STAT
Las proteínas STAT son componentes críticos de la vía de señalización JAK/STAT, que transmite señales extracelulares de citoquinas y factores de crecimiento al núcleo celular, influyendo en la expresión génica. Las proteínas STAT están involucradas en la regulación de respuestas inmunitarias, crecimiento celular, diferenciación y supervivencia. La desregulación de la señalización STAT está implicada en diversas enfermedades, incluido el cáncer, trastornos autoinmunes e inflamación crónica. En CymitQuimica, ofrecemos una amplia gama de moduladores de la vía STAT para apoyar su investigación en transducción de señales, inmunología y desarrollo terapéutico.
Se han encontrado 98 productos de "STAT"
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STAT3-IN-41
<p>STAT3-IN-41 (Compound 16) is a prodrug of compound 1. It gradually releases compound 1, which inhibits the STAT3 signaling pathway. STAT3-IN-41 exhibits antitumor activity against lung cancer, hepatocellular carcinoma, and pancreatic cancer.</p>Fórmula:C22H30F3NO7Forma y color:SolidPeso molecular:477.471STAT3-IN-34
<p>STAT3-IN-34 (Compound 15E) acts as a STAT3 inhibitor, blocking both the nuclear translocation and the transcriptional regulator activity of STAT3. It effectively inhibits HaCaT cell proliferation with an IC50 value of 0.008 μM. Additionally, STAT3-IN-34 reduces IL-17A expression and mitigates Imiquimod-induced psoriasis in mouse models.</p>Fórmula:C19H16N2O4SForma y color:SolidPeso molecular:368.41MNK8
CAS:<p>MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.</p>Fórmula:C15H12N2O2Pureza:99.74%Forma y color:SolidPeso molecular:252.27STX-0119
CAS:<p>STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.</p>Fórmula:C22H14N4O3Pureza:99.61%Forma y color:SolidPeso molecular:382.37STAT5-IN-3
<p>STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer properties. It works by blocking the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites, significantly reducing the expression of the STAT5B protein. This leads to the inhibition of downstream gene transcription, thereby preventing the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 has significant potential in overcoming chemotherapy resistance.</p>Fórmula:C25H27N5OForma y color:SolidPeso molecular:413.51JAK-STAT Compound Library
<p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>Forma y color:Odour SolidEupalinolide K
CAS:<p>Eupalinolide K is a natural product</p>Fórmula:C20H26O6Pureza:98%Forma y color:SolidPeso molecular:362.42Stafib-1
CAS:<p>Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.</p>Fórmula:C26H24N2O11P2Pureza:97.18%Forma y color:SolidPeso molecular:602.42Balsalazide
CAS:<p>Balsalazide (Balsalazido) is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.</p>Fórmula:C17H15N3O6Pureza:99.31%Forma y color:Yellow To Orange Crystalline PowderPeso molecular:357.32C188-9
CAS:<p>C188-9 (TTI-101) is a Stat3 inhibitor with an IC50 of 4-7 μM.</p>Fórmula:C27H21NO5SPureza:98.07% - >99.99%Forma y color:SolidPeso molecular:471.52AS1517499
CAS:<p>AS1517499 is a blood-brain barrier permeable inhibitor of STAT6 phosphorylation (IC50= 21 nM). High-Quality, Low-Cost!</p>Fórmula:C20H20ClN5O2Pureza:98.27% - 98.7%Forma y color:SolidPeso molecular:397.86Protosappanin A
CAS:<p>Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.</p>Fórmula:C15H12O5Pureza:99.42% - 99.82%Forma y color:SolidPeso molecular:272.25Atractylenolide I
CAS:Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.Fórmula:C15H18O2Pureza:97.55% - 99.92%Forma y color:SolidPeso molecular:230.3Picroside I
CAS:<p>Picroside I (6'-Cinnamoylcatalpol), a hepatoprotective agent, is reported to be antimicrobial and used against hepatitis B.</p>Fórmula:C24H28O11Pureza:99.70%Forma y color:SolidPeso molecular:492.47RO8191
CAS:<p>RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.</p>Fórmula:C14H5F6N5OPureza:98% - 98.85%Forma y color:SolidPeso molecular:373.211-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea
CAS:<p>SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib.</p>Fórmula:C21H13ClF3N3O2Pureza:99.41%Forma y color:SolidPeso molecular:431.8Saikosaponin D
CAS:<p>Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.</p>Fórmula:C42H68O13Pureza:98.34% - 99.73%Forma y color:White PowderPeso molecular:780.98HJC0152 hydrochloride
CAS:<p>HJC0152 hydrochloride (HJC0152) is a signal transducer and activator of transcription 3 (STAT3) inhibitor.</p>Fórmula:C15H14Cl3N3O4Pureza:99.01% - 99.06%Forma y color:SolidPeso molecular:406.64AS1810722
CAS:<p>AS1810722, a fused bicyclic pyrimidine derivative, is an orally active and potent inhibitor of STAT6, demonstrating an IC50 of 1.9 nM.</p>Fórmula:C25H25F2N7OPureza:99.13%Forma y color:SolidPeso molecular:477.51TPCA-1
CAS:<p>TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases</p>Fórmula:C12H10FN3O2SPureza:95.03% - 97.86%Forma y color:SolidPeso molecular:279.29
