Apoptosis
Los inhibidores de la apoptosis son compuestos que previenen o retrasan el proceso de muerte celular programada, conocido como apoptosis. Estos inhibidores son vitales para estudiar los mecanismos de supervivencia celular y se utilizan para investigar enfermedades donde la apoptosis está desregulada, como el cáncer, los trastornos neurodegenerativos y las enfermedades autoinmunes. Al modular la apoptosis, estos inhibidores pueden ayudar en el desarrollo de terapias dirigidas a controlar la muerte celular. En CymitQuimica, ofrecemos una amplia selección de inhibidores de la apoptosis de alta calidad para apoyar su investigación en biología celular, oncología y campos relacionados.
Subcategorías de "Apoptosis"
- ASK(6 productos)
- BCL(11 productos)
- Caspasa(127 productos)
- FOXO1(3 productos)
- IAP(65 productos)
- Mdm2(12 productos)
- PD-1 / PD-L1(126 productos)
- PDK(9 productos)
- PERK(24 productos)
- Serina / treonina quinasa(15 productos)
- Survivin(13 productos)
- TNF(91 productos)
- c-RET(51 productos)
- p53(62 productos)
Mostrar 6 subcategorías más
Se han encontrado 5622 productos de "Apoptosis"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Silicon naphthalocyanine dichloride
CAS:<p>Silicon naphthalocyanine dichloride is a photosensitizer with potential anti-tumor activity. This compound is employed in photodynamic therapy to inhibit cancer by effectively absorbing specific wavelengths of light, thereby generating oxygen radicals that aid in the destruction of cancer cells. The biocompatibility of Silicon naphthalocyanine dichloride demonstrates promising prospects for medical applications.</p>Fórmula:C48H24Cl2N8SiForma y color:SolidPeso molecular:811.75KRN 5500
CAS:<p>KRN 5500, a derivative of the nucleoside antibiotic spicamycin, has a wide range of antitumor activity against human cancer cell lines.</p>Fórmula:C28H43N7O7Pureza:98%Forma y color:SolidPeso molecular:589.68CYP51/PD-L1-IN-1
<p>CYP51/PD-L1-IN-1 (compound L11), a quinazoline with antifungal properties, simultaneously inhibits CYP51 (IC50: 0.884 μM) and PD-L1 (IC50: 0.083 μM).</p>Fórmula:C20H15N5O2Forma y color:SolidPeso molecular:357.37MI-1061 TFA
CAS:<p>MI-1061 TFA: potent MDM2 inhibitor, orally bioavailable, stable (IC50=4.4 nM, Ki=0.16 nM), activates p53, induces apoptosis in mice tumors.</p>Fórmula:C32H27Cl2F4N3O6Forma y color:SolidPeso molecular:696.47Opnurasib
CAS:Opnurasib (JDQ-443) is an orally available and selective and potent covalent KRAS G12C inhibitor with antitumor activity for the study of advanced non-smallFórmula:C29H28ClN7OPureza:98.88%Forma y color:SolidPeso molecular:526.03Spexin
CAS:<p>Potent GAL2/GAL3 agonist (EC50 = 45.7, 112.2 nM), inactive at GAL1. Reduces appetite, fatty acid uptake in adipocytes, and LH in goldfish; anxiolytic in vivo.</p>Fórmula:C74H114N20O19SPureza:98%Forma y color:SolidPeso molecular:1619.9(E/Z)-Eltrombopag 13C4
CAS:<p>(E/Z)-Eltrombopag 13C4 is a mix of E/Z isotopologues, both 13C-labeled TPO receptor agonists for thrombocytopenia.</p>Fórmula:C25H22N4O4Forma y color:SolidPeso molecular:446.444Se-Aspirin
CAS:<p>Se-Aspirin (Se-NSAID-8) has anticancer activity and gastroprotective effects, inhibits activation of proinflammatory and pro-survival NF-ĸB pathways, and inhibits the expression of anti-apoptotic targets downstream of NF-ĸB (e.g., Bcl-xL, Mcl-1, and survivin).Se-Aspirin induces Cell cycle arrest and activation of apoptosis accelerates ulcer healing and can be used to study pancreatic and colorectal cancer.</p>Fórmula:C12H12N2O3SePureza:98.07%Forma y color:SolidPeso molecular:311.2FF2049
