NF-κB
El factor nuclear kappa-light-chain-enhancer de células B activadas (NF-κB) es un factor de transcripción que regula la expresión de genes involucrados en respuestas inmunitarias, inflamación, supervivencia celular y proliferación. El NF-κB se activa en respuesta a varios estímulos, incluidos citocinas, patógenos y señales de estrés. La desregulación de la señalización de NF-κB está asociada con enfermedades inflamatorias crónicas, cáncer y trastornos autoinmunes. En CymitQuimica, ofrecemos una selección integral de moduladores de la vía NF-κB para apoyar su investigación en inflamación, oncología y regulación inmunitaria.
Se han encontrado 446 productos de "NF-κB"
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Sinomenine hydrochloride
CAS:<p>Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.</p>Fórmula:C19H24ClNO4Pureza:99.43%Forma y color:SolidPeso molecular:365.851Lidocaine
CAS:<p>Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.</p>Fórmula:C14H22N2OPureza:99.95% - >99.99%Forma y color:Needles From Benzene Or Alcohol SolidPeso molecular:234.34GSK3145095
CAS:GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.Fórmula:C20H17F2N5O2Pureza:99.50%Forma y color:SolidPeso molecular:397.38TBK1/IKKε-IN-2
CAS:TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.Fórmula:C26H27N5O3Pureza:98.89%Forma y color:SolidPeso molecular:457.52Erdosteine
CAS:<p>Erdosteine (RV 144), a mucolytic thiol, modulates mucus and aids expectoration, reduces cough, and protects lungs from smoke damage.</p>Fórmula:C8H11NO4S2Pureza:99.43% - 99.94%Forma y color:White Or Almost White Crystalline PowderPeso molecular:249.31Lidocaine Hydrochloride hydrate
CAS:<p>Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.</p>Fórmula:C14H22N2O·HCl·H2OPureza:99.95%Forma y color:SolidPeso molecular:288.82α-Lipoic Acid
CAS:<p>α-Lipoic Acid, a sulfur-containing octanoic acid derivative, is biosynthesized from linoleic acid and used in dietary supplements.</p>Fórmula:C8H14O2S2Pureza:98.39% - 99.73%Forma y color:Forms Yellowish Flakes Light Yellow To Yellow PowderPeso molecular:206.33AZ1495
CAS:AZ1495: oral IRAK4 inhibitor (IC50: 5 nM), IRAK1 (23 nM), treats MYD88L265P DLBCL.Fórmula:C21H31N5O2Pureza:98.81%Forma y color:SolidPeso molecular:385.54-Hydroxychalcone
CAS:<p>4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.</p>Fórmula:C15H12O2Pureza:99.75%Forma y color:Yellow PowderPeso molecular:224.25Naringin dihydrochalcone
CAS:Naringin dihydrochalcone (Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.Fórmula:C27H34O14Pureza:99.07% - 99.73%Forma y color:Solid PowderPeso molecular:582.55Oxaprozin
CAS:<p>Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug.</p>Fórmula:C18H15NO3Pureza:98.53%Forma y color:SolidPeso molecular:293.32Theophylline monohydrate
CAS:Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calciumFórmula:C7H8N4O2·H2OPureza:99.78%Forma y color:SolidPeso molecular:198.18Dihydroartemisinin
CAS:Dihydroartemisinin (Artenimol) is an antimalarial drug. High-Quality, Low-Cost!Fórmula:C15H24O5Pureza:98% - 99.41%Forma y color:White SolidPeso molecular:284.35Mangiferin
CAS:Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.Fórmula:C19H18O11Pureza:99.78% - 99.86%Forma y color:Light Yellow PowderPeso molecular:422.34GLPG2534
CAS:GLPG2534 is an orally active, selective and potent IRAK4 inhibitor with anti-inflammatory activity. GLPG2534 can be used in psoriasis and atopic dermatitis.Fórmula:C21H24N6O4Pureza:99.51% - 99.61%Forma y color:SolidPeso molecular:424.45Metaxalone
CAS:Metaxalone, sold as Skelaxin by King Pharmaceuticals, is a muscle relaxant for pain from strains and sprains.Fórmula:C12H15NO3Pureza:98.84% - 99.94%Forma y color:White To Almost White Crystalline Powder SolidPeso molecular:221.25DRI-C21045
