Apoptosis
Los inhibidores de la apoptosis son compuestos que previenen o retrasan el proceso de muerte celular programada, conocido como apoptosis. Estos inhibidores son vitales para estudiar los mecanismos de supervivencia celular y se utilizan para investigar enfermedades donde la apoptosis está desregulada, como el cáncer, los trastornos neurodegenerativos y las enfermedades autoinmunes. Al modular la apoptosis, estos inhibidores pueden ayudar en el desarrollo de terapias dirigidas a controlar la muerte celular. En CymitQuimica, ofrecemos una amplia selección de inhibidores de la apoptosis de alta calidad para apoyar su investigación en biología celular, oncología y campos relacionados.
Subcategorías de "Apoptosis"
- ASK(6 productos)
- BCL(11 productos)
- Caspasa(125 productos)
- FOXO1(3 productos)
- IAP(66 productos)
- Mdm2(12 productos)
- PD-1 / PD-L1(125 productos)
- PDK(9 productos)
- PERK(25 productos)
- Serina / treonina quinasa(15 productos)
- Survivin(13 productos)
- TNF(92 productos)
- c-RET(51 productos)
- p53(62 productos)
Mostrar 6 subcategorías más
Se han encontrado 5600 productos de "Apoptosis"
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Os30
<p>Os30 is a potent fourth-generation EGFR inhibitor, specifically targeting the EGFRC797S-TK mutation with IC50 values of 18 nM for EGFRDel19/T790M/C797S TK and</p>Pureza:98%Forma y color:Odour SolidEriosematin
CAS:<p>Eriosematin has anti-proliferative and apoptosis-inducing properties and is a compound extracted from the root of Flemingia philippinensis in the Philippines.</p>Fórmula:C19H20O4Pureza:98%Forma y color:SolidPeso molecular:312.36Platycoside G3
CAS:<p>Platycoside G3 is a useful organic compound for research related to life sciences. The catalog number is T124100 and the CAS number is 849758-44-7.</p>Fórmula:C63H102O32Forma y color:SolidPeso molecular:1371.48Polyinosinic-polycytidylic acid potassium
CAS:<p>Poly(I:C) potassium is a synthetic RNA analog, activates TLR3/RIG-I, used as a vaccine adjuvant, and induces apoptosis in cancer cells.</p>Fórmula:(C10H13N4O8P)x·(C9H14N3O8P)x·xKForma y color:SolidRWJ-56110 dihydrochloride
CAS:<p>RWJ-56110 dihydrochloride is a potent PAR-1 inhibitor (IC50=0.44μM), blocking platelet aggregation, angiogenesis, and induces apoptosis. No PAR-2/3/4 effect.</p>Fórmula:C41H44Cl3F2N7O3Forma y color:SolidPeso molecular:827.2Aspidin BB
CAS:<p>Aspidin BB, a phloroglucinol from Dryopteris, inhibits cancer by causing cell cycle arrest and apoptosis in HO-8910 cells.</p>Fórmula:C25H32O8Forma y color:SolidPeso molecular:460.52JNK-1-IN-3
CAS:<p>JNK-1-IN-3 (Compound 9e) downregulates JNK1 and phosphorylated JNK1, reduces c-Jun and c-Fos expression in tumours, and restores p53 activity.</p>Fórmula:C19H17FN4O3Pureza:97.551%Forma y color:SolidPeso molecular:368.36DiPT-4
<p>DiPT-4, a dual TOP1/PARP1 inhibitor, effectively induces DNA double-strand breaks (DSBs), cell cycle arrest, and apoptosis in cancer cells, with potential to</p>Fórmula:C32H22FN5O4SPureza:98%Forma y color:SolidPeso molecular:591.61FC-116
CAS:<p>FC-116 is a potent Tubulin inhibitor with antitumour activity and inhibits tumour growth in mice.FC-116 induces apoptosis and promotes protein degradation.</p>Fórmula:C21H20FNO4Pureza:98.18%Forma y color:SoildPeso molecular:369.39Antitumor agent-116
