Apoptosis
Los inhibidores de la apoptosis son compuestos que previenen o retrasan el proceso de muerte celular programada, conocido como apoptosis. Estos inhibidores son vitales para estudiar los mecanismos de supervivencia celular y se utilizan para investigar enfermedades donde la apoptosis está desregulada, como el cáncer, los trastornos neurodegenerativos y las enfermedades autoinmunes. Al modular la apoptosis, estos inhibidores pueden ayudar en el desarrollo de terapias dirigidas a controlar la muerte celular. En CymitQuimica, ofrecemos una amplia selección de inhibidores de la apoptosis de alta calidad para apoyar su investigación en biología celular, oncología y campos relacionados.
Subcategorías de "Apoptosis"
- ASK(9 productos)
- BCL(1 productos)
- Caspasa(154 productos)
- FOXO1(2 productos)
- IAP(67 productos)
- Mdm2(12 productos)
- PD-1 / PD-L1(109 productos)
- PDK(9 productos)
- PERK(26 productos)
- Serina / treonina quinasa(18 productos)
- Survivin(14 productos)
- TNF(64 productos)
- c-RET(61 productos)
- p53(63 productos)
Mostrar 6 subcategorías más
Se han encontrado 6100 productos de "Apoptosis"
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Tubulin inhibitor 17
Compound 3b inhibits tubulin polymerization, IC50 12.38 µM, with anticancer properties and promotes cell apoptosis.Fórmula:C17H16N2OForma y color:SolidPeso molecular:264.32TP-030-2
CAS:TP-030-2 is a RIPK1 inhibitor (human K i =0.43 nM ; mouse IC 50 =100 nM) .Fórmula:C23H21BrN4O3Forma y color:SolidPeso molecular:481.34GLI1-IN-1
CAS:GLI1-IN-1 (CBC-1), a GLI-1 inhibitor, exhibits superior water solubility and anticancer properties. It effectively induces apoptosis and inhibits colorectal cancer growth by targeting the Hedgehog (HH) pathway (IC 50 = 1.3 μM) [1].Fórmula:C42H60N2O9Forma y color:SolidPeso molecular:736.93MJC13
CAS:MJC13 is an FKBP52-targeting agent with antitumor activity, suitable for prostate cancer research.Fórmula:C13H15Cl2NOForma y color:SolidPeso molecular:272.17Autophagy-IN-1
Autophagy-IN-1 blocks autophagy in cancer cells, hinders tumor growth in mice, and aids in studying colorectal cancer.Fórmula:C23H25NO7Forma y color:SolidPeso molecular:427.45HC-7366
CAS:HC-7366 (GCN2 modulator-1) is an orally active GCN2 kinase activator with antitumor activity, inducing tumor growth inhibition.Fórmula:C20H15ClF2N6O4SPureza:99.84%Forma y color:SolidPeso molecular:508.89NCI-006
CAS:NCI-006, an LDH inhibitor, slows tumor growth and enhances pyruvate's role in mitochondrial metabolism.Fórmula:C31H24F2N4O4S3Forma y color:SolidPeso molecular:650.74BMS-751324
CAS:BMS-751324: p38α MAPK inhibitor with carbamyl-methyl, esters, phosphate from HPA. Reduces rat arthritis swelling and TNFα.Fórmula:C32H35N6O10PForma y color:SolidPeso molecular:694.63VEGFR-2-IN-52
CAS:VEGFR-2-IN-52 (compound 14d) serves as a powerful inhibitor of VEGFR-2, exhibiting an IC 50 of 191.1 nM. It effectively reduces the protein expression levels of p-VEGFR-2, MMP9, p-ERK1/2, and p-MEK1. In addition, VEGFR-2-IN-52 demonstrates cytotoxic properties by inducing apoptosis and arresting the cell cycle at the G0/G1 phase, and it enhances the levels of ROS.Fórmula:C20H25ClN4O2SForma y color:SolidPeso molecular:420.96RET-IN-10
CAS:RET-IN-10: Potent RET inhibitor, may treat congenital megacolon and tumors (Patent WO2021135938A1, compound 18).Fórmula:C29H28N8OSForma y color:SolidPeso molecular:536.65ASK1 ligand 1
