Apoptosis
Los inhibidores de la apoptosis son compuestos que previenen o retrasan el proceso de muerte celular programada, conocido como apoptosis. Estos inhibidores son vitales para estudiar los mecanismos de supervivencia celular y se utilizan para investigar enfermedades donde la apoptosis está desregulada, como el cáncer, los trastornos neurodegenerativos y las enfermedades autoinmunes. Al modular la apoptosis, estos inhibidores pueden ayudar en el desarrollo de terapias dirigidas a controlar la muerte celular. En CymitQuimica, ofrecemos una amplia selección de inhibidores de la apoptosis de alta calidad para apoyar su investigación en biología celular, oncología y campos relacionados.
Subcategorías de "Apoptosis"
- ASK(6 productos)
- BCL(11 productos)
- Caspasa(127 productos)
- FOXO1(3 productos)
- IAP(65 productos)
- Mdm2(12 productos)
- PD-1 / PD-L1(126 productos)
- PDK(9 productos)
- PERK(24 productos)
- Serina / treonina quinasa(15 productos)
- Survivin(13 productos)
- TNF(91 productos)
- c-RET(51 productos)
- p53(62 productos)
Mostrar 6 subcategorías más
Se han encontrado 5622 productos de "Apoptosis"
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Moflerafusp alfa
CAS:<p>Moflerafusp alfa is a fusion protein that targets the human signal-regulatory protein alpha (SIRPα) variant V2 D1 domain and human programmed death-ligand 1 (PD-L1). It shows potential for research in various cancer treatments.</p>Forma y color:LiquidThalidomide-O-amido-C3-PEG3-C1-NH2
CAS:<p>Thalidomide-based E3 ligase linker for PROTACs with a 3-unit PEG chain.</p>Fórmula:C27H35F3N4O11Forma y color:SolidPeso molecular:648.5897-epi-Isogarcinol
CAS:<p>7-epi-Isogarcinol, a PPAP, hinders STAT3 to induce apoptosis and curbs cell migration with moderate antiproliferative effects.</p>Fórmula:C38H50O6Forma y color:SolidPeso molecular:602.8Thalidomide-O-amido-C8-NH2
CAS:<p>Thalidomide-O-amido-C8-NH2 is a thalidomide-based ligand-linker for PROTAC synthesis.</p>Fórmula:C23H30N4O6Pureza:98%Forma y color:SolidPeso molecular:458.51DCZ3301
CAS:<p>DCZ3301 is a novel aryl-guanidino inhibitor.</p>Fórmula:C20H16ClF3N6O2Pureza:99.89%Forma y color:SolidPeso molecular:464.83RD-23
CAS:<p>RD-23 is an orally active and selective RET PROTAC degrader. It facilitates the ubiquitination and degradation of the RETG810C mutant with a DC50 value of 11.7 nM. Additionally, RD-23 inhibits the activation of downstream Shc signaling and induces apoptosis (Apoptosis). It is useful for studying RET-related cancers.</p>Fórmula:C52H56N12O4Forma y color:SolidPeso molecular:913.079FeTPPS
CAS:<p>FeTPPS, a decomposition catalyst for 5,10,15,20-tetrakis(4-sulfonatophenyl) porphyrin iron(III) chloride peroxynitrite, neuroprotective.</p>Fórmula:C44H28ClFeN4O12S4Forma y color:SolidPeso molecular:1024.27RET ligand-1
CAS:<p>RETligand-1 is a target protein ligand that specifically interacts with RET and can be utilized in the synthesis of the PROTAC LDD39.</p>Fórmula:C28H24F2N6O3Forma y color:SolidPeso molecular:530.525Lacto-N-fucopentaose I
CAS:<p>Lacto-N-fucopentaose I is a milk oligosaccharide.</p>Fórmula:C32H55NO25Forma y color:SolidPeso molecular:853.774Z-WEHD-FMK
CAS:Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).Fórmula:C37H42FN7O10Pureza:98%Forma y color:SolidPeso molecular:763.78ADPM06
