhibits cytotoxicity towards Vero cells with an IC50 of 28.52 μM.</p>Fórmula:C18H13Cl2N5O2Forma y color:SolidPeso molecular:402.23STK17A/B-IN-1 hydrochloride
STK17A/B-IN-1 hydrochloride is a potent, selective, orally active inhibitor of STK17A/B, displaying an IC50 value of 23 nM against STK17A. It is utilized in the research of tumors.Fórmula:C26H28ClN7OForma y color:SolidPeso molecular:490.00SZU-B6
CAS:SZU-B6, a PROTAC degrader, targets and degrades SIRT6 with DC50 values of 45 nM in SK-HEP-1 cells and 154 nM in Huh-7 cells. It inhibits the proliferation of SK-HEP-1 cells with an IC50 of 1.51 μM and suppresses colony formation in both SK-HEP-1 and Huh-7 cell lines. Additionally, SZU-B6 induces apoptosis in SK-HEP-1 cells and causes cell cycle arrest at the G2/M phase. It demonstrates anti-tumor activity in murine models.Fórmula:C29H32FN7O6Forma y color:SolidPeso molecular:593.6115-Acetoxyscirpenol
CAS:<p>15-acetoxyscirpenol: ASM that induces apoptosis, inhibits Jurkat T cell growth dose-dependently, and activates caspases other than caspase-3.</p>Fórmula:C17H24O6Pureza:98%Forma y color:SolidPeso molecular:324.373Tengonermin
CAS:<p>Tengonermin (ARENEGYR), a vascular agent, is TNF-α fused with CNGRCG peptide, enhancing chemo and T-cell access in tumors.</p>Forma y color:LiquidThiocolchicine
CAS:Thiocolchicine inhibits tubulin polymerization (IC50: 2.5 µM, Ki: 0.7 µM), induces apoptosis, and serves as an ADC cytotoxin.Fórmula:C22H25NO5SPureza:98.19%Forma y color:SolidPeso molecular:415.5ChoKα inhibitor-5
<p>ChoKα Inhibitor-5, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoKα1 with an IC50 value of 0.64 μM and induces apoptosis.</p>Fórmula:C54H68Br2N4S4Forma y color:SolidPeso molecular:1061.21PEAQX tetrasodium hydrate
<p>PEAQX tetrasodium hydrate: potent/selective oral NMDA antagonist, IC50 270 nM (1A/2A), 29600 nM (1A/2B).</p>Fórmula:C17H15BrN3Na4O6PPureza:99%Forma y color:SolidPeso molecular:560.15Diethyl phthalate
CAS:<p>Diethyl phthalate disrupts endocrine and induces apoptosis in PC12 cells; common in plastics, personal care items.</p>Fórmula:C12H14O4Pureza:99.68% - 99.8%Forma y color:SolidPeso molecular:222.24PD-1-IN-20
<p>PD-1-IN-20 is the less active enantiomer of PD-1-IN-1.</p>Fórmula:C12H20N6O7Pureza:98%Forma y color:SolidPeso molecular:360.327,3′,5′-Trihydroxyflavanone
CAS:<p>7,3′,5′-Trihydroxyflavanone, a flavanoid derivative, promotes apoptotic cell death in MCF-7 cells by augmenting Bax expression.</p>Fórmula:C15H12O5Forma y color:SolidPeso molecular:272.25Inuviscolide
CAS:<p>Inuviscolide induces apoptosis, G2/M arrest in melanoma, and has anti-cancer, anti-inflammatory effects.</p>Fórmula:C15H20O3Forma y color:SolidPeso molecular:248.32AKT-IN-24
<p>AKT-IN-24 (Compound M17) is an allosteric inhibitor of AKT exhibiting antitumor activity. In combination with Trametinib, it targets the AKT/mTOR and MEK/ERK signaling pathways while inhibiting epithelial-mesenchymal transition, resulting in a synergistic suppression effect on TNBC. This combination promotes apoptosis and inhibits cell proliferation and migration.</p>Fórmula:C32H28N2O10Forma y color:SolidPeso molecular:600.572NLRP3-IN-60
<p>NLRP3-IN-60 (Compound 39) is an orally bioavailable inhibitor of NLRP3. It effectively suppresses pyroptosis in THP-1 cells with an IC50 of 13 nM and inhibits IL-1β release in human whole blood, exhibiting an IC50 of 225 nM.</p>Fórmula:C23H24F2N4O4SForma y color:SolidPeso molecular:490.523Chol-CTPP
<p>Chol-CTPP targets the BBB and glioma cells; when combined with Chol-TPP, forms Lip-CTPP, enhancing anti-glioma drug efficacy.</p>Fórmula:C144H263N3O53Forma y color:SolidPeso molecular:2884.62Iparomlimab
CAS:<p>Iparomlimab: anti-PD-1 IgG4κ antibody, targets PSB103 γ4/κ-chains, forms dimers, used in cancer research.</p>Forma y color:LiquidKT-253
CAS:<p>KT-253 is a p53 stabilizer and a PROTAC degrader of MDM2 (DC50=0.4 nM). It inhibits the proliferation of cancer cells RS4;11 with an IC50 of 0.3 nM, induces cell cycle arrest in the G2/M phase, and triggers apoptosis. In mouse models, KT-253 demonstrates antitumor activity. (Pink: ligand for target protein MDM2 ligand 4; Black: linker; Blue: ligand for E3 ligase cereblon)</p>Fórmula:C48H52Cl2FN7O6Forma y color:SolidPeso molecular:912.874Metronidazole hydrochloride
CAS:<p>Oral nitroimidazole antibiotic; treats anaerobic infections; may cause inflammation and muscle contractions with long-term use.</p>Fórmula:C6H10ClN3O3Forma y color:SolidPeso molecular:207.62HPCR
CAS:<p>HPCR exhibits antiproliferative activity against various cancer cells and is involved in apoptosis (apoptosis).</p>Fórmula:C52H40O12Forma y color:SolidPeso molecular:856.867LD4172
CAS:<p>LD4172 is a PROTAC degrader capable of degrading RIP kinase (RIPK1) with a DC50 in the nanomolar range. When used in combination with TNF-α, LD4172 can induce apoptosis in B16F10 cells. In mouse models, it demonstrates antitumor activity. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase VHL)</p>Fórmula:C61H75F3N10O7SForma y color:SolidPeso molecular:1149.37Echitamine chloride