<p>Antitumor Agent-116 (Compound 6C) is an anti-tumor agent that exhibits anti-proliferative properties and induces apoptosis.</p>Fórmula:C31H23BrN4O4SPureza:98%Forma y color:SolidPeso molecular:627.51Toremifene citrate
CAS:<p>Toremifene citrate is a selective estrogen receptor modulator (SERM). It is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on the mammary and uterine tissue.</p>Fórmula:C32H36ClNO8Pureza:99.83% - >99.99%Forma y color:White Or Almost White PowderPeso molecular:598.08Dehydroaltenusin
CAS:<p>Dehydroaltenusin is a selective eukaryotic DNA polymerase α inhibitor and a type of antibiotic produced by a fungus (IC50: 0.68 μM).</p>Fórmula:C15H12O6Pureza:98%Forma y color:SolidPeso molecular:288.2553MB-PP1
CAS:<p>3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor.</p>Fórmula:C17H21N5Pureza:99.96%Forma y color:White SolidPeso molecular:295.38Cannflavin A
CAS:<p>Cannflavin A, isolated from Cannabis sativa L., exhibits anti-cancer, neuroprotective, and anti-inflammatory activities by inhibiting Aβ1-42 aggregation and</p>Fórmula:C26H28O6Forma y color:SolidPeso molecular:436.5SL-01
CAS:<p>SL-01, an oral gemcitabine derivative, potently induces apoptosis to hinder breast cancer more effectively than gemcitabine.</p>Fórmula:C18H18ClNO3Pureza:98%Forma y color:White PowderPeso molecular:331.79Halenaquinone
CAS:<p>Halenaquinone: PI3K inhibitor, stops RAD51 DNA binding & osteoclastogenesis, induces PC12 cell apoptosis.</p>Fórmula:C20H12O5Pureza:98%Forma y color:SolidPeso molecular:332.31Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2
CAS:<p>Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate compound that combines a Thalidomide-based cereblon ligand and a linker, which is commonly</p>Fórmula:C25H34N4O9Pureza:98%Forma y color:SolidPeso molecular:534.566VTP50469 fumarate
CAS:<p>VTP50469 fumarate is a highly selective and orally active inhibitor of Menin-MLL interaction (Ki: 104 pM), and has potently anti-leukemia activity.</p>Fórmula:C76H106F2N12O20S2Pureza:98%Forma y color:SolidPeso molecular:1609.86Thalidomide-O-amido-PEG4-propargyl
<p>Thalidomide-O-amido-PEG4-propargyl is a polyethylene glycol (PEG)-based linker employed for the synthesis of proteolysis targeting chimeras (PROTACs)[1].</p>Fórmula:C26H31N3O10Pureza:98%Forma y color:SolidPeso molecular:545.54A011
<p>A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycle</p>Fórmula:C27H28N6OPureza:98%Forma y color:SolidPeso molecular:452.55F1324
<p>F1324: potent BCL6 inhibitor, IC50=1nM, binding t1/2=441s, strongly inhibits BCL6 PPI.</p>Fórmula:C83H121N21O20SPureza:98%Forma y color:SolidPeso molecular:1765.04Thalidomide-O-amido-C3-PEG3-C1-NH2
CAS:<p>Thalidomide-based E3 ligase linker for PROTACs with a 3-unit PEG chain.</p>Fórmula:C27H35F3N4O11Forma y color:SolidPeso molecular:648.589CSF1R-IN-26
<p>CSF1R-IN-26 (Compound III-1) is an inhibitor of CSF-1R with an IC50 of 20.07 nM. It promotes the polarization of M2 macrophages to M1 macrophages, inducing apoptosis in MC-38 cancer cells. CSF1R-IN-26 inhibits the activation of the AKT/ERK/STAT3 signaling pathways, remodels the tumor immune microenvironment, and exhibits antitumor activity in mouse models. In SD rats, CSF1R-IN-26 demonstrates favorable pharmacokinetic properties, with a half-life of 1.86 hours and an oral bioavailability of 79.22%.</p>Forma y color:Odour SolidNauclefine
