Apoptosis
Los inhibidores de la apoptosis son compuestos que previenen o retrasan el proceso de muerte celular programada, conocido como apoptosis. Estos inhibidores son vitales para estudiar los mecanismos de supervivencia celular y se utilizan para investigar enfermedades donde la apoptosis está desregulada, como el cáncer, los trastornos neurodegenerativos y las enfermedades autoinmunes. Al modular la apoptosis, estos inhibidores pueden ayudar en el desarrollo de terapias dirigidas a controlar la muerte celular. En CymitQuimica, ofrecemos una amplia selección de inhibidores de la apoptosis de alta calidad para apoyar su investigación en biología celular, oncología y campos relacionados.
Subcategorías de "Apoptosis"
- ASK(6 productos)
- BCL(11 productos)
- Caspasa(125 productos)
- FOXO1(3 productos)
- IAP(66 productos)
- Mdm2(12 productos)
- PD-1 / PD-L1(125 productos)
- PDK(9 productos)
- PERK(25 productos)
- Serina / treonina quinasa(15 productos)
- Survivin(13 productos)
- TNF(92 productos)
- c-RET(51 productos)
- p53(62 productos)
Mostrar 6 subcategorías más
Se han encontrado 5600 productos de "Apoptosis"
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Thalidomide-PEG4-NH2 hydrochloride
CAS:<p>Thalidomide-PEG4-NH2 HCl, a cereblon ligand-linker for PROTAC.</p>Fórmula:C21H28ClN3O8Forma y color:SolidPeso molecular:485.92Arisostatin A
CAS:<p>Arisostatin A is a secondary metabolite produced by microorganisms, recognized as an antibiotic (antibiotic) with activity against Gram-positive bacteria. This compound also exhibits potent antitumor properties. It induces apoptosis (apoptosis) by activating caspase-3 and generating reactive oxygen species (ROS) in AMC-HN-4 cells.</p>Fórmula:C69H100N2O24Forma y color:SolidPeso molecular:1341.53AZD5582 dihydrochloride
CAS:<p>Dimeric Smac mimetic inhibits XIAP, cIAP1/2 (IC50: 15/15/21 nM); binds BIR3 domain; degrades cIAPs; induces apoptosis in cancer cells; shrinks tumors in mice.</p>Fórmula:C58H80Cl2N8O8Forma y color:SolidPeso molecular:1088.23HSP90-IN-18
<p>HSP90-IN-18 inhibits Hsp90 with 0.39 μM IC50, useful for viral, neurodegenerative, and inflammatory research.</p>Fórmula:C25H33FO3Forma y color:SolidPeso molecular:400.53GPX4-IN-6
CAS:<p>GPX4-IN-6 is a GPX4 inhibitor with antitumor activity.GPX4-IN-6 induces iron death and is used for the treatment and prevention of triple-negative breast cancer</p>Fórmula:C18H17BrFNO5Pureza:99.54%Forma y color:SoildPeso molecular:426.23(±)-Indoxacarb
CAS:<p>(±)-Indoxacarb is a pyrazoline insecticide with insecticidal activity and cytotoxicity, blocks sodium channels in insect neurons, and can induce apoptosis.</p>Fórmula:C22H17ClF3N3O7Forma y color:SolidPeso molecular:527.83PB28
CAS:<p>PB28: A potent σ2 agonist (Ki 0.68 nM), σ1 antagonist (Ki 0.38 nM), with anti-tumor properties and inhibits SARS-CoV-2 interactions.</p>Fórmula:C24H38N2OForma y color:SolidPeso molecular:370.581MDMX/MDM2-IN-2
<p>MDMX/MDM2-IN-2 is a potent dual inhibitor of p53-MDM2/MDMX, demonstrating dissociation constants (Kis) of 0.23 μM for MDM2 and 2.45 μM for MDMX.</p>Fórmula:C28H25Cl3FN3O3Forma y color:SolidPeso molecular:576.8784-B10
CAS:<p>84-B10 provides protection in cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors.</p>Fórmula:C25H22F3NO5Pureza:99.76%Forma y color:SolidPeso molecular:473.44Antiproliferative agent-25
