Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Se han encontrado 2235 productos de "Cromatina / Epigenética"
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PJ34 hydrochloride
CAS:<p>PJ34 hydrochloride (PJ34 HCl) is a potent specific inhibitor of PARPl/2.</p>Fórmula:C17H18ClN3O2Pureza:98.87% - ≥95%Forma y color:SolidPeso molecular:331.8G007-LK
CAS:<p>G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.</p>Fórmula:C25H16ClN7O3SPureza:97.63% - 98.17%Forma y color:SolidPeso molecular:529.96JQKD82
CAS:<p>JQKD82 is a selective inhibitor of KDM5 and increases H3K4me3. JQKD82 can be used in studies about the treatment of multiple myeloma.</p>Fórmula:C27H40N4O5Pureza:100.00%Forma y color:SolidPeso molecular:500.63Itacitinib
CAS:<p>Itacitinib (INCB039110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.</p>Fórmula:C26H23F4N9OPureza:96.4% - 99.5%Forma y color:SolidPeso molecular:553.51MPT0G211 mesylate
CAS:<p>MPT0G211 mesylate: potent, selective HDAC6 inhibitor (IC50=0.291nM), oral, BBB-penetrating, anti-tau and metastasis, potential anticancer.</p>Fórmula:C18H19N3O5SForma y color:SolidPeso molecular:389.43CPI203
CAS:<p>CPI203 (CPI 203) is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).</p>Fórmula:C19H18ClN5OSPureza:99.13% - 99.77%Forma y color:SolidPeso molecular:399.9UPF 1069
CAS:<p>UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1.</p>Fórmula:C17H13NO3Pureza:98.80% - 99.88%Forma y color:SolidPeso molecular:279.29ZM-447439
CAS:<p>ZM 447439 selectively inhibits Aurora A/B (IC50: 110/130 nM); 8x less effective on MEK1, Src, Lck; minimal impact on CDK1/2/4, Plk1, Chk1.</p>Fórmula:C29H31N5O4Pureza:99.11% - 99.59%Forma y color:Pale Yellow SolidPeso molecular:513.59Atractylenolide I
CAS:<p>Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.</p>Fórmula:C15H18O2Pureza:97.55% - 99.92%Forma y color:SolidPeso molecular:230.3JNJ-42041935
CAS:<p>JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.</p>Fórmula:C12H6ClF3N4O3Pureza:99.58% - ≥95%Forma y color:SolidPeso molecular:346.65HJ-PI01
CAS:<p>HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.</p>Fórmula:C14H11NO2Pureza:98.92%Forma y color:SolidPeso molecular:225.24Pacritinib
CAS:<p>Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).</p>Fórmula:C28H32N4O3Pureza:99.25% - 99.49%Forma y color:SolidPeso molecular:472.58ABBV-744
CAS:<p>ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.</p>Fórmula:C28H30FN3O4Pureza:97.03% - >99.99%Forma y color:SolidPeso molecular:491.55Chlorogenic Acid
CAS:<p>Chlorogenic acid is a natural phenol. Chlorogenic acid has anti-inflammatory, antitumor, and antimicrobial effects. Cost-effective and quality-assured.</p>Fórmula:C16H18O9Pureza:98.84% - 99.67%Forma y color:SolidPeso molecular:354.31GSK484 hydrochloride
CAS:<p>GSK484 hydrochloride (GTPL8577) is a reversible peptidyl-arginine deiminase 4 (PAD4) inhibitor.Cost-effective and quality-assured.</p>Fórmula:C27H32ClN5O3Pureza:98.32% - 99.62%Forma y color:SolidPeso molecular:510.03MRTX-1719
CAS:<p>MRTX-1719 is a potent and selective inhibitor of the PRMT5/MTA complex with an IC50 value of <10 nM against PRMT5/MTAMTAPDELSDMA cell lines.Cost-effective and quality-assured.</p>Fórmula:C23H18ClFN6O2Pureza:98.27% - 99.18%Forma y color:SolidPeso molecular:464.88Bisindolylmaleimide IV
