Apoptosis
Los inhibidores de la apoptosis son compuestos que previenen o retrasan el proceso de muerte celular programada, conocido como apoptosis. Estos inhibidores son vitales para estudiar los mecanismos de supervivencia celular y se utilizan para investigar enfermedades donde la apoptosis está desregulada, como el cáncer, los trastornos neurodegenerativos y las enfermedades autoinmunes. Al modular la apoptosis, estos inhibidores pueden ayudar en el desarrollo de terapias dirigidas a controlar la muerte celular. En CymitQuimica, ofrecemos una amplia selección de inhibidores de la apoptosis de alta calidad para apoyar su investigación en biología celular, oncología y campos relacionados.
Subcategorías de "Apoptosis"
- ASK(6 productos)
- BCL(11 productos)
- Caspasa(127 productos)
- FOXO1(3 productos)
- IAP(66 productos)
- Mdm2(12 productos)
- PD-1 / PD-L1(126 productos)
- PDK(9 productos)
- PERK(23 productos)
- Serina / treonina quinasa(15 productos)
- Survivin(13 productos)
- TNF(91 productos)
- c-RET(51 productos)
- p53(62 productos)
Mostrar 6 subcategorías más
Se han encontrado 5618 productos de "Apoptosis"
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Pexelizumab
CAS:<p>Pexelizumab is a humanized antibody targeting C5 to inhibit apoptosis and treat cerebral IR injury and myocardial infarction.</p>Forma y color:LiquidIzuralimab
CAS:<p>Izuralimab is a bispecific IgG1 antibody that targets both the inducible T-cell costimulator (ICOS/CD278) and PD-1 [1].</p>Forma y color:LiquidOnfekafusp alfa
CAS:<p>Onfekafusp alfa (L19TNF), a trimeric fusion of L19 scFv and human TNF, targets malignant glioma.</p>Forma y color:Liquid(R)-MIK665
CAS:<p>(R)-MIK665 is the less active enantiomer of MIK665. MIK665 is a special inhibitor of Mcl-1(IC50 of 1.81 nM).</p>Fórmula:C47H44ClFN6O6SPureza:98%Forma y color:SolidPeso molecular:875.41AMG-7209
CAS:<p>AMG-7209 is an effective and selective MDM2-p53 interaction inhibitor.</p>Fórmula:C37H41Cl2FN2O7SForma y color:SolidPeso molecular:747.7Dimethachlor
CAS:<p>Dimethachlor is a pesticide and herbicide used in wetland areas.</p>Fórmula:C13H18ClNO2Forma y color:SolidPeso molecular:255.74PROTAC RIPK degrader-2
CAS:PROTAC RIPK degrader-2 is a nonpeptidic PROTAC ,and potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation.Fórmula:C52H65N7O11S3Pureza:98%Forma y color:SolidPeso molecular:1060.31Sanggenon G
CAS:<p>Sanggenon G inhibits XIAP by binding its BIR3 domain; affinity is 34.26 μM, boosting caspase activation.</p>Fórmula:C40H38O11Forma y color:SolidPeso molecular:694.72HDAC6 degrader-5
<p>HDAC6degrader-5 (Compound 6) exhibits inhibitory and degradative activity against HDAC6, with an IC50 of 4.95 nM and a DC50 of 0.96 nM. It suppresses the release of TNF-α, IL-1β, and IL-6, and prevents apoptosis in liver cells. Additionally, HDAC6degrader-5 demonstrates anti-inflammatory properties in a mouse model of APAP-induced liver injury.</p>Fórmula:C21H22N4O3Forma y color:SolidPeso molecular:378.424Secalonic acid D
CAS:<p>Secalonic acid D, from Aspergillus aculeatus, is anti-tumor, activates GSK3-β, degrades β-catenin, inhibits c-Myc, and induces apoptosis.</p>Fórmula:C32H30O14Forma y color:SolidPeso molecular:638.57Thalidomide-NH-C8-NH2 hydrochloride
