HIF / HIF Prolilhidroxilasa
El Factor Inducible por Hipoxia (HIF) es un factor de transcripción que desempeña un papel crucial en las respuestas celulares a bajos niveles de oxígeno (hipoxia). La actividad del HIF está regulada estrictamente por las prolil-hidroxilasas de HIF, que dirigen al HIF para su degradación en condiciones normóxicas. Los inhibidores de la prolil-hidroxilasa de HIF pueden estabilizar el HIF, promoviendo la expresión de genes involucrados en la angiogénesis, la eritropoyesis y el metabolismo. Estos inhibidores son de gran interés en el tratamiento de afecciones como la anemia, las enfermedades isquémicas y el cáncer. En CymitQuimica, ofrecemos inhibidores de HIF/prolil-hidroxilasa HIF para apoyar su investigación en biología de la hipoxia, terapia del cáncer y regulación metabólica.
Se han encontrado 145 productos para "HIF / HIF Prolilhidroxilasa".
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Roxadustat
CAS:Roxadustat (FG-4592) is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.Fórmula:C19H16N2O5Pureza:99% - 99.88%Forma y color:Yellow SolidPeso molecular:352.34SYP-5
CAS:SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.Fórmula:C18H16O3SPureza:98.31%Forma y color:SolidPeso molecular:312.38HIF-2α-IN-2
CAS:HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).Fórmula:C17H13F2NO4SPureza:99.24%Forma y color:White SolidPeso molecular:365.35Amifostine
CAS:Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.Fórmula:C5H15N2O3PSPureza:99.59% - 99.91%Forma y color:White SolidPeso molecular:214.22(-)-Hydroxycitric acid lactone
CAS:(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent.(-)-Hydroxycitric acid lactone was a potent inhibitor of ATP citrate lyase, whichFórmula:C6H6O7Pureza:99.85% - 99.91%Forma y color:White SolidPeso molecular:190.11Molidustat
CAS:Molidustat (BAY 85-3934) 是新型HIF-PH 抑制剂，对PHD1(IC50:480 nM)、PHD2(IC50:280 nM)、PHD3(IC50:450 nM)。Fórmula:C13H14N8O2Pureza:98.79% - 99.79%Forma y color:White SolidPeso molecular:314.3Vadadustat
CAS:Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.Fórmula:C14H11ClN2O4Pureza:99.02% - 99.80%Forma y color:SolidPeso molecular:306.7Albendazole
CAS:Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.Fórmula:C12H15N3O2SPureza:98.21% - 98.76%Forma y color:Colorless Crystals SolidPeso molecular:265.33EHP-101
CAS:EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.Fórmula:C28H35NO3Pureza:98.36%Forma y color:SolidPeso molecular:433.58Ref: TM-T13289
1mg101,00€5mg178,00€1mL*10mM (DMSO)203,00€10mg295,00€25mg485,00€50mg677,00€100mg888,00€Deferoxamine Mesylate
CAS:Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.Fórmula:C26H52N6O11SPureza:94.68% - 99.91%Forma y color:White SolidPeso molecular:656.79PT2399
CAS:PT2399, an oral HIF-2 inhibitor, blocks HIF-2α/1β dimerization, showing strong in vivo antitumor effects.Fórmula:C17H10F5NO4SPureza:98.8% - 99.45%Forma y color:White SolidPeso molecular:419.32Ref: TM-T12675L
1mg88,00€5mg212,00€1mL*10mM (DMSO)233,00€10mg318,00€25mg575,00€50mg848,00€100mg1.189,00€Minocycline hydrochloride
CAS:Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.Fórmula:C23H28ClN3O7Pureza:99.71% - >99.99%Forma y color:Yellow SolidPeso molecular:493.94Oltipraz
CAS:Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties.Fórmula:C8H6N2S3Pureza:98.79% - 99.77%Forma y color:SolidPeso molecular:226.34Glucosamine
CAS:Glucosamine (Chitosamine) is used as a dietary supplement. Glucosamine has pharmacological effects on osteoarthritis cartilage. High-Quality, Low-Cost!Fórmula:C6H13NO5Pureza:99.68% - 99.8%Forma y color:SolidPeso molecular:179.17Hydroxycitric acid tripotassium hydrate
CAS:Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits HIF, has antioxidation, anti-inflammation, and anti-tumor effects.Fórmula:C6H7K3O8Pureza:99.85%Forma y color:White Solid CrystallinePeso molecular:324.41Glucosamine hydrochloride