CAS:<p>Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - 0.55 μM)</p>Fórmula:C20H13N3O2Pureza:98.83%Forma y color:Dark Red SolidPeso molecular:327.34Ilorasertib
CAS:<p>Ilorasertib (ABT-348) inhibits Aurora kinases A/B/C & RET, PDGFRβ, Flt1 (IC50: 1-120 nM).</p>Fórmula:C25H21FN6O2SPureza:96.17% - 97.49%Forma y color:SolidPeso molecular:488.54AZ6102
CAS:<p>AZ6102: Potent TNKS1/2 inhibitor, 100x selective over PARPs, IC50 = 5 nM in DLD-1 Wnt pathway.</p>Fórmula:C25H28N6OPureza:97.98% - 99.91%Forma y color:SolidPeso molecular:428.53PKC-iota inhibitor 1
CAS:<p>PKC-iota inhibitor 1 is an inhibitor of protein kinase C-iota (PKC-ι ; IC50 : 0.34 μM)</p>Fórmula:C21H22N6OPureza:98.82%Forma y color:SolidPeso molecular:374.44RBN012759
CAS:<p>RBN012759 inhibits PARP14 protein and is more than 300-fold selective over all PARP family members.Cost-effective and quality-assured.</p>Fórmula:C19H23FN2O3SPureza:98.87% - 99.96%Forma y color:SolidPeso molecular:378.46Pacritinib hydrochloride
CAS:<p>Pacritinib HCl: strong JAK2/Wild-type & JAK2V617F inhibitor (IC50: 23/19 nM), used in AML & MF research.</p>Fórmula:C28H32N4O3·xClHForma y color:SolidMS436
CAS:<p>MS436 is a selective, small-molecule inhibitor for the BRD4 bromodomains.</p>Fórmula:C18H17N5O3SPureza:97.95% - 98.92%Forma y color:SolidPeso molecular:383.42OAC1
CAS:<p>OAC1 (BAS 00287861) activates Oct4, boosts iPSC efficiency, and speeds up reprogramming.</p>Fórmula:C14H11N3OPureza:99.49% - 99.65%Forma y color:SolidPeso molecular:237.26Fraxinellone
CAS:<p>1.</p>Fórmula:C14H16O3Pureza:99.35% - 99.92%Forma y color:SolidPeso molecular:232.27TFMB-(R)-2-HG
CAS:<p>TFMB-(R)-2-HG, a carcinogen in AML, hinders SCF ER-Hoxb8 differentiation after estrogen loss.</p>Fórmula:C13H11F3O4Pureza:97.15%Forma y color:SolidPeso molecular:288.22(Z)-LFM-A13
CAS:<p>(Z)-LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.</p>Fórmula:C11H8Br2N2O2Pureza:99.88%Forma y color:SolidPeso molecular:360SGC-SMARCA-BRDVIII
CAS:<p>SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM,</p>Fórmula:C19H25N5O3Pureza:99.54% - 99.92%Forma y color:SolidPeso molecular:371.43Pim1/AKK1-IN-1
CAS:<p>Pim1/AKK1-IN-1: LKB1/AAK1 inhibitor with Kd 35/53/75/380 nM for Pim1/AKK1/MST2/LKB1, also targets MPSK1, TNIK.</p>Fórmula:C20H13N5OPureza:97.03% - 98.69%Forma y color:SolidPeso molecular:339.35Hispidulin
CAS:<p>Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).</p>Fórmula:C16H12O6Pureza:98.53% - 99.87%Forma y color:SolidPeso molecular:300.26Iniparib
CAS:<p>Iniparib (BSI-201) (BSI-201) , a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC).</p>Fórmula:C7H5IN2O3Pureza:98.93%Forma y color:SolidPeso molecular:292.03SMI-16a
CAS:<p>SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (</p>Fórmula:C13H13NO3SPureza:99.99%Forma y color:SolidPeso molecular:263.31AT9283
CAS:<p>AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).</p>Fórmula:C19H23N7O2Pureza:99.83% - 99.98%Forma y color:SolidPeso molecular:381.43NI-57
