Ferroptosis
La ferroptosis es una forma de muerte celular regulada caracterizada por la acumulación de peróxidos lipídicos y el estrés oxidativo dependiente de hierro. A diferencia de la apoptosis, la ferroptosis no está impulsada por caspasas, sino por el fallo de las defensas antioxidantes celulares, lo que conduce a la muerte celular. Los inhibidores e inductores de la ferroptosis son fundamentales para estudiar esta vía única de muerte celular, que está implicada en diversas enfermedades, como el cáncer, la neurodegeneración y el daño por isquemia-reperfusión. En CymitQuimica, ofrecemos una amplia gama de moduladores de la ferroptosis de alta calidad para apoyar su investigación en mecanismos de muerte celular, estrés oxidativo y patología de enfermedades.
Se han encontrado 234 productos para "Ferroptosis".
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Ammonium iron(III) citrate
CAS:Ammonium iron(III) citrate (Ferric ammonium citrate) is a physiological form of non-ferritin-bound iron that causes intracellular iron overload and iron death.Fórmula:C12H22FeN3O14Pureza:99.88%Forma y color:Ferric Ammonium Citrate Is A Yellowish Brown To Red Solid With A Faint Odor Of AmmoniaPeso molecular:488.16U-73122
CAS:U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.Fórmula:C29H40N2O3Pureza:97.50% - 98.66%Forma y color:White SolidPeso molecular:464.64UAMC-3203
CAS:UAMC-3203 is a potent and selective Ferroptosis inhibitor (IC50: 12 nM).Fórmula:C25H37N5O2SPureza:97.05% - 99.72%Forma y color:White SolidPeso molecular:471.66FINO2
CAS:FINO2, a strong ferroptosis trigger, blocks GPX4, oxidizes Fe2+, stable in different pH, causes lipid peroxidation.Fórmula:C15H28O3Pureza:97.27%Forma y color:SolidPeso molecular:256.38Frataxin-IN-1
CAS:Frataxin-IN-1 inhibits the mitochondrial protein Frataxin with IC50 45 μM and is used in Friedreich’s ataxia research linked to mitochondrial defects.Fórmula:C20H23NO6Pureza:99.34%Forma y color:SolidPeso molecular:373.4Anti-Mouse IL-1b Antibody (B122)
Anti-Mouse IL-1b Antibody (B122) is a mab inhibitor, blocks IL-1β signaling, reducing monocyte infiltration and alleviating T cell exhaustion.Forma y color:Transparent LiquidJKE-1716
CAS:JKE-1716 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of the GPX4 inhibitor ML-210 .1JKE-1716 reduces viability of LOX-IMVI cancer cells in a concentration-dependent manner and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 . 1.Eaton, J.K., Furst, L., Ruberto, R.A., et al.Selective covalent targeting of GPX4 using masked nitrile-oxide electrophilesNat. Chem. Biol.16(5)497-506(2020)Fórmula:C20H20Cl2N4O4Forma y color:SolidPeso molecular:451.3Pioglitazone-D4
CAS:Pioglitazone D4 is a deuterium labeled Pioglitazone. Pioglitazone is a agonist of PPARγ .Fórmula:C19H20N2O3SPureza:98%Forma y color:SolidPeso molecular:360.46Ferroptosis-IN-17
Ferroptosis-IN-17 (Compound 18) is an inhibitor of ferroptosis with an EC50 value of 0.57 μM. It effectively reduces the accumulation of intracellular ferrous ions and lipid peroxidation while restoring levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4). In rat plasma, Ferroptosis-IN-17 demonstrates good solubility and notable metabolic stability. This compound holds potential for research in tumor suppression, neurodegenerative diseases, and cardiovascular disorders.Fórmula:C21H26N4O5SForma y color:SolidPeso molecular:446.52CGP 65015
CAS:CGP 65015 is an oral iron chelator and can mobilize iron deposits.Fórmula:C14H15NO4Pureza:98%Forma y color:SolidPeso molecular:261.27CN128 hydrochloride
CAS:CN128 hydrochloride is an oral, selective hydroxypyridone iron chelator for β-thalassemia research.Fórmula:C15H18ClNO3Forma y color:SolidPeso molecular:295.76YL-939
YL-939 is a potent inhibitor of ferroptosis, targeting the PHB2/ferritin/iron axis to impede this form of cell death.Fórmula:C25H26N6OForma y color:SolidPeso molecular:426.51Anticancer agent 147
CAS:Compound 6j (Anticancer agent 147), a sophoridine derivative and ferroptosis inducer, promotes intracellular accumulation of Fe2+, reactive oxygen species (ROSFórmula:C32H40BrN3O2Pureza:98%Forma y color:SolidPeso molecular:578.58Ferroptosis inducer-1
CAS:Ferroptosis inducer-1 is a Ferroptosis inducer with antitumor potential .Fórmula:C25H21ClN2O5Forma y color:SolidPeso molecular:464.9Ferroptosis-IN-13
Ferroptosis-IN-13 (compound NY-26) is an inhibitor of ferroptosis. It effectively suppresses RSL3-induced ferroptosis in 786-O cells, with an EC50 value of 62 nM.Fórmula:C32H30F2N4O3Forma y color:SolidPeso molecular:556.602W1131
CAS:W1131 is a potent STAT3 inhibitor and ferroptosis trigger, reducing cancer progression and 5-FU resistance.Fórmula:C23H19N5O4Forma y color:SolidPeso molecular:429.43Microtubule inhibitor 8
CAS:Microtubule Inhibitor 8 (MP-HJ-1b) serves as a potent disruptor of microtubule function, inducing cell death via ferroptosis and demonstrating anti-tumor effects [1] [2].Fórmula:C21H15N3O2SForma y color:SolidPeso molecular:373.43Tubulin inhibitor 30
CAS:Tubulin Inhibitor 30 is a tubulin polymerization inhibitor (IC₅₀=0.52 μM) that also induces ferroptosis for anticancer and ferroptosis studies.Fórmula:C22H19N3O5Forma y color:SolidPeso molecular:405.40IM-93
CAS:IM-93 inhibits ferroptosis and NETosis with an IC< sub>50 of 0.45 μM for cell death inhibition [1].Fórmula:C21H28N4O2Forma y color:SolidPeso molecular:368.47NPD4928
CAS:NPD4928 boosts cancer cell sensitivity to GPX4 inhibitors, hinting at therapeutic potential through ferroptosis.Fórmula:C29H32N2O6Forma y color:SolidPeso molecular:504.57