CAS:<p>ADPM06: nonporphyrin PDT agent; leads in apoptosis, strong IC50 in µM against human tumors.</p>Fórmula:C34H24BBr2F2N3O2Forma y color:SolidPeso molecular:715.19Diazepinomicin
CAS:<p>Diazepinomicin, from Micromonospora, blocks EGF-Ras-ERK pathway and induces apoptosis; an anti-tumor agent for K-Ras mutants.</p>Fórmula:C28H34N2O4Pureza:98%Forma y color:SolidPeso molecular:462.58Golimumab
CAS:Golimumab (CNTO-148), an anti-TNFα IgG1κ monoclonal antibody with anti-inflammatory and anti-cancer activity, can be used to prevent inflammation and cartilage.Forma y color:LiquidPeso molecular:146.93 kDaAcetyl coenzyme A
CAS:<p>Acetyl coenzyme A (Acetyl-CoA) is a pivotal molecule connecting multiple cellular metabolic pathways in the tricarboxylic acid cycle, fatty acid synthesis</p>Fórmula:C23H38N7O17P3SForma y color:SolidPeso molecular:809.57(R)-MIK665
CAS:<p>(R)-MIK665 is the less active enantiomer of MIK665. MIK665 is a special inhibitor of Mcl-1(IC50 of 1.81 nM).</p>Fórmula:C47H44ClFN6O6SPureza:98%Forma y color:SolidPeso molecular:875.41PZ703b hydrochloride
PZ703b hydrochloride, a Bcl-xl PROTAC, triggers apoptosis and halts cancer growth; used in bladder cancer studies.Fórmula:C80H103Cl2F3N10O11S4Forma y color:SolidPeso molecular:1636.9Thalidomide-O-amido-C8-NH2 hydrochloride
<p>Thalidomide-O-amido-C8-NH2 hydrochloride, a synthetic cereblon ligand-linker for PROTAC synthesis.</p>Fórmula:C23H31ClN4O6Pureza:98%Forma y color:SolidPeso molecular:494.97RET ligand-3
<p>RETligand-3 is the ligand for PROTAC QZ2135, which targets RET.</p>Fórmula:C38H42N10O3Forma y color:SolidPeso molecular:686.81(±)-Enterodiol
CAS:<p>"(±)-Enterodiol, the racemate of Enterodiol, is metabolized from lignans found in whole-grain cereals, nuts, legumes, flaxseed, and vegetables by human intestinal bacteria. This compound exhibits apoptotic effects in colorectal cancer (CRC) cells and has been identified to possess anti-cancer activities [1] [2]."</p>Fórmula:C18H22O4Forma y color:SolidPeso molecular:302.36W1131 TFA
<p>W1131 TFA is a STAT3 inhibitor and ferroptosis inducer that regulates the IL6-JAK-STAT3 and ferroptosis pathways,gastric cancer.</p>Fórmula:C25H20F3N5O6Pureza:98.1%Forma y color:SolidPeso molecular:543.45KH16
<p>KH16 is an HDAC inhibitor.KH16 stimulates apoptosis and is able to inhibit gene expression patterns in a variety of tumor cells.</p>Fórmula:C18H20N6O2Pureza:98.15%Forma y color:SolidPeso molecular:352.39APG-1387
CAS:<p>APG-1387 inhibits IAPs, degrades cIAP1/2, XIAP, boosts chemosensitivity, and induces apoptosis in NPC.</p>Fórmula:C60H72N10O10S2Forma y color:SolidPeso molecular:1157.41Pegsunercept
CAS:<p>Pegsunercept (PEG sTNF-RI), a pegylated monoclonal antibody, selectively binds to TNFA, incorporating a polyethylene glycol (pegol) moiety [1].</p>Forma y color:LiquidTD1092
<p>TD1092, a pan-IAP degrader, activates caspase 3/7, induces apoptosis in cancer cells, inhibits NF-κB, and is used in cancer research.</p>Fórmula:C55H70N8O9Forma y color:SolidPeso molecular:987.19Diethanolamine hydrochloride
CAS:<p>Diethanolamine hydrochloride is HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4) and pregnane X receptor (PXR), p53 Estrogen receptor.</p>Fórmula:C4H12ClNO2Pureza:99.69%Forma y color:SolidPeso molecular:141.6Echitamine chloride