CAS:<p>NI-57 inhibits BRPF family proteins: BRPF1 (IC50=3.1nM), BRPF2 (IC50=46nM), BRPF3 (IC50=140nM).</p>Fórmula:C19H17N3O4SPureza:99.88% - >99.99%Forma y color:SolidPeso molecular:383.42Menin-MLL inhibitor MI-2
CAS:<p>Menin-MLL inhibitor MI-2 (MI2) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.</p>Fórmula:C18H25N5S2Pureza:97.46%Forma y color:SolidPeso molecular:375.55RVX-297
CAS:<p>RVX-297 selectively inhibits BD2 domains of BET bromodomains, binding preferentially to BET proteins.</p>Fórmula:C24H29N3O4Pureza:99.62%Forma y color:SolidPeso molecular:423.5RK-287107
CAS:<p>RK-287107 is an effective and specific inhibitor of tankyrase (IC50s: 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively).</p>Fórmula:C22H26F2N4O2Pureza:99.64%Forma y color:SolidPeso molecular:416.46BRD4 Inhibitor 30
CAS:<p>4-(2-fluorophenyl)-1,3-thiazol-2-one: has anti-inflammatory, antibacterial, antifungal, and antitumor properties.</p>Fórmula:C9H6FNOSPureza:99.68%Forma y color:SolidPeso molecular:195.21EED226
CAS:<p>EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.</p>Fórmula:C17H15N5O3SPureza:98.14% - 99.33%Forma y color:SolidPeso molecular:369.4Ro 31-8220 Mesylate
CAS:<p>Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor, and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.</p>Fórmula:C25H23N5O2S·CH4O3SPureza:98.79% - 99.02%Forma y color:SolidPeso molecular:553.65PF-06726304
CAS:<p>PF-06726304: potent EZH2 inhibitor, effective against tumors, Kis at 0.7 nM (wild-type) and 3.0 nM (Y641N mutant).</p>Fórmula:C22H21Cl2N3O3Pureza:98.19% - 99.51%Forma y color:SolidPeso molecular:446.33AZ505
CAS:<p>AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).</p>Fórmula:C29H38Cl2N4O4Pureza:98.18%Forma y color:SolidPeso molecular:577.54Reversine
CAS:<p>Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).</p>Fórmula:C21H27N7OPureza:98% - 98.42%Forma y color:SolidPeso molecular:393.49MLN8054
CAS:<p>MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.</p>Fórmula:C25H15ClF2N4O2Pureza:98.07% - 98.26%Forma y color:SolidPeso molecular:476.86SETDB1-TTD-IN-1
CAS:<p>SETDB1-TTD-IN-1 is a potent and selective inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD, Kd = 88 nM).Cost-effective and quality-assured.</p>Fórmula:C28H31N5O2Pureza:98.26% - 99.96%Forma y color:SolidPeso molecular:469.58GSK1379725A
CAS:<p>GSK1379725A is a selective BPTF ligand (Kd = 2.8 μM).</p>Fórmula:C23H23FN6O3Pureza:99.51%Forma y color:SolidPeso molecular:450.47Bromosporine
CAS:<p>Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.</p>Fórmula:C17H20N6O4SPureza:99.65% - 99.79%Forma y color:SolidPeso molecular:404.444-amino-1,8-Naphthalimide
CAS:<p>4-amino-1,8-Naphthalimide (4-ANI) is a PARP inhibitor with IC50 of 180 nM</p>Fórmula:C12H8N2O2Pureza:95.13%Forma y color:Yellow Solid PowderPeso molecular:212.2ORY1001
CAS:<p>ORY1001: Oral LSD1/KDM1A inhibitor, highly selective, IC50 <20 nM.</p>Fórmula:C15H22N2·2HClPureza:99.85% - 99.96%Forma y color:SolidPeso molecular:303.27Ruboxistaurin mesylate
CAS:<p>Ruboxistaurin: PKC beta inhibitor, eases oxidative stress, heart issues & nephropathy in diabetic rats, halts retinal neovascularization.</p>Fórmula:C29H32N4O6SPureza:98%Forma y color:SolidPeso molecular:564.65TP-064
