CCR
Los receptores de quimiocinas C-C (CCRs) son un grupo de GPCR que responden a las quimiocinas, moléculas de señalización que guían la migración de células inmunitarias hacia sitios de inflamación o infección. Los CCR desempeñan un papel crucial en las respuestas inmunitarias, la inflamación y el desarrollo de diversas enfermedades, incluidas las enfermedades autoinmunes y el cáncer. La modulación de la actividad de los CCR se está explorando como una estrategia terapéutica para afecciones como la artritis reumatoide, la esclerosis múltiple y la infección por VIH. En CymitQuimica, ofrecemos una gama de moduladores de CCR de alta calidad para apoyar su investigación en inmunología, inflamación y desarrollo terapéutico.
Se han encontrado 166 productos para "CCR".
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Denikitug
Denikitug (GS-1811) is an Fc-optimized humanized anti-CCR8 antibody that can bind human CCR8 and antagonize CCL1 signaling, and induces NK-dependent ADCC against CCR8-high-expressing cells, facilitating tumor immunology research centered on Tregs.Pureza:95%Forma y color:Odour LiquidPeso molecular:~148 kDaTivumecirnon
CAS:Tivumecirnon (FLX475) is a selective and oral CCR4 antagonist inhibits the infiltration and migration of Treg into the tumour microenvironment, antitumourFórmula:C24H27Cl2F3N6OPureza:99.88%Forma y color:SolidPeso molecular:543.41Nebokitug
Nebokitug is a humanized IgG1κ antibody targeting CCL24, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Forma y color:Odour LiquidLanerkitug
Lanerkitug (BAY3375968) is a fully humanized anti-CCR8 IgG1 mAb that depletes CCR8+ Tregs via ADCC and ADCP, with potential in solid tumor therapy.Pureza:95%Forma y color:Odour LiquidPeso molecular:~148 kDaEnzelkitug
CAS:Enzelkitug is a humanized IgG1-κ monoclonal antibody targeting CCR8 that blocks CCR8 signaling and modulates the tumor immune microenvironment.Peso molecular:~150 kDaCafelkibart
Cafelkibart is a chimeric IgG1κ monoclonal antibody targeting CCR8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Forma y color:Odour LiquidMLN3126
CAS:MLN3126: Oral CCR9 blocker, hinders CCL25-triggered chemotaxis/thymocyte calcium influx, IC50 of 6.3 nM.Fórmula:C21H19ClN2O5SForma y color:SolidPeso molecular:446.904S-531011
S-531011 is a human IgG1 monoclonal antibody that targets CCR8. It reduces tumor-infiltrating CCR8+ Tregs and exhibits antitumor activity in CT26.WT and EMT6 tumor-bearing mouse models. S-531011 is useful for cancer immunotherapy research. The recommended isotype control is HumanIgG1kappa, Isotype Control.AT008
AT008 is a monoclonal antibody that targets GPCR and inhibits the binding of chemokine ligands to their cell surface receptor, CCR4. [AT008] is applicable in the study of certain hematological cancers and solid tumors.Anti-Human CCR8 Antibody (10A11)
Anti-CCR8 Antibody (10A11) is a humanized IgG1 monoclonal antibody targeting CCR8.HGS004
HGS004 is a humanized IgG4 monoclonal antibody inhibitor targeting CCR5. It exhibits potent antiviral activity against various CCR5-tropic HIV-1 strains, including those resistant to other treatments (such as Maraviroc-resistant strains). HGS004 is applicable for research in HIV-1 infection.Forma y color:Odour LiquidCCR1 antagonist 7
CAS:CCR1 antagonist 7 (compound 16r) is an antagonist of chemokine receptor 1 (CCR1) with an IC 50 of 4 nM [1].Fórmula:C21H24ClN5O3SPureza:98%Forma y color:SolidPeso molecular:461.96BMS-457
CAS:BMS-457 is a potent, CCR1-selective antagonist.Fórmula:C24H35ClN2O4Pureza:98%Forma y color:SolidPeso molecular:451JNJ-27141491
CAS:JNJ-27141491 is a potent, noncompetitive antagonist of human CCR2.Fórmula:C17H15F2N3O3SPureza:98%Forma y color:SolidPeso molecular:379.38TAK-220
CAS:TAK-220: Oral CCR5 antagonist. IC50: 3.5 nM (RANTES), 1.4 nM (MIP-1α).Fórmula:C31H41ClN4O3Pureza:98%Forma y color:SolidPeso molecular:553.135AZD-1678
CAS:AZD-1678 is a potent CCR4 receptor antagonist.Fórmula:C11H8Cl2FN3O3SForma y color:SolidPeso molecular:352.17ALK4290
CAS:ALK4290 (AKST4290), a potent oral CCR3 inhibitor with a Ki of 3.2 nM, may treat macular degeneration and Parkinsonism.Fórmula:C27H34ClN5O3Forma y color:SolidPeso molecular:512.044RPT193
CAS:RPT193 is an oral CCR4 inhibitor reducing Th2 cell migration in atopic dermatitis, asthma, and allergies.Fórmula:C27H34Cl3N5O2Forma y color:SolidPeso molecular:566.95CCR2 antagonist 3
CAS:CCR2 antagonist 3 (AZD-2927) is an antagonist of CCR2.Fórmula:C17H25FN2O2Pureza:99.87%Forma y color:SolidPeso molecular:308.391PNU-177864 hydrochloride
CAS:PNU-177864 hydrochloride is a potent, selective and orally active antagonist of dopamine D3 receptor.Fórmula:C18H22ClF3N2O3SPureza:99.95%Forma y color:SolidPeso molecular:438.89