CAS:<p>Echitamine chloride, an alkaloid in Alstonia scholaris, has anti-cancer properties and inhibits pancreatic lipase (IC50: 10.92 µM).</p>Fórmula:C22H29ClN2O4Forma y color:SolidPeso molecular:420.93AZT triphosphate TEA
AZT triphosphate TFA, a Zidovudine metabolite, inhibits HIV & HBV replication and triggers mitochondrial apoptosis.Forma y color:SolidMofarotene
CAS:<p>Mofarotene (Ro-40-8757) is a small molecule compound that shows considerable antitumor activity in many cancer cell lines and can be used for the treatment of</p>Fórmula:C29H39NO2Pureza:99.96%Forma y color:SolidPeso molecular:433.63Mcl-1 inhibitor 12
CAS:<p>Mcl-1 Inhibitor 12 (Example 10), with a K i of 0.22 nM, functions as an MCL-1 inhibitor. It is utilized in cancer research [1].</p>Fórmula:C47H45ClFN7O6Forma y color:SolidPeso molecular:858.35Amino-PEG6-Thalidomide
<p>Amino-PEG6-Thalidomide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.</p>Fórmula:C27H39N3O10Pureza:98%Forma y color:SolidPeso molecular:565.61Thalidomide-NH-PEG8-Ts
CAS:<p>Thalidomide-NH-PEG8-Ts: a synthesized Thalidomide-PEG8 E3 ligase linker for PROTAC-mediated IDO1 degradation.</p>Fórmula:C36H49N3O14SForma y color:SolidPeso molecular:779.86Ganoderic acid Mf
CAS:<p>Ganoderic acid Mf: antitumor triterpenoid, arrests G1 cell cycle, selective for cancer cells, triggers apoptosis via mitochondria.</p>Fórmula:C32H48O5Forma y color:SolidPeso molecular:512.72Malformin A
CAS:Malformin A, from A. niger, is a plant growth regulator and has anti-TMV and cancer cell cytotoxic properties. Intraperitoneal LD50 in mice is 3.1 mg/kg.Fórmula:C23H39N5O5S2Forma y color:SolidPeso molecular:529.72Ono 3403
CAS:<p>Ono 3403, a synthetic serine protease inhibitor, blocks TNF-alpha, NO production, and has antitumor properties.</p>Fórmula:C26H31N3O8SPureza:98%Forma y color:SolidPeso molecular:545.6HDAC-IN-84
<p>HDAC-IN-84 (compound 4a) is a potent HDAC inhibitor with IC50 values of 0.0045, 0.015, 0.013, 0.038, 5.8, and 26 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC11, respectively. It effectively inhibits the proliferation of leukemia cells without causing toxicity.</p>Fórmula:C17H21N3O5SForma y color:SolidPeso molecular:379.431SZUH280
CAS:<p>SZUH280 is a potent, selective PROTAC (proteolysis targeting chimera) HDAC8 (histone deacetylase 8) degrader, demonstrating a DC50 of 0.58 μM in A549 cells.</p>Fórmula:C36H34N8O8Forma y color:SolidPeso molecular:706.7MDM2/4-p53-IN-2
<p>MDM2/4-p53-IN-2 (2q) is a dual MDM2/MDM4 inhibitor, p53 activator; IC50: 70.7 nM(MDM2), 81.4 nM(MDM4); tumor suppressor.</p>Fórmula:C25H17Cl3FN3O3Forma y color:SolidPeso molecular:532.78ZLDI-8
CAS:<p>ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.</p>Fórmula:C24H23N3O3SPureza:98.09%Forma y color:SolidPeso molecular:433.52eIF4A3-IN-5
CAS:<p>eIF4A3-IN-5 potently inhibits eIF4AI/II, promising for cancer research.</p>Fórmula:C26H22N2O7Forma y color:SolidPeso molecular:474.469EAD1
CAS:<p>EAD1 is a useful organic compound for research related to life sciences. The catalog number is T35329 and the CAS number is 1644388-26-0.</p>Fórmula:C24H27Cl2N7Pureza:98%Forma y color:SolidPeso molecular:484.42Chetomin
CAS:<p>Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar</p>Fórmula:C31H30N6O6S4Pureza:98%Forma y color:Off-White To Fawn SolidPeso molecular:710.87Asunercept
CAS:<p>Asunercept (APG101/CAN008) is a CD95-Fc protein targeting CD95L, used in GBM, MDS, and GvHD research.</p>Forma y color:LiquidCalcimycin hemimagnesium
CAS:<p>Calcimycin hemimagnesium is an antibiotic, ionophore, and ATPase inhibitor that boosts intracellular Ca2+, causing cell death and apoptosis.</p>Fórmula:C58H72MgN6O12Forma y color:SolidPeso molecular:1069.53Thalidomide-NH-PEG4-COOH
CAS:<p>Thalidomide-NH-PEG4-COOH is a E3 ligase ligand-linker for synthesizing the selective degrader dCBP-1 targeting p300/CBP.</p>Fórmula:C24H31N3O10Forma y color:SolidPeso molecular:521.523DefNEtTrp
<p>DefNEtTrp is an iron bis-chelating ligand composed of Def and Trp groups. It demonstrates potent broad-spectrum antiproliferative and cytotoxic effects in cancer cell lines. DefNEtTrp induces apoptosis and ferroptosis, exhibiting cytotoxicity with an IC50 value of 0.77 μM.</p>Fórmula:C30H27N9O3SForma y color:SolidPeso molecular:593.659(+)-Mcl-1 inhibitor 21
CAS:<p>(+)-Mcl-1 inhibitor 21 (Example 1-37) is a chemical compound that acts as an Mcl-1 inhibitor with an IC50 value of 172 nM. It demonstrates pro-apoptotic and antiproliferative activities in SUDHL5 and SUDHL10 cell lines, making it useful for cancer research.</p>Fórmula:C32H33N3O4Forma y color:SolidPeso molecular:523.622AM-8553
CAS:<p>AM-8553 is potent and selective piperidine the MDM2-p53 interaction inhibitor.</p>Fórmula:C25H29Cl2NO4Forma y color:SolidPeso molecular:478.41BC13
<p>BC13 is a CDK6/BRD4 inhibitor with IC50 values of 234 nM for CDK6 and 36 nM for BRD4. It exhibits antiproliferative properties, induces apoptosis (cell death) and DNA damage, and elevates ROS levels.</p>Fórmula:C37H39N7O5Forma y color:SolidPeso molecular:661.75DP-15