CAS:<p>Thalidomide-based E3 ligase ligand-linker for PROTAC, with cereblon ligand and C8-NH2 hydrochloride.</p>Fórmula:C21H29ClN4O4Forma y color:SolidPeso molecular:436.94AlbA-DCA
<p>AlbA-DCA, a compound of Albiziabioside A and dichloroacetate, boosts ROS and reduces lactic acid in tumors, killing cancer cells and triggering apoptosis.</p>Fórmula:C43H67Cl2NO12Pureza:98%Forma y color:SolidPeso molecular:860.9RIP1-IN-1
<p>RIP1-IN-1 is an orally bioavailable RIP1 inhibitor with a high binding affinity (Kd: 110 nM). This compound exhibits significant activity against necroptosis and effectively suppresses necrosome formation by inhibiting the phosphorylation of RIP1, RIP3, and MLKL pathways. RIP1-IN-1 can inhibit necroptosis and is applicable in research on acute liver injury.</p>Forma y color:Odour SolidChalcones A-N-5
CAS:<p>Chalcones A-N-5, a non-cytotoxic trihydroxy chalcone, aids cell growth & neuroprotection, inhibits ferroptosis, and targets AD research.</p>Fórmula:C21H20N4O4Forma y color:SolidPeso molecular:392.41QN523
CAS:<p>QN523 has drug-like traits, kills cancer cells in vitro, effective in vivo against pancreatic cancer, works via autophagy.</p>Fórmula:C14H10N4OPureza:99.83%Forma y color:SolidPeso molecular:250.26Rosomidnar
CAS:<p>PNT100: 24-base DNA oligo targeting BCL-2 regulatory region; halts tumor cell growth, induces death.</p>Fórmula:C227H291O141P23Forma y color:SolidPeso molecular:7220.63SDH-IN-26
<p>SDH-IN-26 (Compound C3) is a succinate dehydrogenase (SDH) inhibitor with significant inhibitory activity against various plant pathogenic fungi, including solanrhizoctonia and Botrytis cinerea. It exhibits an EC50 value of 0.270 μg/mL against solanrhizoctonia. SDH-IN-26 compromises fungal cell membrane integrity, increases membrane permeability, disrupts cell structure, reduces mitochondrial count, and affects normal hyphal growth. It also decreases mitochondrial membrane potential, inducing apoptosis. SDH-IN-26 holds potential for studying plant diseases caused by fungi.</p>Forma y color:Odour SolidDidocosahexaenoin
CAS:<p>Didocosahexaenoin, omega-3 diglyceride, disrupts mitochondria, induces ROS, apoptosis, and is cytotoxic to prostate cancer cells.</p>Fórmula:C25H40O5Forma y color:SolidPeso molecular:420.58STM3006
CAS:<p>STM3006 is an orally active, selective and and potent METTL3 inhibitor with antitumor activity for the study of acute myeloid leukemia (AML).</p>Fórmula:C25H27BrN8Pureza:97.16%Forma y color:SoildPeso molecular:519.44PZ703b
CAS:PZ703b is a novel BCL-XL PROTAC degrader with enhanced BCL-2 inhibition.Fórmula:C80H102ClF3N10O11S4Forma y color:SolidPeso molecular:1600.44PL120131
<p>PL120131 is a PD-1/PD-L1 inhibitory peptide that disrupts the interaction between PD-1 and PD-L1 by binding to PD-1. This compound can inhibit the apoptosis signaling pathway mediated by PD-1, thereby preventing apoptosis (apoptosis) in Jurkat cells and primary lymphocytes. Additionally, PL120131 supports cytotoxic T lymphocytes (CTL) in exhibiting antitumor activity.</p>Fórmula:C62H105N19O18Forma y color:SolidPeso molecular:1404.61RIPK3-IN-3
<p>RIPK3-IN-3 (compound 20) is a selective RIPK3 inhibitor that demonstrates potent activity with an IC50 value of 10 nM.</p>Fórmula:C16H11N5SForma y color:SolidPeso molecular:305.36hMAO-B-IN-11
