Apoptosis
Los inhibidores de la apoptosis son compuestos que previenen o retrasan el proceso de muerte celular programada, conocido como apoptosis. Estos inhibidores son vitales para estudiar los mecanismos de supervivencia celular y se utilizan para investigar enfermedades donde la apoptosis está desregulada, como el cáncer, los trastornos neurodegenerativos y las enfermedades autoinmunes. Al modular la apoptosis, estos inhibidores pueden ayudar en el desarrollo de terapias dirigidas a controlar la muerte celular. En CymitQuimica, ofrecemos una amplia selección de inhibidores de la apoptosis de alta calidad para apoyar su investigación en biología celular, oncología y campos relacionados.
Subcategorías de "Apoptosis"
- ASK(9 productos)
- BCL(1 productos)
- Caspasa(154 productos)
- FOXO1(2 productos)
- IAP(67 productos)
- Mdm2(12 productos)
- PD-1 / PD-L1(116 productos)
- PDK(9 productos)
- PERK(24 productos)
- Serina / treonina quinasa(18 productos)
- Survivin(14 productos)
- TNF(65 productos)
- c-RET(61 productos)
- p53(63 productos)
Mostrar 6 subcategorías más
Se han encontrado 6114 productos de "Apoptosis"
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UCN-01
CAS:inhibitor of Akt, protein kinase C, PDK1 and cyclin-dependent kinasesFórmula:C28H26N4O4Pureza:98%Forma y color:SolidPeso molecular:482.53YCW-E11
CAS:YCW-E11 is an antiapoptotic Bcl-2 family proteins inhibitor.Fórmula:C25H21Cl2N3O6S2Pureza:98%Forma y color:SolidPeso molecular:594.49ZIF-8
CAS:ZIF-8 is an anticancer agent that can inherently trigger pyroptosis through a caspase-1/gasdermin D (GSDMD)-dependent pathway.Fórmula:C4H6N2ZnForma y color:SolidPeso molecular:147.513MDK-3345
CAS:MDK-3345 is a reversible covalent inhibitor for Mcl-1.Fórmula:C36H34BN3O7Pureza:98%Forma y color:SolidPeso molecular:631.484-Hydroxyresveratrol
CAS:4-Hydroxyresveratrol (3,4,5,4'-Tetrahydroxystibene) is a resveratrol analog that variably induces the expression of pro-apoptotic genes such as p53 and Bax. It triggers apoptosis in SV40 virus-transformed WI38 cells (WI38VA), but not in WI38 cells. Additionally, 4-Hydroxyresveratrol significantly increases the expression of p53, GADD45, and Bax genes in WI38VA cells, while suppressing the expression of the bcl-2 gene.Fórmula:C14H12O4Forma y color:SolidPeso molecular:244.243Antitumor agent-184
CAS:Antitumor Agent-184 (compound 12aa) triggers apoptosis in various cell lines, exhibiting IC50 values of 2.35 μM in B16-F10 cells, 7.32 μM in 4T1 cells, and 10.31 μM in CT26 cells.Fórmula:C22H16N4O2SForma y color:SolidPeso molecular:400.45NLRP3-IN-72
CAS:NLRP3-IN-72 (Compound 2) is a benzimidazole derivative. It exhibits anti-inflammatory and antioxidant properties, with an IC50 of 0.3 μM for NLRP3 IL-1β, a PD50 of 0.4 μM for protection against cell pyroptosis, and an EC50 of 0.6 μM for inducing HO-1.Fórmula:C19H20FN5OForma y color:SolidPeso molecular:353.393NCAO
CAS:N-ω-chloroacetyl-L-ornithine (NCAO) serves as a powerful reversible competitive inhibitor of ornithine decarboxylase (ODC), displaying cytotoxic and antiproliferative properties against various tumor cell lines, with EC50 values spanning from 1 to 50.6 µM. In vitro studies reveal that NCAO promotes Apoptosis and restricts tumor cell migration. Additionally, it demonstrates significant antitumor efficacy in a mouse model, targeting both solid and ascitic tumors using the myeloma (Ag8) cell line. NCAO holds promise in the development of antitumor agents.Fórmula:C7H13ClN2O3Forma y color:SolidPeso molecular:208.64Urease-IN-20
