Proteasas / Proteasoma
Los inhibidores de proteasas y proteasomas son compuestos que bloquean la actividad de las proteasas y del proteasoma, que están involucrados en la degradación y renovación de proteínas. Estos inhibidores son vitales para estudiar la regulación de la homeostasis proteica, el control del ciclo celular y la apoptosis. Los inhibidores de proteasas y proteasomas también se utilizan en el tratamiento de enfermedades como el cáncer, donde la degradación anormal de proteínas desempeña un papel en la progresión de la enfermedad. Al inhibir las proteasas o el proteasoma, estos compuestos pueden inducir la muerte celular en células cancerosas y son herramientas esenciales tanto en la investigación básica como en el desarrollo terapéutico. En CymitQuimica, ofrecemos una amplia gama de inhibidores de proteasas y proteasomas de alta calidad para apoyar su investigación en bioquímica, biología celular y desarrollo de fármacos.
Subcategorías de "Proteasas / Proteasoma"
- Acetil-CoA Carboxilasa(36 productos)
- Cisteína proteasa(110 productos)
- DPP-4(22 productos)
- Glutaminasa(45 productos)
- Proteasa del VIH(507 productos)
- PAI-1(26 productos)
- Inhibidores de la proteasa(50 productos)
- Receptor activado por proteasa(54 productos)
- Proteasoma(94 productos)
- Serina proteasa(55 productos)
- p97(15 productos)
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Se han encontrado 1058 productos de "Proteasas / Proteasoma"
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RBx-0597
CAS:RBx-0597 is a selective DPP-IV inhibitor with IC50 values of 32 nM, 31 nM, and 39 nM for human, mouse, and rat plasma DPP-IV, respectively. It is utilized in research focused on type 2 diabetes.Fórmula:C19H20F2N4O2Forma y color:SolidPeso molecular:374.384PNU-248686A
CAS:PNU-248686A is an inhibitor of matrix metalloproteinase (MMP).Fórmula:C22H18ClNaO5S2Pureza:98%Forma y color:SolidPeso molecular:484.95HCV-IN-40
CAS:HCV-IN-39 is a potent oral drug inhibiting HCV, effective on GT1a (EC50: 0.259μM), GT1b (EC50: 0.434μM), GT1b CES1 (EC50: 0.069μM) replicons.Fórmula:C21H26BrFN3O9PForma y color:SolidPeso molecular:594.32GSK5852
GSK5852, an HCV NS5B inhibitor, has IC50 of 50 nM; potently fights HCV with EC50 of 3.0 nM for GT1a and 1.7 nM for GT1b.Fórmula:C27H27BF2N2O6SForma y color:SolidPeso molecular:556.39CatD-IN-1
CAS:CatD-IN-1 (Compound 5) is a Cathepsin D inhibitor with an IC50 of 0.44 μM, and it shows potential for research in the field of osteoarthritis.Fórmula:C18H18Cl2N4O5Forma y color:SolidPeso molecular:441.265Cathepsin C-IN-4
Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM).Fórmula:C21H14ClF3N4SForma y color:SolidPeso molecular:446.88Narlaprevir
CAS:Narlaprevir (SCH 900518) is an HCV NS3 inhibitor with anti-HCV activity, inhibiting SARS-CoV-2, and useful in virus infection research.Fórmula:C36H61N5O7SPureza:98%Forma y color:SolidPeso molecular:707.96Zetomipzomib
CAS:KZR-616: Immunoproteasome inhibitor targeting LMP7 (IC50: 39/57 nM) & LMP2 (IC50: 131/179 nM), potential in autoimmune disease research.Fórmula:C30H42N4O8Forma y color:SolidPeso molecular:586.68JBIR-22
CAS:JBIR-22 is a natural inhibitor for protein−protein interaction of the homodimer of proteasome assembly factor 3.Fórmula:C23H33NO6Forma y color:SolidPeso molecular:419.51GLS-1-IN-1
GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor that inhibits Hep G2, MCF 7 and MCF 10A cells.Fórmula:C26H25FN4OSForma y color:SolidPeso molecular:460.57Freselestat
CAS:Freselestat (ONO-6818) inhibits neutrophil elastase, reduces interleukin 8, C5B-9, and inflammation in cardiopulmonary bypass.Fórmula:C23H28N6O4Forma y color:SolidPeso molecular:452.51DPP-4-IN-15
CAS:DPP-4-IN-15 (Compound 22) is a non-competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 value of 8.24 μM.Fórmula:C17H14F3N3O2SForma y color:SolidPeso molecular:381.372CM-352
CAS:CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.Fórmula:C24H29N3O6SPureza:97.24%Forma y color:SolidPeso molecular:487.57Tyrosinase-IN-33
CAS:Tyrosinase-IN-33 (compound 5), a pyridine-based compound, acts as an effective inhibitor of diphenolase activity in mushroom tyrosinase. It significantly reduces enzyme activity with an IC50 of 9.0 μM.Fórmula:C19H17NS2Forma y color:SolidPeso molecular:323.48BI-1942
CAS:BI-1942 is a chymase inhibitor with an IC50 value of 0.4 nM against human chymase. It is applicable for research in ophthalmic diseases.
Fórmula:C24H26N4O4Forma y color:SolidPeso molecular:434.488Freselestat quarterhydrate
ONO-6818 quarterhydrate: oral neutrophil elastase inhibitor, Ki 12.2 nM; >100x less effective on other proteases; strong anti-inflammatory.Fórmula:C23H30N6O5Forma y color:SolidPeso molecular:457.03Cathepsin K inhibitor 2
CAS:Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.Fórmula:C30H33F4N5O3Forma y color:SolidPeso molecular:587.61RIPK1-IN-26
CAS:RIPK1-IN-26 is a potent inhibitor of Receptor-Interacting Serine/Threonine Kinase 1 (RIPK1), exhibiting anti-necrotic properties in cells. This compound demonstrates good metabolic stability and binding specificity in mice. RIPK1-IN-26 holds potential for development as a PET imaging probe and in the research of neurodegenerative diseases.
Fórmula:C15H20FNO2Forma y color:SolidPeso molecular:265.32Plasma kallikrein-IN-2
Plasma kallikrein-IN-2: PKal inhibitor, IC50=0.1 nM. Used in angioedema, diabetic eye disease research.Fórmula:C28H24ClF3N8O3Forma y color:SolidPeso molecular:612.99Anti-infective agent 10
CAS:Anti-infective agent 10 (Compound Example 30) is an ns5b polymerase inhibitor that functions as an anti-HCV agent.Fórmula:C26H25N3O7SForma y color:SolidPeso molecular:523.56Immunoproteasome activator 1
CAS:Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.Fórmula:C24H23N3O3Forma y color:SolidPeso molecular:401.46M826
M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity inFórmula:C28H45N7O6Pureza:98%Forma y color:SolidPeso molecular:575.7Dup-714
CAS:Dup-714 is a thrombin inhibitor.Fórmula:C21H33BN6O5Pureza:98%Forma y color:SolidPeso molecular:460.33(2S,4R)-Teneligliptin
CAS:(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.Fórmula:C22H30N6OSForma y color:SolidPeso molecular:426.578Verducatib
CAS:Verducatib is an inhibitor of cathepsins (cathepsin).Fórmula:C31H35FN4O3Forma y color:SolidPeso molecular:530.633Napsagatran hydrate
CAS:Napsagatran hydrate is a novel and specific inhibitor of thrombin.Fórmula:C26H36N6O7SPureza:98%Forma y color:SolidPeso molecular:576.66BI 224436
CAS:BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.Fórmula:C27H26N2O4Forma y color:SolidPeso molecular:442.51AMG-222 tosylate