CAS:<p>TP-064: Potent, selective PRMT4 inhibitor, IC50 < 10nM for H3 methylation, 100x selectivity, blocks MED12 methylation at 43nM.</p>Fórmula:C28H34N4O2Pureza:97.85%Forma y color:SolidPeso molecular:458.6LLY-507
CAS:<p>LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.</p>Fórmula:C36H42N6OPureza:99.58% - 99.93%Forma y color:SolidPeso molecular:574.76Picolinamide
CAS:<p>Picolinamide (Picolinoylamide) is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.</p>Fórmula:C6H6N2OPureza:99.6%Forma y color:SolidPeso molecular:122.12UNC1999
CAS:<p>UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45).</p>Fórmula:C33H43N7O2Pureza:99.19% - >99.99%Forma y color:SolidPeso molecular:569.74AT-9283 HCl
CAS:<p>AT-9283, a multi-targeted kinase inhibitor, is used potentially for the treatment of multiple myeloma.</p>Fórmula:C19H24ClN7O2Forma y color:SolidPeso molecular:417.89KDM4D-IN-1
CAS:<p>KDM4D-IN-1 is a KDM4D inhibitor (IC50: 0.41±0.03 μM).</p>Fórmula:C11H7N5OPureza:99.51% - >99.99%Forma y color:SolidPeso molecular:225.21JMJD7-IN-1
CAS:<p>JMJD7-IN-1 (Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester) is a potent JMJD7 inhibitor, with an IC50 of 6.62 μM.</p>Fórmula:C16H8Cl2N2O4Pureza:99.66%Forma y color:SolidPeso molecular:363.15Naphthol AS-E
CAS:<p>Naphthol AS-E (nAS-E) is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.</p>Fórmula:C17H12ClNO2Pureza:99.33%Forma y color:Grey Solid PowderPeso molecular:297.748-CHLOROQUINAZOLIN-4(1H)-ONE
CAS:<p>8-CHLOROQUINAZOLIN-4(1H)-ONE is inhibitor of Poly [ADP-ribose] polymerase 1 (human)</p>Fórmula:C8H5ClN2OPureza:98.79%Forma y color:SolidPeso molecular:180.59ICG001
CAS:<p>ICG001 antagonizes Wnt signaling, binds CBP with 3 μM IC50, not p300.</p>Fórmula:C33H32N4O4Pureza:99.06% - 99.95%Forma y color:SolidPeso molecular:548.63(R)-(-)-JQ1 Enantiomer
CAS:<p>(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)</p>Fórmula:C23H25ClN4O2SPureza:99.38%Forma y color:SolidPeso molecular:456.99AZ9482
CAS:<p>AZ9482, a potent PARP inhibitor with 2-piperazinyl-3-cyano-pyridine linkage, causes centrosome declustering in HeLa cells with an EC50 < 18 nM.</p>Fórmula:C26H22N6O2Pureza:99.18% - 99.86%Forma y color:SolidPeso molecular:450.49JQEZ5
CAS:<p>JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM).</p>Fórmula:C30H38N8O2Pureza:98.14% - ≥98%Forma y color:SolidPeso molecular:542.68Rucaparib hydrochloride
CAS:<p>Rucaparib hydrochloride (AG014699) is an oral PARP inhibitor with Ki 1.4 nM for PARP1 and hinders H6PD, studied in CRPC research.</p>Fórmula:C19H19ClFN3OForma y color:SolidPeso molecular:359.83XMD8-92
CAS:<p>XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).</p>Fórmula:C26H30N6O3Pureza:98.21%Forma y color:SolidPeso molecular:474.55Rucaparib acetate
CAS:<p>Rucaparib acetate, an oral PARP-1, -2, -3 inhibitor (Ki 1.4 nM for PARP1), also moderately inhibits H6PD; promising for CRPC research.</p>Fórmula:C21H22FN3O3Forma y color:SolidPeso molecular:383.423IOX1
CAS:<p>IOX1, a broad-spectrum 2OG oxygenase inhibitor, IC50: KDM4A - 0.6uM, KDM3A - 0.1uM.</p>Fórmula:C10H7NO3Pureza:99.67%Forma y color:SolidPeso molecular:189.17Menin-MLL inhibitor 20
