Apoptosis
Los inhibidores de la apoptosis son compuestos que previenen o retrasan el proceso de muerte celular programada, conocido como apoptosis. Estos inhibidores son vitales para estudiar los mecanismos de supervivencia celular y se utilizan para investigar enfermedades donde la apoptosis está desregulada, como el cáncer, los trastornos neurodegenerativos y las enfermedades autoinmunes. Al modular la apoptosis, estos inhibidores pueden ayudar en el desarrollo de terapias dirigidas a controlar la muerte celular. En CymitQuimica, ofrecemos una amplia selección de inhibidores de la apoptosis de alta calidad para apoyar su investigación en biología celular, oncología y campos relacionados.
Subcategorías de "Apoptosis"
- ASK(6 productos)
- BCL(11 productos)
- Caspasa(125 productos)
- FOXO1(3 productos)
- IAP(66 productos)
- Mdm2(12 productos)
- PD-1 / PD-L1(125 productos)
- PDK(9 productos)
- PERK(25 productos)
- Serina / treonina quinasa(15 productos)
- Survivin(13 productos)
- TNF(92 productos)
- c-RET(51 productos)
- p53(62 productos)
Mostrar 6 subcategorías más
Se han encontrado 5600 productos de "Apoptosis"
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Diethyl phthalate
CAS:<p>Diethyl phthalate disrupts endocrine and induces apoptosis in PC12 cells; common in plastics, personal care items.</p>Fórmula:C12H14O4Pureza:99.68% - 99.8%Forma y color:SolidPeso molecular:222.24Thalidomide-PEG2-C2-NH2
CAS:<p>Thalidomide-O-amido-PEG3-C2-NH2 is a cereblon ligand-linked E3 ligase used in PROTAC with a 2-unit PEG.</p>Fórmula:C19H24N4O6Pureza:98%Forma y color:SolidPeso molecular:404.42Thalidomide-O-amido-PEG2-C2-NH2
CAS:<p>Thalidomide-O-amido-PEG2-C2-NH2, which combines an E3 ligase ligand with a linker, serves as an immunomodulator for cancer treatment.</p>Fórmula:C21H26N4O8Forma y color:SolidPeso molecular:462.459Sudubrilimab
<p>Sudubrilimab (HS636) is an IgG1-κ monoclonal antibody targeting PDL1, fused with TGFBR2-ECD to block PD-1/PDL1 and TGF-β in tumors.</p>Forma y color:Odour LiquidIzuralimab
CAS:<p>Izuralimab is a bispecific IgG1 antibody that targets both the inducible T-cell costimulator (ICOS/CD278) and PD-1 [1].</p>Forma y color:LiquidOnfekafusp alfa
CAS:<p>Onfekafusp alfa (L19TNF), a trimeric fusion of L19 scFv and human TNF, targets malignant glioma.</p>Forma y color:LiquidPexelizumab
CAS:<p>Pexelizumab is a humanized antibody targeting C5 to inhibit apoptosis and treat cerebral IR injury and myocardial infarction.</p>Forma y color:LiquidHolothurin A
CAS:<p>Holothurin A is a triterpene glycoside.</p>Fórmula:C54H86NaO27SForma y color:SolidPeso molecular:1222.3MPP hydrochloride
<p>MPP hydrochloride is a selective estrogen receptor (ERR) modulator.</p>Fórmula:C29H32ClN3O3Pureza:99.75% - 99.9%Forma y color:SolidPeso molecular:506.04AMG-7209
CAS:<p>AMG-7209 is an effective and selective MDM2-p53 interaction inhibitor.</p>Fórmula:C37H41Cl2FN2O7SForma y color:SolidPeso molecular:747.75-LOX-IN-8
<p>5-LOX-IN-8 is a 5-LOX inhibitor with anti-inflammatory properties. It suppresses IL-6, IL-1β, TNF-α, and IFN-γ in macrophages and reduces IL-8 secretion in SW480 cells. Additionally, 5-LOX-IN-8 decreases the disease activity index in DSS colitis models. This compound is applicable for research in inflammatory bowel disease (IBD).</p>Forma y color:Odour SolidAntagonist G
CAS:<p>Antagonist G is an anticancer peptide and is also a broad spectrum neuropeptide growth factor antagonist.</p>Fórmula:C49H66N12O6SPureza:98%Forma y color:SolidPeso molecular:951.19GL392
