Proteasas / Proteasoma
Los inhibidores de proteasas y proteasomas son compuestos que bloquean la actividad de las proteasas y del proteasoma, que están involucrados en la degradación y renovación de proteínas. Estos inhibidores son vitales para estudiar la regulación de la homeostasis proteica, el control del ciclo celular y la apoptosis. Los inhibidores de proteasas y proteasomas también se utilizan en el tratamiento de enfermedades como el cáncer, donde la degradación anormal de proteínas desempeña un papel en la progresión de la enfermedad. Al inhibir las proteasas o el proteasoma, estos compuestos pueden inducir la muerte celular en células cancerosas y son herramientas esenciales tanto en la investigación básica como en el desarrollo terapéutico. En CymitQuimica, ofrecemos una amplia gama de inhibidores de proteasas y proteasomas de alta calidad para apoyar su investigación en bioquímica, biología celular y desarrollo de fármacos.
Subcategorías de "Proteasas / Proteasoma"
- Acetil-CoA Carboxilasa(35 productos)
- Cisteína proteasa(96 productos)
- DPP-4(20 productos)
- Glutaminasa(40 productos)
- Proteasa del VIH(450 productos)
- PAI-1(25 productos)
- Inhibidores de la proteasa(50 productos)
- Receptor activado por proteasa(53 productos)
- Proteasoma(94 productos)
- Serina proteasa(50 productos)
- p97(14 productos)
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Se han encontrado 1044 productos de "Proteasas / Proteasoma"
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XL-784
CAS:XL-784 is a selective MMP inhibitor with low IC50s for MMP-1,2,3,8,9,13, modulating extracellular matrix remodeling, tumor invasion, and metastasis in cancer.Fórmula:C42H42Cl2F4MgN6O16S2Pureza:98%Forma y color:SolidPeso molecular:1122.15O-Benzoylhydroxylamine
CAS:<p>O-Benzoyl hydroxylamine exhibits properties as a dipeptidyl peptidase-IV (DPP-IV) inhibitor and demonstrates antidiabetic effects[1].</p>Fórmula:C7H7NO2Forma y color:SolidPeso molecular:137.14Neurodegenerative Disorder-Targeting Compound 1
CAS:<p>Neurodegenerative Disorder-Targeting Compound 1 is an inhibitor of calpain [1].</p>Fórmula:C28H28N4O4Pureza:98%Forma y color:SolidPeso molecular:484.55BMS-189664
CAS:<p>BMS-189664 is an inhibitor of thrombin.</p>Fórmula:C22H34N6O4SPureza:98%Forma y color:SolidPeso molecular:478.61MMP-3 Inhibitor VIII
CAS:<p>Matrix metalloproteinase-3 (MMP-3), also known as stromelysin-1, is a critical enzyme involved in tissue remodeling and repair through its role in degrading extracellular matrix proteins, facilitating cell migration. This enzyme has been implicated in various physiological processes including vascular remodeling associated with aneurysm formation, wound healing, the progression of atherosclerosis, and tumor initiation. MMP-3 inhibitor VIII, a cell-permeable sulfonamide-based hydroxamic acid, effectively inhibits MMP-3 by binding to its active site (Ki = 23 nM), thus blocking its enzymatic activity. Additionally, this inhibitor has been demonstrated to suppress the activity of mouse macrophage metalloelastase MME/MMP-12, with an IC50 value of 13 nM, highlighting its potential utility in research on tissue remodeling and disease processes involving MMPs.</p>Fórmula:C20H26N2O5SForma y color:SolidPeso molecular:406.5GSK-625433