<p>Antiproliferative Agent-25 (Compound 3s4) is a selective PRMT5 inhibitor displaying an IC50 of 0.11 μM.</p>Fórmula:C20H21BrN2O2Pureza:98%Forma y color:SolidPeso molecular:401.3AZD5582 TFA
<p>AZD5582 TFA is a potent IAP antagonist that binds to the BIR3 domain of cIAP1, cIAP2, and XIAP with IC50 values of 15, 21, and 15 nM, respectively.AZD5582 TFA</p>Fórmula:C60H79F3N8O10Pureza:99.89%Forma y color:SoildPeso molecular:1129.31Diazepinomicin
CAS:<p>Diazepinomicin, from Micromonospora, blocks EGF-Ras-ERK pathway and induces apoptosis; an anti-tumor agent for K-Ras mutants.</p>Fórmula:C28H34N2O4Pureza:98%Forma y color:SolidPeso molecular:462.58anti-TNBC agent-9
<p>Anti-TNBC agent-9 (Compound 3as) is an anticancer agent used for treating triple-negative breast cancer (TNBC). It exhibits significant inhibitory activity against MDA-MB-453 cells, with an IC50 value of 8.5 μM. Anti-TNBC agent-9 impedes tumor cell migration by upregulating E-cadherin and downregulating N-cadherin, matrix metalloproteinase 2 (MMP2), and MMP9. Additionally, it inhibits tumor cell proliferation by inducing apoptosis, achieved through the increased expression of pro-apoptotic protein BAX and decreased expression of anti-apoptotic protein BCL-2.</p>Forma y color:Odour SolidRET ligand-1
CAS:<p>RETligand-1 is a target protein ligand that specifically interacts with RET and can be utilized in the synthesis of the PROTAC LDD39.</p>Fórmula:C28H24F2N6O3Forma y color:SolidPeso molecular:530.525Kurzipene D
CAS:<p>Kurzipene D: anticancer, induces apoptosis, halts HepG2 at S phase, anti-tumor in zebrafish, inhibits tumor growth and spread.</p>Fórmula:C26H36O8Forma y color:SolidPeso molecular:476.56HKB99
CAS:<p>HKB99 suppresses NSCLC growth, metastasis, and overcomes erlotinib resistance.</p>Fórmula:C23H18N2O6SPureza:97.35% - 97.35%Forma y color:SolidPeso molecular:450.46Antitumor agent-61
CAS:<p>Antitumor agent-61, a potent Irinotecan derivative, exhibits IC50s of 0.92-3.23 μM in 6 cancer cells, inducing apoptosis via mitochondrial pathways.</p>Fórmula:C54H63FN5O10PForma y color:SolidPeso molecular:992.08Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine
CAS:<p>Cereblon ligand for PROTAC R&D; has E3 ligase, alkylC1-PEG3-alkylC3 linker, terminal amine. Part of Arvinas-licensed tool molecules.</p>Fórmula:C25H35ClN4O9Forma y color:SolidPeso molecular:571.02Anticancer agent 130
<p>Anticancer agent 130 (compound 8d) significantly induces apoptosis in A549 cells [1].</p>Fórmula:C38H46FN5O5Pureza:98%Forma y color:SolidPeso molecular:671.8DJ4
CAS:<p>DJ4 induces a dose-dependent pro-apoptotic effect in the micromolar range.</p>Fórmula:C19H16N4OSPureza:≥98%Forma y color:SoildPeso molecular:348.42TG101209 analog 1
<p>TG101209 analog 1 (Compound 8h) serves as an inhibitor of BUB1B, exhibiting an IC50 of 10.36 μM. It also possesses cytotoxic properties, demonstrated by an IC50 of 1.347 μM against Caki-1 cells, and can induce necrosis and apoptosis.</p>Fórmula:C24H31N5O5SForma y color:SolidPeso molecular:501.598Targaprimir-96 TFA
<p>Targaprimir-96 TFA is a selective inhibitor of miR-96 in cancer, inducing apoptosis with high affinity for pri-miR-96 but not affecting healthy cells.</p>Fórmula:C79H103F3N18O9Forma y color:SolidPeso molecular:1505.77Asparanin A