CAS:AMG-222 tosylate is a DPP-IV inhibitor in clinical development for type II diabetes.Fórmula:C39H47N9O6SForma y color:SolidPeso molecular:769.91Beclabuvir
CAS:Beclabuvir blocks HCV NS5B polymerase at thumb site 1, effective on genotypes 1, 3, 4, 5 with IC50 <28 nM.Fórmula:C36H45N5O5SPureza:99.87% - 99.93%Forma y color:SolidPeso molecular:659.84RXP03
CAS:RXP03 is an MMPs inhibitor with K_i values of 20 nM for MMP-2, 2.5 nM for MMP-8, 10 nM for MMP-9, 5 nM for MMP-11, and 105 nM for MMP-14 [1].Fórmula:C39H43N4O6PForma y color:SolidPeso molecular:694.76RO5461111
CAS:RO5461111: Oral Cathepsin S inhibitor, IC50 of 0.4 nM (human) & 0.5 nM (mouse), reduces T/B cell activation, treats lung inflammation & lupus nephritis.Fórmula:C27H24F6N4O4SForma y color:SolidPeso molecular:614.56Duazomycin sodium
CAS:Duazomycin (Duazomycin A) sodium acts as a glutamine antagonist. It significantly enhances the efficacy of 6-Mercaptopurine (6-MP) in treating experimental autoimmune encephalomyelitis (EAE) without increasing toxicity.Fórmula:C8H10N3NaO4Forma y color:SolidPeso molecular:235.17JBJ-08-178-01
CAS:JBJ-08-178-01, a mutant-selective tyrosine kinase inhibitor, targets (HER2) human epidermal growth factor receptor 2 and exhibits antitumoral activity. This compound not only diminishes HER2's kinase activity and protein levels through the induction of proteasomal degradation of the receptor but also shows promise in non-small-cell lung cancer research.Fórmula:C31H30N8O3Forma y color:SolidPeso molecular:562.62Marizomib
CAS:Marizomib is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L, CT-T-laspase-like, and trypsin-like 20S proteasomes.Cost-effective and quality-assured.Fórmula:C15H20ClNO4Pureza:98.03% - 99.41%Forma y color:SolidPeso molecular:313.78GW311616 hydrochloride
CAS:GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).Fórmula:C19H32ClN3O4SPureza:98%Forma y color:SolidPeso molecular:433.99HsClpP activator-1
CAS:HsClpP activator-1 (compound 24) is a potent activator of HsClpP, with an EC50 of 0.22 μM. It effectively inhibits cancer cell growth, exhibiting IC50 values ranging from 0.1 to 1 μM.Fórmula:C23H20F5N3O2Forma y color:SolidPeso molecular:465.42Belactin A
CAS:Belactin A acts as an inhibitor of vasohibin-1 [VASH-1] with an IC50 of 0.18 µg/ml.Fórmula:C17H21ClN2O4Forma y color:SolidPeso molecular:352.81MeO-Suc-Ala-Ala-Pro-Ala-CMK
CAS:MeO-Suc-Ala-Ala-Pro-Ala-CMK (MSACK) is an inhibitor of human neutrophil elastase (HNE) with an IC50 of 20.3 μM. It effectively inhibits the hydrolysis of substrates like lung tissue elastin by HNE and is applicable in studies related to conditions such as chronic obstructive pulmonary disease (COPD).Fórmula:C20H31ClN4O7Forma y color:SolidPeso molecular:474.936GSK-2878175
CAS:GSK-2878175, a NS5B inhibitor, is used potentially for the treatment of HCV infection.Fórmula:C27H23BClFN2O6SPureza:98%Forma y color:SolidPeso molecular:568.81BAY-7598
CAS:BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).Fórmula:C28H31N3O6Pureza:98%Forma y color:SolidPeso molecular:505.56Tilpisertib fosmecarbil
CAS:Tilpisertib fosmecarbil is a potent inhibitor of serine/threonine kinases with anti-inflammatory properties.Fórmula:C35H36ClN8O7PForma y color:SolidPeso molecular:747.14Gemigliptin tartrate hydrate
