Apoptosis
Los inhibidores de la apoptosis son compuestos que previenen o retrasan el proceso de muerte celular programada, conocido como apoptosis. Estos inhibidores son vitales para estudiar los mecanismos de supervivencia celular y se utilizan para investigar enfermedades donde la apoptosis está desregulada, como el cáncer, los trastornos neurodegenerativos y las enfermedades autoinmunes. Al modular la apoptosis, estos inhibidores pueden ayudar en el desarrollo de terapias dirigidas a controlar la muerte celular. En CymitQuimica, ofrecemos una amplia selección de inhibidores de la apoptosis de alta calidad para apoyar su investigación en biología celular, oncología y campos relacionados.
Subcategorías de "Apoptosis"
- ASK(6 productos)
- BCL(11 productos)
- Caspasa(125 productos)
- FOXO1(3 productos)
- IAP(66 productos)
- Mdm2(12 productos)
- PD-1 / PD-L1(125 productos)
- PDK(9 productos)
- PERK(25 productos)
- Serina / treonina quinasa(15 productos)
- Survivin(13 productos)
- TNF(92 productos)
- c-RET(51 productos)
- p53(62 productos)
Mostrar 6 subcategorías más
Se han encontrado 5600 productos de "Apoptosis"
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MALT1-IN-13
<p>MALT1-IN-13 (compound 10m) is an inhibitor of the mucosa-associated lymphoid tissue lymphoma translocation protein (MALT1), forming a covalent and irreversible bond with the MALT1 protease, thereby inhibiting its activity with an IC50 of 1.7 μM. It suppresses the proliferation of ABC-DLBCL and induces apoptosis in ABC-DLBCL HBL1 cells. Additionally, MALT1-IN-13 regulates the mTOR and PI3K-Akt pathways.</p>Fórmula:C20H15BrClN3O3S2Peso molecular:522.94267MS1943
CAS:<p>MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).</p>Fórmula:C42H54N8O3Pureza:95.41% - 95.82%Forma y color:SolidPeso molecular:718.93Albanol B
CAS:<p>Albanol B, from mulberries, combats Alzheimer's, bacteria, and oxidation, hinders cancer growth, and triggers cell arrest and apoptosis.</p>Fórmula:C34H22O8Forma y color:SolidPeso molecular:558.53CS4
<p>CS4 is a selective HDAC inhibitor, with IC50 values for HDAC1, HDAC6, HDAC8, HDAC4, and HDAC11 reported as 38 nM, 12 nM, 5.8 μM, 19 μM, and 61 μM, respectively. It enhances the acetylation of α-tubulin and histone 3 (histone 3). Additionally, CS4 activates PPARγ and blocks glycolysis (glycolysis). It induces cell cycle arrest at the G2 phase and triggers apoptosis (apoptosis), exhibiting anticancer effects both in vitro and in vivo.</p>Forma y color:Odour SolidGPLGIAGQ acetate
<p>GPLGIAGQ acetate: MMP2-cleavable peptide; stimulus-sensitive linker for MMP2-targeted liposomal/micellar carriers in photodynamic therapy.</p>Fórmula:C33H57N9O12Pureza:97.85%Forma y color:SolidPeso molecular:771.86p53 and MDM2 proteins-interaction-inhibitor dihydrochloride
<p>p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is a interaction inhibitor between p53 and MDM2 proteins.</p>Fórmula:C40H51Cl4N5O4Pureza:98%Forma y color:SolidPeso molecular:807.68DHFR-IN-23
<p>DHFR-IN-23 (compound 5) is a dual inhibitor of DNA binders/DHFR, exhibiting an IC50 value of 0.08 μM against hDHFR. It serves as an apoptosis inducer and is applicable in research on ER+ breast cancer.</p>Forma y color:Odour SolidD-Trimannuronic acid
CAS:<p>D-Trimannuronic acid from seaweed induces TNF-α in mouse macrophages; useful in pain, dementia studies.</p>Fórmula:C18H26O19Forma y color:SolidPeso molecular:546.387CDK/HDAC-IN-4
<p>CDK/HDAC-IN-4 is a highly selective dual inhibitor of cyclin-dependent kinase (CDK) and histone deacetylase (HDAC), with IC50 values of 88.4 nM and 168.9 nM, respectively. This compound exhibits antiproliferative effects in both hematologic and solid tumor cells. Additionally, CDK/HDAC-IN-4 induces apoptosis and S-phase cell cycle arrest in MV-4-11 cells. It has also demonstrated significant antitumor efficacy in an MV-4-11 xenograft model.</p>Forma y color:Odour SolidPRDX1-IN-2
