Kinesina
Los inhibidores de cinesina se dirigen a las proteínas motoras cinesinas, responsables del transporte de carga celular a lo largo de los microtúbulos y que desempeñan un papel clave en la división celular, especialmente durante la mitosis. Las cinesinas están involucradas en el movimiento de cromosomas y otros orgánulos durante la división celular. Inhibir las cinesinas puede interrumpir estos procesos, lo que lleva al arresto del ciclo celular y a la posible muerte celular, lo que hace que estos inhibidores sean valiosos en la investigación del cáncer. En CymitQuimica, ofrecemos una gama diversa de inhibidores de cinesina de alta calidad para apoyar su investigación en biología celular, mitosis y terapia contra el cáncer.
Se han encontrado 66 productos de "Kinesina"
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Paprotrain
CAS:<p>Paprotrain ((alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile) inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM.</p>Fórmula:C16H11N3Pureza:99.91%Forma y color:SolidPeso molecular:245.28BOS-172722
CAS:BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint(IC50 of 2 nM).Fórmula:C24H30N8OPureza:99.37%Forma y color:SolidPeso molecular:446.55Mps1-IN-3
CAS:<p>Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).</p>Fórmula:C26H31N7O4SPureza:99.25%Forma y color:SolidPeso molecular:537.63KIF18A-IN-16
CAS:<p>KIF18A-IN-16 (Compound 15) is a polycyclic KIF18A inhibitor. It is applicable in research related to tumors, including colon cancer, breast cancer, and lung cancer.</p>Fórmula:C30H37N5O4SForma y color:SolidPeso molecular:563.71KIF18A-IN-15
CAS:<p>KIF18A-IN-15 (Compound Example 36) is a KIF18A inhibitor, available in two forms, EX36-A and its enantiomer EX36-B, both with an IC50 range of 0.01-0.1 μM. These compounds inhibit the viability of OVCAR-3 cells, with IC50 values of 0.01-0.1 μM for EX36-A and 0-0.01 μM for EX36-B. KIF18A-IN-15 is applicable in research on tumors, including colon, breast, and lung cancers.</p>Fórmula:C25H33F3N6O5SForma y color:SolidPeso molecular:586.63KIF2C-IN-1
<p>KIF2C-IN-1 (Compound 7S9) is a selective and potent small molecule inhibitor of KIF2C. It stabilizes the interaction between KIF2C and microtubule proteins, preventing the depolymerization of polyglutamylated microtubules. KIF2C-IN-1 enhances the cytotoxicity of Paclitaxel in Paclitaxel-resistant triple-negative breast cancer (TNBC) cells and, when combined with Paclitaxel, significantly reduces tumor growth in mouse models.</p>Fórmula:C36H39ClN4O9SForma y color:SolidPeso molecular:738.21263KIF18A-IN-14
CAS:<p>KIF18A-IN-14 (Compound Example 81) is an inhibitor of KIF18A that exists in two forms, EX81-A and its enantiomer EX81-B. EX81-A and EX81-B inhibit the viability of OVCAR-3 cells with IC50 values of 0-0.01 μM and 0.01-0.1 μM, respectively. KIF18A-IN-14 can be utilized in tumor research, including studies on colon cancer, breast cancer, and lung cancer.</p>Fórmula:C26H32F3N5O6SForma y color:SolidPeso molecular:599.62Solidagonic acid
CAS:<p>Solidagonic acid inhibits HSET, prevents fission yeast cell death, and hinders L. sativa and L. multiflorum seedling growth.</p>Fórmula:C22H34O4Forma y color:SolidPeso molecular:362.511H-Benzo[a]carbazole
CAS:<p>11H-Benzo[a]carbazole is a kinesin-like protein KIF11 inhibitor that can inhibit the viability of HeLa cells.</p>Fórmula:C16H11NPureza:99.14%Forma y color:SolidPeso molecular:217.27Mps1-IN-6
<p>Mps1-IN-6 is a potent Mps1 inhibitor that demonstrates antiproliferative and antitumor activities, exhibiting an IC50 of 2.596 nM [1].</p>Fórmula:C35H39N9O3Forma y color:SolidPeso molecular:633.74Eg5-IN-1
<p>Eg5-IN-1 is a potent inhibitor of the kinesin family of motor proteins (Eg5) with an IC50 value of 1.97 µM for Eg5.Eg5-IN-1 can be used in cancer research.</p>Fórmula:C23H16ClFN4OPureza:98.21%Forma y color:SolidPeso molecular:418.85Filanesib TFA
CAS:<p>Filanesib (ARRY-520) inhibits KSP, triggering mitotic arrest and cell death in dividing tumor cells.</p>Fórmula:C22H23F5N4O4SPureza:98%Forma y color:SolidPeso molecular:534.5(S)-Monastrol
CAS:<p>Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.</p>Fórmula:C14H16N2O3SPureza:98%Forma y color:SolidPeso molecular:292.35GW406108X
CAS:GW406108X is a Kif15 and ULK1 inhibitor; IC50: 0.82 µM (ATPase), pIC50: 6.37; blocks autophagy.Fórmula:C20H11Cl2NO4Pureza:98%Forma y color:SolidPeso molecular:400.21AZ82
CAS:<p>AZ82 is an inhibitor of the kinesin-like protein KIFC1, which induces multipolar mitosis and apoptosis in prostate cancer cells.</p>Fórmula:C28H31F3N4O3SPureza:99.31%Forma y color:SolidPeso molecular:560.63Kinesore
CAS:<p>Kinesore is a cell-permeable modulator that binds to the microtubule motor protein kinesin-1, thereby inhibiting the interaction between KLC2 and SKIP.</p>Fórmula:C20H16Br2N4O4Pureza:97.24%Forma y color:SolidPeso molecular:536.17Mps1-IN-3 hydrochloride
<p>Mps1-IN-3 HCl: potent Mps1 inhibitor (IC50: 50 nM), hampers glioblastoma growth, enhances vincristine efficacy in vivo.</p>Fórmula:C26H32ClN7O4SForma y color:SolidPeso molecular:574.09Mps1-IN-1 dihydrochloride
CAS:<p>Mps1-IN-1 dihydrochloride, a potent ATP-competitive inhibitor of Mps1 kinase, exhibits an IC50 of 367 nM.</p>Fórmula:C28H35Cl2N5O4SForma y color:SolidPeso molecular:608.58SB-743921 hydrochloride
CAS:<p>SB-743921 hydrochloride (SB743921 HCl) is an effective inhibitor of kinesin spindle protein, KSP, (Ki =0.1 nM).</p>Fórmula:C31H34Cl2N2O3Pureza:95.58% - 99.70%Forma y color:SolidPeso molecular:553.52GW406108X(Z/E)
CAS:<p>GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1 .</p>Fórmula:C20H11Cl2NO4Pureza:98.23%Forma y color:SolidPeso molecular:400.21
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