Apoptosis
Los inhibidores de la apoptosis son compuestos que previenen o retrasan el proceso de muerte celular programada, conocido como apoptosis. Estos inhibidores son vitales para estudiar los mecanismos de supervivencia celular y se utilizan para investigar enfermedades donde la apoptosis está desregulada, como el cáncer, los trastornos neurodegenerativos y las enfermedades autoinmunes. Al modular la apoptosis, estos inhibidores pueden ayudar en el desarrollo de terapias dirigidas a controlar la muerte celular. En CymitQuimica, ofrecemos una amplia selección de inhibidores de la apoptosis de alta calidad para apoyar su investigación en biología celular, oncología y campos relacionados.
Subcategorías de "Apoptosis"
- ASK(6 productos)
- BCL(11 productos)
- Caspasa(125 productos)
- FOXO1(3 productos)
- IAP(66 productos)
- Mdm2(12 productos)
- PD-1 / PD-L1(125 productos)
- PDK(9 productos)
- PERK(25 productos)
- Serina / treonina quinasa(15 productos)
- Survivin(13 productos)
- TNF(92 productos)
- c-RET(51 productos)
- p53(62 productos)
Mostrar 6 subcategorías más
Se han encontrado 5600 productos de "Apoptosis"
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Etoposide phosphate disodium
CAS:<p>Etoposide phosphate disodium, a prodrug of etoposide, is a powerful anticancer drug inhibiting DNA topoisomerase II.</p>Fórmula:C29H31Na2O16PForma y color:SolidPeso molecular:712.5MS78
<p>MS78, an acetylation targeting chimera (AceTAC), specifically acetylates the p53Y220C mutant by recruiting the histone acetyltransferase p300/CBP.</p>Fórmula:C57H66FN9O6SForma y color:SolidPeso molecular:1024.25eIF4A3-IN-5
CAS:<p>eIF4A3-IN-5 potently inhibits eIF4AI/II, promising for cancer research.</p>Fórmula:C26H22N2O7Forma y color:SolidPeso molecular:474.469hMAO-B-IN-11
<p>hMAO-B-IN-11 (Compound 12) is a selective and reversible inhibitor of human monoamine oxidase B (hMAO-B) with an IC50 value of 0.11 µM. It operates by competitively binding to the active site of hMAO-B, thereby preventing the oxidative deamination of monoamines and reducing hydrogen peroxide production. Additionally, hMAO-B-IN-11 inhibits pro-inflammatory mediators (NO, TNF-α, IL-1β) in activated microglia. This compound holds potential for research in neurodegenerative diseases such as Parkinson's and Alzheimer's.</p>Forma y color:Odour SolidThalidomide-O-C5-acid
CAS:<p>Thalidomide-O-C5-acid, a synthesized E3 ligase linker, merges cereblon and PROTAC tech.</p>Fórmula:C19H20N2O7Forma y color:SolidPeso molecular:388.376NecroIr1
<p>NecroIr1, an iridium(III) complex, induces necroptosis in Cisplatin-resistant lung cells, targeting mitochondria and disrupting MMP.</p>Fórmula:C40H29ClIrN5OForma y color:SolidPeso molecular:823.36Ro 48-8071
CAS:<p>Oxidosqualene cyclase inhibitor</p>Fórmula:C23H27BrFNO2Pureza:98%Forma y color:SolidPeso molecular:448.37Anti-Mouse PD-1 Antibody (RMP1-14)
<p>Anti-Mouse PD-1 Antibody (RMP1-14) is an IgG2a antibody inhibitor against mouse PD-1 and can block PD-1/PD-L1 signaling. High-Quality, Low-Cost!</p>Pureza:14.68mg/ml - >95%Forma y color:Odour LiquidThalidomide-NH-PEG8-Ts
CAS:<p>Thalidomide-NH-PEG8-Ts: a synthesized Thalidomide-PEG8 E3 ligase linker for PROTAC-mediated IDO1 degradation.</p>Fórmula:C36H49N3O14SForma y color:SolidPeso molecular:779.86Ganoderic acid Mf