CAS:<p>Menin-MLL inhibitor 20 is an irreversible inhibitor of menin-MLL interaction with antitumor activities.</p>Fórmula:C33H40N8O4Pureza:97.77%Forma y color:SolidPeso molecular:612.72γ-Oryzanol
CAS:<p>γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in the</p>Fórmula:C40H58O4Pureza:mixture - mixtureForma y color:White Or White Crystalline Powder OdourlessPeso molecular:602.9Ethyl 3,4-dihydroxybenzoate
CAS:<p>Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.</p>Fórmula:C9H10O4Pureza:99.88%Forma y color:White Crystal Or PowderPeso molecular:182.17Ruboxistaurin
CAS:<p>Ruboxistaurin (LY333531) is a selective PKC beta inhibitor, Ki 2 nM, inhibits beta I/II (IC50: 4.7/5.9 nM), orally active.</p>Fórmula:C28H28N4O3Forma y color:SolidPeso molecular:468.552,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
CAS:<p>2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity and physicochemical properties.</p>Fórmula:C16H13Cl2N3O2Pureza:98.77%Forma y color:SolidPeso molecular:350.2EB-47 dihydrochloride
CAS:<p>EB 47 is an effective inhibitor of PARP-1 (IC50: 45 nM).</p>Fórmula:C24H29Cl2N9O6Forma y color:SolidPeso molecular:610.45SC-43
CAS:<p>SC-43 is a potent and orally active agonist of SHP-1 (PTPN6).</p>Fórmula:C21H13ClF3N3O2Pureza:98.44%Forma y color:SolidPeso molecular:431.8WM-8014
CAS:<p>WM-8014 (MOZ-IN-3) is an inhibitor of MOZ(IC50=55 nM), a member of histone acetyltransferases.</p>Fórmula:C20H17FN2O3SPureza:99.64%Forma y color:SolidPeso molecular:384.42MS31 trihydrochloride
<p>MS31 trihydrochloride: a selective SPIN1 inhibitor, binds H3K4me3 (IC50: 77-243 nM), non-toxic to healthy cells.</p>Fórmula:C20H30Cl3N3O2Forma y color:SolidPeso molecular:450.83Ro 31-8220
CAS:<p>Ro 31-8220: potent PKC inhibitor (IC50: 5-27 nM). Affects MAPKAP-K1b, MSK1, S6K1, GSK3β (IC50: 3-38 nM), not MKK3/4/6/7.</p>Fórmula:C25H23N5O2SForma y color:SolidPeso molecular:457.55Remodelin hydrobromide
CAS:<p>Remodelin hydrobromide (Remodelin HBR) is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.</p>Fórmula:C15H15BrN4SPureza:97.22% - 99.84%Forma y color:SolidPeso molecular:363.275BAY-598
CAS:<p>BAY 598 is a potent and selective competitive inhibitor of SMYD2, exhibiting >100-fold selectivity over SMYD3, SUV420H1, and SUV420H2. Cost-effective and quality-assured.</p>Fórmula:C22H20Cl2F2N6O3Pureza:99.18% - 99.78%Forma y color:SolidPeso molecular:525.346-Bromo-3-methyl-1,4-dihydroquinazolin-2-one
CAS:<p>CHEMBRDG-BB 7118966 is an inhibitor of Bromodomain-containing protein 4 (human).</p>Fórmula:C9H9BrN2OPureza:99.28%Forma y color:SolidPeso molecular:241.08Izilendustat hydrochloride
CAS:<p>Izilendustat hydrochloride inhibits prolyl hydroxylase, stabilizing HIF-1α/HIF-2, with potential to treat various HIF-1α diseases.</p>Fórmula:C22H29Cl2N3O4Forma y color:SolidPeso molecular:470.39Paris saponin VII
CAS:<p>Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.</p>Fórmula:C51H82O21Pureza:99.51% - 99.63%Forma y color:SolidPeso molecular:1031.18PF-9366
CAS:<p>PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor (IC50: 420 nM; Kd: 170 nM).</p>Fórmula:C20H19ClN4Pureza:97.28% - 99.88%Forma y color:SolidPeso molecular:350.84Abrocitinib