<p>PRDX1-IN-2 (compound 15) is a selective inhibitor of the antioxidant enzyme Peroxiredoxin 1 (PRDX1) with an IC50 of 0.35 μM. It reduces mitochondrial membrane potential in SW620 cells, potentially due to increased ROS resulting from PRDX1 inhibition, leading to apoptosis. PRDX1-IN-2 is applicable in colorectal cancer research.</p>Necrosis inhibitor 2 (hydrocholide)
<p>Necrosis inhibitor 2 hydrochloride (Compound B19) is an agent that inhibits cellular necrosis. It is useful for researching diseases associated with necrotic pathways, including inflammation, cancer, metabolic disorders, and neurodegenerative diseases.</p>Fórmula:C24H26ClN5O5Peso molecular:499.16225Anticancer agent 178
<p>Anticanceragent 178 (compound C2) is a potent anticancer compound. It effectively inhibits the proliferation and metabolic activity of MDA-MB 231 cells, with IC50 values of 1.1 and 4.2 μM, respectively. Additionally, Anticanceragent 178 induces ferroptosis and necroptosis in cells.</p>Fórmula:C32H30ClFeN2O6Peso molecular:629.11418Antitumor agent-170
<p>Antitumor agent-170 (Compound C6) inhibits PD-1/PD-L1 interaction and PARP7 with IC50 values of 0.342 μM and 7.05 nM, respectively. It shows high affinity for human PD-L1, with a Ki of 9.31 nM, and can restore T cell function while increasing IFN-γ secretion. In mouse models, Antitumor agent-170 exhibits antitumor effects against melanoma and demonstrates favorable pharmacokinetic properties.</p>Fórmula:C59H69ClF3N11O9Peso molecular:1167.49204Top1-IN-2
<p>Top1-IN-2 (Compound 1a) is an inhibitor of topoisomerase 1 (Top1). It suppresses the growth of P-gp drug-resistant tumor cells and induces apoptosis.</p>Forma y color:Odour SolidRosomidnar
CAS:<p>PNT100: 24-base DNA oligo targeting BCL-2 regulatory region; halts tumor cell growth, induces death.</p>Fórmula:C227H291O141P23Forma y color:SolidPeso molecular:7220.63ECDD-S16
<p>ECDD-S16 is a potent inhibitor of pyroptosis. It effectively suppresses pyroptosis in Raw264.7 cells activated by surface and endosomal TLR ligands.</p>Fórmula:C35H31FO12Peso molecular:662.17995Opnurasib
CAS:<p>Opnurasib (JDQ-443) is an orally available and selective and potent covalent KRAS G12C inhibitor with antitumor activity for the study of advanced non-small</p>Fórmula:C29H28ClN7OPureza:98.88%Forma y color:SolidPeso molecular:526.03RMC-6291
CAS:<p>RMC-6291: Oral, covalent KRAS G12C inhibitor, blocks signaling, forms tri-complex with CypA, suppresses RAS activity in tumors.</p>Fórmula:C55H78FN9O8Pureza:98.73%Forma y color:SolidPeso molecular:1012.26TNF-α (31-45), human
CAS:<p>TNF-α (31-45), human is a peptide of tumor necrosis factor-α.</p>Fórmula:C69H122N26O22Pureza:98%Forma y color:SolidPeso molecular:1667.895WD6305
WD6305 is an effective and selective METTL3-METTL14 PROTAC degrader, with DC50 values of 140 nM and 194 nM for METTL3 and METTL14, respectively. It inhibits m6A modification and the proliferation of acute myeloid leukemia cells while inducing apoptosis. WD6305 also exhibits antitumor activity.Fórmula:C61H75F2N11O5SPeso molecular:1111.56414KT5823
CAS:<p>KT5823 is a cGMP-dependent protein kinase (PKG) inhibitor that increases iodide ion uptake by regulating the expression of sodium iodide symporter protein.</p>Fórmula:C29H25N3O5Pureza:95%Forma y color:SolidPeso molecular:495.53NCA029
<p>NCA029 is a potent activator of human caseinolytic protease P (HsClpP) with an EC50 of 0.15 μM. It targets HsClpPP and triggers an ATF3-dependent integrated stress response, resulting in the death of colon cancer cells.</p>Fórmula:C22H20F3N3OPeso molecular:399.15585SPOP-IN-6lc
