Apoptosis
Los inhibidores de la apoptosis son compuestos que previenen o retrasan el proceso de muerte celular programada, conocido como apoptosis. Estos inhibidores son vitales para estudiar los mecanismos de supervivencia celular y se utilizan para investigar enfermedades donde la apoptosis está desregulada, como el cáncer, los trastornos neurodegenerativos y las enfermedades autoinmunes. Al modular la apoptosis, estos inhibidores pueden ayudar en el desarrollo de terapias dirigidas a controlar la muerte celular. En CymitQuimica, ofrecemos una amplia selección de inhibidores de la apoptosis de alta calidad para apoyar su investigación en biología celular, oncología y campos relacionados.
Subcategorías de "Apoptosis"
- ASK(6 productos)
- BCL(11 productos)
- Caspasa(127 productos)
- FOXO1(3 productos)
- IAP(65 productos)
- Mdm2(12 productos)
- PD-1 / PD-L1(126 productos)
- PDK(9 productos)
- PERK(24 productos)
- Serina / treonina quinasa(15 productos)
- Survivin(13 productos)
- TNF(91 productos)
- c-RET(51 productos)
- p53(62 productos)
Mostrar 6 subcategorías más
Se han encontrado 5622 productos de "Apoptosis"
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Holothurin A
CAS:<p>Holothurin A is a triterpene glycoside.</p>Fórmula:C54H86NaO27SForma y color:SolidPeso molecular:1222.3SA-VA
<p>SA-VA, an intracellular self-assembled PROTAC featuring azide and alkyne groups, selectively degrades VEGFR-2 and EphB4 proteins within U87 cells.</p>Fórmula:C50H53ClF3N11O7SPureza:98%Forma y color:SolidPeso molecular:1044.54WK499
<p>BCL6-IN-10 (Compound WK499) is an inhibitor of BCL6, disrupting its interaction with the SMRT protein and promoting apoptosis, cell cycle arrest, and DNA damage</p>Fórmula:C21H20BrN7O3Forma y color:SolidPeso molecular:498.33Toremifene citrate
CAS:<p>Toremifene citrate is a selective estrogen receptor modulator (SERM). It is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on the mammary and uterine tissue.</p>Fórmula:C32H36ClNO8Pureza:99.83% - >99.99%Forma y color:White Or Almost White PowderPeso molecular:598.08Sudubrilimab
<p>Sudubrilimab (HS636) is an IgG1-κ monoclonal antibody targeting PDL1, fused with TGFBR2-ECD to block PD-1/PDL1 and TGF-β in tumors.</p>Forma y color:Odour Liquidrac-CCT-250863 HCl
<p>rac-CCT-250863 HCl: NEK 2 inhibitor, halts cell cycle, anti-cancer growth, boosts Pomalidomide-induced apoptosis.</p>Fórmula:C24H26ClF3N4O2SPureza:98.21%Forma y color:SoildPeso molecular:527Thalidomide-PEG2-C2-NH2
CAS:<p>Thalidomide-O-amido-PEG3-C2-NH2 is a cereblon ligand-linked E3 ligase used in PROTAC with a 2-unit PEG.</p>Fórmula:C19H24N4O6Pureza:98%Forma y color:SolidPeso molecular:404.42AS-99 TFA
<p>AS-99 TFA: potent ASH1L inhibitor, IC50=0.79 μM, combats leukemia, inhibits cell growth, induces apoptosis.</p>Forma y color:SolidHaemanthamine hydrochloride
<p>Haemanthamine hydrochloride, an alkaloid from Amaryllidaceae, has anticancer, antioxidant, antiviral, antimalarial, and anticonvulsant properties.</p>Fórmula:C17H20ClNO4Forma y color:SolidPeso molecular:337.8MEK/PI3K-IN-1