<p>GL392 is a senolytic agent that delivers the potent senescence-clearing compound Dasatinib specifically to senescent cells. By targeting the LBD domain, it binds lipofuscin in these cells and releases Dasatinib via an ester linkage, inducing apoptosis (Apoptosis) in senescent cells. Additionally, GL392 is encapsulated in PEO-b-PCL microcapsules to ensure efficient intracellular delivery while minimizing systemic toxicity. GL392 is applicable in cancer research.</p>Fórmula:C55H52ClN13O5SForma y color:SolidPeso molecular:1042.6FLT3-IN-29
<p>FLT3-IN-29 (Compound MY-10) is an FLT3 inhibitor with IC50 values of 6.5 nM and 10.3 nM for FLT3-ITD and FLT3-D835Y mutants, respectively. It induces cell cycle arrest at the G0/G1 phase and effectively triggers apoptosis (Apoptosis). Additionally, FLT3-IN-29 reduces reactive oxygen species (ROS) and mitochondrial membrane potential (MMP), displaying anti-leukemic properties.</p>Fórmula:C25H30N6O2Forma y color:SolidPeso molecular:446.545Fosbretabulin [free base]
CAS:<p>Fosbretabulin is a natural cis-stilbene that interferes with cellular tubulin dynamics and selectively destroys tumor blood vessels.</p>Fórmula:C18H21O8PForma y color:SolidPeso molecular:396.33Antioxidant agent-20
<p>Antioxidant agent-20 (Compound 3d) exhibits potent anti-inflammatory and antioxidant activities. It reduces reactive oxygen species (ROS) and apoptosis in a dose-dependent manner. Antioxidant agent-20 demonstrates photoprotective effects on UVB-exposed human skin keratinocytes (HaCaT) (IC50=5.13 µM) by activating Nrf2/HO-1 signaling and inhibiting the NF-κB pathway.</p>Fórmula:C18H24O4Forma y color:SolidPeso molecular:304.381Mitochondria modulator-2
<p>Mitochondria modulator-2 (Compound Ir1) induces depolarization of the mitochondrial membrane potential, generates reactive oxygen species (ROS), inhibits the migration of A549 cells, causes cell cycle arrest at the G2/M phase, and triggers apoptosis in A549 cells.</p>Fórmula:C63H50F12IrN6OP3Forma y color:SolidPeso molecular:1420.23MSU-42011
CAS:<p>MSU-42011: oral RXR-like agonist, inhibits iNOS & p-ERK, antitumor in lung cancer model, effective preclinical treatment.</p>Fórmula:C24H34N2O2Pureza:99.52%Forma y color:SoildPeso molecular:382.54Ankaflavin
CAS:<p>Ankaflavin, from red rice fermentation, is a PPARγ agonist with anti-inflammatory properties and selectively kills cancer cells.</p>Fórmula:C23H30O5Pureza:98%Forma y color:SolidPeso molecular:386.48PTD-p65-P1 Peptide
<p>PTD-p65-P1: a NF-kappaB inhibitor blocking activation from multiple inflammatory stimuli.</p>Fórmula:C168H275N57O44SPureza:98%Forma y color:SolidPeso molecular:3829.5RET ligand-3
<p>RETligand-3 is the ligand for PROTAC QZ2135, which targets RET.</p>Fórmula:C38H42N10O3Forma y color:SolidPeso molecular:686.81MAO-B-IN-30
CAS:<p>MAO-B-IN-30 is a selective and potent MAO-B inhibitor that crosses the blood-brain barrier with antiproliferative activity and inhibits both MAO-A and MAO-B.MAO-B-IN-30 reduces the levels of TNF-alpha, IL-6, and NF-kB in organisms, and can be used to study Parkinson's-type neurological disorders.</p>Fórmula:C15H10BrN3O2Pureza:98.31%Forma y color:SoildPeso molecular:344.16TrxR-IN-7
<p>TrxR-IN-7 (14f) is a potent inhibitor of thioredoxin reductase (TrxR), with an IC50 value of 3.5 µM. It exhibits antiproliferative activity and can induce apoptosis and the production of reactive oxygen species (ROS).</p>Fórmula:C22H21NO3Forma y color:SolidPeso molecular:347.407Valproic acid sodium salt