CAS:<p>DP-15 acts as a degrader of GSPT1 and BRD4, with DC50 values of 5.25 nM and 0.48 nM, respectively. This compound exhibits antiproliferative activity in AML and NHL cells, showing IC50 values in the nanomolar range, induces G1 phase cell cycle arrest, and triggers apoptosis in MOLM13 cells. Additionally, DP-15 demonstrates anti-leukemic properties in the MOLM-13 xenograft mouse model. [Pink: ligand for target protein JQ-1 carboxylic acid; Black: linker; Blue: ligand for E3 ligaseCereblonThalidomide-5-OH]</p>Fórmula:C42H44ClN9O5SForma y color:SolidPeso molecular:822.374AMPK-IN-6
<p>AMPK-IN-6 (compound 13a) is a potent AMPK inhibitor with an IC50 value of 0.093 µM. It induces apoptosis and suppresses autophagy. Additionally, AMPK-IN-6 exhibits antiproliferative activity and holds potential for research into pulmonary arterial hypertension.</p>Fórmula:C18H20FN5OForma y color:SolidPeso molecular:341.383Fludarabine triphosphate trisodium
<p>Fludarabine triphosphate (F-ara-ATP) trisodium inhibits DNA synthesis; IC50 2.3 μM, Ki 6.1 μM, blocks DNA primase, prompts apoptosis.</p>Fórmula:C10H12FN5Na3O13P3Forma y color:SolidPeso molecular:591.12Placulumab
CAS:<p>Placulumab (ART621), an anti-TNF α monoclonal antibody, targets inflammation, potentially aiding arthritis treatment.</p>Forma y color:LiquidPROTAC ROR1 degrader-1
<p>PROTACROR1degrader-1 (Compound 11d) serves as a PROTAC degrader targeting the pseudokinase ROR1, with the capability of degrading ROR1 in NSCLC cells at a DC50 of 40-80 nM. It induces PARP cleavage and apoptosis in NCI-H23 cells. [Pink: ligand for target protein ROR1 ligand-1; Black: linker; Blue: ligand for VHL E3 ligase (S,R,S)-AHPC]</p>Fórmula:C55H74BrN11O5SForma y color:SolidPeso molecular:1081.22TrxR1-IN-2
<p>TrxR1-IN-2 (Compound 6a) acts as a TrxR1 inhibitor that covalently bonds with the Cys475 and Sec498 sites of TrxR1. This interaction hampers TrxR1 activity, resulting in a redox homeostasis disruption and inducing apoptosis and ferroptosis.</p>Fórmula:C19H23NO6Forma y color:SolidPeso molecular:361.389Tasisulam sodium
CAS:<p>Tasisulam triggers apoptosis, halts mitosis, and normalizes blood vessels to combat cancer.</p>Fórmula:C11H5BrCl2NNaO3S2Forma y color:SolidPeso molecular:437.09WD6305
WD6305 is an effective and selective METTL3-METTL14 PROTAC degrader, with DC50 values of 140 nM and 194 nM for METTL3 and METTL14, respectively. It inhibits m6A modification and the proliferation of acute myeloid leukemia cells while inducing apoptosis. WD6305 also exhibits antitumor activity.Fórmula:C61H75F2N11O5SPeso molecular:1111.56414PROTAC GPX4 degrader-2
<p>PROTACGPX4 degrader-2 (compound 18a) is a proteolysis-targeting chimera (PROTAC) that targets the degradation of glutathione peroxidase 4 (GPX4), with a DC50, 48h value of 1.68 μM. It induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. Additionally, PROTACGPX4 degrader-2 exhibits antiproliferative activity.</p>Fórmula:C50H61ClN8O9Peso molecular:952.425155H1
155H1 (Compound 11) is a stapled peptide that covalently binds to hMcl1 (172-323) with an IC50 of 18 nM.Fórmula:C79H120FN19O23SPeso molecular:1753.85092Antimycobacterial agent-5
<p>Antimycobacterial agent-5 (compound 27) is an imidazopyridine amide compound that targets the Mycobacterium electron transport chain (ETC) respiratory CIII2CIV2 supercomplex. It acts on Mycobacterium smegmatis CIII2CIV2 with an IC50 of 441 nM.</p>Fórmula:C25H34ClN3OPeso molecular:427.23904Ilicicolin A
CAS:<p>Ilicicolin A is a useful organic compound for research related to life sciences. The catalog number is T125289 and the CAS number is 22581-06-2.</p>Fórmula:C23H31ClO3Forma y color:SolidPeso molecular:390.95WK369
WK369 is an innovative small molecule inhibitor of BCL6, demonstrating remarkable bioactivity against ovarian cancer by inducing cell cycle arrest and triggering apoptosis. It binds directly to the BCL6-BTB domain, obstructing the interaction between BCL6 and SMRT, which results in the reactivation of p53, ATR, and CDKN1A.Fórmula:C19H20FN5O2Peso molecular:369.1601PROTAC EGFR degrader 9
CAS:<p>PROTACEGFRdegrader 9 (Compound C6) is an orally active, CRBN-based PROTAC EGFR degrader. It has a DC50 of 10.2 nM and a Kd of 240.2 nM against EGFRL858R/T790M/C797S. PROTACEGFRdegrader 9 demonstrates effective degradation activity against various EGFR mutants while not affecting EGFRWT.</p>Fórmula:C45H48F3N9O6SPeso molecular:899.98PROTAC FLT3/CDK9 degrader-1
<p>Potent PROTAC degrader for FLT3/CDK9, induces apoptosis, and shows promise for FLT3-ITD mutated AML research.</p>Fórmula:C48H62N12O7Forma y color:SolidPeso molecular:919.08PRMT5-IN-33
PRMT5-IN-33 (compound A8) is a selective inhibitor of PRMT5 that competes with SAM, exhibiting an IC50 of 10.9 nM. It induces apoptosis and inhibits the proliferation of Z-138 and MOLM-13 cells, demonstrating antitumor activity.Fórmula:C25H24BrN5O3SPeso molecular:553.07832BRD6257