CAS:<p>Echitamine chloride, an alkaloid in Alstonia scholaris, has anti-cancer properties and inhibits pancreatic lipase (IC50: 10.92 µM).</p>Fórmula:C22H29ClN2O4Forma y color:SolidPeso molecular:420.93AFMK
CAS:<p>AFMK (Formyl-N-acetyl-5-methoxykynurenamine) is an active metabolite of Melatonin with antioxidant and free radical scavenging activity.</p>Fórmula:C13H16N2O4Pureza:98.34% - 99.81%Forma y color:SolidPeso molecular:264.28Ac-YVAD-CHO acetate
<p>Ac-YVAD-CHO acetate, potent reversible ICE and caspase-1 inhibitor; K_i: 3.0 nM (mouse), 0.76 nM (human); blocks IL-lβ production.</p>Fórmula:C25H36N4O10Forma y color:SolidPeso molecular:552.57CDK-TCIP1
CAS:<p>CDK-TCIP1 is a bivalent molecule that links the CDK9 inhibitor SNS-032 with the BCL6 ligand BI3812. It effectively and specifically kills cells overexpressing BCL6, with an EC50 of 7.7 nM for SUDHL5 cells.</p>Fórmula:C48H62ClN11O8S2Forma y color:SolidPeso molecular:1020.66DH-18
<p>DH-18 is an inhibitor of matrix metalloproteinase-2 (MMP-2), exhibiting IC50 values of 139.45 nM for MMP-2, 518.11 nM for MMP-9, and 833.34 nM for MMP-8. The compound promotes cell apoptosis and causes cell cycle arrest in the G0/G1 phase. DH-18 also inhibits cell growth, making it potential for research in chronic myeloid leukemia.</p>Fórmula:C26H23F6N3O5SForma y color:SolidPeso molecular:603.53PROTAC EZH2 Degrader-3
<p>PROTAC EZH2 Degrader-3 (compound ZJ-20) is a potent EZH2 degrader that exhibits strong inhibitory effects not only on EZH2 protein expression but also on the levels of other PRC2 subunits and H3k27me3 protein. Additionally, PROTAC EZH2 Degrader-3 demonstrates antiproliferative activity by blocking the cell cycle at the G0-G1 phase and inducing apoptosis (cell death). At a concentration of 5 μM and over a period of 24 hours, it effectively suppresses the expression of these critical proteins involved in cell regulation and growth.</p>Fórmula:C56H68N8O8Forma y color:SolidPeso molecular:981.19F1324 TFA
<p>F1324 TFA is a potent, high affinity peptidic inhibitor of B cell lymphoma 6 (BCL6), with an IC50 of 1 nM.</p>Fórmula:C85H122N21F3O22SPureza:98%Forma y color:SolidPeso molecular:1879.06Finotonlimab
<p>Finotonlimab (SCT-I10A), a humanized IgG PD-1 monoclonal antibody, shows potential in the research of solid tumors or lymphomas [1].</p>Forma y color:Odour LiquidFGFR1/VEGFR2-IN-3
<p>FGFR1/VEGFR2-IN-3 (Compound 8m) acts as a dual inhibitor of FGFR1 and VEGFR2. This compound exhibits both anti-cancer cell proliferation and anti-migration activities, and it also has the capability to induce cell apoptosis (apoptosis).</p>Fórmula:C27H18N4O4Forma y color:SolidPeso molecular:462.46ROS inducer 5
ROS inducer 5 (compound 6e) induces intracellular ROS accumulation and subsequent nuclear fragmentation. It can provoke apoptosis in MCF-7 cells with an IC50 of 3.85 μM. ROS inducer 5 is useful for cancer research applications.Fórmula:C20H15ClN4O2S3Forma y color:SolidPeso molecular:475.01STK17A/B-IN-1 hydrochloride
STK17A/B-IN-1 hydrochloride is a potent, selective, orally active inhibitor of STK17A/B, displaying an IC50 value of 23 nM against STK17A. It is utilized in the research of tumors.Fórmula:C26H28ClN7OForma y color:SolidPeso molecular:490.00SZU-B6