<p>hMAO-B-IN-11 (Compound 12) is a selective and reversible inhibitor of human monoamine oxidase B (hMAO-B) with an IC50 value of 0.11 µM. It operates by competitively binding to the active site of hMAO-B, thereby preventing the oxidative deamination of monoamines and reducing hydrogen peroxide production. Additionally, hMAO-B-IN-11 inhibits pro-inflammatory mediators (NO, TNF-α, IL-1β) in activated microglia. This compound holds potential for research in neurodegenerative diseases such as Parkinson's and Alzheimer's.</p>Forma y color:Odour SolidBcl-2-IN-2
CAS:<p>Bcl-2-IN-2 is a highly potent and selective inhibitor targeting Bcl-2 and Bcl-xL.</p>Fórmula:C48H57N7O7SForma y color:SolidPeso molecular:876.09Thalidomide-Piperazine-PEG2-NH2
CAS:<p>Thalidomide-Piperazine-PEG2-NH2 is a synthetic E3 ligase ligand-linker for PROTAC, combining cereblon ligand with a PEG2 linker.</p>Fórmula:C23H31N5O6Forma y color:SolidPeso molecular:473.53PROTAC EGFR degrader 5
CAS:<p>PROTAC EGFR degrader 5 effectively breaks down EGFR Del19 in HCC827 cells at 34.8 nM, inducing apoptosis and G1 arrest.</p>Fórmula:C57H72FN13O5SForma y color:SolidPeso molecular:1070.33Placulumab
CAS:<p>Placulumab (ART621), an anti-TNF α monoclonal antibody, targets inflammation, potentially aiding arthritis treatment.</p>Forma y color:LiquidFludarabine triphosphate trisodium
<p>Fludarabine triphosphate (F-ara-ATP) trisodium inhibits DNA synthesis; IC50 2.3 μM, Ki 6.1 μM, blocks DNA primase, prompts apoptosis.</p>Fórmula:C10H12FN5Na3O13P3Forma y color:SolidPeso molecular:591.12AM-8553
CAS:<p>AM-8553 is potent and selective piperidine the MDM2-p53 interaction inhibitor.</p>Fórmula:C25H29Cl2NO4Forma y color:SolidPeso molecular:478.41Anticancer agent 273
<p>Anticanceragent 273 (Compound 9q) is an effective anticancer compound identified from matrine. It inhibits cancer cell proliferation, with an IC50 of 4.48 μM against HeLa cells. Anticanceragent 273 exerts its anticancer effects by modulating PI3K/AKT expression and activating activating transcription factor 4 (ATF4), which induces endoplasmic reticulum stress and triggers apoptosis. It holds potential for cancer research, including cervical cancer.</p>Forma y color:Odour SolidAnkaflavin
CAS:<p>Ankaflavin, from red rice fermentation, is a PPARγ agonist with anti-inflammatory properties and selectively kills cancer cells.</p>Fórmula:C23H30O5Pureza:98%Forma y color:SolidPeso molecular:386.48Thalidomide-NH-PEG4-COOH
CAS:<p>Thalidomide-NH-PEG4-COOH is a E3 ligase ligand-linker for synthesizing the selective degrader dCBP-1 targeting p300/CBP.</p>Fórmula:C24H31N3O10Forma y color:SolidPeso molecular:521.523G-Glu-Val
CAS:<p>G-Glu-Val (γ-glutamyl-L-valine, H-Glu-Val -OH), a flavour-regulating dipeptide, is a major contributor to "mellow".</p>Fórmula:C10H18N2O5Forma y color:SolidPeso molecular:246.26Calcimycin hemimagnesium
CAS:<p>Calcimycin hemimagnesium is an antibiotic, ionophore, and ATPase inhibitor that boosts intracellular Ca2+, causing cell death and apoptosis.</p>Fórmula:C58H72MgN6O12Forma y color:SolidPeso molecular:1069.53Asunercept
CAS:<p>Asunercept (APG101/CAN008) is a CD95-Fc protein targeting CD95L, used in GBM, MDS, and GvHD research.</p>Forma y color:LiquidMDM2/4-p53-IN-2