CAS:<p>GSK-625433: Homochiral inhibitor blocks HCV genotypes 1a/1b polymerase.</p>Fórmula:C26H32N4O5SForma y color:SolidPeso molecular:512.62DS-1040 Tosylate
CAS:<p>DS-1040 Tosylate is a thrombin-activated fibrinolysis inhibitor (TAFI) inhibitor and a fibrinolysis enhancer, used for researching thromboembolic diseases.</p>Fórmula:C23H35N3O5SForma y color:SolidPeso molecular:465.61Dim16
CAS:<p>Dim16, a dual inhibitor of PCSK9/HMG-CoAR, demonstrates potent activity with an IC50 of 19 nM against PCSK9 and significantly impedes PCSK9-LDLR interaction</p>Fórmula:C29H38IN5Forma y color:SolidPeso molecular:583.55HCV-IN-43
CAS:<p>HCV-IN-43 (compound 2), an HCV NS5B protein inhibitor, efficiently inhibits HCV virus replication and is utilized in the study of HCV infection [1].</p>Fórmula:C26H26FN3O5SForma y color:SolidPeso molecular:511.57EP1013
CAS:<p>EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.</p>Fórmula:C18H23FN2O6Pureza:98%Forma y color:SolidPeso molecular:382.38MMP-7-IN-3
CAS:<p>MMP-7-IN-3 (compound 15) is a potent and selective MMP-7 inhibitor, inhibiting renal fibrosis in a unilateral ureteral obstruction mouse model.</p>Fórmula:C34H43ClF3N7O9SPureza:99.915%Forma y color:SolidPeso molecular:818.26Beclabuvir HCl
CAS:<p>Beclabuvir (BMS-791325) is an HCV inhibitor targeting NS5B polymerase with sub-28 nM potency for genotypes 1, 3, 4, 5.</p>Fórmula:C36H46ClN5O5SForma y color:SolidPeso molecular:696.3Paltimatrectinib
CAS:Paltimatrectinib (PBI-200) is a tyrosine kinase inhibitor with anticancer activity, and is used in the study of bladder, breast, and colorectal cancers.Fórmula:C20H15F5N6Pureza:99.96%Forma y color:SolidPeso molecular:434.37Mergetpa
CAS:<p>Mergetpa, a carboxypeptidase inhibitor, impedes the conversion of kinins and B2 receptor antagonists into metabolites devoid of the C-terminal arginine [1].</p>Fórmula:C7H15N3O2S2Pureza:98%Forma y color:SolidPeso molecular:237.34LU-002i
CAS:<p>LU-002i is a selective inhibitor targeting the human proteasome subunits β2c and β2i, demonstrating an inhibitory concentration (IC50) of 220 nM for β2i [1].</p>Fórmula:C35H52N4O7Pureza:98%Forma y color:SolidPeso molecular:640.81MMP3 inhibitor 1
CAS:MMP3 inhibitor 1 is a potent and highly selective inhibitor of MMP-3 (IC50 of 1 nM).Fórmula:C23H31N3O6SPureza:98%Forma y color:SolidPeso molecular:477.57Proteasome-IN-5
CAS:<p>Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1].</p>Fórmula:C20H30BN5O7Pureza:98%Forma y color:SolidPeso molecular:463.29M867
CAS:<p>M867 is a selective, reversible caspase-3 inhibitor, possessing an IC50 of 1.4 nM and a Ki value of 0.7 nM, demonstrating anti-apoptotic activity [1].</p>Fórmula:C27H43N7O6Pureza:98%Forma y color:SolidPeso molecular:561.67Proteasome β2c/i-IN-1
CAS:<p>Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].</p>Fórmula:C32H48N4O7Pureza:98%Forma y color:SolidPeso molecular:600.75ABP 25
CAS:<p>ABP 25 is a highly potent and selective activity-based probe (ABP) for cathepsin K imaging.</p>Fórmula:C55H66ClN5O3Forma y color:SolidPeso molecular:880.6Azt-pmap
CAS:<p>AZT-PMPA, an aryl phosphate derivative of AZT and a nucleoside analogue, demonstrates anti-HIV activity[1].</p>Fórmula:C20H25N6O8PPureza:98%Forma y color:SolidPeso molecular:508.42NCI-B16
CAS:<p>NCI-B16 is a small-molecule RNA binder that inhibits HCV (hepatitis C virus) replication [1].</p>Fórmula:C27H26N8O4Forma y color:SolidPeso molecular:526.55MMP13-IN-3