CAS:SZU-B6, a PROTAC degrader, targets and degrades SIRT6 with DC50 values of 45 nM in SK-HEP-1 cells and 154 nM in Huh-7 cells. It inhibits the proliferation of SK-HEP-1 cells with an IC50 of 1.51 μM and suppresses colony formation in both SK-HEP-1 and Huh-7 cell lines. Additionally, SZU-B6 induces apoptosis in SK-HEP-1 cells and causes cell cycle arrest at the G2/M phase. It demonstrates anti-tumor activity in murine models.Fórmula:C29H32FN7O6Forma y color:SolidPeso molecular:593.61HJC0416 hydrochloride
CAS:<p>HJC0416 hydrochloride: potent oral STAT3 inhibitor, better anticancer effects than Stattic, promising for breast cancer research.</p>Fórmula:C18H18Cl2N2O4SForma y color:SolidPeso molecular:429.31hMAO-B-IN-11
<p>hMAO-B-IN-11 (Compound 12) is a selective and reversible inhibitor of human monoamine oxidase B (hMAO-B) with an IC50 value of 0.11 µM. It operates by competitively binding to the active site of hMAO-B, thereby preventing the oxidative deamination of monoamines and reducing hydrogen peroxide production. Additionally, hMAO-B-IN-11 inhibits pro-inflammatory mediators (NO, TNF-α, IL-1β) in activated microglia. This compound holds potential for research in neurodegenerative diseases such as Parkinson's and Alzheimer's.</p>Forma y color:Odour SolidThalidomide-4-C3-NH2 hydrochloride
CAS:<p>Thalidomide-4-C3-NH2 HCl is a cereblon ligand for CRBN recruitment, used to make PROTACs with a linker.</p>Fórmula:C16H18ClN3O4Forma y color:SolidPeso molecular:351.785Sarglaroids F
<p>Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+</p>Fórmula:C38H44O12Pureza:98%Forma y color:SolidPeso molecular:692.75Rosomidnar
CAS:<p>PNT100: 24-base DNA oligo targeting BCL-2 regulatory region; halts tumor cell growth, induces death.</p>Fórmula:C227H291O141P23Forma y color:SolidPeso molecular:7220.63QN523
CAS:<p>QN523 has drug-like traits, kills cancer cells in vitro, effective in vivo against pancreatic cancer, works via autophagy.</p>Fórmula:C14H10N4OPureza:99.83%Forma y color:SolidPeso molecular:250.26Nargenicin
CAS:<p>Nargenicin: a macrolide antibiotic effective against S. aureus, MRSA, M. luteus; inhibits bacterial DnaE and reduces inflammation and leukemia cell growth.</p>Fórmula:C28H37NO8Forma y color:SolidPeso molecular:515.6Thalidomide-PEG4-NH2 hydrochloride
CAS:<p>Thalidomide-PEG4-NH2 HCl, a cereblon ligand-linker for PROTAC.</p>Fórmula:C21H28ClN3O8Forma y color:SolidPeso molecular:485.92Thalidomide-O-C8-NH2 hydrochloride
CAS:<p>Thalidomide-derived cereblon ligand with PROTAC linker as an E3 ligase ligand-linker conjugate, in hydrochloride form.</p>Fórmula:C21H28ClN3O5Forma y color:SolidPeso molecular:437.92Relfovetmab
CAS:<p>Relfovetmab is an anti- NGF monoclonal antibody (mAb) [1] .</p>Forma y color:LiquidSatratoxin G
CAS:<p>Satratoxin G, from Stachybotrys chartarum, triggers apoptosis in nasal and brain OSNs.</p>Fórmula:C29H36O10Forma y color:SolidPeso molecular:544.597Haemanthamine hydrochloride
<p>Haemanthamine hydrochloride, an alkaloid from Amaryllidaceae, has anticancer, antioxidant, antiviral, antimalarial, and anticonvulsant properties.</p>Fórmula:C17H20ClNO4Forma y color:SolidPeso molecular:337.8HTH-01-091 TFA
<p>HTH-01-091 TFA: Potent, selective MELK inhibitor (IC50=10.5 nM); also targets PIM1/2/3, RIPK2, DYRK3, smMLCK, CLK2; used in breast cancer research.</p>Fórmula:C28H29Cl2F3N4O4Forma y color:SolidPeso molecular:613.46