CAS:<p>Ganoderic acid Mf: antitumor triterpenoid, arrests G1 cell cycle, selective for cancer cells, triggers apoptosis via mitochondria.</p>Fórmula:C32H48O5Forma y color:SolidPeso molecular:512.72Malformin A
CAS:Malformin A, from A. niger, is a plant growth regulator and has anti-TMV and cancer cell cytotoxic properties. Intraperitoneal LD50 in mice is 3.1 mg/kg.Fórmula:C23H39N5O5S2Forma y color:SolidPeso molecular:529.72Fluorescein-diisobutyrate-6-amide
CAS:<p>Fluorescein-diisobutyrate-6-amide, a powerful inducer of ferroptosis, shows promise for cancer research applications [1].</p>Fórmula:C62H61ClN6O16Forma y color:SolidPeso molecular:1181.63Amino-PEG6-Thalidomide
<p>Amino-PEG6-Thalidomide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.</p>Fórmula:C27H39N3O10Pureza:98%Forma y color:SolidPeso molecular:565.61Apoptosis inducer 12
CAS:<p>Apoptosis Inducer 12 (Compound 3z) is a compound that promotes cell death via the mitochondrial pathway and is utilized in cancer research [1].</p>Fórmula:C26H27N3O5Forma y color:SolidPeso molecular:461.51Lipustobart
CAS:<p>Lipustobart is an IgG4-kappa humanized monoclonal antibody targeting PDCD1 (programmed cell death 1, PD1, PD-1, CD279), with immunostimulant and antineoplastic</p>Pureza:98%Forma y color:LiquidAc-YVAD-CHO acetate
<p>Ac-YVAD-CHO acetate, potent reversible ICE and caspase-1 inhibitor; K_i: 3.0 nM (mouse), 0.76 nM (human); blocks IL-lβ production.</p>Fórmula:C25H36N4O10Forma y color:SolidPeso molecular:552.57AZT triphosphate TEA
AZT triphosphate TFA, a Zidovudine metabolite, inhibits HIV & HBV replication and triggers mitochondrial apoptosis.Forma y color:SolidMofarotene
CAS:<p>Mofarotene (Ro-40-8757) is a small molecule compound that shows considerable antitumor activity in many cancer cell lines and can be used for the treatment of</p>Fórmula:C29H39NO2Pureza:99.96%Forma y color:SolidPeso molecular:433.63HEMTAC CDK4/6 degrader 1
CAS:<p>HEMTAC CDK4/6 degrader 1, a PROTAC targeting HSP90/CDK4/6, Kd of 35.7 μM, disrupts B16F10 melanoma cell cycle, and induces apoptosis.</p>Fórmula:C48H53ClN16O4Forma y color:SolidPeso molecular:953.49Polyphyllin G
CAS:<p>Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas.</p>Fórmula:C51H84O22Pureza:98%Forma y color:SolidPeso molecular:1049.21Delmitide
CAS:<p>Delmitide, a TNF-alpha production inhibitor, is used potentially for the treatment of Crohn's disease and ulcerative colitis.</p>Fórmula:C59H105N17O11Pureza:98%Forma y color:SolidPeso molecular:1228.579,11-Dehydroergosterol peroxide
CAS:<p>9,11-Dehydroergosterol peroxide is a useful organic compound for research related to life sciences.</p>Fórmula:C28H42O3Forma y color:SolidPeso molecular:426.641MBC-11 trisodium
CAS:<p>MBC-11 trisodium, a bisphosphonate-Ara-C conjugate, may treat TIBD.</p>Fórmula:C11H17N3Na3O14P3Pureza:98%Forma y color:SolidPeso molecular:577.16TD1092
<p>TD1092, a pan-IAP degrader, activates caspase 3/7, induces apoptosis in cancer cells, inhibits NF-κB, and is used in cancer research.</p>Fórmula:C55H70N8O9Forma y color:SolidPeso molecular:987.19Tubulin polymerization-IN-73