CAS:MMP13-IN-3 is an oral, selective MMP-13 inhibitor with IC50 of 1 nM, >1000x selective, for osteoarthritis treatment.Fórmula:C24H22N4O5Pureza:99.76%Forma y color:SolidPeso molecular:446.46NK3201
CAS:<p>NK3201, a specific chymase inhibitor, suppresses bleomycin-induced pulmonary fibrosis in hamsters.</p>Fórmula:C31H29N5O6Pureza:98%Forma y color:SolidPeso molecular:567.59Reverse transcriptase-IN-1
CAS:<p>Reverse transcriptase-IN-1 is a diarylbenzopyrimidine (DABP) analogue and a potent inhibitor of HIV-1 nonnucleoside reverse transcriptase with an IC50of 13.7</p>Fórmula:C25H17N7O2Pureza:99.61%Forma y color:SolidPeso molecular:447.45L-689502
CAS:<p>L-689502 is a potent HIV-l protease inhibitor (IC50: 1 nM).</p>Fórmula:C39H51N3O7Pureza:98%Forma y color:SolidPeso molecular:673.84MK-0674
CAS:<p>MK-0674 is a cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S for metabolism-related diseases.</p>Fórmula:C26H27F6N3O2Pureza:97.3% - 99.91%Forma y color:SolidPeso molecular:527.5Filibuvir
CAS:<p>Filibuvir (PF-00868554) inhibits HCV polymerase genotypes 1a/1b, EC50s 59 nM.</p>Fórmula:C29H37N5O3Pureza:99.28% - >99.99%Forma y color:SolidPeso molecular:503.64PDDC inhibitor
CAS:<p>PDDC inhibitor (Phenyl (R)-(1-(3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl)pyrrolidin-3-yl)carbamate) is an nSMase2 inhibitor.</p>Fórmula:C27H29N5O4Pureza:96.09% - 99.39%Forma y color:SolidPeso molecular:487.55Ac-YVAD-AOM
CAS:<p>Ac-YVAD-AOM is a selective and potent caspase-1 inhibitor showing antitumor activity and potential analgesic activity.</p>Fórmula:C33H42N4O10Pureza:98%Forma y color:SolidPeso molecular:654.71Nesbuvir
CAS:<p>Nesbuvir: HCV NS5B polymerase inhibitor, IC50 9 nM against HCV 1b replicon in liver cancer cells.</p>Fórmula:C22H23FN2O5SPureza:99.99%Forma y color:SolidPeso molecular:446.49ZED-1227
CAS:<p>ZED-1227 (TAK-227) is a TG2 inhibitor with anticancer activity that blocks inflammation-induced TG2 expression and activation for the treatment of Celiac Diseas</p>Fórmula:C26H36N6O6Pureza:99.04%Forma y color:SolidPeso molecular:528.6HIV-1 inhibitor-54
CAS:<p>HIV-1 inhibitor-54: potent anti-HIV (EC50: 32 nM), targets WT HIV-1 IIIB in MT-4 cells for infection research.</p>Fórmula:C27H30N6O4SPureza:98.05% - 99.44%Forma y color:SoildPeso molecular:534.63γ-Glu-Tyr
CAS:<p>gamma-Glu-Tyr (gamma-Glutamyltyrosine) is a kokumi peptide against dipeptidyl peptidase-IV (DPP-IV) and is used in the study of diabetes mellitus.</p>Fórmula:C14H18N2O6Pureza:98.92%Forma y color:SolidPeso molecular:310.3Aderamastat
CAS:<p>Aderamastat (FP-025) is an orally active matrix metalloproteinase 12 (MMP-12) inhibitor indicated for the study of allergic asthma, COPD and pulmonary fibrosis.</p>Fórmula:C21H18N2O4SPureza:99.35%Forma y color:SolidPeso molecular:394.44BMS-212122
CAS:<p>BMS-212122 inhibits MTP, reduces lipids and plaque in animal tests.</p>Fórmula:C43H36F6N4O2Pureza:99.18%Forma y color:SolidPeso molecular:754.76Collagen proline hydroxylase inhibitor-1
CAS:<p>Collagen proline hydroxylase inhibitor-1 具有抗纤维增生活性。</p>Fórmula:C24H21N5O4Pureza:99.62%Forma y color:SolidPeso molecular:443.45VBY-825
CAS:<p>VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.</p>Fórmula:C23H29F4N3O5SPureza:99.91%Forma y color:SolidPeso molecular:535.55Freselestat quarterhydrate