FF2049 is a selective HDAC PROTAC degrader with a DC50 of 257 nM for HDAC1. It facilitates the ubiquitination and degradation of HDAC and promotes apoptosis (Apoptosis). FF2049 is applicable in research involving hematological and solid tumors.Fórmula:C31H38ClN7O7Forma y color:SolidPeso molecular:656.129EAD1
CAS:<p>EAD1 is a useful organic compound for research related to life sciences. The catalog number is T35329 and the CAS number is 1644388-26-0.</p>Fórmula:C24H27Cl2N7Pureza:98%Forma y color:SolidPeso molecular:484.42AMG-7209
CAS:<p>AMG-7209 is an effective and selective MDM2-p53 interaction inhibitor.</p>Fórmula:C37H41Cl2FN2O7SForma y color:SolidPeso molecular:747.7eIF4E-IN-2
CAS:<p>eIF4E-IN-2 effectively inhibits eIF4e, crucial for research on diseases like cancer.</p>Fórmula:C37H33ClF2N8O4S2Forma y color:SolidPeso molecular:791.29TRK-IN-30
<p>TRK-IN-30 (Compound C11) is an inhibitor of tropomyosin receptor kinases (TRK), effectively inhibiting TRKA, TRKB, TRKC, and the resistant mutant TRKAG595R, with IC50 values of 1.8, 0.98, 3.8, and 54 nM, respectively. It also suppresses the activation of downstream PI3K/AKT and MEK/ERK signaling pathways. TRK-IN-30 hinders colony formation and cell migration of Km-12, induces cell cycle arrest at the G0/G1 phase, and triggers apoptosis in Km-12 cells.</p>Fórmula:C24H21N5O3Forma y color:SolidPeso molecular:427.455FKBP12 ligand-1
CAS:<p>FKBP12 ligand-1 is the target protein ligand for MC-25B, which is a PROTAC targeting FKBP12.</p>Fórmula:C32H41NO9Forma y color:SolidPeso molecular:583.669Zeluvalimab
CAS:<p>Zeluvalimab (AMG-404) is a monoclonal antibody designed to target the PD-1 receptor, and is utilized in cancer research [1].</p>Forma y color:LiquidHTH-01-091 TFA
<p>HTH-01-091 TFA: Potent, selective MELK inhibitor (IC50=10.5 nM); also targets PIM1/2/3, RIPK2, DYRK3, smMLCK, CLK2; used in breast cancer research.</p>Fórmula:C28H29Cl2F3N4O4Forma y color:SolidPeso molecular:613.46Azadirone
CAS:<p>Azadirone, a limonoid, sensitizes cancer cells to TRAIL by modulating DR4/DR5, survival, and apoptotic proteins.</p>Fórmula:C9H15N3O5Forma y color:SolidPeso molecular:245.23RET-IN-28
CAS:RET-IN-28 (Compound 16) is an inhibitor of RET (a transmembrane receptor tyrosine kinase). It specifically inhibits the activity of a mutant RET enzyme (RET-V804M) and is utilized in cancer research.Fórmula:C26H29N9Forma y color:SolidPeso molecular:467.57TQB-2858
<p>TQB-2858 is a bifunctional fusion protein composed of an anti-PD-L1 monoclonal antibody fused with the extracellular domain of the TGF-β receptor. It exhibits high affinity for PD-L1, TGF-β1, and TGF-β3, and demonstrates a high target occupancy rate for PD-L1. TQB-2858 can be used in research on osteosarcoma and alveolar soft part sarcoma (ASPS).</p>Forma y color:Odour LiquidResistomycin
CAS:<p>Resistomycin (Geliomycin), a pentacyclic polyketide antibiotic, exhibits potent anticancer properties by triggering apoptosis.</p>Fórmula:C22H16O6Pureza:99.34%Forma y color:SolidPeso molecular:376.36BM-1074
CAS:<p>BM-1074 is a potent and highly efficacious inhibitor of Bcl-2/Bcl-xL with Ki value of < 1nM [1].</p>Fórmula:C50H57ClN8O7S3Forma y color:SolidPeso molecular:1013.69Sarglaroids F