CAS:Gemigliptin (LC15-0444) tartrate hydrate is a selective, reversible, and competitive inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 value of 10.3 nM for human recombinant DPP-4. It exhibits strong anti-glycation properties and is used in research on advanced glycation end product-related diabetic complications.Fórmula:C22H27F8N5O9Forma y color:SolidPeso molecular:657.47SMCypI C31
SMCypIC31, a non-peptide cyclophilin inhibitor, blocks PPIase at 0.1 μM IC50 and fights various HCV genotypes (EC50: 1.20-7.76 μM).Fórmula:C27H30N4O2SForma y color:SolidPeso molecular:474.62MIV-247
CAS:MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.Fórmula:C17H24F3N3O4Pureza:99.27%Forma y color:SolidPeso molecular:391.39Vaniprevir
CAS:Vaniprevir is a competitive HCV NS3/4A protease inhibitor, an antiviral(hepatitis C virus) drug that acts directly and blocks the viral replication process.Fórmula:C38H55N5O9SPureza:97.41%Forma y color:SolidPeso molecular:757.94IDX184
CAS:IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3Fórmula:C25H35N6O9PSPureza:97.15%Forma y color:SolidPeso molecular:626.62JTK-109
CAS:JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.Fórmula:C37H33ClFN3O4Pureza:98.48% - 99.68%Forma y color:SolidPeso molecular:638.13Ref: TM-T27696
1mg313,00€5mg758,00€10mg1.035,00€25mg1.568,00€50mg2.118,00€100mg2.783,00€1mL*10mM (DMSO)A consultarPD 151746
CAS:PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.Fórmula:C11H8FNO2SPureza:98.63% - ≥95%Forma y color:SolidPeso molecular:237.25Sebetralstat
CAS:Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.
Fórmula:C26H26FN5O4Pureza:99.85%Forma y color:SolidPeso molecular:491.512,7,10,12-Tetraazatridecanoic acid, 4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3S,4S,6S,9S)-
CAS:Fórmula:C37H48N6O5S2Pureza:≥98%Forma y color:SolidPeso molecular:720.9442ALLM
CAS:ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].Fórmula:C19H35N3O4SPureza:98%Forma y color:White PowderPeso molecular:401.56IPN60090 dihydrochloride
CAS:IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.Fórmula:C24H29Cl2F3N8O3Forma y color:SolidPeso molecular:605.44ABT-072 potassium trihydrate
CAS:ABT-072, also known as potassium trihydrate, is a highly effective non-nucleoside inhibitor of the HCV NS5B polymerase, administered orally. This compound exhibits potent activity against HCV GT1a (with an EC50 of 1 nM) and HCV GT1b (with an EC50 of 0.3 nM).Fórmula:C24H32KN3O8SForma y color:SolidPeso molecular:561.69MMP13-IN-2
CAS:MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.Fórmula:C24H19FN6O4SForma y color:SolidPeso molecular:506.513-Deazaadenosine
CAS:3-Deazaadenosine, an inhibitor of S-adenosylhomocysteine hydrolase with a Ki of 3.9 μM, exhibits anti-inflammatory, anti-proliferative, and anti-HIV activity.Fórmula:C11H14N4O4Pureza:98%Forma y color:SolidPeso molecular:266.25Oxindole
CAS:Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.
Fórmula:C8H7NOPureza:99.34%Forma y color:Off-White Crystalline PowderPeso molecular:133.15Butabindide oxalate
CAS:CCK-inactivating serine protease (tripeptidyl peptidase II) inhibitorFórmula:C19H27N3O6Pureza:98%Forma y color:SolidPeso molecular:393.43Davelizomib
CAS:Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].
Fórmula:C21H26BF2N3O7Pureza:98%Forma y color:SolidPeso molecular:481.25
