Proteasas / Proteasoma
Los inhibidores de proteasas y proteasomas son compuestos que bloquean la actividad de las proteasas y del proteasoma, que están involucrados en la degradación y renovación de proteínas. Estos inhibidores son vitales para estudiar la regulación de la homeostasis proteica, el control del ciclo celular y la apoptosis. Los inhibidores de proteasas y proteasomas también se utilizan en el tratamiento de enfermedades como el cáncer, donde la degradación anormal de proteínas desempeña un papel en la progresión de la enfermedad. Al inhibir las proteasas o el proteasoma, estos compuestos pueden inducir la muerte celular en células cancerosas y son herramientas esenciales tanto en la investigación básica como en el desarrollo terapéutico. En CymitQuimica, ofrecemos una amplia gama de inhibidores de proteasas y proteasomas de alta calidad para apoyar su investigación en bioquímica, biología celular y desarrollo de fármacos.
Subcategorías de "Proteasas / Proteasoma"
- Acetil-CoA Carboxilasa(35 productos)
- Cisteína proteasa(96 productos)
- DPP-4(20 productos)
- Glutaminasa(40 productos)
- Proteasa del VIH(451 productos)
- PAI-1(25 productos)
- Inhibidores de la proteasa(50 productos)
- Receptor activado por proteasa(53 productos)
- Proteasoma(94 productos)
- Serina proteasa(49 productos)
- p97(14 productos)
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Se han encontrado 1039 productos de "Proteasas / Proteasoma"
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Rivulariapeptolides 988
<p>Rivulariapeptolides 988 inhibits serine proteases: chymotrypsin (IC50 = 95.46 nM), elastase (15.29 nM), proteinase K (85.50 nM).</p>Fórmula:C50H68N8O13Forma y color:SolidPeso molecular:989.12TWH106
<p>TWH106 is an inhibitor of the cyclophilin (Cyp) enzyme, exhibiting strong affinity for CypA and CypB with dissociation constants (KD) of 53 nM and 139 nM, respectively. It effectively inhibits the replication of HIV and HCV, demonstrating antiviral activity.</p>Forma y color:Odour SolidH-Gly-Pro-Hyp-OH
CAS:<p>H-Gly-Pro-Hyp-OH is a potent and oral anti-photoaging collagen peptide and improves the hydration of human skin, elasticity and anti-wrinkle properties.</p>Fórmula:C12H19N3O5Pureza:98.47%Forma y color:SolidPeso molecular:285.3PROTAC CG167
<p>PROTAC CG167 is a potent and selective PROTAC degrader of CypA. It degrades CypA in a dose-dependent manner in Jurkat cells, with a DC50 of 123 nM. Additionally, PROTAC CG167 exhibits antiviral activity by inhibiting HIV-1 and HCV. (Pink: CypA Ligand; Black: Linker; Blue: E3LigaseLigand)</p>Fórmula:C65H79N13O11SForma y color:SolidPeso molecular:1250.47Bortezomib analog
<p>Bortezomibanalog (Compound 13) is an analog of Bortezomib, functioning as an active control ligand for the 20S proteasome subunit β5.</p>Forma y color:Odour Solid5-epi-Arvestonate A
CAS:<p>5-epi-Arvestonate A, a sesquiterpenoid from Seriphidium transiliense, stimulates melanogenesis and suppresses IFN-γ-chemokine in HaCaT cells.</p>Fórmula:C16H26O5Forma y color:SolidPeso molecular:298.37HIV-1 Rev (34-50)
CAS:<p>HIV-1 Rev (34-50) (HIV-1 rev Protein (34-50)) is a 17 amino acid peptide with anti-HIV-1 activity.</p>Fórmula:C97H173N51O24Pureza:99.91%Forma y color:SolidPeso molecular:2437.74Rivulariapeptolides 1185
<p>Rivulariapeptolides 1185 inhibits serine proteases; IC50: chymotrypsin 13.17 nM, elastase 23.59 nM, proteinase K 55.26 nM.</p>Fórmula:C61H87N9O15Forma y color:SolidPeso molecular:1186.39Cathepsin D and E FRET Substrate
CAS:Mca-GKPILFFRL-Dpa-r-amide, FRET substrate for cathepsin D and E. Also cleaved by napsin A.Fórmula:C85H122N22O19Forma y color:SolidPeso molecular:1756.046MMP Inhibitor 4
MMP Inhibitor4 (compound 4 B) is an effective MMP inhibitor with anti-proliferative properties. It induces cell cycle arrest at the subG1 phase and reduces the mRNA expression of MMP2, MMP9, and VEGFA.Fórmula:C16H18BrClN2O5Forma y color:SolidPeso molecular:433.68Acetyl-Calpastatin (184-210)(human) acetate
<p>Acetyl-Calpastatin acetate inhibits µ-calpain (Ki=0.2nM) and cathepsin L (Ki=6μM) selectively and reversibly.</p>Fórmula:C144H234N36O46SPureza:97.84% - 98.16%Forma y color:SolidPeso molecular:3237.68FFAGLDD
<p>"FFAGLDD: MMP9 peptide for controlled DOX delivery inside cells."</p>Fórmula:C37H49N7O12Pureza:98%Forma y color:SolidPeso molecular:783.82Ac-Phe-Gly-pNA
CAS:<p>Ac-Phe-Gly-pNA is the chymotrypsin specific substrate [1] .</p>Fórmula:C19H20N4O5Forma y color:SolidPeso molecular:384.39Nostosin G
<p>Nostosin G, a linear peptide with Hpla, Hty, and argininal, inhibits trypsin effectively (IC50 = 0.1 μM).</p>Fórmula:C25H33N5O6Forma y color:SolidPeso molecular:499.56Ac-PAL-AMC
CAS:<p>Ac-PAL-AMC is a β1i/LMP2-specific substrate that fluoresces when cleaved; useful for measuring immunoproteasome activity.</p>Fórmula:C26H34N4O6Forma y color:SolidPeso molecular:498.57MMP-2 Inhibitor-4
<p>MMP-2Inhibitor-4 (Compound 5g) is an MMP-2 inhibitor with an IC50 of 152.62 nM. It effectively reduces MMP-2 levels in K562 cell lines by stably binding to the active site of MMP-2 and exhibits strong anti-angiogenic effects in ACHN cell lines. MMP-2Inhibitor-4 shows potential for research in chronic myelogenous leukemia (CML).</p>Fórmula:C19H23N3O5SForma y color:SolidPeso molecular:405.468GCPII-IN-1
CAS:<p>GCPII-IN-1, a potent PSMA inhibitor, binds with 44.3 nM affinity.</p>Fórmula:C12H21N3O7Forma y color:SolidPeso molecular:319.314Iso-VQA-ACC acetate
<p>Iso-VQA-ACC acetate serves as a substrate for the constitutive proteasome.</p>Forma y color:Odour SolidAristololactam IIIa
CAS:<p>Aristololactam IIIa inhibits superoxide and elastase generation; IC50: 0.12 μg/mL and 0.20 μg/mL.</p>Fórmula:C16H9NO4Forma y color:SolidPeso molecular:279.256,6′-Dihydroxythiobinupharidine
CAS:<p>6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-fold</p>Fórmula:C30H42N2O4SForma y color:SolidPeso molecular:526.73