<p>Tubulin polymerization-IN-73 (Compound 37) is an inhibitor of microtubule polymerization with an IC50 of 1.8 μM. It induces cell cycle arrest at the G2/M phase and triggers apoptosis in A549 cells. The compound inhibits the proliferation of both A549 WT and A549/T resistant cells with IC50 values of 0.023 μM and 0.057 μM, respectively. Additionally, Tubulin polymerization-IN-73 demonstrates antitumor activity in mouse models.</p>Fórmula:C23H23N3O4Forma y color:SolidPeso molecular:405.446SZUH280
CAS:<p>SZUH280 is a potent, selective PROTAC (proteolysis targeting chimera) HDAC8 (histone deacetylase 8) degrader, demonstrating a DC50 of 0.58 μM in A549 cells.</p>Fórmula:C36H34N8O8Forma y color:SolidPeso molecular:706.710-SLF
CAS:<p>10-SLF is a PROTAC FKBP12 degrader. It facilitates the formation of a ternary complex between FKBP12 and FBXW7-R465C, leading to the proteasomal degradation of FKBP12 in a FBXW7-R465C-dependent manner. 10-SLF selectively reduces FKBP12 levels in cells that express FBXW7-R465C.</p>Fórmula:C59H76Cl2N4O13Forma y color:SolidPeso molecular:1120.16FW-1
<p>FW-1 is a type I inhibitor of FLT3, with an IC50 of approximately 1 μM. It exhibits cytotoxic effects in FLT3-mutant AML cells, causes cell cycle arrest at the G0/G1 phase, and induces apoptosis in MV4-11 and MOLM-13 cells.</p>Fórmula:C24H27N7OForma y color:SolidPeso molecular:429.517Ropeginterferon alfa-2b
CAS:<p>Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft), a monopegylated interferon-alpha (IFN-α), is utilized in the study of myeloproliferative neoplasms [1].</p>Forma y color:LiquidC188
CAS:<p>C188, a naphthol-based STAT3 inhibitor, blocks IL-6-induced STAT3 activity in HepG2 cells, sparing STAT1.</p>Fórmula:C19H15NO7S2Forma y color:SolidPeso molecular:433.45Mechercharmycin A
CAS:<p>Mechercharmycin A, a cytotoxic compound, was isolated from Thermoactinomyces sp. YM3-251, a marine source. It demonstrates potent antitumor activity.</p>Fórmula:C35H32N8O7SForma y color:SolidPeso molecular:708.75PD-1-IN-20
<p>PD-1-IN-20 is the less active enantiomer of PD-1-IN-1.</p>Fórmula:C12H20N6O7Pureza:98%Forma y color:SolidPeso molecular:360.32Garivulimab
CAS:<p>Garivulimab (BGB-A333), a humanized IgG1 monoclonal antibody, binds to PD-L1, blocking PD-1 interaction and exhibiting antitumor activity.</p>Forma y color:LiquidC-Met/Axl-IN-1
<p>C-Met/Axl-IN-1 (Compound 22a) is an oral, selective type II c-Met/Axl inhibitor with IC50 values of 1 nM and 10 nM, respectively. It effectively suppresses tumor cell proliferation, induces cell cycle arrest, and apoptosis (apoptosis), showcasing potent anti-tumor activity.</p>Fórmula:C25H18F2N6O2Forma y color:SolidPeso molecular:472.45EGFR/HER2/DHFR-IN-3
<p>EGFR/HER2/DHFR-IN-3 (compound 4c) serves as an efficacious dual inhibitor specifically targeting EGFR/HER2, exhibiting IC50 values of 0.138 μM for EGFR and 0.</p>Pureza:98%Forma y color:Odour SolidChoKα inhibitor-5
<p>ChoKα Inhibitor-5, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoKα1 with an IC50 value of 0.64 μM and induces apoptosis.</p>Fórmula:C54H68Br2N4S4Forma y color:SolidPeso molecular:1061.21Pegsunercept
CAS:<p>Pegsunercept (PEG sTNF-RI), a pegylated monoclonal antibody, selectively binds to TNFA, incorporating a polyethylene glycol (pegol) moiety [1].</p>Forma y color:LiquidTanfanercept