CAS:Urease-IN-20 (compound XBP2) is an inhibitor of Helicobacter pylori (H. pylori), with an IC50 of 0.14 μM for H. pylori inhibition. It effectively decreases apoptosis in GES-1 cells infected with H. pylori and reduces levels of ROS and γH2AX. Urease-IN-20 also demonstrates significant gastric mucosal protective effects, making it suitable for H. pylori research.Fórmula:C14H8FNO2SeForma y color:SolidPeso molecular:320.18DOR agonist 2
CAS:Compound 3 (DOR agonist 2) acts as a Delta Opioid Receptor agonist. It inhibits the expression of TNF-α, obstructs NF-κB transportation to the nucleus, and activates the G protein-mediated ERK1/2 pathway. This compound is useful for research into neurodegenerative diseases.Fórmula:C29H26N2O3Forma y color:SolidPeso molecular:450.53RIPK1-IN-24
CAS:RIPK1-IN-24 is an inhibitor of receptor-interacting protein kinase 1 (RIPK1) with an IC50 of 1.3 μM. It is utilized in research on inflammatory diseases.Fórmula:C26H21FN6O2Forma y color:SolidPeso molecular:468.48HR-19011
CAS:HR-19011 (Compound 40) is an inducer of eIF2α phosphorylation that increases expression levels of downstream proteins ATF and CHOP,antiproliferative.Fórmula:C25H19F6N3O3Pureza:99.89%Forma y color:SolidPeso molecular:523.43Ref: TM-T63665
2mg85,00€5mg130,00€10mg207,00€25mg418,00€50mg666,00€100mg1.046,00€200mg1.420,00€1mL*10mM (DMSO)150,00€p53 Stabilizer 2
CAS:p53 Stabilizer 2 (Compound 17a16) is a p53 stabilizing agent. It can induce S-phase arrest and apoptosis in both p53-functional and p53-deficient cancer cells. Additionally, p53 Stabilizer 2 triggers mitochondrial stress and activates two immune checkpoint pathways: NA-PKcs dependent p53 stabilization and the ATR-Chk1 axis activation. It also inhibits tumor growth in p53-deficient xenograft models.Fórmula:C30H37NO7SeForma y color:SolidPeso molecular:602.58hCAIX/XII-IN-1
hCAIX/XII-IN-1: potent CAIX inhibitor (KI=0.48μM), CAXII (KI=0.83μM), antiproliferative, induces apoptosis in MCF-7 cells.Fórmula:C19H11NO5S2Forma y color:SolidPeso molecular:397.42PARP/NAMPT-IN-1
CAS:PARP/NAMPT-IN-1 (Compound 13j) is a dual-target inhibitor of PARP and NAMPT, with IC50 values of 0.8 nM for PARP1 and 18 nM for NAMPT. It suppresses breast cancer cell proliferation and migration, inducing apoptosis. PARP/NAMPT-IN-1 is applicable for research on triple-negative breast cancer.Fórmula:C34H36FN7O3Forma y color:SolidPeso molecular:609.693PARP1-IN-12
PARP1-IN-12: potent PARP1 inhibitor, IC50 2.99 nM, triggers cell apoptosis, G2/M arrest, induces DSBs in BRCA-deficient cells.Fórmula:C43H56FN5O5Forma y color:SolidPeso molecular:741.93Antitumor agent-37
Antitumor agent-37: strong anti-growth, anti-spread, induces DNA damage, apoptosis via Bcl-2/Bax/caspase3, boosts immune response.Fórmula:C16H18Cl2N2O4PtForma y color:SolidPeso molecular:568.32HDAC-IN-34
HDAC-IN-34 inhibits HDAC1 (IC50: 0.022 μM) & HDAC6 (IC50: 0.45 μM), binds DNA causing damage, and halts HCT-116 cell growth (IC50: 1.41 μM).Fórmula:C24H26N6O3Forma y color:SolidPeso molecular:446.5ZB-R-55
CAS:ZB-R-55 is an oral and highly potent bimodal RIPK1 inhibitor with excellent kinase selectivity in lps-induced sepsis models for the study of SIRS and sepsis.Fórmula:C25H23N5O3Pureza:98.26%Forma y color:SolidPeso molecular:441.48PDEδ/NAMPT IN-1
CAS:PDEδ/NAMPT IN-1 (Compound 17d) is a dual inhibitor targeting phosphodiesterase 6 (PDE6) with a dissociation constant (KD) of 0.410 nM and nicotinamide phosphoribosyltransferase (NAMPT) with an inhibitory concentration (IC50) of 2.21 nM. It disrupts KRAS-related signaling by inhibiting NAMPT's role in the synthesis of nicotinamide adenine dinucleotide (NAD+), consequently inducing apoptosis in pancreatic cancer cells with KRAS mutations. This compound holds potential for research in KRAS-mutant pancreatic cancer.Fórmula:C26H30N4O4SForma y color:SolidPeso molecular:494.61