CAS:<p>Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).</p>Fórmula:C14H21N5O2SPureza:99.09% - 99.91%Forma y color:SolidPeso molecular:323.41SNS-314
CAS:<p>SNS-314 inhibits Aurora kinases A and B, blocking cell division in AK-overexpressing tumors.</p>Fórmula:C18H15ClN6OS2Pureza:98%Forma y color:SolidPeso molecular:430.93PF 477736
CAS:<p>PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (</p>Fórmula:C22H25N7O2Pureza:97.58% - 99.94%Forma y color:SolidPeso molecular:419.48Peficitinib
CAS:<p>Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.</p>Fórmula:C18H22N4O2Pureza:98.67% - 99.4%Forma y color:SolidPeso molecular:326.39Phthalazinone pyrazole
CAS:<p>Phthalazinone pyrazole: a potent, selective oral Aurora-A kinase inhibitor, overexpressed in tumors with oncogenic activity.</p>Fórmula:C18H15N5OPureza:97.03%Forma y color:SolidPeso molecular:317.34653-47
CAS:<p>653-47 enhances the effects of 666-15 on inhibiting CREB and is a mild CREB inhibitor itself (IC50: 26.3μM).</p>Fórmula:C20H19ClN2O3Forma y color:SolidPeso molecular:370.83WHI-P97
CAS:<p>WHI-P97 is a rationally designed potent inhibitor of JAK-3.</p>Fórmula:C16H13Br2N3O3Pureza:99.93%Forma y color:SolidPeso molecular:455.1Daphnetin
CAS:<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Fórmula:C9H6O4Pureza:97.47% - 99.8%Forma y color:SolidPeso molecular:178.14Pyridone 6
CAS:<p>Pyridone 6, a selective JAK1/2/3 and Tyk2 inhibitor with IC50s: JAK1=15 nM, JAK2=1 nM, JAK3 (Ki=5 nM), Tyk2=1 nM; weakly binds other kinases (130 nM-10 μM).</p>Fórmula:C18H16FN3OPureza:97.1% - 98.74%Forma y color:SolidPeso molecular:309.34GN44028
CAS:<p>GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but not mRNA or protein levels, or dimerization.</p>Fórmula:C18H15N3O2Pureza:99.52%Forma y color:SolidPeso molecular:305.33XAV-939
CAS:<p>XAV-939 (NVP-XAV939) shows the selective inhibition against Wnt/β-catenin-mediated transcription by tankyrase1/2 inhibition (IC50: 11/4 nM in cell-free assay).</p>Fórmula:C14H11F3N2OSPureza:97.47% - 99.67%Forma y color:SolidPeso molecular:312.311,5-Isoquinolinediol
CAS:<p>1,5-Isoquinolinediol, a PARP1 inhibitor (IC50: 0.39 μM), is used in DNA repair and cell death studies.</p>Fórmula:C9H7NO2Pureza:98.29% - 99.35%Forma y color:Of White To White PowderPeso molecular:161.16MS7972
CAS:<p>MS7972 is CREBBP inhibitor that blocks human p53 and CREB binding protein association. MS7972 can almost completely block this BRD interaction at 50 μM</p>Fórmula:C14H13NO2Pureza:99.78%Forma y color:SolidPeso molecular:227.26Molibresib
CAS:<p>Molibresib (GSK525762) is an inhibitor of BET proteins (IC50: about 35 nM).</p>Fórmula:C22H22ClN5O2Pureza:97.70% - 99.08%Forma y color:SolidPeso molecular:423.9dCBP-1
CAS:<p>dCBP-1 selectively degrades p300/CBP via CRBN, killing multiple myeloma cells.</p>Fórmula:C51H63F2N11O10Pureza:98.21% - 99.12%Forma y color:SolidPeso molecular:1028.11GSK 690 Hydrochloride
CAS:<p>GSK 690 (Hydrochloride) is a reversible lysine specific demethylase 1 (LSD1) inhibitor with a Kd value of 9 nM and IC 50 of 37 nM.</p>Fórmula:C24H24ClN3OPureza:98%Forma y color:SolidPeso molecular:405.92