CAS:<p>Sodium valproate is an anti-epileptic, boosting brain GABA levels and possibly affecting potassium channels for membrane stability.</p>Fórmula:C8H15NaO2Pureza:98.43% - 99.78%Forma y color:White PowderPeso molecular:166.2Necroptosis-IN-3
CAS:<p>Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis.</p>Fórmula:C12H17NOSPureza:99.85%Forma y color:SoildPeso molecular:223.33FMP
<p>FMP is a platinum (IV) complex. It significantly upregulates the expression of γ-H2AX and p53, enhances ROS production, and markedly increases the expression of apoptosis (Apoptosis) related proteins (DR5, Fas, caspase-8, Cyt-c, caspase-3, cleaved-PARP1, Bax). FMP exhibits antiproliferative activity against breast cancer.</p>Fórmula:C18H18Cl2N2O7PtForma y color:SolidPeso molecular:640.33DNMT-IN-4
<p>DNMT-IN-4 (Compound 4d) is a DNMT inhibitor with an IC50 value of 5.78 µM. It induces apoptosis and exhibits anticancer activity.</p>Fórmula:C22H25ClN4S2Forma y color:SolidPeso molecular:445.04TNF-α-IN-9
CAS:<p>TNF-α-IN-9 is an NDM-1 inhibitor-3 analog and is a TNF-α inhibitor.TNF-α-IN-9 shows low inhibitory activity.</p>Fórmula:C17H14O4Pureza:98.28%Forma y color:SoildPeso molecular:282.29PROTAC FLT-3 degrader 1
CAS:<p>PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 degrader of internal tandem duplication (ITD)(IC50 0.6 nM),with anti-proliferative activity.</p>Fórmula:C52H61N9O9S2Pureza:98%Forma y color:SolidPeso molecular:1020.23LD4172
CAS:<p>LD4172 is a PROTAC degrader capable of degrading RIP kinase (RIPK1) with a DC50 in the nanomolar range. When used in combination with TNF-α, LD4172 can induce apoptosis in B16F10 cells. In mouse models, it demonstrates antitumor activity. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase VHL)</p>Fórmula:C61H75F3N10O7SForma y color:SolidPeso molecular:1149.37TRF2-IN-1
<p>TRF2-IN-1 (compound F2) is a potent inhibitor of telomere repeat-binding factor 2 (TRF2). It exhibits antiproliferative activity and induces apoptosis. TRF2-IN-1 binds directly to the TRF2TRFH domain, selectively inhibiting TRF2 protein expression and telomere localization. Additionally, TRF2-IN-1 possesses anticancer properties and shows potential for osteosarcoma research.</p>Fórmula:C18H17BrO4Forma y color:SolidPeso molecular:377.229PL120131
<p>PL120131 is a PD-1/PD-L1 inhibitory peptide that disrupts the interaction between PD-1 and PD-L1 by binding to PD-1. This compound can inhibit the apoptosis signaling pathway mediated by PD-1, thereby preventing apoptosis (apoptosis) in Jurkat cells and primary lymphocytes. Additionally, PL120131 supports cytotoxic T lymphocytes (CTL) in exhibiting antitumor activity.</p>Fórmula:C62H105N19O18Forma y color:SolidPeso molecular:1404.61Enpp/Carbonic anhydrase-IN-2
CAS:<p>Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.</p>Fórmula:C23H24FNO4SPureza:99.46%Forma y color:SoildPeso molecular:429.5PI3K-AKT-mTOR Compound Library
<p>A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with</p>Forma y color:Odour SolidPZ703b
CAS:<p>PZ703b is a novel BCL-XL PROTAC degrader with enhanced BCL-2 inhibition.</p>Fórmula:C80H102ClF3N10O11S4Forma y color:SolidPeso molecular:1600.44PROTAC KDM4 degrader-1
<p>PROTACKDM4 degrader-1 (Compound 11) is a proteolysis-targeting chimera (PROTAC) degrader specifically designed for KDM4. It effectively degrades KDM4A-C while sparing KDM4D. In esophageal cancer cells, PROTACKDM4 degrader-1 demonstrates strong antiproliferative activity, inducing apoptosis and cell cycle arrest, and inhibits lysine demethylation of histone H3.</p>Forma y color:Odour SolidG-Glu-Val