CAS:<p>Nauclefine, a plant alkaloid, triggers cancer cell death through PDE3A-SLFN12, binding but not inhibiting PDE3A.</p>Fórmula:C18H13N3OPureza:99.92%Forma y color:SolidPeso molecular:287.32BRD4 Inhibitor-38
<p>BRD4 Inhibitor-38 (Compound 25) is an orally active BRD4 inhibitor, exhibiting IC50 values of 3.64 μM for BRD4 BD1 and 0.12 μM for BRD4 BD2. It also demonstrates anti-inflammatory properties, with an IC50 value of 1.98 μM for nitric oxide (NO) production.</p>Fórmula:C19H18N2O4Forma y color:SolidPeso molecular:338.357HDSI-18
<p>HDSI-18 is an orally active selective inhibitor of HDAC6 with an IC50 of 1.6 nM. It exhibits cytotoxic effects against K562, MV4-11, MOLM-13, THP-1, and Jurkat cells with IC50 values of 0.48, 0.58, 0.91, 1.79, and 4.31 μM, respectively. HDSI-18 can activate Caspase-3, induce mitochondrial depolarization, and trigger apoptosis (Apoptosis), demonstrating antitumor activity.</p>Fórmula:C28H28N4O5Forma y color:SolidPeso molecular:500.20597Xerophilusin B
CAS:<p>Xerophilusin B from Isodon xerophilus halts ESCC cell growth, causes G2/M arrest, and induces apoptosis.</p>Fórmula:C20H26O5Forma y color:SolidPeso molecular:346.42Stem bromelain
CAS:<p>Stem bromelain: cysteine protease from pineapple stem with fibrinolytic, anti-inflammatory, antitumoral properties.</p>Forma y color:SolidTop1-IN-2
<p>Top1-IN-2 (Compound 1a) is an inhibitor of topoisomerase 1 (Top1). It suppresses the growth of P-gp drug-resistant tumor cells and induces apoptosis.</p>Forma y color:Odour SolidD-Trimannuronic acid
CAS:<p>D-Trimannuronic acid from seaweed induces TNF-α in mouse macrophages; useful in pain, dementia studies.</p>Fórmula:C18H26O19Forma y color:SolidPeso molecular:546.387RET ligand-1
CAS:<p>RETligand-1 is a target protein ligand that specifically interacts with RET and can be utilized in the synthesis of the PROTAC LDD39.</p>Fórmula:C28H24F2N6O3Forma y color:SolidPeso molecular:530.525Lacto-N-fucopentaose I
CAS:<p>Lacto-N-fucopentaose I is a milk oligosaccharide.</p>Fórmula:C32H55NO25Forma y color:SolidPeso molecular:853.774Thalidomide-O-C8-COOH
CAS:<p>Thalidomide-O-C8-COOH, also known as Cereblon ligand 3, is a Thalidomide-derived compound that serves as a Cereblon (CRBN) ligand for the targeted recruitment</p>Fórmula:C22H26N2O7Forma y color:SolidPeso molecular:430.45Z-WEHD-FMK
CAS:<p>Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).</p>Fórmula:C37H42FN7O10Pureza:98%Forma y color:SolidPeso molecular:763.78ADPM06
CAS:<p>ADPM06: nonporphyrin PDT agent; leads in apoptosis, strong IC50 in µM against human tumors.</p>Fórmula:C34H24BBr2F2N3O2Forma y color:SolidPeso molecular:715.19Humulone
<p>Humulone is a natural product and has a wide range of applications in life science related research.</p>Fórmula:C21H30O5Forma y color:SolidPeso molecular:362.47EJMC-1
CAS:<p>EJMC-1 is an inhibitor of TNF-α with an IC50 value of 42 μM and can be used in studies about auto-inflammatory diseases.</p>Fórmula:C17H11ClN2O4SPureza:98.38%Forma y color:SolidPeso molecular:374.8Targaprimir-96 TFA
<p>Targaprimir-96 TFA is a selective inhibitor of miR-96 in cancer, inducing apoptosis with high affinity for pri-miR-96 but not affecting healthy cells.</p>Fórmula:C79H103F3N18O9Forma y color:SolidPeso molecular:1505.77CQ-Mito