CAS:<p>SPOP-IN-6lc is a SPOP inhibitor with oncogenic effects in renal cancer cells.SPOP-IN-6lc can be used to study apoptosis.</p>Fórmula:C26H31N7O2SPureza:99.19%Forma y color:SolidPeso molecular:505.64dFKBP-1
CAS:<p>dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based cereblon ligand and a linker[1].</p>Fórmula:C53H64N6O14Pureza:98%Forma y color:SolidPeso molecular:1009.11PROTAC GPX4 degrader-1
CAS:<p>PROTAC GPX4 Degrader-1 (DC-2) is a PROTAC-based compound that efficiently degrades GPX4, demonstrating a degradation concentration (DC 50) of 0.03 μM in HT1080</p>Fórmula:C50H57ClN10O10Forma y color:SolidPeso molecular:993.52,2'-Dihydroxy chalcone
CAS:<p>2,2'-Dihydroxy chalcone inhibits β-glucuronidase (IC50=1.6 μM) and lysozyme (IC50=1.4 μM), and fights E. coli, S. fowleri, S. albicans, S. aureus.</p>Fórmula:C15H12O3Pureza:99.7%Forma y color:SolidPeso molecular:240.25Pyridinium bisretinoid A2E
CAS:<p>Pyridinium bisretinoid A2E (A2E) is a fluorescent molecule isolated from the lipofuscin of retinal pigment epithelium, a weak photosensitizer.</p>Fórmula:C42H58NOPureza:98.19%Forma y color:SolidPeso molecular:592.92Oligomycin B
CAS:<p>Oligomycin B is an antibiotic isolated from marine Streptomyces, is an eukaryotic ATP synthase inhibitor, induces apoptosis.</p>Fórmula:C45H72O12Pureza:98%Forma y color:SolidPeso molecular:805.05Thalidomide-5-PEG2-Cl
CAS:<p>Thalidomide-5-PEG2-Cl is a cereblon ligand that recruits CRBN protein and forms PROTACs through linker conjugation.</p>Fórmula:C17H17ClN2O6Forma y color:SolidPeso molecular:380.78Acrixolimab
CAS:<p>Acrixolimab is a humanized IgG4-κ monoclonal antibody that selectively targets PD-1 [1] [2].</p>Pureza:98%Forma y color:LiquidWEE1-IN-7
<p>WEE1-IN-7 (compound 12h) is a potent, orally active WEE1 inhibitor with an IC50 value of 2.1 nM. This compound induces apoptosis and causes cell cycle arrest in the S phase, demonstrating antitumor activity.</p>Ledostomig
CAS:<p>Ledostomig is an immunoglobulin (H-γ1-scFv-L-κ) dimer monoclonal antibody that targets human neurotensin receptor type 5 (NTS5) and programmed death-1 (PD-1). It shows potential for research in various cancer types.</p>Forma y color:Liquid(-)-Irofulven
CAS:<p>Irofulven is an agent of DNA-damaging and antitumor. It is used for the treatment of advanced solid tumors, including prostate, ovarian, and pancreatic cancers.</p>Fórmula:C15H18O3Forma y color:SolidPeso molecular:246.30Sincalide ammonium
CAS:<p>Sincalide ammonium, a CCK analog, stimulates bile release, gallbladder contraction, and sphincter relaxation, aiding in diagnoses.</p>Fórmula:C49H65N11O16S3Pureza:98.46%Forma y color:SolidPeso molecular:1160.3Akt/NF-κB/MAPK-IN-1
<p>Akt/NF-κB/MAPK-IN-1 (compound 2m) serves as a potent, orally active inhibitor targeting NO with an IC50 of 7.70 μM and demonstrates low toxicity.</p>Fórmula:C38H56N2O4Pureza:98%Forma y color:SolidPeso molecular:604.86155H1
155H1 (Compound 11) is a stapled peptide that covalently binds to hMcl1 (172-323) with an IC50 of 18 nM.Fórmula:C79H120FN19O23SPeso molecular:1753.85092Tubulin/AKT1-IN-1
<p>Tubulin/AKT1-IN-1 (Compound D1-1) serves as an inhibitor of both tubulin polymerization and AKT pathway activation, effectively suppressing proliferation and</p>Fórmula:C38H34ClNO11Pureza:98%Forma y color:SolidPeso molecular:716.13PARP1-IN-16
<p>PARP1-IN-16 (compound 12a) serves as a potent PARP1 inhibitor, exhibiting an IC50 value of 1.89 nM.</p>Pureza:98%Forma y color:Odour SolidFPR1 antagonist 1
<p>Compound 24a, an FPR1 antagonist, demonstrates potent inhibition of the formyl peptide receptor 1 (FPR1) with an IC50 value of 25 nM.</p>Fórmula:C25H28O5Forma y color:SolidPeso molecular:408.49Ru-Poma