CAS:<p>MEK/PI3K-IN-1 (6r) is a dual MEK/PI3K inhibitor; IC50: 124 nM (MEK1), 130 nM (PI3Kα), 236 nM (PI3Kδ). It reduces pAKT, pERK1/2, and hinders tumor growth.</p>Fórmula:C36H37F5IN9O6Forma y color:SolidPeso molecular:913.63Thalidomide-O-amido-PEG4-azide
CAS:Thalidomide-O-amido-PEG4-azide is a polyethylene glycol (PEG) derivative serving as a linker for Proteolysis Targeting Chimeras (PROTACs) synthesis [1].Fórmula:C25H32N6O10Pureza:98%Forma y color:SolidPeso molecular:576.56ZS3-046
<p>ZS3-046 is a TAF1 PROTAC degrader that facilitates the ubiquitination and subsequent degradation of TAF1. It can activate p53 and induce apoptosis in acute myeloid leukemia (AML) cells. Additionally, ZS3-046 demonstrates anti-tumor efficacy in AML xenograft mouse models.</p>Fórmula:C49H57N9O7Forma y color:SolidPeso molecular:883.4381CRA-026440 hydrochloride
CAS:<p>CRA-026440 hydrochloride is a potent and broad-spectrum HDAC inhibitor.</p>Fórmula:C23H25ClN4O4Pureza:99.78%Forma y color:SoildPeso molecular:456.92Satratoxin G
CAS:<p>Satratoxin G, from Stachybotrys chartarum, triggers apoptosis in nasal and brain OSNs.</p>Fórmula:C29H36O10Forma y color:SolidPeso molecular:544.597Relfovetmab
CAS:<p>Relfovetmab is an anti- NGF monoclonal antibody (mAb) [1] .</p>Forma y color:Liquid3MB-PP1
CAS:<p>3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor.</p>Fórmula:C17H21N5Pureza:99.96%Forma y color:White SolidPeso molecular:295.38Thalidomide-O-C8-NH2 hydrochloride
CAS:<p>Thalidomide-derived cereblon ligand with PROTAC linker as an E3 ligase ligand-linker conjugate, in hydrochloride form.</p>Fórmula:C21H28ClN3O5Forma y color:SolidPeso molecular:437.92VEGFR-2-IN-36
<p>VEGFR-2-IN-36 (compound 15) serves as a potent VEGFR-2 inhibitor, exhibiting an IC50 value of 0.067 μM, and acts as an apoptosis inducer with demonstrated</p>Fórmula:C24H23N7O5Pureza:98%Forma y color:SolidPeso molecular:489.48Cannflavin A
CAS:<p>Cannflavin A, isolated from Cannabis sativa L., exhibits anti-cancer, neuroprotective, and anti-inflammatory activities by inhibiting Aβ1-42 aggregation and</p>Fórmula:C26H28O6Forma y color:SolidPeso molecular:436.5Thalidomide-O-PEG4-azide
CAS:Thalidomide-O-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].Fórmula:C23H29N5O9Pureza:98%Forma y color:SolidPeso molecular:519.5Thalidomide-PEG4-NH2 hydrochloride
CAS:<p>Thalidomide-PEG4-NH2 HCl, a cereblon ligand-linker for PROTAC.</p>Fórmula:C21H28ClN3O8Forma y color:SolidPeso molecular:485.92Nargenicin
CAS:<p>Nargenicin: a macrolide antibiotic effective against S. aureus, MRSA, M. luteus; inhibits bacterial DnaE and reduces inflammation and leukemia cell growth.</p>Fórmula:C28H37NO8Forma y color:SolidPeso molecular:515.6Aromatase-IN-5
<p>Aromatase-IN-5 (Compound 10) is a potent inhibitor of aromatase with an IC50 value of 0.06 μM. It effectively blocks estrogen production and inhibits the proliferation of breast cancer cell lines such as MCF-7, arresting the cell cycle in the G1 phase and inducing apoptosis. Aromatase-IN-5 shows promise for breast cancer research.</p>Forma y color:Odour SolidHexapeptide-11
