
MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 901 productos para "MAPK". Se muestran los primeros 500.
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K-Ras G12C-IN-4
CAS:K-Ras G12C-IN-4 是一种 KRAS G12C 共价抑制剂。Fórmula:C31H33ClN4O4Pureza:99.41%Forma y color:White SolidPeso molecular:561.07Ref: TM-T11738
1mg71,00€5mg161,00€1mL*10mM (DMSO)192,00€10mg236,00€25mg403,00€50mg532,00€100mg783,00€200mg1.054,00€ACBI3
CAS:ACBI3 is a selective pan-KRAS degrader with anticancer activity that degrades oncogenic KRAS. ACBI3 inhibits the growth of most cancer cell lines driven by KRAS mutations.Fórmula:C50H62N14O6S2Pureza:99.24% - 99.41%Forma y color:White SolidPeso molecular:1019.25MRTX-1257
CAS:MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.Fórmula:C33H39N7O2Pureza:96.76% - 97.3%Forma y color:SolidPeso molecular:565.71Ref: TM-T16143
1mg60,00€2mg85,00€5mg124,00€1mL*10mM (DMSO)166,00€10mg195,00€25mg351,00€50mg512,00€100mg743,00€200mg982,00€(R)-BI-2852
CAS:(R)-5-hydroxy isoindolin-1-one is an RAS protein inhibitor with antiproliferative and antitumor properties.Fórmula:C31H28N6O2Pureza:97.80%Forma y color:SoildPeso molecular:516.59INH154
CAS:INH154 is a potent Nek2 and Hec1 binding (INH) inhibitor with IC50s of 120 nM in MB468 cells and 200 nM in Hela cells for INH.Fórmula:C22H24N4OSPureza:99.95%Forma y color:SolidPeso molecular:392.52Ref: TM-T11657
2mg34,00€5mg54,00€1mL*10mM (DMSO)59,00€10mg82,00€25mg136,00€50mg203,00€100mg299,00€200mg416,00€PF-3644022
CAS:PF-3644022 is a selective MK2 inhibitor, effective against TNFα (IC50: 5.2 nM, Ki: 3 nM), with anti-inflammatory properties. Also blocks MK3 and PRAK.Fórmula:C21H18N4OSPureza:98.13%Forma y color:SolidPeso molecular:374.46Ref: TM-T16501
1mg34,00€5mg105,00€1mL*10mM (DMSO)177,00€10mg192,00€25mg394,00€50mg587,00€100mg788,00€500mg1.575,00€Divarasib
CAS:Divarasib (GDC-6036), an investigational KRAS G12C inhibitor for solid tumors, has an IC50 of <0.01 μM.Fórmula:C29H32ClF4N7O2Pureza:99.23% - 99.83%Forma y color:SolidPeso molecular:622.06Ref: TM-T9972
1mg220,00€5mg522,00€1mL*10mM (DMSO)707,00€10mg737,00€25mg1.161,00€50mg1.603,00€100mg2.133,00€KRAS G12C inhibitor 19
CAS:KRAS G12C inhibitor 19 is a potent KRAS G12C inhibitor that shows anti-tumor activity in cellular assays, and the family inhibits tumor growth.Fórmula:C25H19ClF2N4O3SPureza:97.46%Forma y color:SolidPeso molecular:528.96CC-90003
CAS:CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.Fórmula:C22H21F3N6O2Pureza:99.42%Forma y color:SolidPeso molecular:458.44LUT014
CAS:LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.Fórmula:C27H19F3N8OPureza:99.03%Forma y color:SolidPeso molecular:528.49MRTX0902
CAS:MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.Fórmula:C22H24N6OPureza:99.69%Forma y color:SolidPeso molecular:388.47BI-3406
CAS:BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.Fórmula:C23H25F3N4O3Pureza:99.2% - 99.66%Forma y color:SolidPeso molecular:462.46Ref: TM-T12979
1mg70,00€5mg152,00€1mL*10mM (DMSO)166,00€10mg236,00€25mg439,00€50mg628,00€100mg872,00€500mg1.738,00€SU3327
CAS:SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).Fórmula:C5H3N5O2S3Pureza:98.39%Forma y color:SolidPeso molecular:261.3MAP4K4-IN-3
CAS:MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.Fórmula:C15H12ClN5Pureza:98.07%Forma y color:White SolidPeso molecular:297.74Ref: TM-T11942
5mg44,00€1mL*10mM (DMSO)48,00€10mg74,00€25mg144,00€50mg222,00€100mg354,00€200mg523,00€500mg797,00€ARS-1630
CAS:ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.Fórmula:C21H17ClF2N4O2Pureza:97.78%Forma y color:SolidPeso molecular:430.84Ref: TM-T10376
1mg38,00€5mg86,00€1mL*10mM (DMSO)88,00€10mg112,00€25mg216,00€50mg310,00€100mg408,00€200mg580,00€BAS 00489700
CAS:BAS 00489700 is a N-UTR interaction inhibitor. BAS 00489700 inhibits virus replication in cell culture.Fórmula:C19H16N2O4Pureza:99.78%Forma y color:SolidPeso molecular:336.34Ref: TM-T67854
1mg85,00€5mg170,00€1mL*10mM (DMSO)170,00€10mg250,00€25mg371,00€50mg522,00€100mg712,00€200mg954,00€MK2-IN-3 hydrate
CAS:MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)Fórmula:C21H18N4O2Pureza:99.58%Forma y color:SolidPeso molecular:358.39Ref: TM-T12058
1mg34,00€5mg60,00€1mL*10mM (DMSO)73,00€10mg87,00€25mg172,00€50mg250,00€100mg350,00€200mg480,00€BAY 2965501
CAS:BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor that induces pERK activation.BAY 2965501 can be used in the study of cancer.Fórmula:C20H19FN4O3SPureza:99.89%Forma y color:SolidPeso molecular:414.45ETC-206
CAS:ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).Fórmula:C25H20N4O2Pureza:99.72% - 99.79%Forma y color:SolidPeso molecular:408.45Ref: TM-T15250
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg92,00€25mg140,00€50mg215,00€100mg318,00€500mg692,00€Tanzisertib
CAS:Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.Fórmula:C21H23F3N6O2Pureza:98.66% - 99.28%Forma y color:SolidPeso molecular:448.44
