Raf

B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor.

Sorafenib is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).

LXH254 is a potent C-Raf and B-Raf inhibitor.

Sorafenib is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-4/B-Raf).

Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for …

LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions …

PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC …

SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).

Sorafenib-d3 is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and …

Sulindac sulfide is a non-steroidal anti-inflammatory compound that has a high affinity for COX-1 and …

GNE-9815 is a high kinase-selective inhibitor of RAF and targets KRAS-mutant cancers through combination therapy.

Zabofloxacin hydrochloride is a potent and seletive bacterial type II and IV topoisomerases inhibitor, has …

B-Raf IN 2 is a potent and selective BRAF inhibitor extracted from patent WO2021116055A1, compound …

GSK1904529A is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .

KG5 is a dual allosteric inhibitor of PDGFRβ and B-Raf with a Kd of 520 …

Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent …

CCT241161 is an orally active pan- RAF inhibitor with IC 50 s of 3, 6, …

MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 …

PLX7904, also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is …

MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used …

Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for …

Dabrafenib Mesylate is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, …

Pelitinib (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).

TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E …

LGX818 is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.

BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).

Doramapimod is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits …

NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR …

RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for …

CEP-32496 is a highly potent inhibitor of BRAF.

Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase …

BI-882370 is a specific RAF kinase inhibitor. BI-882370 inhibits the oncogenic BRAFV600E-mutant, the WT BRAF …

AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 …

K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).

SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay). The selectivity …

PLX-4032 is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.

Lonafarnib is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).

I-37 free base is a novel benzylamino substituted pyridopyrimidinone as SOS1 inhibitor.

Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor (IC50s: 1.5/2.5/4.2/7/13/22 nM for RET/C-RAF/VEGFR2/c-Kit/VEGFR1/PDGFRβ).

Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, …

ZM 336372 is a potent and selective c-Raf inhibitor.

OSI-930, an orally active inhibitor of c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2), …

Rineterkib is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.

ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that …

L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays >7, > 30 and …

PLX-4720 is a potent and selective inhibitor of B-Raf (V600E) (IC50: 13 nM), equally potent …

Indirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 uM …

CID-25014542 is novel inhibitor of Raf kinases.

GDC-0879 is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with …

PLX8394 is an orally active inhibitor of serine/threonine-protein kinase B-Raf (BRAF) protein. PLX8394 can selectively …

Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.

Regorafenib Hydrochloride is a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine …

Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells …

Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with …

N-(3-(5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide is a novel selective inhibitor. The DFG-in conformation of the B-Raf kinase V600E mutant …