P-gp
La P-glicoproteína es una bomba de eflujo dependiente de ATP que transporta una amplia variedad de sustratos, incluidos medicamentos, toxinas y lípidos, fuera de las células. Desempeña un papel crucial en la resistencia a los medicamentos, particularmente en el cáncer, al reducir la concentración intracelular de agentes quimioterapéuticos. La P-gp también está involucrada en la barrera hematoencefálica, influyendo en la exposición del sistema nervioso central a varios compuestos. En CymitQuimica, ofrecemos una gama de moduladores de la P-gp para apoyar su investigación en resistencia a los medicamentos, farmacocinética y desarrollo terapéutico.
Se han encontrado 53 productos de "P-gp"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Atazanavir
CAS:<p>Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.</p>Fórmula:C38H52N6O7Pureza:98% - 99.95%Forma y color:Crystalline SolidPeso molecular:704.86Glibenclamide
CAS:<p>Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.</p>Fórmula:C23H28ClN3O5SPureza:99.05% - 99.75%Forma y color:SolidPeso molecular:494.00Verapamil hydrochloride
CAS:<p>Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.</p>Fórmula:C27H39ClN2O4Pureza:98.7% - 99.98%Forma y color:White To Off-White PowderPeso molecular:491.06Zamicastat
CAS:<p>Zamicastat (BIA 5-1058) inhibits DBH, P-gp (IC50=73.8μM), and BCRP (IC50=17.0μM).</p>Fórmula:C21H21F2N3OSPureza:99.58%Forma y color:SolidPeso molecular:401.47Norverapamil hydrochloride
CAS:<p>Norverapamil HCl, a Verapamil metabolite, blocks L-type calcium channels and inhibits P-gp function.</p>Fórmula:C26H37ClN2O4Pureza:99.47%Forma y color:SolidPeso molecular:477.04Piperine
CAS:<p>Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.</p>Fórmula:C17H19NO3Pureza:98.41% - 98.51%Forma y color:SolidPeso molecular:285.34Encequidar mesylate
CAS:<p>Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.</p>Fórmula:C39H40N6O10SPureza:99.84%Forma y color:SolidPeso molecular:784.83Dofequidar fumarate
CAS:<p>Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through the</p>Fórmula:C34H35N3O7Pureza:99.93%Forma y color:SolidPeso molecular:597.66(20S)-Protopanaxadiol
CAS:<p>(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type</p>Fórmula:C30H52O3Pureza:97.07% - 98.91%Forma y color:SolidPeso molecular:460.73Atazanavir sulfate
CAS:<p>Atazanavir sulfate, an azapeptide HIV-protease inhibitor, treats HIV/AIDS alongside other anti-HIV drugs.</p>Fórmula:C38H52N6O7·H2SO4Pureza:99.31% - 99.40%Forma y color:SolidPeso molecular:802.93Risperidone
CAS:<p>Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.</p>Fórmula:C23H27FN4O2Pureza:99.73%Forma y color:Crystalline SolidPeso molecular:410.48Trifluoperazine dihydrochloride
CAS:<p>Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.</p>Fórmula:C21H26Cl2F3N3SPureza:99.57% - 99.96%Forma y color:Cream Fine PowderPeso molecular:480.43Tariquidar methanesulfonate hydrate
CAS:<p>m-PEG8-Ms is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC compounds.</p>Fórmula:C40H58N4O18S2Pureza:98.13%Forma y color:SolidPeso molecular:947.04Laniquidar TFA
<p>Laniquidar TFA (R101933), a non-competitive P-gp inhibitor, has an IC50 of 0.51 μM; used to study AML and MDS, but with limited bioavailability.</p>Fórmula:C39H37F3N4O5Pureza:99.85%Forma y color:SoildPeso molecular:698.73Evodine
CAS:<p>1. Evodine has antinociceptive activity.</p>Fórmula:C18H19NO5Pureza:98%Forma y color:SolidPeso molecular:329.35P-gp inhibitor 14
CAS:<p>Compound 8a, also known as P-gp inhibitor 14, demonstrates high affinity as a P-gp inhibitor and effectively reverses P-gp-mediated multidrug resistance (EC 50 = 48.74 nM). Additionally, this compound exhibits a weak inhibitory effect on CYP3A4 activity [1].</p>Fórmula:C37H38N2O8Forma y color:SolidPeso molecular:638.71CPI1
<p>CPI1 is an effective and highly specific inhibitor of multidrug resistance protein 1 (MRP1). It exhibits inhibitory activity against MRP1 at the nanomolar level (Ki: 100 nM) and has minimal effect on P-glycoprotein (Pgp). CPI1 competes with LTC4 for binding to the same site on MRP1, inhibiting ATP hydrolysis and substrate transport. It is useful in research related to drug delivery and addressing cancer chemotherapy resistance.</p>Fórmula:C111H131N23O30SForma y color:SolidPeso molecular:2299.43Valspodar
CAS:<p>Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.</p>Fórmula:C63H111N11O12Pureza:95% - >99.99%Forma y color:SolidPeso molecular:1214.62P-gb-IN-1
CAS:<p>P-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow.</p>Fórmula:C30H28N2O6Pureza:99.58%Forma y color:SoildPeso molecular:512.55YS-370
CAS:<p>YS-370 orally blocks P-gp, moderately inhibits CYP3A4, reverses drug resistance, and enhances paclitaxel's anticancer effects.</p>Fórmula:C37H35BrN4O3Pureza:98.055%Forma y color:SolidPeso molecular:663.6