CAS:Dri-c21045 inhibits NF-kB (IC50=17.1μM) and B cell proliferation (IC50=4.5μM), selectively blocking CD40-CD40L interaction (IC50=0.17μM).Fórmula:C32H24N2O7SPureza:97.20%Forma y color:SolidPeso molecular:580.61BAY-985
CAS:BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.Fórmula:C27H30F3N9OPureza:99.62%Forma y color:SolidPeso molecular:553.58Baicalin
CAS:Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIVFórmula:C21H18O11Pureza:90.08% - 99.32%Forma y color:Yellow PowderPeso molecular:446.36Articaine hydrochloride
CAS:Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.Fórmula:C13H21ClN2O3SPureza:99.76%Forma y color:White Crystalline PowderPeso molecular:320.84DMAPT
CAS:DMAPT is a water-soluble PTL analogue, orally active NF-κB inhibitor with 1.7 μM LD50 in acute myeloid leukemia cells.Fórmula:C17H27NO3Pureza:99.91%Forma y color:SolidPeso molecular:293.4Sodium salicylate
CAS:<p>Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.</p>Fórmula:C7H5NaO3Pureza:99.36% - 99.92%Forma y color:White Solid AmorphousPeso molecular:160.11Aspirin
CAS:Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.Fórmula:C9H8O4Pureza:99.78% - 99.91%Forma y color:White Solid CrystallinePeso molecular:180.16RIPK1-IN-7
CAS:<p>RIPK1-IN-7: Strong, selective RIPK1 inhibitor (Kd=4 nM, IC50=11 nM) with great antimetastasis effects in B16 melanoma.</p>Fórmula:C25H22F3N5O2Pureza:98.02% - 98.18%Forma y color:SolidPeso molecular:481.47Sulindac
CAS:Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity.Fórmula:C20H17FO3SPureza:99.09% - 99.15%Forma y color:Yellow SolidPeso molecular:356.41Urolithin B
CAS:Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropicalFórmula:C13H8O3Pureza:99.45%Forma y color:SolidPeso molecular:212.2Nimbolide
CAS:Nimbolide, from neem, inhibits CDK4/6, NF-κB, Wnt, PI3K-Akt, MAPK, JAK-STAT pathways and induces apoptosis.Fórmula:C27H30O7Pureza:95.84% - 99.4%Forma y color:SolidPeso molecular:466.52Mevastatin
CAS:Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.Fórmula:C23H34O5Pureza:99.12%Forma y color:White-Yellowish To Yellow Powder Solid PowderPeso molecular:390.51IRAK4-IN-4
CAS:<p>IRAK4-IN-4 (compound 15) inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4)</p>Fórmula:C22H16N2O2Pureza:99.52%Forma y color:SolidPeso molecular:340.375-Aminosalicylic Acid
CAS:<p>5-Aminosalicylic Acid (5-ASA) is a specific PPARγ agonist and also inhibits P21-activated kinase 1 (PAK1) and NF-Κb. High-Quality, Low-Cost!</p>Fórmula:C7H7NO3Pureza:98.88% - 99.49%Forma y color:Purplish-Tan Solid PowderPeso molecular:153.14DCZ0415
CAS:DCZ0415: Potent TRIP13 inhibitor; combats myeloma in vitro, in vivo, and in drug-resistant patients; hinders DNA repair and NF-κB activity.Fórmula:C23H20N2O2Pureza:99.34% - 99.95%Forma y color:SolidPeso molecular:356.42(E/Z)-BCI
CAS:<p>(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS</p>Fórmula:C22H23NOPureza:99.94%Forma y color:SolidPeso molecular:317.42Asatone
CAS:Asatone from Radix et Rhizoma Asari has anti-inflammatory properties, acting on NF-κB and suppressing p-MAPK pathways (ERK, JNK, p38).Fórmula:C24H32O8Pureza:99.84% - 99.92%Forma y color:SolidPeso molecular:448.51Sulfasalazine
CAS:Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative. Sulfasalazine induces ferroptosis and inhibits NF-κB. Cost effective and quality assured.Fórmula:C18H14N4O5SPureza:98.00% - 99.28%Forma y color:Minute Brownish-Yellow CrystalsPeso molecular:398.39Methylthiouracil
CAS:Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.Fórmula:C5H6N2OSPureza:99.89% - >99.99%Forma y color:Crystals Saturated Aqueous Solution Is Neutral Or Slightly Acidic (Ntp 1992)Peso molecular:142.18IMD-0560