<p>ONO-6818 quarterhydrate: oral neutrophil elastase inhibitor, Ki 12.2 nM; >100x less effective on other proteases; strong anti-inflammatory.</p>Fórmula:C23H30N6O5Forma y color:SolidPeso molecular:457.03RO5461111
CAS:<p>RO5461111: Oral Cathepsin S inhibitor, IC50 of 0.4 nM (human) & 0.5 nM (mouse), reduces T/B cell activation, treats lung inflammation & lupus nephritis.</p>Fórmula:C27H24F6N4O4SForma y color:SolidPeso molecular:614.56PNU-248686A
CAS:<p>PNU-248686A is an inhibitor of matrix metalloproteinase (MMP).</p>Fórmula:C22H18ClNaO5S2Pureza:98%Forma y color:SolidPeso molecular:484.95Antiplatelet agent 3
CAS:<p>Antiplatelet agent 3 (Compound K-10) is a compound with antiplatelet aggregation activity, exhibiting IC50 values of 2.55, 3.22, and 2.09 mg/mL for platelet aggregation induced by ADP, AA, and COL, respectively. It holds potential for research in cardiovascular diseases.</p>Fórmula:C38H32N2O5Forma y color:SolidPeso molecular:596.671Tilpisertib fosmecarbil
CAS:<p>Tilpisertib fosmecarbil is a potent inhibitor of serine/threonine kinases with anti-inflammatory properties.</p>Fórmula:C35H36ClN8O7PForma y color:SolidPeso molecular:747.14Faldaprevir
CAS:Faldaprevir is an orally effective, selective, non-covalent HCV NS3/4A protease inhibitor with high inhibitory activity against HCV 1a and 1b genotype.Fórmula:C40H49BrN6O9SPureza:99.04% - 99.19%Forma y color:SolidPeso molecular:869.82Plodicitinib
CAS:<p>Plodicitinib is an inhibitor of Janus tyrosine kinase 3/TEC family kinase, exhibiting anti-inflammatory properties.</p>Fórmula:C19H22FN7O2Forma y color:SolidPeso molecular:399.422Dup-714
CAS:<p>Dup-714 is a thrombin inhibitor.</p>Fórmula:C21H33BN6O5Pureza:98%Forma y color:SolidPeso molecular:460.33Freselestat
CAS:<p>Freselestat (ONO-6818) inhibits neutrophil elastase, reduces interleukin 8, C5B-9, and inflammation in cardiopulmonary bypass.</p>Fórmula:C23H28N6O4Forma y color:SolidPeso molecular:452.51RBx-0597
CAS:<p>RBx-0597 is a selective DPP-IV inhibitor with IC50 values of 32 nM, 31 nM, and 39 nM for human, mouse, and rat plasma DPP-IV, respectively. It is utilized in research focused on type 2 diabetes.</p>Fórmula:C19H20F2N4O2Forma y color:SolidPeso molecular:374.384(1R,3S)-THCCA-Asn
<p>(1R,3S)-THCCA-Asn (4j) is a selective inhibitor of thrombin (IC50: 0.07-0.14 μM) with anti-thrombotic effects.</p>Fórmula:C24H24N4O6Forma y color:SolidPeso molecular:464.47Verducatib
CAS:<p>Verducatib is an inhibitor of cathepsins (cathepsin).</p>Fórmula:C31H35FN4O3Forma y color:SolidPeso molecular:530.633Human enteropeptidase-IN-2
<p>Human enteropeptidase-IN-2 is a potent inhibitor of enteropeptidase (enteropeptidase) and can be used in anti-obesity studies.</p>Fórmula:C20H19F3N4O7Forma y color:SolidPeso molecular:484.38GSK5852
<p>GSK5852, an HCV NS5B inhibitor, has IC50 of 50 nM; potently fights HCV with EC50 of 3.0 nM for GT1a and 1.7 nM for GT1b.</p>Fórmula:C27H27BF2N2O6SForma y color:SolidPeso molecular:556.39HCV-IN-40
CAS:<p>HCV-IN-39 is a potent oral drug inhibiting HCV, effective on GT1a (EC50: 0.259μM), GT1b (EC50: 0.434μM), GT1b CES1 (EC50: 0.069μM) replicons.</p>Fórmula:C21H26BrFN3O9PForma y color:SolidPeso molecular:594.32Zetomipzomib
CAS:<p>KZR-616: Immunoproteasome inhibitor targeting LMP7 (IC50: 39/57 nM) & LMP2 (IC50: 131/179 nM), potential in autoimmune disease research.</p>Fórmula:C30H42N4O8Forma y color:SolidPeso molecular:586.68Deleobuvir