<p>CQ-Mito, a derivative of CQ, demonstrates excellent phototherapeutic efficacy with a PI value of 167. This compound induces cell death through mechanisms such as apoptosis and ferroptosis. It mediates mitochondrial dysfunction, characterized by alterations in mitochondrial morphology and loss of MMP. Additionally, CQ-Mito effectively inhibits tumor growth in 3D multicellular tumor spheroid models.</p>Fórmula:C45H42BrN6O4PForma y color:SolidPeso molecular:841.73YF135
CAS:<p>YF135 is a reversible-covalent KRAS G12C PROTAC that degrades its target via the VHL-proteasome pathway.</p>Fórmula:C63H75ClN12O7SForma y color:SolidPeso molecular:1179.86Opamtistomig
CAS:<p>Opamtistomig is a humanized monoclonal antibody immunoglobulin (H-γ1-scFv-L-κ) dimer targeting human programmed death-ligand 1 (PD-L1), CD274, and tumor necrosis factor receptor superfamily member 9 (TNFRSF9). It is anticipated for use in research on various solid tumors and hematologic malignancies.</p>Forma y color:LiquidINF200
<p>INF200 (compound 5), a sulfonylurea-based inhibitor of NLRP3 and associated pyroptosis, exhibits cardiometabolic benefits in a rat model of high-fat diet (HFD)-</p>Fórmula:C13H13ClN2O4Pureza:98%Forma y color:SolidPeso molecular:296.71CPD-10
CAS:<p>CPD-10 is a potent bifunctional PROTAC degrader targeting CCND1 and CDK4 and exhibits antiproliferative effects. It induces apoptosis and reduces the protein expression of Cyclin D1, Cyclin D3, CDK4, and P-Rb(5807/811) in a dose-dependent manner.</p>Fórmula:C46H61N15O4Forma y color:SolidPeso molecular:888.08MG-277
<p>MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.</p>Fórmula:C41H42Cl2FN5O5Pureza:98%Forma y color:SolidPeso molecular:774.71Secalonic acid D
CAS:<p>Secalonic acid D, from Aspergillus aculeatus, is anti-tumor, activates GSK3-β, degrades β-catenin, inhibits c-Myc, and induces apoptosis.</p>Fórmula:C32H30O14Forma y color:SolidPeso molecular:638.57Thalidomide-NH-C8-NH2 hydrochloride
CAS:<p>Thalidomide-based E3 ligase ligand-linker for PROTAC, with cereblon ligand and C8-NH2 hydrochloride.</p>Fórmula:C21H29ClN4O4Forma y color:SolidPeso molecular:436.94RIP1-IN-1
<p>RIP1-IN-1 is an orally bioavailable RIP1 inhibitor with a high binding affinity (Kd: 110 nM). This compound exhibits significant activity against necroptosis and effectively suppresses necrosome formation by inhibiting the phosphorylation of RIP1, RIP3, and MLKL pathways. RIP1-IN-1 can inhibit necroptosis and is applicable in research on acute liver injury.</p>Forma y color:Odour SolidPI3Kα-IN-14
<p>PI3Kα-IN-14 (compound F8), a potent PI3Kα inhibitor, exhibits an IC50 value of 0.14 nM and markedly diminishes mitochondrial membrane potential, resulting in</p>Pureza:98%Forma y color:Odour SolidBcl-xL antagonist 2
CAS:<p>Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM.</p>Fórmula:C21H16N4O3S2Pureza:99.81%Forma y color:SolidPeso molecular:436.51PL120131
<p>PL120131 is a PD-1/PD-L1 inhibitory peptide that disrupts the interaction between PD-1 and PD-L1 by binding to PD-1. This compound can inhibit the apoptosis signaling pathway mediated by PD-1, thereby preventing apoptosis (apoptosis) in Jurkat cells and primary lymphocytes. Additionally, PL120131 supports cytotoxic T lymphocytes (CTL) in exhibiting antitumor activity.</p>Fórmula:C62H105N19O18Forma y color:SolidPeso molecular:1404.61