CAS:IMD-0560 is a novel inhibitor of IκB kinase β.Fórmula:C15H8BrF6NO2Pureza:99.51%Forma y color:SolidPeso molecular:428.12SN50 acetate (213546-53-3 free base)
SN50 acetate is a cell permeable inhibitor of NF-κB translocation.Fórmula:C131H234N36O31SPureza:99.86%Forma y color:SolidPeso molecular:2841.55Ergolide
CAS:Ergolide, from Inula Britannica, inhibits iNOS and COX-2 by deactivating NF-κB in macrophages.Fórmula:C17H22O5Pureza:99.64%Forma y color:SolidPeso molecular:306.35NIK SMI1
CAS:<p>NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).</p>Fórmula:C20H19N3O4Pureza:99.04% - 99.99%Forma y color:SolidPeso molecular:365.38Theophylline
CAS:Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and centralFórmula:C7H8N4O2Pureza:99.65% - 99.98%Forma y color:White Solid PowderPeso molecular:180.16CDDO-dhTFEA
CAS:CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor.Fórmula:C33H45F3N2O3Pureza:95.61% - 99.59%Forma y color:SolidPeso molecular:574.72Lidocaine hydrochloride
CAS:<p>Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.</p>Fórmula:C14H23ClN2OPureza:99.81% - 99.92%Forma y color:White Crystal PowderPeso molecular:270.798Indacaterol maleate
CAS:<p>Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist.</p>Fórmula:C28H32N2O7Pureza:99.03% - 99.67%Forma y color:SolidPeso molecular:508.56Guaiacol
CAS:<p>Guaiacol, a flavorant precursor, has medicinal uses and serves as an oxygen indicator turning yellow-brown at 470 nm.</p>Fórmula:C7H8O2Pureza:99.95%Forma y color:Colourless To Pale Yellow Solid CrystallinePeso molecular:124.14NF-κΒ activator 1
CAS:NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns.Fórmula:C16H11FN2O2SPureza:99.58%Forma y color:SolidPeso molecular:314.33Anti-inflammatory agent 51
CAS:Anti-inflammatory agent 51 amide/sulfonamide anti-inflammatory and anti-tumor activity inhibition of NF-κB activation acute lung injury and ulcerative colitis.Fórmula:C22H22N6O6SPureza:99.76%Forma y color:SoildPeso molecular:498.51(R)-(-)-Ibuprofen
CAS:(R)-(-)-Ibuprofen ((R)-Ibuprofen) is the R enantiomer of Ibuprofen and inhibits NF-κB activation.Fórmula:C13H18O2Pureza:99.86%Forma y color:SolidPeso molecular:206.28IKK-IN-3
CAS:IKK-IN-3: potent IKK2 inhibitor (IC50=19nM), affects IKK1(IC50=400nM).Fórmula:C17H17N5SForma y color:SolidPeso molecular:323.42EN450
CAS:EN450 is a targeted cysteine degrader of NF-κB with antiproliferative activity and potential anticancer activity for the study of leukemia.Fórmula:C11H13ClN2O3SPureza:98.39%Forma y color:SoildPeso molecular:288.75PROTAC IRAK4 ligand-4
CAS:PROTAC IRAK4 ligand-4, a Ligand for Target Protein for PROTAC (Ligand for Target Protein for PROTAC), exhibits anti-tumor activity and is utilized in synthesizing PROTAC IRAK4 degrader-12. This compound serves as a targeted ligand with specific applications in the development of cancer therapeutics.Fórmula:C24H26F2N6O3Forma y color:SolidPeso molecular:484.5CIB-1476
<p>CIB-1476, a caspase-1 inhibitor, effectively reduces joint swelling in mouse models of arthritis and demonstrates lasting anti-inflammatory effects. This compound achieves its benefits by blocking IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis, all of which are triggered by the NLRP3 inflammasome.</p>Fórmula:C28H28N2O6SForma y color:SolidPeso molecular:520.6Cyclo(L-Pro-L-Val)
CAS:<p>Cyclo(L-Pro-L-Val), from Mycobacterium spp., has anti-inflammatory effects, hinders phytopathogens, and suppresses IKKα, NF-κB, iNOS, and COX-2 activation.</p>Fórmula:C10H16N2O2Pureza:98.18%Forma y color:SolidPeso molecular:196.25PS 1145 dihydrochloride
