MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 894 productos de "MAPK"
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Butein
CAS:Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.Fórmula:C15H12O5Pureza:98.76% - >99.99%Forma y color:SolidPeso molecular:272.25ASP2453
CAS:ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.Fórmula:C40H48F3N7O4Pureza:99.71%Forma y color:SolidPeso molecular:747.85ERK-IN-4
CAS:<p>ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.</p>Fórmula:C14H17ClN2O3SPureza:98.92% - 99.84%Forma y color:SolidPeso molecular:328.814Raf inhibitor 1
CAS:B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.Fórmula:C26H19ClN8Pureza:99.91%Forma y color:SolidPeso molecular:478.94GW284543
CAS:GW284543 (UNC10225170) is a selective inhibitor of MEK5 .Fórmula:C23H20N2O3Pureza:99.75%Forma y color:SolidPeso molecular:372.42Ulixertinib hydrochloride
CAS:Ulixertinib hydrochloride (Ulixertinib HCl) is an ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosisFórmula:C21H23Cl3N4O2Pureza:99.85%Forma y color:SolidPeso molecular:469.79TBAP-001
CAS:TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.Fórmula:C27H23F2N7O3Pureza:99.58%Forma y color:SolidPeso molecular:531.51VX-702
CAS:<p>VX-702: selective p38α MAPK inhibitor, potent anti-cytokine for rheumatoid arthritis.</p>Fórmula:C19H12F4N4O2Pureza:99% - >99.99%Forma y color:SolidPeso molecular:404.32NCB-0846
CAS:NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).Fórmula:C21H21N5O2Pureza:97.04% - 99.89%Forma y color:SolidPeso molecular:375.42AMG410
CAS:AMG410 is a non-covalent, dual-modality KRAS inhibitor effective against both GDP (OFF) and GTP (ON) binding independently of the cell cycle and other mutants,Fórmula:C31H32ClF2N7O5Pureza:98.01% - 99.84%Forma y color:SoildPeso molecular:656.08AZD0022
CAS:AZD0022 is a selective, reversible, and orally active KRAS G12D inhibitor, exhibits tumour marker inhibition in PDAC and NSCLC models.Fórmula:C34H30F4N6OPureza:98.73%Forma y color:SoildPeso molecular:614.64Trametiglue
CAS:Trametiglue, a potent Trametinib derivative, selectively targets KSR-MEK and RAF-MEK through unique binding.Fórmula:C25H24FIN6O5SForma y color:SolidPeso molecular:666.46ASK1-IN-6
CAS:ASK1-IN-6 (Compound 32), a selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor, exhibits an IC50 of 25 nM. This compound readily crosses the blood-brain barrier, as evidenced by rat pharmacokinetics showing a clearance/unchanged clearance rate of 1.6/56 L/h/kg and an unbound partition coefficient (Kp,uu) of 0.46. Additionally, ASK1-IN-6 demonstrates anti-inflammatory activity and effectively improves symptoms in the Alzheimer's Disease Tg4510 mouse model.Fórmula:C17H14F4N6O2Peso molecular:410.33SC-68376
CAS:SC-68376 is a potent, reversible, cell-permeable, ATP-competitive, and selective inhibitor of p38 MAP kinase.Fórmula:C15H12N2OPureza:98%Forma y color:SolidPeso molecular:236.27Cephradine monohydrate
CAS:<p>Cephradine monohydrate is a β-lactam cephalosporin antibiotic exhibiting broad-spectrum activity against Gram-positive and Gram-negative pathogens.</p>Fórmula:C16H21N3O5SPureza:99.91%Forma y color:SolidPeso molecular:367.42Deltarasin
CAS:<p>Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.</p>Fórmula:C40H37N5OPureza:99.4%Forma y color:SolidPeso molecular:603.75FMK
CAS:<p>FMK 是一种不可逆的 RSK2 抑制剂，能够共价修饰 RSK 的 C 末端区域。</p>Fórmula:C18H19FN4O2Pureza:99.71%Forma y color:SolidPeso molecular:342.37ETC-168
CAS:ETC-168 is a selective, orally active MNK inhibitor with IC50 values of 23 nM for MNK1 and 43 nM for MNK2. It demonstrates antiproliferative efficacy both in vivo and in vitro [1].Fórmula:C24H19N5O2Forma y color:SolidPeso molecular:409.446H05
CAS:6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).Fórmula:C20H30ClN3O2S3Pureza:98%Forma y color:SolidPeso molecular:476.12PLX7904
CAS:PLX7904 (PB04), a selective RAF inhibitor, blocks ERK1/2 in mutant BRAF melanoma without activating it in RAS mutants.Fórmula:C24H22F2N6O3SPureza:99.51% - 99.66%Forma y color:SolidPeso molecular:512.53