CAS:Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.Fórmula:C6H13NO5·HClPureza:99.77% - 99.96%Forma y color:White SolidPeso molecular:215.63Citric acid trilithium salt tetrahydrate
CAS:Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy ofFórmula:C6H13Li3O11Pureza:99.88%Forma y color:White SolidPeso molecular:281.98Hydralazine hydrochloride
CAS:Hydralazine hydrochloride, an antihypertensive phthalazine, induces vasodilation and may inhibit tumor DNA methylation.Fórmula:C8H9ClN4Pureza:99.85% - 99.86%Forma y color:White SolidPeso molecular:196.64Enarodustat
CAS:Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.Fórmula:C17H16N4O4Pureza:99.73% - 99.75%Forma y color:SolidPeso molecular:340.33Ref: TM-T15219
1mg37,00€2mg52,00€5mg74,00€1mL*10mM (DMSO)86,00€10mg109,00€25mg178,00€50mg295,00€100mg439,00€Chloramphenicol
CAS:Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.Fórmula:C11H12Cl2N2O5Pureza:99.6% - 99.90%Forma y color:White SolidPeso molecular:323.13Tilorone dihydrochloride
CAS:Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.Fórmula:C25H36Cl2N2O3Pureza:98% - 99.86%Forma y color:Orange SolidPeso molecular:483.47ISM012-042
ISM012-042 is an orally active inhibitor of PHD1 and PHD2, with IC50 values of 1.9 and 2.5 nM, respectively. At a concentration of 2.5 μM, ISM012-042 protects Caco-2 cells from DSS-induced barrier damage. Additionally, in LPS-induced bone marrow-derived dendritic cells (BMDC) from mice, ISM012-042 exhibits anti-inflammatory properties by dose-dependently reducing the expression of IL-12 subunit IL-12p35 and TNF. It also restores intestinal barrier function and alleviates intestinal inflammation in various experimental colitis models. ISM012-042 is useful for studying intestinal mucosal repair and immune disorders.Fórmula:C26H28N6O4Forma y color:SolidPeso molecular:488.538HIF-1α-IN-2 hydrochloride
HIF-1α-IN-2 hydrochloride is a potent HIF-1α inhibitor exhibiting anticancer activity, demonstrated by IC50 values of 28 nM in MDA-MB-231 cells and 15 nM inFórmula:C21H20ClN3OSPureza:98%Forma y color:SolidPeso molecular:397.92HIF-1α-IN-6
HIF-1α-IN-6 (compound 3s) is a potent inhibitor of HIF-1α, demonstrating IC50 values of 0.6 nM and 53.3 nM in MiaPaCa-2 and MDA-MB-231 cells, respectively.Pureza:98%Forma y color:Odour SolidAxl-IN-16
Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptorFórmula:C14H19ClO8Pureza:98%Forma y color:SolidPeso molecular:350.75(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine
CAS:(S,R,S)-AHPC-C2-amide targets Smad3 degradation and boosts HIF-α; it has anti-fibrotic and renal protective roles.Fórmula:C41H46N6O6SForma y color:SolidPeso molecular:750.91ML228
CAS:ML228 activates HIF pathway and VEGF, with EC50 of 1μM, effective in vitro.Fórmula:C27H21N5Pureza:99.54%Forma y color:SolidPeso molecular:415.49VHL-IN-1
VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α andFórmula:C28H37FN4O4SPureza:98%Forma y color:SolidPeso molecular:544.68HIF-1 α (556-574)
CAS:HIF-1 alpha (556-574) is a 19-mer fragment vital for gene expression in low oxygen; it binds VHL with critical proline 564 for stability.Fórmula:C101H150D2N20O34S2Pureza:98%Forma y color:SolidPeso molecular:2254.6Adaptaquin
CAS:Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].Fórmula:C21H16ClN3O2Pureza:99.75%Forma y color:SolidPeso molecular:377.82ZG-2033
CAS:ZG-2033 (Compound 26) is an orally active HIF-2α agonist that exhibits nanomolar activity (EC50 = 490 nM) in a luciferase reporter assay. It demonstrates an anti-anemic effect and shows synergistic effects with AKB-6548 in anemia, making it useful for the study of renal anemia.Fórmula:C15H14N2O2SForma y color:SolidPeso molecular:286.35HIV-IN-7