CAS:IκB kinase (IKK) inhibitorFórmula:C17H13Cl3N4OPureza:98%Forma y color:SolidPeso molecular:395.67Gliotoxin
CAS:Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.Fórmula:C13H14N2O4S2Pureza:98%Forma y color:SolidPeso molecular:326.39Aloenin aglycone
CAS:Aloenin aglycone (compound 13), an inhibitor of NF-κB, can be sourced from aloe exudate.Fórmula:C13H12O5Pureza:98%Forma y color:SolidPeso molecular:248.23RIPK1-IN-27
RIPK1-IN-27 (compound 19) is an inhibitor of RIPK1.Fórmula:C27H28N4O3Forma y color:SolidPeso molecular:456.54Lemnalol
CAS:<p>Lemnalol, from Lemnalia cervicorni, has anti-inflammatory and analgesic properties.</p>Fórmula:C15H24OPureza:98%Forma y color:SolidPeso molecular:220.35Coronalolic acid
CAS:Coronalolic acid is a natural product extracted from the Gardenia sootepenesis Hutch. It inhibits TNF-α-induced NF-κB activity and NO production.Fórmula:C30H46O4Pureza:98%Forma y color:SolidPeso molecular:470.68CAY10657
CAS:<p>CAY10657 has a wide range of applications in life science related research.</p>Fórmula:C17H20N4O3SForma y color:SolidPeso molecular:360.4317-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
CAS:<p>DPA metabolite 17-oxo-DPA, found in fish oil, spurs antioxidant genes, modulates inflammation, and activates PPARγ (EC50 ≈ 200 nM).</p>Fórmula:C22H32O3Forma y color:SolidPeso molecular:344.495PROTAC IRAK4 degrader-12
CAS:PROTAC IRAK4 degrader-12, a Cereblon ligand-based PROTAC, induces a maximum degradation of IRAK4 in K562 cells at 108.46% with an IC50 value of 4.87 nM. (Structure Note: Pink, IRAK4 Inhibitor; Blue, E3; Black, linker.)Fórmula:C46H50ClF2N11O6Forma y color:SolidPeso molecular:926.41HS-243
CAS:<p>HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.</p>Fórmula:C17H16N4O3Pureza:98.62%Forma y color:SolidPeso molecular:324.33Eupenicisirenin C
CAS:Eupenicisirenin C (compound 1), a sirenin derivative, exhibits strong NF-κB inhibitory activities and suppresses the cGAS-STING pathway. Additionally, Eupenicisirenin C inhibits RANKL-induced osteoclast differentiation in bone marrow macrophage cells [1].Fórmula:C13H18O4Peso molecular:238.28Nasunin
CAS:<p>Delphanin, also known as Nasunin, is an anthocyanin isolated as purple colored crystals from eggplant peels.</p>Fórmula:C42H47ClO23Forma y color:SolidPeso molecular:955.26Halleridone
CAS:Halleridone, a natural product, is identified in <i>Teuanchum decipiens</i> and <i>Abeliophyllum distichum</i>.Fórmula:C8H10O3Forma y color:SolidPeso molecular:154.06299NBD peptide
CAS:<p>NBD peptide inhibits the NF-κB signaling pathway by preventing the binding of the NEMO-IKK complex. It exhibits anti-inflammatory activity by blocking the production of pro-inflammatory cytokines. Additionally, NBD peptide demonstrates immunosuppressive effects through the regulation of immune cells. It enhances transmembrane capacity by conjugating with the cell-penetrating peptide HIV-TAT.</p>Fórmula:C62H88N14O20Forma y color:SolidPeso molecular:1349.44RIPK1-IN-25
<p>RIPK1-IN-25 (WL8) is a RIPK1 inhibitor with blood-brain barrier permeability, displaying an EC50 of 19.9 nM and a Kd of 25 nM. It is utilized in the research of neurodegenerative diseases.</p>Forma y color:Odour SolidAnti-osteoporosis agent-8
Anti-osteoporosis agent-8 (Compound 4aa) is a RANKL inhibitor, capable of preventing RANKL-induced osteoclastogenesis and osteoclast differentiation, with an IC50 of 2.41 μM. Furthermore, Anti-osteoporosis agent-8 has been shown to mitigate bone loss in an ovariectomized (OVX) mouse model.Fórmula:C18H19F3N2O2SePeso molecular:432.05638Pratensein
CAS:Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.Fórmula:C16H12O6Pureza:99.90%Forma y color:SolidPeso molecular:300.26SU1261