<p>Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+</p>Fórmula:C38H44O12Pureza:98%Forma y color:SolidPeso molecular:692.75Lactoferrin (17-41)
CAS:<p>Amino acids 17-41 of lactoferrin, lactoferricin B, enhance anti-fungal effects, targeting Candida Albicans.</p>Fórmula:C141H224N46O29S3Pureza:98%Forma y color:SolidPeso molecular:3123.77(R)-JAK2/STAT3-IN-10a
CAS:<p>(R)-JAK2/STAT3-IN-10a is the R-isomer of JAK2/STAT3-IN-1.JAK2/STAT3-IN-1 is a structural domain inhibitor of GP130 D1 with antitumor activity.</p>Fórmula:C34H35BrF3N5O2Pureza:97.99%Forma y color:SoildPeso molecular:682.57Boanmycin
CAS:<p>Boanmycin, an antibiotic exhibiting antitumor activity, induces cellular senescence and apoptosis [1] [2] [3].</p>Fórmula:C60H96N20O21S2Forma y color:SolidPeso molecular:1497.66EGFR kinase inhibitor 7
<p>EGFRkinase inhibitor 7 (compound 18i) is an EGFR inhibitor with an IC50 of 42.3 nM, exhibiting anticancer properties. This compound demonstrates significant in vitro cytotoxicity and capacity to induce apoptosis. Furthermore, EGFRkinase inhibitor 7 displays anti-proliferative activity against human colon cancer cell line HCT116 and human non-small cell lung cancer cell line A549, with IC50 values of 4.82 µM and 1.43 µM, respectively.</p>Fórmula:C28H26Cl2FN3O3SSeForma y color:SolidPeso molecular:653.45ILS-920
CAS:<p>ILS-920, a Rapamycin analog, has reduced immunosuppression, enhanced neuroprotection, and preferentially binds FKBP52 and L-type VGCC β1.</p>Fórmula:C57H86N2O14Pureza:98%Forma y color:SolidPeso molecular:1023.3Thalidomide-O-PEG2-propargyl
CAS:<p>Thalidomide-O-PEG2-propargyl is a cereblon-based E3 ligase ligand with a PEG linker for PROTAC-induced protein degradation.</p>Fórmula:C20H20N2O7Pureza:98%Forma y color:SolidPeso molecular:400.38MRIA9
CAS:<p>MRIA9 inhibits SIK1/2/3 & PAK2/3 with IC50: SIK1 (516 nM), SIK2 (180 nM), SIK3 (127 nM); ATP-competitive.</p>Fórmula:C24H22ClFN6O3Forma y color:SolidPeso molecular:496.92Malformin A
CAS:Malformin A, from A. niger, is a plant growth regulator and has anti-TMV and cancer cell cytotoxic properties. Intraperitoneal LD50 in mice is 3.1 mg/kg.Fórmula:C23H39N5O5S2Forma y color:SolidPeso molecular:529.72Mcl-1 antagonist 1
CAS:Mcl-1 antagonist 1 is a Mcl-1 protein antagonist.Fórmula:C41H54ClF2N5O8SPureza:98%Forma y color:SolidPeso molecular:850.42VEGFR-2-IN-64
<p>VEGFR-2-IN-64 (Compound 28) is an inhibitor of VEGFR2 with an IC50 of 27.8 nM. It suppresses the proliferation of cancer cells A549, T-47D, and Caco-2, exhibits anti-migration and anti-colony formation activities in T-47D cells, and induces apoptosis in T-47D cells.</p>Fórmula:C72H123N9O6Forma y color:SolidPeso molecular:1210.8Leucettamol A
CAS:<p>Leucettamol A, from Leucetta microraphis, blocks LTB4 receptor and prevents Ubc13-Uev1A complex formation.</p>Fórmula:C30H52N2O2Pureza:98%Forma y color:SolidPeso molecular:472.758Sotigalimab
CAS:<p>Sotigalimab (APX 005) is a monoclonal antibody targeting CD40 with anticancer activity for the study of metastatic pancreatic cancer.</p>Pureza:98.50% - 98.50%Forma y color:LiquidThalidomide-NH-PEG8-Ts
CAS:<p>Thalidomide-NH-PEG8-Ts: a synthesized Thalidomide-PEG8 E3 ligase linker for PROTAC-mediated IDO1 degradation.</p>Fórmula:C36H49N3O14SForma y color:SolidPeso molecular:779.86dMCL1-2