CAS:ASK1ligand 1 is a binding ligand for ASK1 and can be utilized to synthesize PROTACs such as dASK1-VHL.Fórmula:C17H16F2N6OForma y color:SolidPeso molecular:358.35eIF4A-IN-3
CAS:eIF4A-IN-3 (Compound 71E) is an inhibitor of the eukaryotic translation initiation factor 4A (eIF4A). This compound can be utilized as a cytotoxic payload for antibody-drug conjugates (ADCs).Fórmula:C34H37N3O7Forma y color:SolidPeso molecular:599.67BRD-K44839765
CAS:BRD-K44839765 selectively targets Bcl-2, exhibiting an IC50 of 5.6 μM in IMR-90 cells. This compound is also orally active.Fórmula:C23H19N3O2S2Forma y color:SolidPeso molecular:433.55BRD-K20733377
CAS:BRD-K20733377 is a Bcl-2 inhibitor that exhibits selective cytotoxicity toward senescent cells, specifically inhibiting the activity of etoposide-induced senescent IMR-90 cells with an IC50 of 10.7 μM. Additionally, BRD-K20733377 reduces the mRNA expression of aging-related genes p16, p21, and KI67 in aged mouse models.Fórmula:C23H18N4O3SForma y color:SolidPeso molecular:430.48HDAC-IN-81
CAS:HDAC-IN-81 (Compound 11g) is an HDAC inhibitor capable of effectively inhibiting HDAC1 with an IC50 value of 4.5 nM. Additionally, it exhibits anticancer activity by inhibiting cell proliferation and can induce cell apoptosis (apoptosis).Fórmula:C20H27N3O3Forma y color:SolidPeso molecular:357.45eIF4A-IN-1
CAS:eIF4A-IN-1 is an eIF4A inhibitor used in tumor research.Fórmula:C31H33N3O5Forma y color:SolidPeso molecular:527.61Evo312
CAS:Evo312 is an inhibitor of protein kinase C beta I (PKCβI) with an IC50 of 117.34 nM and exhibits dose-dependent characteristics. It acts by inhibiting the expression of the PKCβI protein, which leads to cell cycle arrest and apoptosis in PANC-GR (gemcitabine-resistant pancreatic cancer cells). Evo312 also demonstrates antiproliferative effects in pancreatic cancer cells PANC-1 and PANC-GR, with IC50 values of 0.08 μM and 0.07 μM respectively, while presenting an IC50 of 2.95 μM in normal human pancreatic ductal epithelial cells HPDE6-c7. Additionally, Evo312 has shown antitumor activity in a mouse xenograft model using PANC-GR cells.Fórmula:C21H19N3O3Forma y color:SolidPeso molecular:361.39Enpp-1-IN-25
CAS:Enpp-1-IN-25 (Compound 30) is an ENPP1 inhibitor with an IC50 of 8.05 nM and exhibits low oral bioavailability. By inhibiting cGAMP degradation, it effectively activates the intracellular STING pathway. Enpp-1-IN-25 can enhance immune cell infiltration and type I interferon response in the tumor microenvironment, thereby increasing the antitumor efficacy of anti-PD-L1 antibodies. It is applicable for research in cancer immunotherapy.Fórmula:C15H21N5O4SForma y color:SolidPeso molecular:367.423Tandutinib sulfate
CAS:Tandutinib (MLN518) sulfate is an effective and selective inhibitor of FLT3, with an IC50 value of 0.22 μM. It also inhibits c-Kit and PDGFR, displaying IC50 values of 0.17 μM and 0.20 μM respectively. This compound can be utilized in the treatment of acute myeloid leukemia and has the capability to cross the blood-brain barrier.Fórmula:C31H44N6O8SForma y color:SolidPeso molecular:660.78PD-1/PD-L1-IN-30
CAS:PD-1/PD-L1-IN-30: Cancer research inhibitor with 0.018 μM IC50.Fórmula:C29H28F3NO5Forma y color:SolidPeso molecular:527.53