SU1261, an IKK inhibitor, exhibits Ki values of 10 nM for IKKα and 680 nM for IKKβ. It effectively inhibits non-canonical NF-κB signaling in U2OS osteosarcoma cells.Forma y color:Odour SolidLY2409881
CAS:LY2409881 is a selective IκB kinase β ( IKK2 ) inhibitor with an IC 50 of 30 nM.Fórmula:C24H29ClN6OSForma y color:SolidPeso molecular:485.05SN50 TFA
SN50 TFA is an inhibitor of NF-κB and attenuates alveolar hypercoagulation and fibrinolysis inhibition. SN50 TFA can be used in studies about ARDS.Fórmula:C129H230N36O29S·XCF3COOHForma y color:SolidPeso molecular:2781.5 (free base)Diprovocim-1
CAS:Diprovocim-1: TLR1/2 agonist; triggers TNF-α in THP-1 cells; boosts ovalbumin IgG1 & CTLs against tumors with anti-PD-L1 in mice.Fórmula:C56H56N6O6Forma y color:SolidPeso molecular:909.1NLRP3-IN-51
<p>NLRP3-IN-51 (Compound 3q) is an effective activator of the cholinergic anti-inflammatory pathway (CAP). This compound demonstrates potential for treating gouty arthritis as it inhibits the production of IL-1β in THP-1 cells induced by monosodium urate (MSU). Furthermore, NLRP3-IN-51 suppresses the phosphorylation of NF-κBp65 triggered by MSU without impacting the self-cleavage and activation of NLRP3, pro-caspase 1, or the second messenger caspase-1. Therefore, the initial stage of NLRP3 inhibition by NLRP3-IN-51 occurs through the activation of CAP.</p>Forma y color:Odour SolidCOX-2-IN-48
COX-2-IN-48 (5-25) serves as an inhibitor of COX-2, exhibiting an IC50 of 51.7 nM against human COX-2. It displays anti-inflammatory and analgesic effects in various rodent models through inhibition of the NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS.Forma y color:Odour SolidTBK1/IKKε-IN-6
CAS:TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.Fórmula:C31H36F2N8O4Forma y color:SolidPeso molecular:622.678Licoagrochalcone C
CAS:Licoagrochalcone C, a flavonoid, inhibits NF-κB and NO production effectively.Fórmula:C21H22O5Forma y color:SolidPeso molecular:354.47-O-Methylaloeasinol
CAS:7-O-Methylaloeasinol is a useful organic compound for research related to life sciences. The catalog number is T126468 and the CAS number is 105317-69-9.Fórmula:C20H26O9Forma y color:SolidPeso molecular:410.419Mesalamine impurity P
CAS:<p>Mesalamine impurity P, a 5-Aminosalicylic acid derivative, is a PPARγ agonist, inhibiting PAK1 and NF-κB.</p>Fórmula:C13H11NO6SForma y color:SolidPeso molecular:309.30Anti-inflammatory agent 7
Anti-inflammatory Agent 7 suppresses proinflammatory cytokines by hindering the NF-κB/MAPK signaling pathway in both LPS-treated RAW 264.7 cells and mice.Fórmula:C36H40N4O9Forma y color:SolidPeso molecular:672.72Ginger extract
CAS:<p>Ginger extract demonstrates (exhibits) anti-cancer, anti-inflammatory, and chemotherapeutic properties in living organisms (in vivo).</p>Forma y color:SolidNF-κB-IN-9
NF-κB-IN-9, a nuclear factor kappa B (NF-κB) targeting sonosensitizer with excitation and emission wavelengths (λex/λem) of 489/628 nm, features dualFórmula:C62H50N4O4SForma y color:SolidPeso molecular:947.153-(2-Hydroxyethyl) thio withaferin A
3-(2-Hydroxyethyl) thio withaferin A, a steroidal lactone, blocks NF-kB, targets vimentin, and inhibits EPCR shedding.Fórmula:C30H44O7SForma y color:SolidPeso molecular:548.73Salicortin
CAS:<p>Salicortin, a phenolic glycoside from Populus and Salix, has anti-adipogenic, anti-amnesic, and immune effects.</p>Fórmula:C20H24O10Pureza:98%Forma y color:SolidPeso molecular:424.4012-Oxo phytodienoic acid
CAS:<p>12-oxo PDA boosts alkaloid production in E. californica, enhances B. dioica tendril curls, and blocks JA-induced cell death in A. fru mutants.</p>Fórmula:C18H28O3Pureza:98%Forma y color:SolidPeso molecular:292.41Murrayafoline A