<p>BRD6257 is an orally active inhibitor of protein phosphatase 1D (proteinphosphatase, Mg2+/Mn2+ dependent 1D, PPM1D) with an IC50 of 5 nM. It activates the p53 signaling pathway (EC50 of 51 nM), enhances p21 expression, and inhibits the proliferation of cancer cells MOLM13 (IC50 = 2.8 μM). BRD6257 demonstrates good metabolic stability in human and rat liver microsomes.</p>Fórmula:C24H22F4N6O3SForma y color:SolidPeso molecular:550.53Betifisolimab
CAS:<p>Betifisolimab (MSB-2311) is a humanized antibody targeting PD-L1 for solid tumors and blood cancer research.</p>Forma y color:LiquidFR900359
CAS:<p>FR900359 is a macrocyclic Gq protein inhibitor that inhibits melanoma cell proliferation and can be used to study asthma, inflammation and cancer.</p>Fórmula:C49H75N7O15Pureza:98%Forma y color:SolidPeso molecular:1002.16Human PD-L1 inhibitor IV
CAS:<p>PD-L1 inhibitor IV, a polypeptide, competitively blocks hPD-1 with a Kd of 1.38 μM, preventing hPD-1/hPD-L1 interaction.</p>Fórmula:C80H113N25O27Forma y color:SolidPeso molecular:1856.932Pantinin-1
CAS:<p>Pantinin-1 is an antimicrobial peptide found in the venom of the emperor scorpion (Pandinus imperator). This compound exhibits strong antibacterial activity against Gram-positive bacteria and fungi, but has weaker effects on Gram-negative bacteria. Additionally, Pantinin-1 demonstrates very low hemolytic activity on human red blood cells and possesses anticancer properties, specifically inducing apoptosis in tumor cells.</p>Fórmula:C75H119N17O18Forma y color:SolidPeso molecular:1546.85DMUP
CAS:<p>DMUP inhibits CD47-SIRPα, induces apoptosis, boosts macrophage activity in A549 cells, and has antitumor properties.</p>Fórmula:C24H24Cl2N2O10PtForma y color:SolidPeso molecular:766.45BIIB023
<p>BIIB023 is a human monoclonal antibody (mAb) that targets TNFRSF12A/TWEAKR/CD266. It is applicable for research in lupus nephritis and rheumatoid arthritis.</p>Forma y color:Odour LiquidUNC10245380
<p>UNC10245380 is a CIB1 inhibitor with an IC50 of 8 μM. It also inhibits the phosphorylation of AKT and ERK while upregulating the expression of TRAIL-R1/D5. UNC10245380 specifically kills cancer cells that are dependent on CIB1, demonstrating its potential value in the development of CIB1 probes and cancer research.</p>Forma y color:Odour SolidAc-LEVD-CHO
CAS:<p>Ac-LEVD-CHO, a caspase-4 inhibitor, is a peptide with the sequence Ac-Leu-Glu-Val-Asp-al [1].</p>Fórmula:C22H36N4O9Forma y color:SolidPeso molecular:500.54Trilexium
CAS:<p>Trilexium (TRX-E-009-1), a third-generation benzopyran structurally related to TRX-E-002-1, increases p21 protein expression, induces apoptosis, depolymerizes microtubules, and demonstrates broad anti-cancer activity [1] [2].</p>Fórmula:C24H23FO6Forma y color:SolidPeso molecular:426.43Boc-Asp(OBzl)-CMK
CAS:Boc-Asp(OBzl)-CMK, an inhibitor of IL-1 converting enzyme (ICE, caspase1), prevents the death of CHP100 neuroblastoma cells and inhibits IL-1β release induced by the viral coat protein [1].Fórmula:C17H22ClNO5Forma y color:SolidPeso molecular:355.81ERK-IN-6
<p>ERK-IN-6, a potent agent, inhibits ESCC growth and induces apoptosis through the ERK pathway.</p>Fórmula:C19H18BrN3O3SForma y color:SolidPeso molecular:448.33Thalidomide-NH-PEG2-COOH
CAS:<p>Thalidomide-NH-PEG2-COOH: a synthesized E3 ligase ligand-linker with cereblon ligand and PROTAC linker.</p>Fórmula:C20H23N3O8Forma y color:SolidPeso molecular:433.417PBE-AMF
PBE-AMF is a prodrug that activates H2O2 and exhibits anticancer activity. It impedes tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing cell death (apoptosis), and blocking the cell cycle. PBE-AMF effectively and selectively inhibits the proliferation of MDA-MB-231 cells (IC50=6.4 μM) while sparing non-cancerous MCF-10A cells.Forma y color:Odour Solid(Rac)-BIO8898
CAS:<p>(Rac)-BIO8898 is a chemical compound that serves as an inhibitor of the co-stimulatory interaction between CD40 and CD154.</p>Fórmula:C53H64N8O6Forma y color:SolidPeso molecular:909.13CQ1373
<p>CQ1373 is a potent RET inhibitor that demonstrates cellular activity against BaF3 cells expressing CCDC6-RET, CCDC6-RET-G810C, and CCDC6-RET-G810R, with IC50 values of 13.0, 25.7, and 28.4 nM, respectively. It shows excellent selectivity for wild-type RET and solvent front mutants G810C/R, with IC50 values of 4.2, 7.1, and 32.4 nM. CQ1373 inhibits RET phosphorylation and downstream signaling through SHC. Additionally, it induces apoptosis (Apoptosis) and cell cycle arrest in BaF3 cells. CQ1373 possesses antitumor efficacy, making it a candidate for cancer research.</p>Fórmula:C25H22ClF3N6O3Forma y color:SolidPeso molecular:546.93Lenercept
CAS:<p>Lenercept (Ro 45-2081) is a recombinant fusion protein combining the soluble TNF-receptor (p55) with the Fc portion of human IgG1 [1].</p>Forma y color:LiquidTripchlorolide
<p>Tripchlorolide is a useful organic compound for research related to life sciences and the catalog number is T126047.</p>Fórmula:C20H25ClO6Forma y color:SolidPeso molecular:396.86Atibuclimab
CAS:<p>Atibuclimab is a chimeric monoclonal antibody targeting CD14, consisting of a mouse variable region and a human IgG4 Fc region.</p>Pureza:> 95% - > 95%Forma y color:LiquidPeso molecular:145.28 kDa(E/Z)-Eltrombopag 13C4
