Apoptosis
Los inhibidores de la apoptosis son compuestos que previenen o retrasan el proceso de muerte celular programada, conocido como apoptosis. Estos inhibidores son vitales para estudiar los mecanismos de supervivencia celular y se utilizan para investigar enfermedades donde la apoptosis está desregulada, como el cáncer, los trastornos neurodegenerativos y las enfermedades autoinmunes. Al modular la apoptosis, estos inhibidores pueden ayudar en el desarrollo de terapias dirigidas a controlar la muerte celular. En CymitQuimica, ofrecemos una amplia selección de inhibidores de la apoptosis de alta calidad para apoyar su investigación en biología celular, oncología y campos relacionados.
Subcategorías de "Apoptosis"
- ASK(9 productos)
- BCL(1 productos)
- Caspasa(154 productos)
- FOXO1(2 productos)
- IAP(67 productos)
- Mdm2(12 productos)
- PD-1 / PD-L1(116 productos)
- PDK(9 productos)
- PERK(24 productos)
- Serina / treonina quinasa(18 productos)
- Survivin(14 productos)
- TNF(65 productos)
- c-RET(61 productos)
- p53(63 productos)
Mostrar 6 subcategorías más
Se han encontrado 6114 productos de "Apoptosis"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Pim-1 kinase inhibitor 2
CAS:Compound 13, a potent Pim-1 inhibitor, induces apoptosis with potential for cancer research.Fórmula:C24H14N4O3Forma y color:SolidPeso molecular:406.39ER covalent antagonist-1
CAS:ER covalent antagonist-1 (Compound 39D) acts as an antagonist of the estrogen receptor α (ERα). This compound inhibits the proliferation of ERα-positive MCF-7 cells with an IC50 of 0.98 μM, induces cell cycle arrest at the G0/G1 phase, and triggers apoptosis. Additionally, ER covalent antagonist-1 demonstrates antitumor activity in mouse models.Fórmula:C33H32N2O5SForma y color:SolidPeso molecular:568.683S100A2-p53-IN-1
CAS:S100A2-p53-IN-1 inhibits S100A2-p53 in pancreatic cancer, stunting MiaPaCa-2 cell growth at 1.2-3.4 μM.Fórmula:C20H20F6N2O4SForma y color:SolidPeso molecular:498.44TAS-117 hydrochloride
TAS-117 HCl: potent oral Akt inhibitor (Akt1 IC50: 4.8nM, Akt2: 1.6nM, Akt3: 44nM), boosts anti-myeloma effects, induces cell death.Fórmula:C26H25ClN4O2Forma y color:SolidPeso molecular:460.96Soquelitinib
CAS:Soquelitinib (CPI-818) is a selective ITK inhibitor， inhibits tumor growth,T-cell, up-regulatCXCR3, IFNγ, TNFα, and CD107a expression in normal CD8 cells.Fórmula:C25H30N4O4S2Pureza:99.54%Forma y color:SolidPeso molecular:514.66Ref: TM-T87429
1mg170,00€5mg411,00€10mg677,00€25mg1.349,00€50mg2.023,00€100mg2.745,00€200mg3.695,00€1mL*10mM (DMSO)465,00€Anticancer agent 54
Anticancer agent 54 blocks cell cycle in G0/G1, induces apoptosis, and fights cancer via DNA embedding and ROS.Fórmula:C33H36N6Forma y color:SolidPeso molecular:516.68PKM2 modulator 2
CAS:PKM2 modulator 2 (compound C599) is a potent inhibitor of PKM2, displaying antiproliferative activity and inducing apoptosis. This compound holds potential for research in glioblastoma.Fórmula:C21H13FN4O3Forma y color:SolidPeso molecular:388.351MY-875
MY-875 inhibits microtubule formation, binds like colchicine (IC50: 0.92 μM), activates Hippo pathway, and induces apoptosis with anticancer properties.Fórmula:C21H25NO6Forma y color:SolidPeso molecular:387.43DDO-8958
CAS:DDO-8958 is an orally active and selective BET BD1 inhibitor, exhibiting a KD of 5.6 nM for BRD4 BD1. It shows low nanomolar inhibitory activity across all BET BD1 bromodomains except for BRDT BD1. DDO-8958 inhibits tumor cell proliferation and migration, induces apoptosis and cell cycle arrest, and demonstrates antitumor activity.Fórmula:C22H22FN5O2Forma y color:SolidPeso molecular:407.441L5-DA