CAS:Murrayafoline A is a useful organic compound for research related to life sciences. The catalog number is T124835 and the CAS number is 4532-33-6.Fórmula:C14H13NOForma y color:SolidPeso molecular:211.264N-Acetyldopamine dimer-2
CAS:Compound 2, an N-acetyldopamine dimer from Periostracum Cicadae, exhibits antioxidant and anti-inflammatory properties.Fórmula:C20H20N2O6Forma y color:SolidPeso molecular:384.38Apo A-I mimetic 5A peptide
Apo A-I mimetic 5A peptide is a synthetic peptide molecule designed based on the structure and function of naturally occurring apolipoprotein A-I (Apo A-I). It facilitates the efflux of cholesterol from inside cells, helping to reduce intracellular cholesterol accumulation. Additionally, Apo A-I mimetic 5A peptide exhibits anti-inflammatory properties, lowering inflammatory markers in blood and tissues. This peptide is used in cardiovascular disease research.Fórmula:C197H295N47O56Peso molecular:4215.16808MRT67307
CAS:Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.Fórmula:C26H36N6O2Pureza:99.25% - 99.84%Forma y color:SolidPeso molecular:464.6SjDX5-271
CAS:<p>SjDX5-271 is a 3 kDa peptide that inhibits the TLR4/MyD88/NF-κB signaling pathway. It induces cell polarization, alleviates liver inflammation, and protects mice from liver ischemia-reperfusion injury.</p>Fórmula:C137H215N47O49SForma y color:SolidPeso molecular:3336.52Transcription Factor-Targeted Compound Library
Well-chosen xnum compounds with unique structures targeting transcription factor;Forma y color:Odour SolidMJ210
<p>MJ210 is an orally active and blood-brain barrier-permeable modulator of the NF-κB and MAPK pathways, exhibiting neuroprotective properties. In vitro, 5 μM MJ210 can increase the survival rate of rotenone-treated SH-SY5Y cells to 81.9% and reduce levels of ROS. In vivo, 5 mg/kg MJ210 improves motor dysfunction in rat models of Parkinson's disease. MJ210 is useful for research in neurological disorders, including Parkinson's disease.</p>Forma y color:Odour SolidR-HP210
R-HP210 blocks LPS-triggered IL-1β, IL-6, COX-2 gene transcription and has a 3.80 μM IC50 for NF-κB inhibition without activating GCs.Fórmula:C22H19N3O2S2Forma y color:SolidPeso molecular:421.54Antidesmone
CAS:Antidesmone from Ajuga decumbens inhibits acute lung injury by modulating MAPK and NF-κB.Fórmula:C19H29NO3Pureza:98%Forma y color:SolidPeso molecular:319.44IKKγ NBD Inhibitory Peptide
CAS:<p>A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF</p>Fórmula:C170H259N49O42S1Pureza:98%Forma y color:SolidPeso molecular:3693.3CAY10512
CAS:CAY10512, a resveratrol analog, is 100x more potent, inhibiting NF-κB with an IC50 of 0.15 μM versus resveratrol's 20 μM.Fórmula:C15H13FOForma y color:SolidPeso molecular:228.266NF-κB Signaling Compound Library
A unique collection of xnum compounds targeting NF-κB signaling for high throughput screening and high content screening;Forma y color:Odour SolidHelenalin
CAS:Helenalin: anti-inflammatory sesquiterpene, inhibits NF-κB by alkylating p65 cysteine groups, blocks DNA binding.Fórmula:C15H18O4Pureza:98%Forma y color:SolidPeso molecular:262.3PROTAC STING degrader-3
PROTACSTING degrader-3 (Compound ST9) is a STINGPROTAC-type degrader with a DC50 of 0.62 μM. It induces STING degradation via the ubiquitin-proteasome pathway. This compound exerts anti-inflammatory effects by inhibiting the STING/TBK1/NF-κB signaling. Additionally, it offers renal protection and can be used in research on acute kidney injury.Forma y color:Odour SolidR1-ICR-5
CAS:R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.Fórmula:C54H70N8O7S2Forma y color:SolidPeso molecular:1007.31