CAS:<p>(E/Z)-Eltrombopag 13C4 is a mix of E/Z isotopologues, both 13C-labeled TPO receptor agonists for thrombocytopenia.</p>Fórmula:C25H22N4O4Forma y color:SolidPeso molecular:446.444Antagonist G TFA
<p>Potent vasopressin blocker, Antagonist G TFA also mildly inhibits GRP & Bradykinin, triggers AP-1, enhances chemo response.</p>Fórmula:C51H67F3N12O8SForma y color:SolidPeso molecular:1065.21cis-Clovamide
CAS:<p>cis-Clovamide is a naturally occurring phenolic compound with noteworthy antioxidant, anti-inflammatory, and antiapoptotic properties.</p>Fórmula:C18H17NO7Forma y color:SolidPeso molecular:359.334FOXO4-DRI
CAS:<p>FOXO4-DRI: a peptide blocking FOXO4/p53 interaction; induces senescent cells' apoptosis.</p>Fórmula:C228H388N86O64Forma y color:SolidPeso molecular:5358.06CDC20-IN-2
<p>CDC20-IN-2 (14c) is an inhibitor of Cdc20 with a KD of 7.65 μM, inducing G2/M phase arrest, promoting DNA damage accumulation, and stabilizing key substrates such as Cyclin B1 and Bim. This leads to enhanced apoptosis, as well as inhibition of tumor cell proliferation and migration.</p>Forma y color:Odour SolidNecroptosis-IN-5
<p>Necroptosis-IN-5 (Compound 26) is an orally active inhibitor of necroptotic cell death (necroptosis). This compound also exhibits potent inhibitory activity against receptor-interacting protein kinase 1 (RIPK1). It can be utilized in research related to inflammatory diseases, neurodegenerative disorders, and cancer associated with necroptosis.</p>Forma y color:Odour SolidRET Ligand-Linker Conjugate-1
<p>RET Ligand-Linker Conjugate-1 consists of a complex formed by a RET ligand and a linker, which can be utilized in the synthesis of QZ2135.</p>Fórmula:C40H44N10OForma y color:SolidPeso molecular:680.84BcI-2/BcI-xI ligand 1
CAS:<p>BcI-2/BcI-xI ligand 1, functioning as a BcI-2/BcI-xI ligand, is utilized in the synthesis of PROTAC BcI-2/BcI-xI Degrader-1 .</p>Fórmula:C53H64ClF3N6O8S3Forma y color:SolidPeso molecular:1101.75Nur77 modulator 4
<p>Nur77 modulator 4 (Compound 15h) is a Nur77 inducer with a KD of 0.477 μM. It significantly promotes Nur77 expression and apoptosis, exhibiting excellent growth inhibitory effects on HepG2 and MCF-7 cells, with an IC50 of less than 5 μM. Nur77 modulator 4 activates Nur77-mediated ER stress through the PERK-ATF4 and IRE1 signaling pathways, leading to apoptosis. This compound is applicable in cancer research.</p>Fórmula:C26H28ClN5O2Forma y color:SolidPeso molecular:477.99Anticancer agent 134
<p>Anticancer Agent 134 (Compound 6a), an environment-sensitive fluorescent probe, induces apoptosis and selectively differentiates between tumor and normal</p>Fórmula:C34H36ClN7O3S2Pureza:98%Forma y color:SolidPeso molecular:690.28SSE1806
<p>SSE1806, a podophyllotoxin derivative (a natural antimitotic agent), functions as a microtubule/tubulin inhibitor, exhibiting potent anticancer and</p>Fórmula:C21H18N2O5Forma y color:SolidPeso molecular:378.38Terrein
CAS:<p>Terrain (NSC 291308), a fungal metabolite, reduces age-related inflammation via Nrf2/ERK1/2/HO-1 and inhibits IL-6 in human fibroblasts.</p>Fórmula:C8H10O3Forma y color:SolidPeso molecular:154.16Diprovocim-1
CAS:<p>Diprovocim-1: TLR1/2 agonist; triggers TNF-α in THP-1 cells; boosts ovalbumin IgG1 & CTLs against tumors with anti-PD-L1 in mice.</p>Fórmula:C56H56N6O6Forma y color:SolidPeso molecular:909.1eIF4E-IN-5
<p>eIF4E-IN-5 (Compound 6n) is a cell-permeable eIF4E inhibitor that binds to capped mRNA, thereby inhibiting cap-dependent translation [1].</p>Fórmula:C30H39Cl2N6O8PForma y color:SolidPeso molecular:713.55hCAIX-IN-13
CAS:<p>hCAIX-IN-13 (Pt2) inhibits CAIX with 6.57 μM IC50, curbs cancer cell growth, and induces apoptosis for cancer research.</p>Fórmula:C37H33F3N6O7PtS2Forma y color:SolidPeso molecular:989.9SRE-II
<p>SRE-II, an amide derivative, serves as an activatable photosensitizer tailored for photodynamic cancer research, exhibiting diminished fluorescence and</p>Fórmula:C15H9ClINO2Pureza:98%Forma y color:SolidPeso molecular:397.59LL-K9-3
CAS:<p>LL-K9-3, a selective hydrophobic tagging technology (HyT)-based degrader, specifically targets the CDK9-cyclin T1 complex, displaying DC50 values of 589 nM for</p>Fórmula:C31H49N5O6S3Forma y color:SolidPeso molecular:683.94BODIPY FL thalidomide
CAS:<p>BODIPY FL thalidomide is a fluorescent probe that binds human cereblon protein with high affinity, exhibiting a dissociation constant (Kd) of 3.6 nM [1].</p>Fórmula:C37H43BF2N6O7Forma y color:SolidPeso molecular:732.58fac-[Re(CO)3(L3)(H2O)][NO3]
<p>Fac-[Re(CO)3(L3)(H2O)][NO3] (Compound 3), a rhenium(I) tricarbonyl aqua complex, acts as an anticancer agent through the induction of mitochondrial dysfunction.</p>Fórmula:C25H17N6O8ReForma y color:SolidPeso molecular:715.64Thalidomide-Piperazine 5-fluoride hydrochloride
CAS:<p>Thalidomide-Piperazine 5-fluoride hydrochloride, a derivative of the cereblon (CRBN) inhibitor Thalidomide, serves as a ligand for E3 ubiquitin ligase (Ligands for E3 Ligase), facilitating the synthesis of PROTACs [1].</p>Fórmula:C17H18ClFN4O4Forma y color:SolidPeso molecular:396.8Hypoxia inducer-1