CAS:<p>Deleobuvir(BI207127) is an inhibitor of non-nucleoside hepatitis C virus NS5B polymerase for the treatment of hepatitis C.</p>Fórmula:C34H33BrN6O3Forma y color:SolidPeso molecular:653.57Monosodium 2-sulfoterephthalate
CAS:<p>Monosodium 2-sulfoterephthalate (8) is an inhibitor of glutamate carboxypeptidase II.</p>Fórmula:C8H5NaO7SForma y color:SolidPeso molecular:268.176GW311616
CAS:<p>GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).</p>Fórmula:C19H31N3O4SForma y color:SolidPeso molecular:397.53SCO-792
<p>SCO-792: potent, reversible oral enteropeptidase inhibitor, with slow in vitro dissociation and in vivo protein digestion blocking.</p>Fórmula:C22H22N4O8·xH2OForma y color:SolidEnantiomer of Sofosbuvir
Inactive enantiomer of Sofosbuvir, used for chronic hepatitis C; lacks reported biological activity.Fórmula:C22H29FN3O9PPureza:98%Forma y color:SolidPeso molecular:529.45ABT-072
CAS:<p>ABT-072 is a nonnucleoside NS5B polymerase inhibitor and a candidate drug evaluated for treatment of hepatitis C virus.</p>Fórmula:C24H27N3O5SPureza:98%Forma y color:SolidPeso molecular:469.55Cyclophilin inhibitor 1
CAS:<p>Cyclophilin inhibitor 1: orally available, Kd 5 nM, potent against HCV, EC50 for HCV 2a is 98 nM.</p>Fórmula:C31H39N5O7Pureza:98%Forma y color:SolidPeso molecular:593.67MeO-Suc-Ala-Ala-Pro-Ala-CMK
CAS:<p>MeO-Suc-Ala-Ala-Pro-Ala-CMK (MSACK) is an inhibitor of human neutrophil elastase (HNE) with an IC50 of 20.3 μM. It effectively inhibits the hydrolysis of substrates like lung tissue elastin by HNE and is applicable in studies related to conditions such as chronic obstructive pulmonary disease (COPD).</p>Fórmula:C20H31ClN4O7Forma y color:SolidPeso molecular:474.936UK-370106
CAS:<p>UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-</p>Fórmula:C35H44N2O5Pureza:98%Forma y color:SolidPeso molecular:572.73SBI-581
<p>SBI-581: oral, potent TAO3 inhibitor, IC50=42nM, alters TKS5α at RAB11+ vesicles, blocks invadopodia, good mouse pharmacokinetics, anti-tumor.</p>Fórmula:C24H21N3O2Forma y color:SolidPeso molecular:383.44CE-2072
CAS:<p>CE-2072 is a synthetic host serine proteases inhibitor.</p>Fórmula:C33H41N5O6Pureza:98%Forma y color:SolidPeso molecular:603.71Tyrosinase-IN-20
CAS:<p>Tyrosinase-IN-20 (compound 6a) acts as a potent Tyrosinase inhibitor, demonstrating an IC 50 value of 28.50 μM [1].</p>Fórmula:C17H18N2O2SForma y color:SolidPeso molecular:314.4DPP-4-IN-15
CAS:<p>DPP-4-IN-15 (Compound 22) is a non-competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 value of 8.24 μM.</p>Fórmula:C17H14F3N3O2SForma y color:SolidPeso molecular:381.372Immunoproteasome activator 1
CAS:Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.Fórmula:C24H23N3O3Forma y color:SolidPeso molecular:401.46Anti-infective agent 10
CAS:<p>Anti-infective agent 10 (Compound Example 30) is an ns5b polymerase inhibitor that functions as an anti-HCV agent.</p>Fórmula:C26H25N3O7SForma y color:SolidPeso molecular:523.56Valopicitabine dihydrochloride
CAS:<p>Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>Fórmula:C15H25ClN4O6Forma y color:SolidPeso molecular:392.84TGase2-IN-1