L5-DA, a G-quadruplex ligand, stabilizes G4s in HeLa cells, induces apoptosis, and is cytotoxic with an IC50 of 4.3 μM.Fórmula:C32H34N6O2Forma y color:SolidPeso molecular:534.65MG28
CAS:MG28 exhibits significant cytotoxic effects, likely stemming from its direct and potent DNA-damaging activity. The compound is utilized in cancer research.Fórmula:C27H25NO3SForma y color:SolidPeso molecular:443.56Caspase-3-IN-2
CAS:Caspase-3-IN-2 (Compound 4d) acts as an inhibitor of α-Chymotrypsin. It also exhibits inhibitory activity against HIV protease and caspase 3, with inhibition rates of 57% and 51% respectively at a concentration of 100 μM.Fórmula:C10H6ClNO5Forma y color:SolidPeso molecular:255.611Casuarinin
CAS:Casuarinin, an ellagitannin found in pomegranates and certain Casuarina/Stachyurus plants, is a carbonic anhydrase inhibitor and astringent.Fórmula:C41H28O26Forma y color:SolidPeso molecular:936.65PI4KIII β inhibitor 4
CAS:PI4KIII beta inhibitor 4 (Compound 16) is a selective inhibitor of PI4KIIIβ with an IC50 of 0.005 μM. By inhibiting the PI3K/AKT pathway, PI4KIII beta inhibitor 4 induces apoptosis, causes cell cycle arrest, and triggers autophagy in tumor cells. This compound is applicable for tumor research.Fórmula:C24H36N4O6S2Forma y color:SolidPeso molecular:540.696CIL-102
CAS:CIL-102 is an apoptosis inducer that functions as an MMP-2/MMP-9 inhibitor, effectively reducing both the protein expression and mRNA levels of MMP-2/MMP-9. CIL-102 also demonstrates anticancer activity.Fórmula:C19H14N2O2Forma y color:SolidPeso molecular:302.327Enpp-1-IN-25
CAS:Enpp-1-IN-25 (Compound 30) is an ENPP1 inhibitor with an IC50 of 8.05 nM and exhibits low oral bioavailability. By inhibiting cGAMP degradation, it effectively activates the intracellular STING pathway. Enpp-1-IN-25 can enhance immune cell infiltration and type I interferon response in the tumor microenvironment, thereby increasing the antitumor efficacy of anti-PD-L1 antibodies. It is applicable for research in cancer immunotherapy.Fórmula:C15H21N5O4SForma y color:SolidPeso molecular:367.423PD-L1/HDAC6-IN-1
CAS:PD-L1/HDAC6-IN-1 (Compound HP29) is an inhibitor targeting both PD-L1 and HDAC6, effectively disrupting the PD-L1/PD-1 interaction and inhibiting HDAC6 activity, with IC50 values of 26.8 nM and 69 nM, respectively. This compound enhances the cytotoxicity of Jurkat T cells against HepG2 cells, exhibiting an IC50 of 3.4 μM. In rats, PD-L1/HDAC6-IN-1 demonstrates favorable pharmacokinetics, showing a drug exposure level of 871.62 ng·h/mL, and displays antitumor activity in a B16-F10 xenograft mouse model.Fórmula:C27H33N3O3Forma y color:SolidPeso molecular:447.569Rezatapopt
CAS:Rezatapopt (PC14586) is a p53 reactivator with antitumor activity for the study of locally advanced or metastatic solid tumors.Fórmula:C28H31F4N5O2Pureza:98.12%Forma y color:SolidPeso molecular:545.57Apoptosis inducer 5
Apoptosis Inducer 5, a lignan enantiomer extracted from Crataegus pinnatifida, demonstrates cytotoxic properties through inducing apoptosis and autophagy inFórmula:C23H26O7Forma y color:SolidPeso molecular:414.45Ferroptosis-IN-15
CAS:Ferroptosis-IN-15 (compound 12) serves as an effective inhibitor of ferroptosis, exhibiting EC50 values of 0.76 μM and 0.67 μM in A375 cells and 786-O cells, respectively. It acts as a potential iron chelator and radical-scavenging antioxidant.Fórmula:C17H14O5Forma y color:SolidPeso molecular:298.29