<p>Hypoxia inducer-1 (Compound N6) is a NO donor compound that is orally active and activated under hypoxic conditions. It exhibits high selectivity in releasing NO, inhibiting apoptosis, necrosis, and elevated levels of reactive oxygen species (ROS) associated with hypoxia. It modulates vasodilation and shows protective effects in a mouse model of myocardial hypoxic injury, making it useful for coronary heart disease research.</p>Fórmula:C14H12FN3O4Forma y color:SolidPeso molecular:305.261TAT-NEP1-40 acetate
<p>TAT-NEP1-40 acetate, a potential therapeutic for axonal regeneration and functional recovery post-stroke, safeguards PC12 cells from oxygen and glucose</p>Fórmula:C268H438N88O77·xC2H4O2Pureza:98%Forma y color:SolidPeso molecular:6124.89 (free base)Antitumor agent-113
<p>Antitumor Agent-113 exhibits cytotoxicity in A549 cells, with an IC50 of 46.60 μM, and induces apoptosis, making it applicable for research in non-small cell</p>Fórmula:C21H22ClN5O2SPureza:98%Forma y color:SolidPeso molecular:443.95PD-L1/VISTA-IN-2
<p>PD-L1/VISTA-IN-2 (Compound S8) is an orally active dual inhibitor targeting PD-L1 and VISTA, with an IC50 of 1.4 μM for PD-L1 and a KD of 2.1 μM for VISTA. This compound can activate the tumor immune microenvironment, exerting anticancer effects.</p>Fórmula:C22H22N2O3Forma y color:SolidPeso molecular:362.422-deoxy-D-Glucose-13C6
CAS:<p>2-deoxy-D-Glucose-13C6 is an internal standard for GC/LC-MS, a glycolysis inhibitor, and induces apoptosis in certain cells at 2 mg/ml.</p>Fórmula:C5CH12O5Forma y color:SoildPeso molecular:165.15Thalidomide-NH-(CH2)2-NH2 TFA
CAS:<p>Thalidomide-NH-(CH2)2-NH2 TFA is an alkyl-modified derivative of Thalidomide serving as a Cereblon ligand to recruit CRBN proteins and a pivotal intermediate in</p>Fórmula:C17H17F3N4O6Forma y color:SolidPeso molecular:430.34TP4 (Nile tilapia piscidin)
CAS:<p>TP4 (Nile tilapia piscidin) is an orally active piscidin-like antimicrobial peptide that exhibits inhibition of various gram-positive and negative bacterial</p>Fórmula:C135H226N50O27Pureza:98%Forma y color:SolidPeso molecular:2981.56TAT-NEP1-40 TFA
<p>TAT-NEP1-40 TFA, a blood-brain barrier-permeable peptide, safeguards PC12 cells against oxygen and glucose deprivation (OGD) and fosters neurite outgrowth.</p>Fórmula:C268H438N88O77·xC2HF3O2Pureza:98%Forma y color:SolidPeso molecular:6124.89 (free base)Tubulin polymerization-IN-72
<p>Tubulin polymerization-IN-72 (Compound 4a4) is a microtubule synthesis inhibitor with anticancer properties. By binding to the colchicine site, it disrupts the polymerization of tubulin, resulting in the arrest of cancer cells at the G2/M phase and inducing apoptosis (Apoptosis). The IC50 for its activity against cancer cells is 0.4-2.7 nM.</p>Fórmula:C19H19FN4OForma y color:SolidPeso molecular:338.379TNF-α-IN-6
CAS:<p>TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα ( K D = 6.8 nM).</p>Fórmula:C26H25N9O2Forma y color:SolidPeso molecular:495.547EGFR-IN-78
<p>EGFR-IN-78 (compound A5), a 2-aminopyrimidine derivative, serves as a reversible EGFR C797S-TK inhibitor and an apoptosis inducer.</p>Fórmula:C23H32BrN7O2SPureza:98%Forma y color:SolidPeso molecular:550.51Tubulin/HDAC-IN-2
<p>Tubulin/HDAC-IN-2 (Compound II-19k) is a dual inhibitor targeting Tubulin and HDAC, exhibiting IC50 values of 0.403 μM for HDAC1, 0.591 μM for HDAC2, 3.552 μM</p>Fórmula:C21H19FN2O4Forma y color:SolidPeso molecular:382.38GPX4-IN-7
<p>GPX4-IN-7 (Compound 31), an indirubin derivative, serves as a ferroptosis inducer in colon cancer treatment.</p>Fórmula:C25H23ClN4O4Pureza:98%Forma y color:SolidPeso molecular:478.93fac-[Re(CO)3(L6)(H2O)][NO3]
<p>Compound 6, fac-[Re(CO)3(L6)(H2O)][NO3], a rhenium(I) tricarbonyl aqua complex, serves as an anticancer agent by disrupting mitochondrial function.</p>Fórmula:C24H14N5O7ReSPureza:98%Forma y color:SolidPeso molecular:702.678-Aminoadenosine
CAS:<p>8-Aminoadenosine reduces ATP, blocks mRNA synthesis, and Akt/mTOR signaling, triggering autophagy and apoptosis independently of p53, with antitumor effects.</p>Fórmula:C10H14N6O4Forma y color:SolidPeso molecular:282.26Boanmycin
CAS:<p>Boanmycin, an antibiotic exhibiting antitumor activity, induces cellular senescence and apoptosis [1] [2] [3].</p>Fórmula:C60H96N20O21S2Forma y color:SolidPeso molecular:1497.66Anticancer agent 133
<p>Compound Rh2 (Anticancer agent 133) is a cytotoxic and antimetastatic agent that induces cell cycle arrest, apoptosis, and autophagy.</p>Fórmula:C24H19Cl3N5ORhPureza:98%Forma y color:SolidPeso molecular:602.71Antimycin A2c
<p>Anticancer Agent 141 (Compound AE), an antimycin alkaloid, exhibits inhibitory potential against HPV-infected cervical cancer.</p>Fórmula:C28H40N2O9Pureza:98%Forma y color:SolidPeso molecular:548.63Thalidomide-5-propoxyethanamine
CAS:<p>Thalidomide-5-propoxyethanamine acts as a cereblon (CRBN) ligand derived from Thalidomide, and it serves the purpose of recruiting the CRBN protein.</p>Fórmula:C18H21N3O5Forma y color:SolidPeso molecular:359.38YL5084