CAS:Hexapeptide-11 is a novel proteostasis network modulator in human diploid fibroblasts.Fórmula:C36H48N6O7Pureza:98%Forma y color:SolidPeso molecular:676.8Monensin
CAS:<p>Monensin, from Streptomyces cinnamonensis, inhibits Wnt/β-catenin. Potential anticancer agent.</p>Fórmula:C36H62O11Pureza:98%Forma y color:Crystals White Or Off-White CrystalsPeso molecular:670.873-Hydroxykynurenine
CAS:<p>3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) is an active metabolite of tryptophan and inhibits yeast and rat liver aldehyde dehydrogenase by 97 and 69%.</p>Fórmula:C10H12N2O4Pureza:98.83% - 99.69%Forma y color:SolidPeso molecular:224.21GLP-2(rat)
CAS:<p>intestinal epithelium-specific growth factor</p>Fórmula:C166H256N44O56SPureza:98%Forma y color:SolidPeso molecular:3796.17Indinavir
CAS:<p>Indinavir is an HIV protease inhibitor,HAART. inhibits the activation of MMP-2 in endothelial cells and exhibits affinity for α7-nAchR and SARS-CoV-2 Mpro.</p>Fórmula:C36H47N5O4Forma y color:SolidPeso molecular:613.79GPX4-IN-5
CAS:GPX4-IN-5 is a GPX4 inhibitor with antitumor activity.GPX4-IN-5 induces iron death and may be used for the treatment of triple negative breast cancer.Fórmula:C18H17ClFNO5Pureza:99.58%Forma y color:SoildPeso molecular:381.78FKBP12 PROTAC dTAG-7
CAS:dTAG-7 selectively degrades BRD4 and FKBP12F36V by linking BET bromodomains to E3 ligase CRBN; it's a heterobifunctional degrader.Fórmula:C63H79N5O19Pureza:98%Forma y color:SolidPeso molecular:1210.32BT44
CAS:<p>BT44, a potent second-gen GDNF mimetic, is a lead for treating neurodegeneration.</p>Fórmula:C28H27F4N3O4SPureza:99.87%Forma y color:SoildPeso molecular:577.59RIPK1-IN-30
<p>RIPK1-IN-30 (compound 24) is a potent RIPK1 inhibitor with an IC50 of 2.01 μM. It demonstrates a protective effect in the HT-29 cell model of TSZ-induced necroptosis, with an EC50 of 6.77 μM.</p>Fórmula:C27H25FN2O4Forma y color:SolidPeso molecular:460.17984Thalidomide-5,6-Cl
CAS:Thalidomide-5,6-Cl is a cereblon ligand derivative that recruits CRBN protein and forms PROTACs with a linker.Fórmula:C13H8Cl2N2O4Forma y color:SolidPeso molecular:327.12Thalidomide-O-C7-NH2
CAS:<p>Thalidomide-O-C7-NH2 is a cereblon ligand-linked E3 ligase for PROTAC use.</p>Fórmula:C20H25N3O5Forma y color:SolidPeso molecular:387.436P1D-34
<p>P1D-34 is a Pin1 PROTAC degrader with a DC50 value of 177 nM. It downregulates Pin1 substrate proteins, including Cyclin D1, Rb, Mcl-1, Akt, and c-Myc. Additionally, P1D-34 exhibits antiproliferative activity across various acute myeloid leukemia (AML) cell lines and induces DNA damage and apoptosis by generating reactive oxygen species (ROS).</p>Forma y color:Odour SolidMEK/PI3K-IN-2
CAS:<p>MEK/PI3K-IN-2 is a potent dual inhibitor (MEK1 IC50: 352 nM, PI3Kα: 107 nM, PI3Kδ: 137 nM) that reduces pAKT, pERK1/2, and hinders tumor cell growth.</p>Fórmula:C38H41F5IN9O7Forma y color:SolidPeso molecular:957.68QN523
CAS:<p>QN523 has drug-like traits, kills cancer cells in vitro, effective in vivo against pancreatic cancer, works via autophagy.</p>Fórmula:C14H10N4OPureza:99.83%Forma y color:SolidPeso molecular:250.26Rosomidnar