CAS:<p>TGase2-IN-1 (Compound 22) is an orally effective TGase2 inhibitor with an IC50 of 1.12 µM. It inhibits TGase2 in human retinal microvascular endothelial cells with a strikingly lower IC50 of 0.07 µM. The oral bioavailability of TGase2-IN-1 is 74.6%. Additionally, it can suppress retinal vascular leakage in a mouse model of diabetes induced by Streptozotocin.</p>Fórmula:C23H25N3O3Forma y color:SolidPeso molecular:391.463-Aminobenzene-1,2-diol
CAS:<p>3-Aminobenzene-1,2-diol (compound C8) is an inhibitor of matrix metalloproteinases (MMP), with IC50 values of 20, 26, 16, and 16.3 μM against MMP-2, MMP-8, MMP-9, and MMP-14, respectively.</p>Fórmula:C6H7NO2Forma y color:SolidPeso molecular:125.13Boc3Arg
<p>Boc 3 Arg is a tert-butyl carbamate-protected arginine compound. It serves as an efficient tag that induces degradation by directly targeting proteins to the 20S proteasome.</p>Fórmula:C21H39N5O7Forma y color:SolidPeso molecular:473.56LK-732
CAS:<p>LK-732 is a thrombin inhibitor with antithrombotic activity. It exhibits dose-dependent inhibition in models of hypercoagulability, with an IC50 value of 1.3 mg/kg. LK-732 is used in cardiovascular and cerebrovascular research.</p>Fórmula:C25H29N5O3SForma y color:SolidPeso molecular:479.59Isobutylamido thiazolyl resorcinol
CAS:<p>Isobutylamido thiazolyl resorcinol is a tyrosinase (Tyrosinase) inhibitor that prevents pigment deposition induced by ultraviolet radiation.</p>Fórmula:C13H14N2O3SForma y color:SolidPeso molecular:278.33Idraparinux Na
CAS:<p>Idraparinux Na is an Antithrombotic, Indirect, Selective, Synthetic Factor Xa Inhibitor</p>Fórmula:C38H55Na9O49S7Forma y color:SolidPeso molecular:1727.14(2R,3S)-Emricasan
CAS:<p>(2R,3S)-Emricasan ((2R,3S)-PF 03491390) is an isomer of Emricasan. This compound acts as an orally effective irreversible pan-caspase inhibitor. (2R,3S)-Emricasan inhibits the increase in caspase-3 activity induced by Zika virus (ZIKV) and protects human cortical neural progenitor cells.</p>Fórmula:C26H27F4N3O7Forma y color:SolidPeso molecular:569.5BI-1942
CAS:<p>BI-1942 is a chymase inhibitor with an IC50 value of 0.4 nM against human chymase. It is applicable for research in ophthalmic diseases.</p>Fórmula:C24H26N4O4Forma y color:SolidPeso molecular:434.488HCV-IN-7
CAS:HCV-IN-7: potent oral HCV NS5A inhibitor, pan-genotypic, IC50s 3-47 pM, good pharmacokinetics, favorable liver uptake.Fórmula:C40H48N8O6SPureza:98%Forma y color:SolidPeso molecular:768.92GB111-NH2
CAS:GB111-NH2, a cysteine cathepsin inhibitor, is applicable in cancer research [1].Fórmula:C33H39N3O6Forma y color:SolidPeso molecular:573.68Cathepsin C-IN-5
CAS:<p>Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.</p>Fórmula:C21H17ClN6OSForma y color:SolidPeso molecular:436.92JBJ-08-178-01
CAS:JBJ-08-178-01, a mutant-selective tyrosine kinase inhibitor, targets (HER2) human epidermal growth factor receptor 2 and exhibits antitumoral activity. This compound not only diminishes HER2's kinase activity and protein levels through the induction of proteasomal degradation of the receptor but also shows promise in non-small-cell lung cancer research.Fórmula:C31H30N8O3Forma y color:SolidPeso molecular:562.62BI 224436
CAS:<p>BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.</p>Fórmula:C27H26N2O4Forma y color:SolidPeso molecular:442.51Narlaprevir
CAS:<p>Narlaprevir (SCH 900518) is an HCV NS3 inhibitor with anti-HCV activity, inhibiting SARS-CoV-2, and useful in virus infection research.</p>Fórmula:C36H61N5O7SPureza:98%Forma y color:SolidPeso molecular:707.96Beclabuvir