CAS:<p>Tanfanercept (HL036337) is an anti-TNF-α antibody, improving corneal erosions in dry eye mice.</p>Forma y color:LiquidMBC-11 triethylamine
<p>MBC-11 triethylamine, a first-in-class etidronate-araC conjugate, may treat TIBD.</p>Fórmula:C17H35N4O14P3Pureza:98%Forma y color:SolidPeso molecular:612.4LIB3S0280
<p>LIB3S0280 is a potent inhibitor of TBK1, with an IC50 of 493.9 nM. It suppresses TBK1 downstream signaling by reducing the phosphorylation of IκBα and AKT. LIB3S0280 causes G2/M phase arrest and induces apoptosis in pancreatic cancer cells. Notably, it exhibits significant inhibitory effects on pancreatic cancer cell lines with high TBK1 expression, with a 96-hour IC50 value ranging from 6.64-10.98 μM. LIB3S0280 shows potential for research in pancreatic ductal adenocarcinoma (PDAC).</p>Forma y color:Odour SolidAc-Pro-Gly-Pro-OH
CAS:<p>Ac-Pro-Gly-Pro-OH can be used as a CXCR2 agonist with bactericidal and anti-inflammatory activity for the study of sepsis and lung inflammation.</p>Fórmula:C14H21N3O5Pureza:98.32%Forma y color:SolidPeso molecular:311.33PG-11047 2HCl
<p>PG-11047 2HCl treats genitourinary, immune, genetic, ocular, blood/lymphatic disorders, and aids lymphoma/prostate cancer research.</p>Fórmula:C14H34Cl2N4Pureza:97.47%Forma y color:SolidPeso molecular:329.35G-Glu-Val
CAS:<p>G-Glu-Val (γ-glutamyl-L-valine, H-Glu-Val -OH), a flavour-regulating dipeptide, is a major contributor to "mellow".</p>Fórmula:C10H18N2O5Forma y color:SolidPeso molecular:246.26Uvarigrin
CAS:<p>Uvarigrin induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation. Uvarigrin is isolated from the roots of Uvaria calamistrata.</p>Fórmula:C37H68O6Pureza:98%Forma y color:SolidPeso molecular:608.93JAK/HDAC-IN-2
<p>JAK/HDAC-IN-2, a potent 2-amino-4-phenylaminopyrimidine dual-target inhibitor, effectively suppresses JAK1/2 and HDAC3/6 at nanomolar concentrations.</p>Fórmula:C28H38N6O5SPureza:98%Forma y color:SolidPeso molecular:570.7IC 86621
CAS:<p>IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.</p>Fórmula:C12H15NO3Pureza:99.68%Forma y color:SolidPeso molecular:221.25Ankaflavin
CAS:<p>Ankaflavin, from red rice fermentation, is a PPARγ agonist with anti-inflammatory properties and selectively kills cancer cells.</p>Fórmula:C23H30O5Pureza:98%Forma y color:SolidPeso molecular:386.48p38-α MAPK-IN-8
<p>p38-α MAPK-IN-8 (Compound 13) is a lipophilic cationic derivative. It exhibits cytotoxicity toward various tumor cells, inducing cell cycle arrest and apoptosis, as well as increasing reactive oxygen species (ROS) production and causing mitochondrial membrane potential depolarization. Its antitumor activity may be related to the p38α MAPK pathway, making it a potential candidate for cancer research.</p>Fórmula:C49H62BrO4PForma y color:SolidPeso molecular:825.892APG-1387
CAS:<p>APG-1387 inhibits IAPs, degrades cIAP1/2, XIAP, boosts chemosensitivity, and induces apoptosis in NPC.</p>Fórmula:C60H72N10O10S2Forma y color:SolidPeso molecular:1157.41Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride
CAS:<p>Thalidomide-based E3 ligase ligand with PEG2-C2 linker; used as an immunomodulatory cancer treatment.</p>Fórmula:C21H27ClN4O8Pureza:98.09%Forma y color:SolidPeso molecular:498.914
