Canal de sodio
Los canales de sodio son proteínas de membrana esenciales que permiten el paso de iones de sodio (Na+) a través de la membrana celular, generando y propagando señales eléctricas en neuronas, células musculares y otros tejidos excitables. Estos canales son vitales para la iniciación y conducción de potenciales de acción, lo que los hace cruciales en procesos como la transmisión de impulsos nerviosos, la contracción muscular y la función cardíaca. La desregulación de los canales de sodio puede llevar a trastornos neurológicos, arritmias y condiciones de dolor crónico. En CymitQuimica, ofrecemos una variedad de moduladores de canales de sodio para apoyar su investigación en neurobiología, cardiología y manejo del dolor.
Se han encontrado 258 productos de "Canal de sodio"
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NHE-1-IN-2
NHE-1-IN-2 (compound 7g) is a potent NHE-1 inhibitor with an IC50 of 0.78 μM. It mitigates left ventricular systolic dysfunction in mouse models of heart failure.Fórmula:C23H20ClN3O3Forma y color:SolidPeso molecular:421.11932Ceratotoxin-2
CAS:Ceratotoxin-2 (CcoTx2) is a voltage-gated sodium channel inhibitor, demonstrating half maximal inhibitory concentrations (IC50) of 8 nM for Na v 1.2/β 1 and 88Fórmula:C177H260N52O49S6Pureza:98%Forma y color:SolidPeso molecular:4092.67Zoniporide
CAS:Zoniporide (CP-597396) is an NHE-1 inhibitor that inhibits platelet swelling and can be used in the study of cardiovascular diseases.Fórmula:C17H16N6OPureza:99.74%Forma y color:SolidPeso molecular:320.35δ-Buthitoxin-Hj1a
δ-Buthitoxin-Hj1a, a scorpion-venom peptide, functions as a potent agonist for the NaV1.1 channel, exhibiting an EC50 value of 17 nM.Fórmula:C326H482N92O96S8Pureza:98%Forma y color:SolidPeso molecular:7482.39Jingzhaotoxin-34
Jingzhaotoxin-34, a 35-residue neurotoxic polypeptide, selectively inhibits tetrodotoxin-sensitive (TTX-S) sodium currents in rat dorsal root ganglion neuronsFórmula:C154H219N39O45S7Pureza:98%Forma y color:SolidPeso molecular:3561.08m3-Huwentoxin IV
m3-Huwentoxin IV (m3-HwTx-IV) is a potent inhibitor of sodium channels (NaV), exhibiting half-maximal inhibitory concentrations (IC50s) of 3.3 nM for hNaV1.7, 6Fórmula:C170H271N53O46S6Pureza:98%Forma y color:SolidPeso molecular:3985.69ω-Conotoxin CVIB
CAS:ω-Conotoxin CVIB is an antagonist of non-selective N- and P/Q-type voltage-gated calcium channels (VGCCs).Fórmula:C102H173N41O32S7Pureza:98%Forma y color:SolidPeso molecular:2710.18Jingzhaotoxin-II
Jingzhaotoxin-II, a neurotoxin composed of 32 amino acid residues featuring two acidic and two basic residues, selectively inhibits voltage-gated sodiumFórmula:C154H219N39O45S7Pureza:98%Forma y color:SolidPeso molecular:3561.081-(1-Methyl-1h-pyrazol-4-yl)-ethanone
CAS:1-(1-Methyl-1h-pyrazol-4-yl)-ethanone is a high purity biochemical reagent that can be used in research related to life sciences.Fórmula:C6H8N2OPureza:99.92%Forma y color:SolidPeso molecular:124.14µ-Conotoxin KIIIA
CAS:μ-Conotoxin KIIIA, an analgesic compound derived from Conus kinoshitai, selectively inhibits mammalian neuronal voltage-gated sodium channels (VGSCs) (Nav1.2),Fórmula:C70H106N28O22S6Pureza:98%Forma y color:SolidPeso molecular:1884.16Hainantoxin-III
CAS:Jingzhaotoxin-V is a peptide that suppresses potassium currents in Xenopus laevis oocytes, exhibiting an IC50 of 604.2 nM, while concurrently targeting bothFórmula:C154H228N44O45S6Pureza:98%Forma y color:SolidPeso molecular:3608.125-Tridecanol
CAS:5-Tridecanol blocks ion flux in sodium channels.Fórmula:C13H28OPureza:97.87%Forma y color:SolidPeso molecular:200.36APETx2
CAS:ASIC3 inhibitor; IC50: 63 nM (rat), 175 nM (human). Blocks NaV1.8, NaV1.2; analgesic for acid/inflammatory pain.Fórmula:C196H280N54O61S6Pureza:98%Forma y color:SolidPeso molecular:4561.06Mambalgin 1
CAS:ASIC1a inhibitor; IC50: 192 nM (human), 72 nM (dimer); inactive channel binding; selective; pain response delay.Fórmula:C272H429N85O84S10Pureza:98%Forma y color:SolidPeso molecular:6554.51π-TRTX-Hm3a
π-TRTX-Hm3a, a 37-amino acid peptide derived from the venom of the Togo starburst tarantula (Heteroscodra maculata), selectively inhibits the acid-sensing ionFórmula:C186H290N56O49S6Pureza:98%Forma y color:SolidPeso molecular:4287.03µ-Conotoxin BuIIIB
CAS:μ-Conotoxin BuIIIB (Mu-Conotoxin BuIIIB), a selective blocker of mammalian neuronal voltage-gated sodium channels (VGSC), is derived from Cone snail venom andFórmula:C106H172N46O30S6Pureza:98%Forma y color:SolidPeso molecular:2763.18Hm1a
Hm1a, a disulfide-rich spider-venom peptide and NaV1.1 activator, reestablishes the function of inhibitory interneurons in a Dravet syndrome (DS) mouse model [1Fórmula:C170H239N47O54S6Pureza:98%Forma y color:SolidPeso molecular:3997.39ProTx II
CAS:Selective NaV1.7 inhibitor, alters activation, reduces current, 100x more selective for 1.7 over other Na+ channels.
Fórmula:C168H250N46O41S8Pureza:98%Forma y color:SolidPeso molecular:3826.59µ-Conotoxin-CnIIIC acetate
µ-Conotoxin-CnIIIC acetate is a NaV1.4 sodium channel antagonist, a conotoxin peptide consisting of 22 amino acids, used for muscle relaxation and pain relief.Fórmula:C92H139N35O28S6·xC2H4O2Pureza:99.94%Forma y color:SolidPeso molecular:2375.70 (free base)Dc1a
Dc1a, a toxin isolated from the desert bush spider Diguetia canities [1], potently facilitates the opening of the German cockroach Na v channel (BgNa v 1).Fórmula:C276H414N76O84S8Pureza:98%Forma y color:SolidPeso molecular:6397.22