Axl-IN-16 (Compound 4), an Axl inhibitor, not only suppresses Axl expression and HIF activity but also triggers fruiting body formation in Flammulina velutipes.Fórmula:C32H61N3O10P2Pureza:98%Forma y color:SolidPeso molecular:709.79NF-κB/HIF-1α-IN-1
NF-κB/HIF-1α-IN-1 (compound 9c) effectively inhibits the NF-κB activation pathway and demonstrates selective antifibrotic activity. This compound exhibits no significant cytotoxicity in NCI tumor cell lines. In rat models, NF-κB/HIF-1α-IN-1 successfully ameliorates liver fibrosis, suppresses the expression levels of NF-κB and HIF-1α, and induces Nrf2.Fórmula:C24H27N7O4Forma y color:SolidPeso molecular:477.21245HIF-1 inhibitor-4
CAS:HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM.Fórmula:C18H19IN2O2Pureza:99.26%Forma y color:SolidPeso molecular:422.26cisVH 298
CAS:cisVH 298 is a negative control for VH 298. Exhibits no detectable binding of VHL.Fórmula:C27H33N5O4SForma y color:SolidPeso molecular:523.65Izilendustat
CAS:Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.Fórmula:C22H28ClN3O4Pureza:99.86%Forma y color:White SolidPeso molecular:433.93Casdatifan
CAS:Casdaitifan (AB521) is an orally active hypoxia inducible factor 2 alpha (HIF-2 alpha) inhibitor. Casdaitifan exhibits significant anti-tumor effects in the clear cell renal cell carcinoma (ccRCC) model.Fórmula:C21H17F4NO3SPeso molecular:439.42HSP90-IN-30
HSP90-IN-30 (compound 3e) inhibits the activity of the HSP90 molecular chaperone. Under hypoxic conditions, HSP90-IN-30 suppresses HIF-1 transcriptional activity with an IC50 value of 2.16 μM.Fórmula:C20H39B12N4O2Forma y color:SolidPeso molecular:499.41897HIF-PHD-IN-4
HIF-PHD-IN-4 (Compound 13) is an orally active PHD2 inhibitor with an IC50 of 100 nM. At a dose of 2 mg/kg, it effectively enhances G-CSF-induced mobilization of hematopoietic stem cells in mice. HIF-PHD-IN-4 is suitable for research in the oncology field.Forma y color:Odour SolidTAT-cyclo-CLLFVY
CAS:Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).Fórmula:C111H188N42O24S2Pureza:98%Forma y color:SolidPeso molecular:2559.1HIF-1 inhibitor-5
HIF-1 inhibitor-5 (Compound 16e) is a potent inhibitor of HIF-1, exhibiting an IC50 value of 2.38 μM and demonstrating significant anti-angiogenic potential [1Fórmula:C28H35NO5Forma y color:SolidPeso molecular:465.58HIF1-IN-3
CAS:HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used inFórmula:C26H24N2O3Pureza:99.59%Forma y color:White SolidPeso molecular:412.48ZG-2305
CAS:ZG-2305, Selective oral FIH inhibitor (Ki=79.6 nM), increases EGLN3 expression, reduces lipids, for obesity and fatty liver disease research.Fórmula:C17H11Cl2N3O5Forma y color:SolidPeso molecular:408.19HIF-1 α (556-574) (TFA)
HIF-1 alpha (556-574) TFA is a 19-residue fragment of hypoxia-inducible factor-1 (HIF-1), which serves as the master regulator of oxygen homeostasis [1].Pureza:98%Forma y color:Odour SolidMersalyl
CAS:Mersalyl is an organic mercurial diuretic.Fórmula:C13H16HgNNaO6Forma y color:SolidPeso molecular:505.854Fibrostatin C
CAS:Fibrostatin C is an inhibitor of prolyl 4-hydroxylase. It is produced by Streptomyces catenulae subsp.Fórmula:C18H19NO8SForma y color:SolidPeso molecular:409.41Sirtuin modulator 2
CAS:Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.Fórmula:C19H15N3O2SPureza:99.67%Forma y color:Yellow SolidPeso molecular:349.41Zifcasiran
CAS:Zifcasiran reduces HIF synthesis, has antitumor properties, useful in renal carcinoma studies.Fórmula:C737H972F20N211O349P43S8Forma y color:SolidPeso molecular:20339.131,4-DPCA
CAS:1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibitingFórmula:C13H8N2O3Pureza:97.77%Forma y color:SolidPeso molecular:240.21Ref: TM-T21653
5mg49,00€1mL*10mM (DMSO)54,00€10mg79,00€25mg144,00€50mg222,00€100mg356,00€200mg525,00€500mg837,00€Daprodustat
CAS:Daprodustat (GSK1278863) is a HIF-prolyl hydroxylase inhibitor.Fórmula:C19H27N3O6Pureza:97% - 99.82%Forma y color:SolidPeso molecular:393.43