CAS:<p>Beclabuvir blocks HCV NS5B polymerase at thumb site 1, effective on genotypes 1, 3, 4, 5 with IC50 <28 nM.</p>Fórmula:C36H45N5O5SPureza:99.87% - 99.93%Forma y color:SolidPeso molecular:659.84Cathepsin C-IN-4
<p>Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM).</p>Fórmula:C21H14ClF3N4SForma y color:SolidPeso molecular:446.88HCV NS5B polymerase-IN-2
CAS:<p>HCVNS5B polymerase-IN-2 (Compound 298) is an inhibitor of the Ns5b polymerase. It holds potential for research into the treatment of hepatitis C virus (HCV) infections.</p>Fórmula:C26H24N2O4Forma y color:SolidPeso molecular:428.48M826
<p>M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity in</p>Fórmula:C28H45N7O6Pureza:98%Forma y color:SolidPeso molecular:575.7HCV-IN-38
<p>Potent oral HCV inhibitor HCV-IN-38 has 15 nM EC50, 431 SI, high efficacy, and low toxicity.</p>Fórmula:C22H24ClF3N4O4Forma y color:SolidPeso molecular:500.9Feniralstat
CAS:<p>Feniralstat (KVD-824) is a selective and potent kallikrein (kallikrein) inhibitor, useful in immune system diseases and cardiovascular disease research.</p>Fórmula:C26H25F2N5O4Pureza:99.52%Forma y color:SolidPeso molecular:509.51TCL1
CAS:<p>TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.</p>Fórmula:C19H14BrClN4O2SForma y color:SolidPeso molecular:477.762SD-2590 HCl
CAS:<p>SD-2590 HCl is an MMP-2,-3, -9, -8, 13, and -14 inhibitor.</p>Fórmula:C22H26ClF3N2O7SPureza:98%Forma y color:SolidPeso molecular:554.96SMCypI C31
<p>SMCypIC31, a non-peptide cyclophilin inhibitor, blocks PPIase at 0.1 μM IC50 and fights various HCV genotypes (EC50: 1.20-7.76 μM).</p>Fórmula:C27H30N4O2SForma y color:SolidPeso molecular:474.62Napsagatran hydrate
CAS:<p>Napsagatran hydrate is a novel and specific inhibitor of thrombin.</p>Fórmula:C26H36N6O7SPureza:98%Forma y color:SolidPeso molecular:576.66Cathepsin C-IN-3
<p>Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM).</p>Fórmula:C28H21F3N6OSForma y color:SolidPeso molecular:546.57Odiparcil
CAS:<p>Odiparcil is an orally active beta-d-thioxyloside analog.</p>Fórmula:C15H16O6SPureza:98%Forma y color:SolidPeso molecular:324.35ZINC09518833
CAS:<p>ZINC09518833 is an α-ketoamide non-peptide proteasome inhibitor with an IC50 value of 12.4 μM. It can bind with both the active and inactive sites of the proteasome. ZINC09518833 shows promise for use in research related to multiple myeloma (MM).</p>Fórmula:C24H25N3O5Forma y color:SolidPeso molecular:435.47Tyrosinase-IN-37
CAS:<p>Tyrosinase-IN-37 (Compound 3c) is a potent inhibitor of tyrosinase, with an IC50 value of 1.02 μM, which is 14 times more effective than kojic acid (IC50 of 14.74 μM). This compound effectively prevents the browning of Rosa roxburghii and can also inhibit browning not caused by tyrosinase.</p>Fórmula:C12H12N6SForma y color:SolidPeso molecular:272.33Plasma kallikrein-IN-2
<p>Plasma kallikrein-IN-2: PKal inhibitor, IC50=0.1 nM. Used in angioedema, diabetic eye disease research.</p>Fórmula:C28H24ClF3N8O3Forma y color:SolidPeso molecular:612.99TG-2-IN-4
CAS:<p>TG-2-IN-4 (compound 8), an inhibitor of transglutaminase 2 (TG2) with an IC 50 value of less than 0.5 mM, is utilized in the study of inflammatory disorders [1].</p>Fórmula:C34H40N6O5Forma y color:SolidPeso molecular:612.72
