CFTR
El CFTR es una proteína de canal de cloruro que regula el transporte de iones cloruro y bicarbonato a través de las membranas de las células epiteliales, desempeñando un papel crucial en el mantenimiento del equilibrio de fluidos en los tejidos. Las mutaciones en el gen CFTR conducen a la fibrosis quística, un trastorno genético caracterizado por la producción de moco espeso que puede obstruir las vías respiratorias y provocar graves problemas respiratorios y digestivos. En CymitQuimica, ofrecemos una selección de moduladores de CFTR para apoyar su investigación en fibrosis quística, transporte de iones y trastornos genéticos.
Se han encontrado 65 productos de "CFTR"
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Elexacaftor
CAS:Elexacaftor (VX-445) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector.Cost-effective and quality-assured.Fórmula:C26H34F3N7O4SPureza:98.87% - 99.87%Forma y color:SolidPeso molecular:597.65Ref: TM-T14935
1mg87,00€2mg137,00€5mg243,00€10mg393,00€25mg772,00€50mg1.074,00€100mg1.444,00€1mL*10mM (DMSO)320,00€Glibenclamide
CAS:Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.Fórmula:C23H28ClN3O5SPureza:99.05% - 99.75%Forma y color:SolidPeso molecular:494.00CP-628006
CAS:CP-628006 is a small molecule CFTR potentiator that effectively restores ATP-dependent channel gating to G551D-CFTR, the mutant form found in cystic fibrosis.Fórmula:C32H35F3N2O2Forma y color:SolidPeso molecular:536.6394-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine
CAS:4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine is an enantiomericFórmula:C27H28ClFN2OSPureza:99.02%Forma y color:SoildPeso molecular:483.04Ref: TM-T60126
1mg115,00€2mg172,00€5mg255,00€10mg375,00€25mg562,00€50mg787,00€100mg1.074,00€500mgA consultar1mL*10mM (DMSO)304,00€Crofelemer
CAS:Crofelemer (Provir) is an orally active antidiarrheal agent. It targets the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CACC), which are responsible for chloride and fluid secretion in the gastrointestinal tract. Crofelemer is applicable for research in diarrhea-related conditions.Forma y color:Solid(Rac)-Tezacaftor
CAS:(Rac)-Tezacaftor, a racemate, corrects F508del CFTR for cystic fibrosis research.Fórmula:C26H27F3N2O6Forma y color:SolidPeso molecular:520.5Vanzacaftor
CAS:Vanzacaftor is a CFTR modulator improving protein processing and surface trafficking, restoring chloride transport and aiding cystic fibrosis therapy research.Fórmula:C32H39N7O4SPureza:99.14%Forma y color:SolidPeso molecular:617.76Astressin 2B
CAS:<p>CRF2 antagonist with IC50 of 1.3 nM; >500 nM for CRF1. Aids gastric emptying.</p>Fórmula:C183H307N49O53Pureza:98%Forma y color:SolidPeso molecular:4041.69CFTR activator 2
CAS:CFTR activator 2 (WAY-326769) is an activator of mutant CFTR (cystic fibrosis transmembrane conductance regulator), which increases ion transport activity and can be used for research into cystic fibrosis (CF).Fórmula:C27H27N3O3Pureza:99.70%Forma y color:SolidPeso molecular:441.52H2-Gamendazole
CAS:<p>H2-Gamendazole: inhibits spermatogenesis, cancer therapy, targets heat shock proteins & EF1α, regulates Hsp90.</p>Fórmula:C18H13Cl2F3N2O2Pureza:97.36%Forma y color:SolidPeso molecular:417.21WAY-326766
CAS:WAY-326766 increases ion transport through mutant CFTR and can be used to alter the lifespan of eukaryotes.WAY-326766 can be used to treat cystic fibrosis (CF).Fórmula:C21H23N3O5Pureza:99.87%Forma y color:SolidPeso molecular:397.42Zatonacaftor
CAS:Zatonacaftor, a cystic fibrosis transmembrane regulator (CFTR) modulator, is utilized in the research of cystic fibrosis [1] [2].Fórmula:C24H27N3O4SForma y color:SolidPeso molecular:453.55(R)-BPO-27
CAS:(R)-BPO-27 is an orally active and potent ATP-competitive CFTR inhibitor (IC50: 4 nM) for the study of diarrhoea and polycystic kidney.Fórmula:C26H18BrN3O6Pureza:99.1%Forma y color:SolidPeso molecular:548.34Crinecerfont hydrochloride
CAS:SSR-125543, a potent CRF1 receptor non-peptide antagonist, effective in CAH research, taken orally.Fórmula:C27H29Cl2FN2OSForma y color:SolidPeso molecular:519.5KM11060
CAS:KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasmaFórmula:C19H17Cl2N3O2SPureza:98.86%Forma y color:SolidPeso molecular:422.33Icenticaftor
CAS:Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.Fórmula:C12H13F6N3O3Pureza:99.76%Forma y color:SolidPeso molecular:361.24Ref: TM-T9499
1mg160,00€5mg329,00€10mg495,00€25mg792,00€50mg1.111,00€100mg1.578,00€200mg2.137,00€1mL*10mM (DMSO)261,00€Tezacaftor
CAS:Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.Fórmula:C26H27F3N2O6Pureza:98.84% - >99.99%Forma y color:SolidPeso molecular:520.5Ref: TM-T2263
1mg40,00€2mg52,00€5mg82,00€10mg123,00€25mg212,00€50mg343,00€100mg505,00€1mL*10mM (DMSO)88,00€IOWH-032
CAS:IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.Fórmula:C22H15Br2N3O4Pureza:98.92% - ≥95%Forma y color:SolidPeso molecular:545.18Ataluren
CAS:Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations.Fórmula:C15H9FN2O3Pureza:99.16% - 99.84%Forma y color:SolidPeso molecular:284.24Ref: TM-T1805
5mg38,00€10mg57,00€25mg93,00€50mg124,00€100mg188,00€200mg225,00€500mg379,00€1mL*10mM (DMSO)48,00€PPQ-102
CAS:PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).Fórmula:C26H22N4O3Pureza:98.80% - ≥95%Forma y color:SolidPeso molecular:438.48
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