CAS:<p>G-Glu-Val (γ-glutamyl-L-valine, H-Glu-Val -OH), a flavour-regulating dipeptide, is a major contributor to "mellow".</p>Fórmula:C10H18N2O5Forma y color:SolidPeso molecular:246.26Albanol B
CAS:<p>Albanol B, from mulberries, combats Alzheimer's, bacteria, and oxidation, hinders cancer growth, and triggers cell arrest and apoptosis.</p>Fórmula:C34H22O8Forma y color:SolidPeso molecular:558.5327-O-(tert-Butyldimethylsilyl)withaferin A
CAS:<p>Compound 9a, a withanolide, induces apoptosis and has anti-cancer properties.</p>Fórmula:C34H52O6SiForma y color:SolidPeso molecular:584.86RIP1-IN-1
<p>RIP1-IN-1 is an orally bioavailable RIP1 inhibitor with a high binding affinity (Kd: 110 nM). This compound exhibits significant activity against necroptosis and effectively suppresses necrosome formation by inhibiting the phosphorylation of RIP1, RIP3, and MLKL pathways. RIP1-IN-1 can inhibit necroptosis and is applicable in research on acute liver injury.</p>Forma y color:Odour SolidPPA-904 FA
<p>PPA-904 FA is a cationic photosensitizer with antimicrobial activity that can be used to study chronic leg ulcers and diabetic foot ulcers.</p>Fórmula:C29H43N3O2SPureza:98%Forma y color:SolidPeso molecular:497.74TS-IN-6
<p>TS-IN-6 (Compound 10) is a thymidylate synthase (TS) inhibitor with an IC50 value of 0.54 μM, showing significant antiproliferative activity. It can induce G1 phase cell cycle arrest and apoptosis (with notable increases in early and late apoptosis rates) and is useful for research in cancers such as colon, breast, and liver cancer.</p>Fórmula:C29H22F2N6OSForma y color:SolidPeso molecular:540.59Shepherdin (79-87)
CAS:<p>Shepherdin 79-87: Amino acid fragment 79-87 of Hsp90/Survivin antagonist with anticancer properties.</p>Fórmula:C41H64N12O12SPureza:98%Forma y color:SolidPeso molecular:949.09Mcl-1 inhibitor 3
CAS:<p>Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.Mcl-1 inhibitor 3 is a highly potent and orally activate</p>Fórmula:C40H52ClF2N5O7SPureza:98%Forma y color:SolidPeso molecular:820.39PROTAC LZK-IN-1
CAS:<p>PROTAC LZK-IN-1 (Compound 21A) is a PROTAC molecule that targets the degradation of LZK (leucine zipper kinase, encoded by MAP3K13). At a concentration of 10 μM, PROTAC LZK-IN-1 facilitates the degradation of LZK and inhibits the expression of p53 and c-MYC, leading to reduced viability of global head and neck squamous cell carcinoma (HNSCC) cell lines. This compound is applicable in anticancer research.</p>Fórmula:C51H64F2N10O5SForma y color:SolidPeso molecular:967.18ARV-393 HCl
<p>ARV-393 HCl is an orally active and potent PROTAC targeting BCL6 with antitumor activity for the study of non-Hodgkin's lymphoma.</p>Fórmula:C46H54Cl2FN9O7Pureza:99.79%Forma y color:SolidPeso molecular:934.88Thalidomide-NH-C8-NH2 hydrochloride
CAS:<p>Thalidomide-based E3 ligase ligand-linker for PROTAC, with cereblon ligand and C8-NH2 hydrochloride.</p>Fórmula:C21H29ClN4O4Forma y color:SolidPeso molecular:436.94AlbA-DCA
<p>AlbA-DCA, a compound of Albiziabioside A and dichloroacetate, boosts ROS and reduces lactic acid in tumors, killing cancer cells and triggering apoptosis.</p>Fórmula:C43H67Cl2NO12Pureza:98%Forma y color:SolidPeso molecular:860.9PZ703b hydrochloride
<p>PZ703b hydrochloride, a Bcl-xl PROTAC, triggers apoptosis and halts cancer growth; used in bladder cancer studies.</p>Fórmula:C80H103Cl2F3N10O11S4Forma y color:SolidPeso molecular:1636.9MRT-2359
CAS:<p>"MRT-2359: Oral GSPT1 reducer, anti-cancer, targets NSCLC/SCLC, effective on MYC-driven cells."</p>Fórmula:C22H17F4N3O6Pureza:98.69%Forma y color:SoildPeso molecular:495.38
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