CAS:<p>YL5084 is a selective JNK2/3 inhibitor with IC50s: JNK2 (70 nM), JNK3 (84 nM), and antiproliferative, apoptosis-inducing effects.</p>Fórmula:C35H36N8O2Forma y color:SolidPeso molecular:600.71Cefatrizine
CAS:<p>Cefatrizine inhibits eEF-2 kinase, affecting apoptosis, autophagy, and ER stress in cancers.</p>Fórmula:C18H18N6O5S2Pureza:98%Forma y color:SolidPeso molecular:462.5PROTAC FLT-3 degrader 1
CAS:<p>PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 degrader of internal tandem duplication (ITD)(IC50 0.6 nM),with anti-proliferative activity.</p>Fórmula:C52H61N9O9S2Pureza:98%Forma y color:SolidPeso molecular:1020.23PD0166285 dihydrochloride
CAS:<p>PD-166285 is an effective and broadly active inhibitor of protein tyrosine kinase.</p>Fórmula:C26H29Cl4N5O2Forma y color:SolidPeso molecular:585.35Asparanin A
CAS:<p>Asparanin A, an apoptosis inducer with anticancer properties, arrests the cell cycle in the G0/G1 phase via the mitochondria and PI3K/AKT signaling pathways.</p>Fórmula:C39H64O13Pureza:98%Forma y color:SolidPeso molecular:740.92Anticancer agent 130
<p>Anticancer agent 130 (compound 8d) significantly induces apoptosis in A549 cells [1].</p>Fórmula:C38H46FN5O5Pureza:98%Forma y color:SolidPeso molecular:671.8PERK-IN-6
CAS:<p>PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).</p>Fórmula:C23H22N6OPureza:99.62% - 99.92%Forma y color:SolidPeso molecular:398.46Δ8-Tetrahydrocannabinoquinone
CAS:<p>Δ8-Tetrahydrocannabinoquinone (HU-336) is a potent anti-angiogenic agent that inhibits angiogenesis by directly inducing apoptosis in vascular endothelial cells. It achieves this without altering the expression of pro-angiogenic and anti-angiogenic cytokines and receptors. Δ8-Tetrahydrocannabinoquinone also shows significant effectiveness against tumor xenografts in nude mice.</p>Fórmula:C21H28O3Forma y color:SolidPeso molecular:328.45Thalidomide-O-amido-PEG3-C2-NH2
CAS:<p>Thalidomide-O-amido-PEG3-C2-NH2 is a cereblon ligand-linker for PROTACs with a 3-unit PEG.</p>Fórmula:C23H30N4O9Pureza:98%Forma y color:SolidPeso molecular:506.51Fuscin
CAS:<p>Fuscin, a quinonoid from O. fuscum, inhibits ADP/ATP translocase, depletes glutathione, disrupts NADH oxidation, and blocks MIP-1α/CCR5 binding (IC50: 21µM).</p>Fórmula:C15H16O5Forma y color:SolidPeso molecular:276.288BCL-XL-IN-3
CAS:<p>BCL-XL-IN-3 (Compound 11) is an inhibitor of BCL-XL, with a Ki of less than 0.01 nM. It suppresses cell viability in both normal Molt-4 cells and digitonin-permeabilized Molt-4 cells, with EC50 values of 77.8 nM and 0.07 nM, respectively. BCL-XL-IN-3 can be utilized as an ADC toxin for synthesizing Clezutoclax.</p>Fórmula:C46H55N7O6SForma y color:SolidPeso molecular:834.04VEGFR-2-IN-68
<p>VEGFR-2-IN-68 (13b) is an inhibitor of VEGFR-2 with an IC50 value of 41.51 nM. It can induce apoptosis and cause G2/M cell cycle arrest, as well as exhibit anti-cancer metastasis properties.</p>Fórmula:C27H25N5O2SForma y color:SolidPeso molecular:483.1729HFY-4A
CAS:HFY-4A is a novel HDAC inhibitor.HFY-4A has antitumour activity and has shown antiproliferative activity in breast cancer cells.Fórmula:C20H19N3O2Pureza:98.66% - 99.22%Forma y color:SoildPeso molecular:333.38Tilogotamab
CAS:<p>Tilogotamab (GEN-1029) is an agonistic hexameric complex targeting two independent epitopes on DR5, used for studying multiple myeloma (MM).</p>Pureza:95%Forma y color:LiquidDRI-C21041 (DIEA)
<p>DRI-C21041 DIEA serves as an inhibitor of CD40/CD40L interaction, exhibiting an inhibitory concentration (IC50) of 0.31 μM.</p>Fórmula:C38H40N4O7SForma y color:SolidPeso molecular:696.81DHFR-IN-23
<p>DHFR-IN-23 (compound 5) is a dual inhibitor of DNA binders/DHFR, exhibiting an IC50 value of 0.08 μM against hDHFR. It serves as an apoptosis inducer and is applicable in research on ER+ breast cancer.</p>Forma y color:Odour SolidBorrelidin
CAS:<p>Borrelidin (Treponemycin) is an inhibitor of trehalose-6-phosphate synthase, a nitrogen-containing macrolide antibiotic isolated from Streptomyces rochei.</p>Fórmula:C28H43NO6Pureza:98%Forma y color:White To Off-White PowderPeso molecular:489.64Nrf2 activator-9
<p>Nrf2 activator-9 (compound D-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of HUVEC cells induced by oxidized low-density</p>Fórmula:C26H27N5O4Forma y color:SolidPeso molecular:473.52Se-Aspirin
CAS:<p>Se-Aspirin (Se-NSAID-8) has anticancer activity and gastroprotective effects, inhibits activation of proinflammatory and pro-survival NF-ĸB pathways, and inhibits the expression of anti-apoptotic targets downstream of NF-ĸB (e.g., Bcl-xL, Mcl-1, and survivin).Se-Aspirin induces Cell cycle arrest and activation of apoptosis accelerates ulcer healing and can be used to study pancreatic and colorectal cancer.</p>Fórmula:C12H12N2O3SePureza:98.07%Forma y color:SolidPeso molecular:311.2H3B-8800
CAS:<p>H3B-8800 is an SF3B1 modulator that can be used to study transfusion-dependent anemia.</p>Fórmula:C31H45N3O6Pureza:98.31%Forma y color:SoildPeso molecular:555.71Mcl1-IN-12