CAS:<p>Asparanin A, an apoptosis inducer with anticancer properties, arrests the cell cycle in the G0/G1 phase via the mitochondria and PI3K/AKT signaling pathways.</p>Fórmula:C39H64O13Pureza:98%Forma y color:SolidPeso molecular:740.92RIPK2-IN-2
CAS:<p>RIPK2-IN-2, a RIP2 kinase PROTAC inhibitor, blocks proinflammatory signaling in autoinflammatory diseases.</p>Fórmula:C53H65FN14O7S2Forma y color:SolidPeso molecular:1093.3CAY10726
CAS:<p>CAY10726, an arylurea fatty acid, cuts ATP by 28% and promotes apoptosis in breast cancer cells by depleting mitochondrial lipids.</p>Fórmula:C24H36ClF3N2O3Forma y color:SolidPeso molecular:493HLDA-212
CAS:HLDA-212 (Compound 43) is a bifunctional small molecule designed to target HaloTag-tagged protein (target protein, TP) and Aurora kinase A/B (AURKA/B, effector protein, EP). By binding TP and EP, it forms a stable ternary complex (TP:RIPTAC:EP) that inhibits the cell survival functions of EP, inducing apoptosis in cancer cells expressing TP. In 293_HFL cells, HLDA-212 demonstrates antiproliferative activity with a GI50 of 0.011 μM. This compound holds promise for treating cancers with high TP expression, such as prostate cancer and hematological malignancies.Fórmula:C70H90BrFN8O19SPeso molecular:1478.47p53-HDM2-IN-1
p53-HDM2-IN-1 is a potent inhibitor of the p53-HDM2 protein-protein interaction, demonstrating an inhibitory concentration (IC 50) of 0.103 μM.Fórmula:C35H38F6N4O7SForma y color:SolidPeso molecular:772.75Platycoside G3
CAS:<p>Platycoside G3 is a useful organic compound for research related to life sciences. The catalog number is T124100 and the CAS number is 849758-44-7.</p>Fórmula:C63H102O32Forma y color:SolidPeso molecular:1371.48Rosomidnar
CAS:<p>PNT100: 24-base DNA oligo targeting BCL-2 regulatory region; halts tumor cell growth, induces death.</p>Fórmula:C227H291O141P23Forma y color:SolidPeso molecular:7220.63eIF4E-IN-2
CAS:<p>eIF4E-IN-2 effectively inhibits eIF4e, crucial for research on diseases like cancer.</p>Fórmula:C37H33ClF2N8O4S2Forma y color:SolidPeso molecular:791.29DB2115 tertahydrochloride
CAS:<p>DB2115 (tertahydrochloride) inhibits PU.1, key in leukemia; potential for cancer research.</p>Fórmula:C32H34Cl4N8O2Forma y color:SolidPeso molecular:704.48HDAC-IN-57
CAS:<p>HDAC-IN-57 is an orally active pan-inhibitor of histone deacetylase (HDAC), inhibiting HDAC1, HDAC2, HDAC6, and HDAC8 with IC50 values of 2.07 nM, 4.71 nM, 2.4</p>Fórmula:C21H19N3O4Pureza:98.38%Forma y color:SoildPeso molecular:377.39Violacein
CAS:<p>Violacein, a purple antibacterial and antiprotozoal compound from C. violaceum, effective against Gram-positive bacteria and P. falciparum.</p>Fórmula:C20H13N3O3Forma y color:SolidPeso molecular:343.34UZH1a
CAS:<p>UZH1a: METTL3 inhibitor, IC50 280 nM, used for epitranscriptomic modulation and has antitumor properties.</p>Fórmula:C32H42N6O3Forma y color:SoildPeso molecular:558.71Cholicamideβ
<p>Cholicamideβ (compound 6), a self-assembling small molecule cancer vaccine adjuvant, forms low cytotoxicity virus-like particles and upon binding to peptide</p>Fórmula:C55H94N2O6Pureza:98%Forma y color:SolidPeso molecular:879.34Thalidomide-4-C3-NH2 hydrochloride