CAS:<p>PNT100: 24-base DNA oligo targeting BCL-2 regulatory region; halts tumor cell growth, induces death.</p>Fórmula:C227H291O141P23Forma y color:SolidPeso molecular:7220.63Didocosahexaenoin
CAS:<p>Didocosahexaenoin, omega-3 diglyceride, disrupts mitochondria, induces ROS, apoptosis, and is cytotoxic to prostate cancer cells.</p>Fórmula:C25H40O5Forma y color:SolidPeso molecular:420.58PARP1-IN-15
<p>PARP1-IN-15 (Compound 6) is a PARP1 inhibitor that also inhibits tankyrase (TNKS) and promotes DNA double-strand breaks, leading to tumor cell apoptosis.</p>Fórmula:C16H12N2O2Pureza:98%Forma y color:SolidPeso molecular:264.28STM3006
CAS:<p>STM3006 is an orally active, selective and and potent METTL3 inhibitor with antitumor activity for the study of acute myeloid leukemia (AML).</p>Fórmula:C25H27BrN8Pureza:97.16%Forma y color:SoildPeso molecular:519.44(±)-Indoxacarb
CAS:<p>(±)-Indoxacarb is a pyrazoline insecticide with insecticidal activity and cytotoxicity, blocks sodium channels in insect neurons, and can induce apoptosis.</p>Fórmula:C22H17ClF3N3O7Forma y color:SolidPeso molecular:527.83hMAO-B-IN-11
<p>hMAO-B-IN-11 (Compound 12) is a selective and reversible inhibitor of human monoamine oxidase B (hMAO-B) with an IC50 value of 0.11 µM. It operates by competitively binding to the active site of hMAO-B, thereby preventing the oxidative deamination of monoamines and reducing hydrogen peroxide production. Additionally, hMAO-B-IN-11 inhibits pro-inflammatory mediators (NO, TNF-α, IL-1β) in activated microglia. This compound holds potential for research in neurodegenerative diseases such as Parkinson's and Alzheimer's.</p>Forma y color:Odour SolidBcl-2-IN-2
CAS:<p>Bcl-2-IN-2 is a highly potent and selective inhibitor targeting Bcl-2 and Bcl-xL.</p>Fórmula:C48H57N7O7SForma y color:SolidPeso molecular:876.09MDM2-IN-21
CAS:<p>MDM2-IN-21 is a potent MDM2 inhibitor. MDM2-IN-21 can be used for the research of cancer.</p>Fórmula:C34H40Cl2N4O2Forma y color:SolidPeso molecular:607.62Thalidomide-Piperazine-PEG2-NH2
CAS:<p>Thalidomide-Piperazine-PEG2-NH2 is a synthetic E3 ligase ligand-linker for PROTAC, combining cereblon ligand with a PEG2 linker.</p>Fórmula:C23H31N5O6Forma y color:SolidPeso molecular:473.53PROTAC EGFR degrader 5
CAS:<p>PROTAC EGFR degrader 5 effectively breaks down EGFR Del19 in HCC827 cells at 34.8 nM, inducing apoptosis and G1 arrest.</p>Fórmula:C57H72FN13O5SForma y color:SolidPeso molecular:1070.33HJC0416 hydrochloride
CAS:<p>HJC0416 hydrochloride: potent oral STAT3 inhibitor, better anticancer effects than Stattic, promising for breast cancer research.</p>Fórmula:C18H18Cl2N2O4SForma y color:SolidPeso molecular:429.31JGB1741
CAS:<p>JGB1741, a SIRT1 inhibitor (IC50=15µM), modulates apoptosis markers and p53 acetylation in breast cancer research.</p>Fórmula:C27H24N2O2SPureza:99.86%Forma y color:SolidPeso molecular:440.56AM-8553
CAS:<p>AM-8553 is potent and selective piperidine the MDM2-p53 interaction inhibitor.</p>Fórmula:C25H29Cl2NO4Forma y color:SolidPeso molecular:478.41