CAS:<p>Mcl1-IN-12 has anti-tumor activity.It is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively.</p>Fórmula:C45H46N4O6S2Pureza:98%Forma y color:SolidPeso molecular:803β-Glucuronide-dPBD-PEG5-NH2
CAS:<p>β-Glucuronide-dPBD-PEG5-NH2 is a β-glucuronide-linked pyrrolobenzodiazepine dimer that functions as a proagent for the synthesis of the antibody-drug conjugate</p>Fórmula:C78H101N7O35Forma y color:SolidPeso molecular:1696.66BM-1244
CAS:<p>BM-1244 is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively.</p>Fórmula:C54H59ClF4N6O8S4Forma y color:SolidPeso molecular:1159.78Voreloxin
CAS:<p>Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.</p>Fórmula:C18H19N5O4SPureza:98%Forma y color:SolidPeso molecular:401.44Thalidomide-Piperazine-Piperidine
CAS:<p>Thalidomide-based E3 ligase ligand linked to a PROTAC piperazine-piperidine chain.</p>Fórmula:C22H27N5O4Forma y color:SolidPeso molecular:425.489SPOP-IN-6lc
CAS:<p>SPOP-IN-6lc is a SPOP inhibitor with oncogenic effects in renal cancer cells.SPOP-IN-6lc can be used to study apoptosis.</p>Fórmula:C26H31N7O2SPureza:99.19%Forma y color:SolidPeso molecular:505.64Platycoside G3
CAS:<p>Platycoside G3 is a useful organic compound for research related to life sciences. The catalog number is T124100 and the CAS number is 849758-44-7.</p>Fórmula:C63H102O32Forma y color:SolidPeso molecular:1371.48Apoptosis inducer 13
<p>Apoptosis Inducer 13 (Compound Ru4) promotes apoptosis in cancer cells while also suppressing their migration and invasion.</p>Fórmula:C59H54ClF6N8O4PRuPureza:98%Forma y color:SolidPeso molecular:1220.6rac-CCT-250863 HCl
<p>rac-CCT-250863 HCl: NEK 2 inhibitor, halts cell cycle, anti-cancer growth, boosts Pomalidomide-induced apoptosis.</p>Fórmula:C24H26ClF3N4O2SPureza:98.21%Forma y color:SoildPeso molecular:527CDK8-IN-13
CAS:<p>CDK8-IN-13 is a CDK8 inhibitor (IC50: 51.9 nM) with potent, selective and oral activity.</p>Fórmula:C14H11N3OPureza:99.28%Forma y color:SoildPeso molecular:237.26Aspidin BB
CAS:<p>Aspidin BB, a phloroglucinol from Dryopteris, inhibits cancer by causing cell cycle arrest and apoptosis in HO-8910 cells.</p>Fórmula:C25H32O8Forma y color:SolidPeso molecular:460.52Z-Asp-CH2-DCB
CAS:<p>Z-Asp-CH2-DCB is an irreversible inhibitor of broad spectrum caspase.</p>Fórmula:C20H17Cl2NO7Pureza:99.08%Forma y color:SolidPeso molecular:454.26EGFR/BRAFV600E-IN-3
<p>EGFR/BRAFV600E-IN-3 is an inhibitor targeting EGFR, BRAFV600E, and EGFRT790M with IC50 values of 57 nM, 68 nM, and 9.70 nM, respectively.</p>Fórmula:C25H18N4O3Pureza:98%Forma y color:SolidPeso molecular:422.44PH14
<p>PH14, a dual PI3K/HDAC inhibitor, demonstrates potent inhibition with IC50 values of 20.3 nM for PI3Kα and 24.5 nM for HDAC3.</p>Pureza:98%Forma y color:Odour SolidCPD-10
CAS:<p>CPD-10 is a potent bifunctional PROTAC degrader targeting CCND1 and CDK4 and exhibits antiproliferative effects. It induces apoptosis and reduces the protein expression of Cyclin D1, Cyclin D3, CDK4, and P-Rb(5807/811) in a dose-dependent manner.</p>Fórmula:C46H61N15O4Forma y color:SolidPeso molecular:888.08SA-VA
<p>SA-VA, an intracellular self-assembled PROTAC featuring azide and alkyne groups, selectively degrades VEGFR-2 and EphB4 proteins within U87 cells.</p>Fórmula:C50H53ClF3N11O7SPureza:98%Forma y color:SolidPeso molecular:1044.54WK499
<p>BCL6-IN-10 (Compound WK499) is an inhibitor of BCL6, disrupting its interaction with the SMRT protein and promoting apoptosis, cell cycle arrest, and DNA damage</p>Fórmula:C21H20BrN7O3Forma y color:SolidPeso molecular:498.33Thalidomide-PEG2-C2-NH2
CAS:<p>Thalidomide-O-amido-PEG3-C2-NH2 is a cereblon ligand-linked E3 ligase used in PROTAC with a 2-unit PEG.</p>Fórmula:C19H24N4O6Pureza:98%Forma y color:SolidPeso molecular:404.42Sudubrilimab
<p>Sudubrilimab (HS636) is an IgG1-κ monoclonal antibody targeting PDL1, fused with TGFBR2-ECD to block PD-1/PDL1 and TGF-β in tumors.</p>Forma y color:Odour LiquidZ-Ala-Ala-Asp-CMK
CAS:<p>Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) is a selective granzyme B inhibitor that blocks granzyme B protease activity, for inflammatory diseases and tumours.</p>Fórmula:C19H24ClN3O7Pureza:99.967%Forma y color:SolidPeso molecular:441.86HYS-072
<p>HYS-072 is an orally active derivative of chrysin with antitumor properties. It induces apoptosis (Apoptosis) and autophagy (Autophagy) by inhibiting the PI3K/AKT/mTOR signaling pathway, and suppresses tumor growth in xenograft models in vivo by modulating autophagy-related pathways. HYS-072 is applicable for research in treating triple-negative breast cancer.</p>Fórmula:C27H26N2O5Forma y color:SolidPeso molecular:458.51Spexin TFA
<p>Spexin TFA: GAL2/GAL3 agonist (EC50: 45.7/112.2 nM), no activity at GAL1, reduces appetite, fatty acid uptake, and LH secretion; anxiolytic.</p>Fórmula:C76H115F3N20O21SForma y color:SolidPeso molecular:1733.9Oxatomide
CAS:<p>Oxatomide: Dual H1/P2X7 antagonist, antihistamine, anti-allergic, treats immune diseases, IC50: 0.95 μM (P2X7), 0.43 μM (5-HT).</p>Fórmula:C27H30N4OPureza:98.82% - 99.72%Forma y color:White PowderPeso molecular:426.55