CAS:<p>dMCL1-2 is a PROTAC-based MCL1 degrader, binding at 30 nM, and induces apoptosis in leukemia.</p>Fórmula:C61H66N10O12SPureza:98%Forma y color:SolidPeso molecular:1163.3Bfl-1-IN-6
<p>Bfl-1-IN-6 (Compound 20) is an orally active inhibitor of Bcl-2-related protein A1 (BFL1) with an IC50 of 19 nM. This compound can stabilize BFL1 protein, activate cleaved caspase 3, and demonstrates antitumor activity in mouse models.</p>Fórmula:C22H24ClFN2O2Forma y color:SolidPeso molecular:402.89p53-Mdm2 inhibitor 4
CAS:<p>p53-Mdm2 inhibitor 4 inhibits the p53-MDM2 protein-protein interaction.</p>Fórmula:C23H20FN3O3Pureza:98.66%Forma y color:SoildPeso molecular:405.42GSPT1 degrader-1
<p>GSPT1 Degrader-1 (Compound 9q) effectively facilitates the degradation of G1 to S phase transition 1 (GSPT1) through the ubiquitin-proteasome system and induces</p>Fórmula:C28H33ClN4O5Pureza:98%Forma y color:SolidPeso molecular:541.04Azalamellarin N
CAS:<p>Azalamellarin N is a pyroptosis inhibitor that exhibits varying inhibitory effects on different pyroptosis inducers. It functions by targeting molecules upstream of NLRP3 inflammasome activation, instead of directly affecting the components of the NLRP3 inflammasome. Its inhibitory potency against various inducers is ranked as follows: Nigericin > R837 [1].</p>Fórmula:C28H22N2O7Forma y color:SolidPeso molecular:498.48Ro 48-8071
CAS:<p>Oxidosqualene cyclase inhibitor</p>Fórmula:C23H27BrFNO2Pureza:98%Forma y color:SolidPeso molecular:448.37Anti-Mouse PD-1 Antibody (RMP1-14)
Anti-Mouse PD-1 Antibody (RMP1-14) is an IgG2a antibody inhibitor against mouse PD-1 and can block PD-1/PD-L1 signaling. High-Quality, Low-Cost!Pureza:14.68mg/ml - >95%Forma y color:Odour LiquidPROTAC Bcl-xL ligand-1
<p>PROTAC Bcl-xL ligand-1 serves as a ligand targeting Bcl-xL, essential in synthesizing PROTACs [1].</p>Fórmula:C32H29IN4O4S2Forma y color:SolidPeso molecular:724.63Vorsetuzumab
CAS:<p>Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) is a monoclonal antibody targeting the CD70 antibody.</p>Pureza:SDS-PAGE:95% SEC-HPLC:99.29%Forma y color:LiquidPeso molecular:146.1 kDaFerroptosis-IN-1
<p>Ferroptosis-IN-1, a diterpene derived from A.</p>Fórmula:C22H34O5Pureza:98%Forma y color:SolidPeso molecular:378.5GPX4-IN-7
<p>GPX4-IN-7 (Compound 31), an indirubin derivative, serves as a ferroptosis inducer in colon cancer treatment.</p>Fórmula:C25H23ClN4O4Pureza:98%Forma y color:SolidPeso molecular:478.93Photosensitizer-6
CAS:<p>Photosensitizer-6 (Compound 4) is a metal ion complex that inhibits TrxR. It induces apoptosis in 4T1 cells, targeting cancer cells and eliminating tumors through chemophototherapy and immunogenic cell death under illumination. Additionally, Photosensitizer-6 can be utilized for tumor imaging.</p>Fórmula:C47H35AuF6N4P2SForma y color:SolidPeso molecular:1060.78EGFR-IN-78
<p>EGFR-IN-78 (compound A5), a 2-aminopyrimidine derivative, serves as a reversible EGFR C797S-TK inhibitor and an apoptosis inducer.</p>Fórmula:C23H32BrN7O2SPureza:98%Forma y color:SolidPeso molecular:550.51ASR-488
CAS:<p>ASR-488, an activator of the mRNA-binding protein CPEB1, promotes apoptosis and suppresses the growth of bladder cancer [1].</p>Fórmula:C33H40O7SForma y color:SolidPeso molecular:580.73SSE1806
<p>SSE1806, a podophyllotoxin derivative (a natural antimitotic agent), functions as a microtubule/tubulin inhibitor, exhibiting potent anticancer and</p>Fórmula:C21H18N2O5Forma y color:SolidPeso molecular:378.38
