Chk
Los inhibidores de la quinasa de control de ciclo (Chk) se dirigen a las quinasas Chk1 y Chk2, que son reguladores clave de la respuesta al daño del ADN y los puntos de control del ciclo celular. Estas quinasas detienen la progresión del ciclo celular en respuesta al daño en el ADN, permitiendo tiempo para la reparación. Inhibir las quinasas Chk puede evitar el arresto del ciclo celular, forzando a las células dañadas a continuar con el ciclo y, finalmente, someterse a apoptosis. Los inhibidores de Chk son particularmente valiosos en la investigación del cáncer, donde pueden sensibilizar las células tumorales a los agentes que dañan el ADN. En CymitQuimica, ofrecemos una variedad de inhibidores de Chk de alta calidad para apoyar su investigación en la respuesta al daño del ADN, la regulación del ciclo celular y la oncología.
Se han encontrado 48 productos de "Chk"
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CHK1-IN-4 hydrochloride
CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1).Fórmula:C18H19BrClN7O2Pureza:99.29%Forma y color:SoildPeso molecular:480.75Monalizumab
CAS:Monalizumab, a humanized antibody, enhances NK cell function by inhibiting NKG2A; used in HNSCC studies.Pureza:95% - >95.0% (SDS-PAGE); 100% (SEC-HPLC)Forma y color:LiquidPeso molecular:147 kDaCCT241533 dihydrochloride
CAS:Potent Chk2 inhibitor with 3 nM IC50, 63-fold more selective over Chk1, affects 84 kinases, reduces DNA damage response and apoptosis in cells.Fórmula:C23H29Cl2FN4O4Forma y color:SolidPeso molecular:515.41CHK1-IN-9
CHK1-IN-9 (compound 11) is an orally active CHK1 inhibitor with an IC50 of 0.55 nM. It enhances the effects of DNA-damaging agents on tumor cells and exhibits synergistic anticancer activity with Gemcitabine.WAY-230563
CAS:WAY-230563 is a serine/threonine kinase inhibitor that blocks CHK1/CHK2-mediated cell cycle checkpoints, leading to G2/M phase arrest in tumour cellsFórmula:C17H12N2O2SPureza:98.40%Forma y color:SolidPeso molecular:308.35Chk1-IN-6
CAS:Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.
Fórmula:C16H18F3N7Forma y color:SolidPeso molecular:365.364CBP501 Affinity Peptide
CAS:CBP501 Affinity Peptide, a Chk kinase inhibitor, disrupts G2 arrest triggered by DNA-damaging agents and is utilized in cancer research [1].Fórmula:C68H119N21O25SForma y color:SolidPeso molecular:1662.86PROTAC Chk1 degrader-1
CAS:Compound PROTAC-2, also known as PROTAC Chk1 degrader-1, is a potent degrader of Chk1, exhibiting a DC50 of 1.33 μM. It is utilized in cancer research [1].Fórmula:C43H44N14O9Forma y color:SolidPeso molecular:900.9CHK1-IN-12
CHK1-IN-12 (Compound example 1-5) is a highly selective and orally active checkpoint kinase 1 (CHK1) inhibitor, demonstrating an in vitro enzyme IC50 of ≤10 nM and a cellular IC50 of ≤50 nM. This compound suppresses the phosphorylation activity of CHK1 kinase, disrupts DNA damage response pathways, and induces tumor cell cycle arrest and apoptosis. CHK1-IN-12 shows promise for cancer research applications.Fórmula:C19H19N7O2Forma y color:SolidPeso molecular:377.16002GDC-0425
CAS:GDC-0425 (RG-7602), an oral selective ChK1 inhibitor, targets multiple cancers.Fórmula:C18H19N5OForma y color:SolidPeso molecular:321.38CCT244747
CAS:CCT244747 is a potent and selective CHK1 inhibitor oral, ATP-competitive, and cytotoxic, abrogating drug-induced S and G2 blockade and inducing apoptosis .Fórmula:C20H24N8O2Pureza:99.17%Forma y color:SolidPeso molecular:408.46PD 407824
CAS:PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respectively).Fórmula:C20H12N2O3Pureza:98.02%Forma y color:SolidPeso molecular:328.32GDC-0575 dihydrochloride
CAS:GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is a selective, orally active CHK1 inhibitor (IC50: 1.2 nM) that exhibits antitumour effects.Fórmula:C16H22BrCl2N5OForma y color:SolidPeso molecular:451.19Rabusertib
CAS:Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.
Fórmula:C18H22BrN5O3Pureza:98.86% - 99.87%Forma y color:SolidPeso molecular:436.3GDC0575 monohydrochloride
CAS:GDC0575 (ARRY575), a potent Chk1 inhibitor, IC50 1.2nM, disrupts cell cycle arrest, allowing DNA repair before mitosis.Fórmula:C16H21BrClN5OPureza:97.85%Forma y color:SolidPeso molecular:414.73Ref: TM-T27407
1mg43,00€2mg55,00€5mg80,00€10mg103,00€25mg177,00€50mg255,00€100mg356,00€200mg520,00€1mL*10mM (DMSO)93,00€CCT245737
CAS:CCT245737 is an orally active, selective Chk1 inhibitor, and is >1,000-fold selective over CHK2 and CDK1.Cost-effective and quality-assured.Fórmula:C16H16F3N7OPureza:98.28% - 99.93%Forma y color:SolidPeso molecular:379.34Ref: TM-T7080
1mg37,00€2mg49,00€5mg79,00€10mg113,00€25mg213,00€50mg350,00€100mg523,00€1mL*10mM (DMSO)87,00€Baricitinib
CAS:Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. Cost-effective and quality-assured.Fórmula:C16H17N7O2SPureza:99% - >99.99%Forma y color:SolidPeso molecular:371.42Ref: TM-T2485
5mg48,00€10mg70,00€25mg95,00€50mg109,00€100mg137,00€200mg178,00€500mg295,00€1mL*10mM (DMSO)65,00€ML367
CAS:ML367 inhibits ATAD5 stabilization with low micromolar activity, serving as a probe molecule.Fórmula:C19H12F2N4Pureza:99.39%Forma y color:SolidPeso molecular:334.32GDC-0575
CAS:GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).Fórmula:C16H20BrN5OPureza:≥95%Forma y color:SolidPeso molecular:378.27AZD-7762
CAS:AZD-7762, an effective and specific inhibitor of Chk1（IC50=5 nM）, is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.Fórmula:C17H19FN4O2SPureza:98.96% - 99.19%Forma y color:SolidPeso molecular:362.42Ref: TM-T6093
1mg35,00€2mg50,00€5mg77,00€10mg90,00€25mg167,00€50mg265,00€100mg424,00€1mL*10mM (DMSO)84,00€
