Chk
Los inhibidores de la quinasa de control de ciclo (Chk) se dirigen a las quinasas Chk1 y Chk2, que son reguladores clave de la respuesta al daño del ADN y los puntos de control del ciclo celular. Estas quinasas detienen la progresión del ciclo celular en respuesta al daño en el ADN, permitiendo tiempo para la reparación. Inhibir las quinasas Chk puede evitar el arresto del ciclo celular, forzando a las células dañadas a continuar con el ciclo y, finalmente, someterse a apoptosis. Los inhibidores de Chk son particularmente valiosos en la investigación del cáncer, donde pueden sensibilizar las células tumorales a los agentes que dañan el ADN. En CymitQuimica, ofrecemos una variedad de inhibidores de Chk de alta calidad para apoyar su investigación en la respuesta al daño del ADN, la regulación del ciclo celular y la oncología.
Se han encontrado 49 productos para "Chk".
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
CHK1-IN-4 hydrochloride
CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1).Fórmula:C18H19BrClN7O2Pureza:99.29%Forma y color:SolidPeso molecular:480.75Monalizumab
CAS:Monalizumab, a humanized antibody, enhances NK cell function by inhibiting NKG2A; used in HNSCC studies.Pureza:95% - >95.0% (SDS-PAGE); 100% (SEC-HPLC)Forma y color:Transparent LiquidPeso molecular:147 kDaWAY-230563
CAS:WAY-230563 is a serine/threonine kinase inhibitor that blocks CHK1/CHK2-mediated cell cycle checkpoints, leading to G2/M phase arrest in tumour cellsFórmula:C17H12N2O2SPureza:98.40%Forma y color:SolidPeso molecular:308.35CBP501 Affinity Peptide
CAS:CBP501 Affinity Peptide, a Chk kinase inhibitor, disrupts G2 arrest triggered by DNA-damaging agents and is utilized in cancer research [1].Fórmula:C68H119N21O25SForma y color:SolidPeso molecular:1662.86CHK1-IN-12
CHK1-IN-12 (Compound example 1-5) is a highly selective and orally active checkpoint kinase 1 (CHK1) inhibitor, demonstrating an in vitro enzyme IC50 of ≤10 nM and a cellular IC50 of ≤50 nM. This compound suppresses the phosphorylation activity of CHK1 kinase, disrupts DNA damage response pathways, and induces tumor cell cycle arrest and apoptosis. CHK1-IN-12 shows promise for cancer research applications.Fórmula:C19H19N7O2Forma y color:SolidPeso molecular:377.16002CHK1-IN-9
CHK1-IN-9 (compound 11) is an orally active CHK1 inhibitor with an IC50 of 0.55 nM. It enhances the effects of DNA-damaging agents on tumor cells and exhibits synergistic anticancer activity with Gemcitabine.Forma y color:Odour SolidFLT3/CHK1 ligand-1
FLT3/CHK1 ligand-1 is a PROTAC target protein ligand used in the synthesis of PROTACs, such as [PROTAC FLT3/CHK1 Degrader-1]. [PROTAC FLT3/CHK1 Degrader-1] functions as a potent FLT3/CHK1 PROTAC degrader with antitumor activity.CCT241533 dihydrochloride
CAS:Potent Chk2 inhibitor with 3 nM IC50, 63-fold more selective over Chk1, affects 84 kinases, reduces DNA damage response and apoptosis in cells.Fórmula:C23H29Cl2FN4O4Forma y color:SolidPeso molecular:515.41PROTAC Chk1 degrader-1
CAS:Compound PROTAC-2, also known as PROTAC Chk1 degrader-1, is a potent degrader of Chk1, exhibiting a DC50 of 1.33 μM. It is utilized in cancer research [1].Fórmula:C43H44N14O9Forma y color:SolidPeso molecular:900.9CHK1-IN-15
CHK1-IN-15 (compound 9a) is an ATP-competitive inhibitor of checkpoint kinase 1 (CHK1), exhibiting a binding rate of 95% at a concentration of 1.0 µM. It also acts as a Chk1 target protein ligand of MA203 and is applicable for tumor-related research.Chk1-IN-6
CAS:Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.Fórmula:C16H18F3N7Forma y color:SolidPeso molecular:365.364PD 407824
CAS:PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respectively).Fórmula:C20H12N2O3Pureza:98.02%Forma y color:SolidPeso molecular:328.32CCT244747
CAS:CCT244747 is a potent and selective CHK1 inhibitor oral, ATP-competitive, and cytotoxic, abrogating drug-induced S and G2 blockade and inducing apoptosis .Fórmula:C20H24N8O2Pureza:99.17%Forma y color:SolidPeso molecular:408.46GDC-0575 dihydrochloride
CAS:GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is a selective, orally active CHK1 inhibitor (IC50: 1.2 nM) that exhibits antitumour effects.Fórmula:C16H22BrCl2N5OForma y color:SolidPeso molecular:451.19LY2880070
CAS:LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy.Fórmula:C19H23N7O2Pureza:99.77%Forma y color:White SolidPeso molecular:381.43GDC0575 monohydrochloride
CAS:GDC0575 (ARRY575), a potent Chk1 inhibitor, IC50 1.2nM, disrupts cell cycle arrest, allowing DNA repair before mitosis.Fórmula:C16H21BrClN5OPureza:97.85%Forma y color:SolidPeso molecular:414.73Ref: TM-T27407
1mg43,00€2mg55,00€5mg80,00€1mL*10mM (DMSO)93,00€10mg103,00€25mg177,00€50mg255,00€100mg356,00€200mg520,00€CCT245737
CAS:CCT245737 is an orally active, selective Chk1 inhibitor, and is >1,000-fold selective over CHK2 and CDK1.Cost-effective and quality-assured.Fórmula:C16H16F3N7OPureza:98.28% - 99.93%Forma y color:SolidPeso molecular:379.34Ref: TM-T7080
1mg37,00€2mg49,00€5mg79,00€1mL*10mM (DMSO)87,00€10mg113,00€25mg213,00€50mg350,00€100mg523,00€AZD-7762
CAS:AZD-7762, an effective and specific inhibitor of Chk1（IC50=5 nM）, is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.Fórmula:C17H19FN4O2SPureza:98.96% - 99.19%Forma y color:SolidPeso molecular:362.42Ref: TM-T6093
1mg35,00€2mg50,00€5mg77,00€1mL*10mM (DMSO)84,00€10mg90,00€25mg167,00€50mg265,00€100mg424,00€GDC-0575
CAS:GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).Fórmula:C16H20BrN5OPureza:≥95%Forma y color:SolidPeso molecular:378.27M2I-1
CAS:M2I-1 inhibits Mad2 binding to Cdc20, disrupting SAC-related PPI and Mad2 dynamics, blocks Mad2-F-Mbp1 in FP assays.Fórmula:C19H24N4O4SPureza:99.02% - >99.99%Forma y color:Red SolidPeso molecular:404.48