<p>MDM2/4-p53-IN-2 (2q) is a dual MDM2/MDM4 inhibitor, p53 activator; IC50: 70.7 nM(MDM2), 81.4 nM(MDM4); tumor suppressor.</p>Fórmula:C25H17Cl3FN3O3Forma y color:SolidPeso molecular:532.78SZUH280
CAS:<p>SZUH280 is a potent, selective PROTAC (proteolysis targeting chimera) HDAC8 (histone deacetylase 8) degrader, demonstrating a DC50 of 0.58 μM in A549 cells.</p>Fórmula:C36H34N8O8Forma y color:SolidPeso molecular:706.7β-Apopicropodophyllin
CAS:<p>β-Apopicropodophyllin, a natural product isolated from Hyptis wticillata, promotes apoptosis through mechanisms including microtubule disruption, DNA damage,</p>Fórmula:C22H20O7Forma y color:SolidPeso molecular:396.39Malformin A
CAS:Malformin A, from A. niger, is a plant growth regulator and has anti-TMV and cancer cell cytotoxic properties. Intraperitoneal LD50 in mice is 3.1 mg/kg.Fórmula:C23H39N5O5S2Forma y color:SolidPeso molecular:529.72Ganoderic acid Mf
CAS:<p>Ganoderic acid Mf: antitumor triterpenoid, arrests G1 cell cycle, selective for cancer cells, triggers apoptosis via mitochondria.</p>Fórmula:C32H48O5Forma y color:SolidPeso molecular:512.72Thalidomide-NH-PEG8-Ts
CAS:<p>Thalidomide-NH-PEG8-Ts: a synthesized Thalidomide-PEG8 E3 ligase linker for PROTAC-mediated IDO1 degradation.</p>Fórmula:C36H49N3O14SForma y color:SolidPeso molecular:779.86Apoptosis inducer 12
CAS:<p>Apoptosis Inducer 12 (Compound 3z) is a compound that promotes cell death via the mitochondrial pathway and is utilized in cancer research [1].</p>Fórmula:C26H27N3O5Forma y color:SolidPeso molecular:461.51Fluorescein-diisobutyrate-6-amide
CAS:<p>Fluorescein-diisobutyrate-6-amide, a powerful inducer of ferroptosis, shows promise for cancer research applications [1].</p>Fórmula:C62H61ClN6O16Forma y color:SolidPeso molecular:1181.63PEAQX tetrasodium hydrate
<p>PEAQX tetrasodium hydrate: potent/selective oral NMDA antagonist, IC50 270 nM (1A/2A), 29600 nM (1A/2B).</p>Fórmula:C17H15BrN3Na4O6PPureza:99%Forma y color:SolidPeso molecular:560.15Thalidomide-O-amido-C3-COOH
CAS:<p>Thalidomide-O-amido-C3-COOH is a cereblon ligand-linker for PROTACs, melding Thalidomide with a standard linker.</p>Fórmula:C19H19N3O8Pureza:98%Forma y color:SolidPeso molecular:417.37PD-1-IN-20
<p>PD-1-IN-20 is the less active enantiomer of PD-1-IN-1.</p>Fórmula:C12H20N6O7Pureza:98%Forma y color:SolidPeso molecular:360.32Metronidazole hydrochloride
CAS:<p>Oral nitroimidazole antibiotic; treats anaerobic infections; may cause inflammation and muscle contractions with long-term use.</p>Fórmula:C6H10ClN3O3Forma y color:SolidPeso molecular:207.62Anticancer agent 134
<p>Anticancer Agent 134 (Compound 6a), an environment-sensitive fluorescent probe, induces apoptosis and selectively differentiates between tumor and normal</p>Fórmula:C34H36ClN7O3S2Pureza:98%Forma y color:SolidPeso molecular:690.28Mechercharmycin A
CAS:<p>Mechercharmycin A, a cytotoxic compound, was isolated from Thermoactinomyces sp. YM3-251, a marine source. It demonstrates potent antitumor activity.</p>Fórmula:C35H32N8O7SForma y color:SolidPeso molecular:708.75Garivulimab
CAS:<p>Garivulimab (BGB-A333), a humanized IgG1 monoclonal antibody, binds to PD-L1, blocking PD-1 interaction and exhibiting antitumor activity.</p>Forma y color:Liquid
