Nrf2
Nrf2 es un factor de transcripción que regula la expresión de proteínas antioxidantes y enzimas de desintoxicación, desempeñando un papel crucial en la defensa celular contra el estrés oxidativo y la inflamación. La activación de la señalización de Nrf2 proporciona protección contra diversas enfermedades, incluyendo el cáncer, la neurodegeneración y los trastornos cardiovasculares. Los moduladores de Nrf2 están siendo explorados por su potencial en aplicaciones terapéuticas para reducir el daño oxidativo y la inflamación. En CymitQuimica, ofrecemos una gama de moduladores de la vía Nrf2 de alta calidad para apoyar su investigación en estrés oxidativo, inflamación y prevención de enfermedades.
Se han encontrado 78 productos de "Nrf2"
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BPK-29 hydrochloride
CAS:<p>"BPK-29 hydrochloride targets NR0B1, altering C274 and hinders KEAP1-mutant cancer cell growth."</p>Fórmula:C26H33Cl2N3O3Pureza:99.06%Forma y color:SolidPeso molecular:506.46Ezetimibe
CAS:<p>Ezetimibe (SCH 58235) is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption.</p>Fórmula:C24H21F2NO3Pureza:97.28% - 99.77%Forma y color:SolidPeso molecular:409.43NK-252
CAS:<p>NK-252 is a potential activator of Nrf2. It has great Nrf2-activating potential.</p>Fórmula:C13H11N5O3Pureza:98.32%Forma y color:SolidPeso molecular:285.26AA147
CAS:<p>AA147 is an ER proteostasis regulator that selectively activates the ATF6 arm of UPR as a prodrug.</p>Fórmula:C16H17NO2Pureza:99.24%Forma y color:SolidPeso molecular:255.31(E/Z)-BCI
CAS:<p>(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS</p>Fórmula:C22H23NOPureza:99.94%Forma y color:SolidPeso molecular:317.42Deacetylgedunin
CAS:<p>Deacetylgedunin is a limonoid that is the 7-deacetyl derivative of gedunin. It has been isolated from Azadirachta indica.</p>Fórmula:C26H32O6Forma y color:SolidPeso molecular:440.53S217879
<p>S217879 is a potent and selective activator of NRF2 that disrupts the KEAP1-NRF2 interaction, resulting in significant activation of the NRF2 pathway.</p>Fórmula:C29H30N4O7SForma y color:SolidPeso molecular:578.64Keap1/Nrf2/ARE activator 1
<p>Keap1/Nrf2/ARE activator 1 (compound HT-3) functions as an activator of the Keap1/Nrf2/ARE pathway. This compound has antioxidant properties and offers neuroprotective effects.</p>Fórmula:C19H20O6Forma y color:SolidPeso molecular:344.12599Monascin
CAS:<p>Monascin: azaphilonoid in red-mold rice; anti-tumor and anti-inflammatory.</p>Fórmula:C21H26O5Pureza:98%Forma y color:SolidPeso molecular:358.43Keap1-IN-1
<p>Keap1-IN-1 (Compound 27) is an inhibitor of Keap1, functioning by covalently modifying the Cys151 residue on the BTB domain of KEAP1, thereby disrupting the interaction between Keap and Nrf. It enhances the mRNA expression of the antioxidant response element (ARE) dependent gene NQO1, with an EC50 of 160 nM, and exhibits cytotoxicity in U2OS cells, with an EC50 of 527 nM.</p>Fórmula:C17H21Cl2N2O5PS3Forma y color:SolidPeso molecular:531.434Nrf2 activator-8
<p>Nrf2 Activator-8 (Compound 10e), with an EC50 of 37.9 nM, is a potent Nrf2 activator that demonstrates significant antioxidant and anti-inflammatory properties</p>Fórmula:C13H11ClN2O3SForma y color:SolidPeso molecular:310.7617-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
CAS:<p>Aspirin-enhanced COX-2 metabolite of DHA, activates Nrf2 and PPARγ, inhibits inflammation, with EC50 ~200 nM, effective at 5-25 μM.</p>Fórmula:C22H30O3Forma y color:SolidPeso molecular:342.479TPNA10168
CAS:<p>Compound Fr13590, with CAS No. 957942-34-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr13590 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Fórmula:C9H9ClO2S2Forma y color:SolidPeso molecular:248.75Keap1-Nrf2-IN-9
CAS:<p>Keap1-Nrf2-IN-9 inhibits Keap1-Nrf2 PPI with 0.575 µM IC50, boosts Nrf2 genes, non-toxic in ARPE19 cells.</p>Fórmula:C31H30N2O11S2Forma y color:SolidPeso molecular:670.71TAT 14
CAS:<p>TAT 14: a 14-mer peptide Nrf2 activator, anti-inflammatory, boosts Nrf2 protein, targets Keap1, no effect on mRNA.</p>Fórmula:C137H230N48O39Pureza:98%Forma y color:SolidPeso molecular:3173.59Keap1-Nrf2-IN-27
<p>Keap1-Nrf2-IN-27 is an inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI) with a KD2 value of 0.119 μM. It suppresses the expression of pro-inflammatory cytokines TNF-α and IL-6 in an LPS-induced RAW264.7 cell model.</p>Forma y color:Odour SolidButan-1-amine hydrochloride
CAS:<p>1-Butylamine hydrochloride,butylamine, a potential agonist of Nrf2/ARE (Nuclear Factor Erythroid 2 Associated Factor 2/Antioxidant Response Element).</p>Fórmula:C4H12ClNForma y color:SolidPeso molecular:109.6Keap1-Nrf2-IN-3
CAS:<p>Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein protein interaction inhibitor, and with a K d value of 2.5 nM for KEAP1 protein.</p>Fórmula:C31H34N6O3Forma y color:SolidPeso molecular:538.652Pterisolic acid B
<p>Pterisolic acid B is a useful organic compound for research related to life sciences and the catalog number is T125924.</p>Fórmula:C20H26O4Forma y color:SolidPeso molecular:330.424Nrf2/HO-1 activator 3
<p>Nrf2/HO-1 Activator 3 (Compound C3a) is an activator of the Nrf2 signaling pathway that facilitates the translocation of Nrf2 into the nucleus and enhances the expression of heme oxygenase-1 (HO-1). In H9c2 cardiomyocytes subjected to H2O2 or high glucose stimulation, Nrf2/HO-1 Activator 3 inhibits the excessive expression of ROS and MDA, suppressing cell viability and colony formation, thereby exhibiting antioxidant activity.</p>Fórmula:C27H26N2O6Forma y color:SolidPeso molecular:474.51
