AChR
Los inhibidores del receptor de acetilcolina (AChR) son compuestos que bloquean la actividad de los receptores de acetilcolina, que son críticos para la neurotransmisión en los sistemas nerviosos central y periférico. Los AChRs juegan un papel vital en la contracción muscular, la memoria y las funciones cognitivas. Los inhibidores de los AChRs se utilizan para estudiar afecciones como la miastenia gravis, la enfermedad de Alzheimer y otros trastornos neurológicos. Al modular la actividad de los AChRs, estos inhibidores pueden ayudar a desentrañar las complejidades de la señalización colinérgica en el cerebro. En CymitQuimica, ofrecemos una gama de inhibidores de AChR para apoyar su investigación en neurociencia, farmacología y enfermedades neurodegenerativas.
Se han encontrado 625 productos para "AChR".
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8-Aminoadenine
CAS:8-Aminoadenine (7H-purine-6,8-diamine) is a ligand for Adenine Receptor with Ki of 0.0341 μM.Fórmula:C5H6N6Pureza:99.82%Forma y color:SolidPeso molecular:150.14Dicyclomine hydrochloride
CAS:Dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence.Fórmula:C19H36ClNO2Pureza:99.81%Forma y color:SolidPeso molecular:345.948Adiphenine hydrochloride
CAS:Adiphenine hydrochloride (Patrovina), a nicotinic receptor inhibitor, can be used as an antispasmodic drug.Fórmula:C20H26ClNO2Pureza:97.76% - 99.53%Forma y color:White Or Almost White PowderPeso molecular:347.879TAK-071
CAS:TAK-071 is a potent, novel and highly selective modulator of muscarinic acetylcholine receptor 1 (M1R) positive allosteric(EC50 : 520 nM).Fórmula:C24H24FN3O3Pureza:98.02% - 99.82%Forma y color:SolidPeso molecular:421.4641Nefiracetam
CAS:Nefiracetam (DM9384), in Phase 2 trials, enhances GABA, choline, monoamine systems, and treats Ro 5-4864 convulsions.Fórmula:C14H18N2O2Pureza:97.37%Forma y color:SolidPeso molecular:246.3TDI-10229
CAS:TDI-10229: potent oral sAC inhibitor, IC50=195 nM. Good mouse pharmacokinetics for in vivo use.Fórmula:C16H16ClN5Pureza:99.85% - 99.89%Forma y color:White SolidPeso molecular:313.785Rivanicline hydrochloride
Rivanicline (RJR-2403) hydrochloride is an agonist of neuronal nicotinic receptors. It shows high selectivity for nAChR in the rat cerebral cortex (Ki= 26 nM, EC50= 732 nM) and the α4β2 subtype (Ki= 26 nM, EC50= 16 μM). This compound effectively restores learning and cognitive function impairments and is applicable in research on neurodegenerative diseases such as schizophrenia or Alzheimer's disease.M3/PDE4 modulator-1
M3/PDE4 Modulator-1 (compound 10f) serves as a bifunctional entity functioning both as an M3 mAChR antagonist and a PDE4 inhibitor.Fórmula:C38H41Cl2N3O8SForma y color:SolidPeso molecular:770.72Emraclidine
CAS:Emraclidine (CVL-231) is a novel, highly selective allosteric modulator of the muscarinic M4 receptor positive receptor.Cost-effective and quality-assured.Fórmula:C20H21F3N4OPureza:99.63% - 99.96%Forma y color:White SolidPeso molecular:390.4021Guvacoline hydrobromide
CAS:Guvacoline hydrobromide is a pyridine alkaloid and a full agonist of mAChR in the atrium and ileum.Fórmula:C7H12BrNO2Pureza:98%Forma y color:White SolidPeso molecular:222.08N-Ethyl-N-(3-pyridylmethyl)amine
CAS:N-Ethyl-N-(3-pyridylmethyl)amine has affinity for nAChR (Ki = 0.97 µM) and can be used in related research in the field of life sciences.Fórmula:C8H12N2Pureza:99.65%Forma y color:SolidPeso molecular:136.1943Navafenterol
CAS:AZD-8871, a potential COPD and asthma treatment, may work well with ICS.Fórmula:C38H42N6O6S2Forma y color:SolidPeso molecular:742.91Hydroxybupropion
CAS:Hydroxybupropion is the major active metabolite of Bupropion and an antagonist of nACh receptor. Hydroxybupropion inhibits norepinephrine uptake (IC50 = 1.7 μM).Fórmula:C13H18ClNO2Pureza:99.73%Forma y color:Off-White SolidPeso molecular:255.741GeX-2
CAS:GeX-2 is a truncated analogue of αO-conotoxin. It has the ability to activate GABAB receptors and inhibit α9α10nAChR as well as CaV2.2 channels. Additionally, GeX-2 is effective in alleviating pain in a rat model of chronic constriction injury.Fórmula:C103H169N43O27Forma y color:SolidPeso molecular:2441.72ANQ-9040
CAS:ANQ-9040 is a nondepolarizing neuromuscular relaxant of the steroid class.Fórmula:C36H58N2O5SForma y color:SolidPeso molecular:630.92Octamylamine
CAS:Octamylamine is a bioactive chemical.Fórmula:C13H29NForma y color:SolidPeso molecular:199.3761Anabaseine
CAS:Anabaseine is a broad nicotinic agonist, favoring alpha-7 AChRs in muscle/brain, and weakly stimulates alpha-4 beta-2 nAChRs.Fórmula:C10H12N2Forma y color:SolidPeso molecular:160.22nAChR agonist 2
CAS:Compound 8, identified as a selective alpha4beta2 (α4β2) neuronal acetylcholine receptor (nAChR) agonist, demonstrates a dissociation constant (Kd) of 26 nM,Fórmula:C11H16N2Forma y color:SolidPeso molecular:176.263LtIA-F
LtIA-F, a fluorescent LtIA derivative, aids study of α3β2 nAChR's structure, distribution, and binding domain.Fórmula:C86H121N25O22S4Forma y color:SolidPeso molecular:1985.31