CAS:<p>Thalidomide-4-C3-NH2 HCl is a cereblon ligand for CRBN recruitment, used to make PROTACs with a linker.</p>Fórmula:C16H18ClN3O4Forma y color:SolidPeso molecular:351.785Anti-inflammatory agent 61
<p>Compound 5b (Anti-inflammatory agent 61) is a potent anti-inflammatory agent that diminishes TNF-α expression in LPS-induced inflammation within RAW 264.7 cells</p>Forma y color:Odour SolidPhotosensitizer-3
CAS:<p>Photosensitizer-3, generates single-linear oxygen upon near-infrared light excitation in combination with FAP,potent and selective killing cancer cells.</p>Fórmula:C29H33ClI2N2O3Pureza:99.61%Forma y color:SolidPeso molecular:746.85p38α inhibitor 6
<p>p38α inhibitor6 (compound 19) is a p38α inhibitor with an IC50 value of 0.68 μM. It induces apoptosis, arrests the cell cycle in the G0 and G2/M phases, reduces TNF-α concentration, upregulates the expression of the tumor suppressor gene p53, increases the Bax/BCL-2 ratio, and activates caspase3/7.</p>Forma y color:Odour SolidDidocosahexaenoin
CAS:<p>Didocosahexaenoin, omega-3 diglyceride, disrupts mitochondria, induces ROS, apoptosis, and is cytotoxic to prostate cancer cells.</p>Fórmula:C25H40O5Forma y color:SolidPeso molecular:420.58Opnurasib
CAS:<p>Opnurasib (JDQ-443) is an orally available and selective and potent covalent KRAS G12C inhibitor with antitumor activity for the study of advanced non-small</p>Fórmula:C29H28ClN7OPureza:98.88%Forma y color:SolidPeso molecular:526.03VB-85247
<p>VB-85247 is a STING agonist that, by activating the STING pathway, induces the upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as the maturation and activation of dendritic cells. It can lead to the regression of tumors within the bladder and is applicable in bladder cancer research.</p>Forma y color:Odour SolidThalidomide-O-PEG4-amine
CAS:<p>Thalidomide-O-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].</p>Fórmula:C23H31N3O9Pureza:98%Forma y color:SolidPeso molecular:493.51Antitumor agent-103
<p>Antitumor Agent-103 (compound 24l) induces apoptosis and possesses antiproliferative and anti-colony formation properties.</p>Fórmula:C36H36N8O9S2Pureza:98%Forma y color:SolidPeso molecular:788.85BIO8898
<p>BIO8898: potent CD40-CD154 inhibitor, IC50 of 25 µM, prevents CD40L-induced apoptosis.</p>Fórmula:C53H64N8O6Forma y color:SolidPeso molecular:909.13Aphidicolin
CAS:<p>Aphidicolin blocks DNA synthesis, hinders herpes virus growth, and stimulates apoptosis in leukemia cells; it's a mold-derived DNA polymerase inhibitor.</p>Fórmula:C20H34O4Pureza:>99.99%Forma y color:SolidPeso molecular:338.48Polyinosinic-polycytidylic acid potassium
CAS:<p>Poly(I:C) potassium is a synthetic RNA analog, activates TLR3/RIG-I, used as a vaccine adjuvant, and induces apoptosis in cancer cells.</p>Fórmula:(C10H13N4O8P)x·(C9H14N3O8P)x·xKForma y color:SolidNarasin
CAS:<p>Narasin inhibits dengue virus, treats coccidiosis without harm to cells, and induces cancer cell apoptosis.</p>Fórmula:C43H72O11Forma y color:SolidPeso molecular:765.03BM-1197
CAS:<p>BM-1197, a highly potent and specific dual inhibitor of Bcl-2 and Bcl-xL, effectively targets these proteins with IC50 values of 3.5 nM and 5.2 nM for Bcl-2 and</p>Fórmula:C53H59ClF4N6O7S4Forma y color:SolidPeso molecular:1131.77