<p>Ru-Poma is an Ru(II)-based photosensitizer designed to enhance the efficacy of photodynamic therapy (PDT) against tumors resistant to Cisplatin. It targets Pomalidomide to partially degrade CRBN, inducing ferroptosis by increasing lipid peroxides and downregulating GPX4 and GAPDH expression. In A549 cells, Ru-Poma exhibits cytotoxicity with IC50 values of 18.46 μM in the dark and 0.37 μM under illumination.</p>Fórmula:C89H75Cl2N11O11Ru·7H2OARD-61
CAS:<p>ARD-61: potent PROTAC, degrades AR/PR in AR+ cancers, triggers apoptosis, inhibits tumor growth in mice.</p>Fórmula:C61H71ClN8O7SForma y color:SolidPeso molecular:1095.8β-Glucuronide-dPBD-PEG5-NH2 TFA
CAS:<p>β-Glucuronide-dPBD-PEG5-NH2 TFA is a β-glucuronide-linked pyrrolobenzodiazepine dimer employed in the synthesis of the antibody-drug conjugate (ADC) cIRCR201-</p>Fórmula:C80H102F3N7O37Forma y color:SolidPeso molecular:1810.69FeTPPS
CAS:<p>FeTPPS, a decomposition catalyst for 5,10,15,20-tetrakis(4-sulfonatophenyl) porphyrin iron(III) chloride peroxynitrite, neuroprotective.</p>Fórmula:C44H28ClFeN4O12S4Forma y color:SolidPeso molecular:1024.27PROTAC GPX4 degrader-2
<p>PROTACGPX4 degrader-2 (compound 18a) is a proteolysis-targeting chimera (PROTAC) that targets the degradation of glutathione peroxidase 4 (GPX4), with a DC50, 48h value of 1.68 μM. It induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. Additionally, PROTACGPX4 degrader-2 exhibits antiproliferative activity.</p>Fórmula:C50H61ClN8O9Peso molecular:952.425PD-1/PD-L1-IN-39
<p>PD-1/PD-L1-IN-39 (X 14) is an orally active PD-1/PD-L1 inhibitor with an IC50 value of 15.73 nM. It exhibits strong binding affinity to human and mouse PD-L1, with KD values of 14.62 and 392 nM, respectively. PD-1/PD-L1-IN-39 also demonstrates antitumor activity.</p>Fórmula:C23H20ClFN2O3Peso molecular:426.11465Zigakibart
CAS:<p>Zigakibart (BION-1301) is a humanized monoclonal antibody targeting TNFSF13 with anti-inflammatory activity for the study of immunoglobulin A nephropathy (IgAN)</p>Pureza:95.8% (SDS-PAGE); 99.8% (SEC-HPLC) - 95.8% (SDS-PAGE); 99.8% (SEC-HPLC)Forma y color:LiquidNA-Ir
CAS:<p>NA-Ir is a ferroptosis (Ferroptosis) inducer that targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to stimulate ferritin autophagy (). It also induces the production of reactive oxygen species (ROS) through photodynamic therapy (PDT), depletes glutathione (GSH), and downregulates glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and ferroptosis. NA-Ir exhibits enhanced anticancer activity under light exposure and selectively inhibits cancer cells with high H2S content.</p>Fórmula:C49H36F6IrN8O4PForma y color:SolidPeso molecular:1138.04CBI1
<p>CBI1 is a covalent BAX inhibitor. It selectively derivatizes BAX at C126 and inhibits BAX activation by triggering a ligand or through point mutations. CBI1 prevents the lipidation and oligomerization of BAX by t-2-hex. It also inhibits BAX activation induced by BH3 ligands, F116A mutation, or t-2-hex.</p>Fórmula:C15H19BrN4OS2Peso molecular:414.01837HDAC-IN-79
<p>HDAC-IN-79 (compound 4) is an orally active dual inhibitor of xanthine oxidase and HDAC, exhibiting potent anti-hyperuricemia and antitumor activities in vivo (Xanthine oxidase: IC50=6.6 nM; HDAC1: IC50=134 nM; HDAC2: IC50=284 nM; HDAC3: IC50=173 nM; HDAC6: IC50=1.32 nM). Among leukemia cells, it is most effective in inhibiting the growth of HL60 cells (IC50=0.706 μM) and induces both apoptosis and autophagy. HDAC-IN-79 also modulates the expression levels of biomarkers associated with intracellular HDAC inhibition.</p>Forma y color:Odour SolidAphidicolin
CAS:<p>Aphidicolin blocks DNA synthesis, hinders herpes virus growth, and stimulates apoptosis in leukemia cells; it's a mold-derived DNA polymerase inhibitor.</p>Fórmula:C20H34O4Pureza:>99.99%Forma y color:SolidPeso molecular:338.48
